On May 6, 1999, Thompson, Mervyn; Harling, John David; Edwards, Peter David published a patent.Product Details of 90326-61-7 The title of the patent was Preparation of substituted isoquinolines as anticonvulsants. And the patent contained the following:
The title compounds [I; n, p = 1-4 and n + p = 2-5; R1 = H, cycloalkylO, etc.; R2 = H, halo, CN, etc.; R3 = H, halo, NO2, etc.; R2R3 = (un)substituted (un)saturated carbocyclic ring; R4 = H, alkyl, alkenyl, etc.], useful as anticonvulsants, were prepared Thus, conversion of 2-ethoxy-4-isopropyl-5-cyanobenzoic acid into the acid chloride followed by coupling with 5-amino-2-methyl-1,2,3,4-tetrahydroisoquinoline afforded 60% II.HCl which showed a 336% increase in seizure threshold for rat MEST. Compounds I are useful in the prophylaxis and treatment of anxiety, mania, depression, panic disorders and/or aggression, disorders associated with a subarachnoid hemorrhage or neural shock, the effects associated with withdrawal from substances of abuse such as cocaine, nicotine, alc. and benzodiazepines, disorders treatable and/or preventable with anti-convulsive agents, such as epilepsy including post-traumatic epilepsy, Parkinson’s disease, psychosis, migraine, cerebral ischemia, Alzheimer’s disease and other degenerative diseases such as Huntington’s chorea, schizophrenia, obsessive compulsive disorders (OCD), neurol. deficits associated with AIDS, sleep disorders (including circadian rhythm disorders, insomnia and narcolepsy), tics (e.g. Giles de la Tourette’s syndrome), traumatic brain injury, tinnitus, neuralgia, especially trigeminal neuralgia, neuropathic pain, dental pain, cancer pain, inappropriate neuronal activity resulting in neurodysthesias in diseases such as diabetes, multiple sclerosis (MS) and motor neuron disease, ataxias, muscular rigidity (spasticity), temporomandibular joint dysfunction and amyotrophic lateral sclerosis (ALS). The experimental process involved the reaction of 5-Bromo-2-methoxy-4-methylbenzoic acid(cas: 90326-61-7).Product Details of 90326-61-7
The Article related to isoquinoline preparation anticonvulsant, anxiolytic isoquinoline preparation, antidepressant isoquinoline preparation, substance abuse isoquinoline preparation, parkinson disease isoquinoline preparation, alzheimer disease isoquinoline preparation, antipsychotic isoquinoline preparation, huntington chorea isoquinoline preparation and other aspects.Product Details of 90326-61-7
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary