On February 7, 2018, Neuzil, Jiri; Werner, Lukas; Stursa, Jan published a patent.Application of 83152-22-1 The title of the patent was Triphenylphosphonium biguanide analogs, the method of their preparation and their use as a medication. And the patent contained the following:
Biguanides R5R4NC(:NR6)NR3C(:NR7)NR1R2·HX (1, R1-R7 = H, C1-6 alkyl, aralkyl, or substituent ZPPh3+Y-, where Z = linear C2-C20 alkylene, preferably, C8-12 alkylene), useful as antidiabetic agents, for treatment of Diabetes mellitis type II, and diabetes-induced tumors, were prepared by quaternization of PPh3 with 1,ω-dihaloalkanes XZX (2, X = halo), amination of resulting haloalkylphosphonium salts XZPPh3+X- with ammonia or primary amines R1NH2 and reaction with cyanoguanidines R5R4NC(:NR6)NCN. The prepared compounds 1 were examined for growth inhibition and apoptosis of pancreatic cell lines, for suppression of mitochondrial respiration through inhibition of complex I and increase of production of ROS. The experimental process involved the reaction of (6-Bromohexyl)triphenylphosphonium bromide(cas: 83152-22-1).Application of 83152-22-1
The Article related to biguanide phosphonium salt derivative preparation antidiabetic antitumor agent, pancreatic tumor cell line inhibition biguanide phosphonium salt, mitochondrial respiration inhibition tumor cell line biguanide phosphonium salt, reactive oxygen species generation tumor cell line biguanide phosphonium and other aspects.Application of 83152-22-1
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary