One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 2576-47-8, formula is C2H7Br2N, Name is 2-Bromoethylamine hydrobromide, Related Products of 2576-47-8
Huang, Jingsheng;Huang, Jiaguo;Cheng, Penghui;Jiang, Yuyan;Pu, Kanyi research published ã?Near-Infrared Chemiluminescent Reporters for In Vivo Imaging of Reactive Oxygen and Nitrogen Species in Kidneysã? the research content is summarized as follows. Despite the superior sensitivity of chemiluminescence over fluorescence, most chemiluminescence reporters only emit visible light, and have low water solubility, making them poorly equipped for in vivo imaging applications. Herein two near-IR (NIR) chemiluminescent reporters (NCRs) with high renal clearance for real-time imaging of reactive oxygen and nitrogen species in the kidneys were synthesized. NCRs comprise a β-cyclodextrin unit and a modified dicyanomethylene-4H-pyran containing Schaapâ²s dioxetane as the renal-clearance enabler and the chemiluminescent moiety, resp. NCR1 and NCR2 specifically activate their NIR chemiluminescence towards superoxide anion (O2â?) and peroxynitrite (ONOO–), resp. By virtue of their nanomolar sensitivity and high renal clearance, NCRs not only detect subtle upregulation of endogenous RONS in cells but also enable noninvasive monitoring of RONS in the kidneys under nephrotoxic exposure. The earlier activation of NCR1 relative to NCR2 implies the sequential upregulation of O2â? and ONOO– during drug-induced acute kidney injury (AKI). Moreover, detection of the fluorescence of excreted NCRs permits urinalysis of AKI, detecting the upregulation of RONS at least 24 h earlier than histol. anal. Thus, this study not only introduces ultrasensitive NIR chemiluminescent probes but also provides guidelines to transform them into legitimate imaging agents for organ-specific in vivo detection.
2576-47-8, 2-Bromoethylamine hydrobromide is a useful building block for proteomics research.
2-Bromoethylamine hydrobromide is used in the synthesis of analogs of 5,â?0,â?5,â?0-âtetrakis(1-âmethylpyridinium-â?-âyl)âporphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist. It is used to construct C2-symmetric imidazolidinylidene ligands with a dioxolane backbone.
2-Bromoethylamine Hydrobromide is used in the synthesis of analogs of 5,â?0,â?5,â?0-âtetrakis(1-âmethylpyridinium-â?-âyl)âporphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist.
2-Bromoethylamine hydrobromide is a nonsteroidal anti-inflammatory drug that is used to treat inflammation and pain. It is a prodrug that is hydrolyzed in vivo to its active form, 2-Bromoethylamine hydrobromide. The bound form of this drug has been shown to inhibit the development of cell nuclei in the nucleus of cells. This drug also inhibits the production of nitric oxide, which leads to cell death by necrosis. 2-Bromoethylamine hydrobromide has been shown to have an inhibitory effect on the activity of glycol ethers, which are used as solvents for resins in coatings and adhesives., Related Products of 2576-47-8
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary