Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides. 402-49-3, formula is C8H6BrF3, Name is 1-(Bromomethyl)-4-(trifluoromethyl)benzene. Organic compounds having carbon bonded to bromine are called organic bromides. Recommanded Product: 1-(Bromomethyl)-4-(trifluoromethyl)benzene.
Judge, Neil R.;Chacktas, Geraud;Ma, Ling;Schink, Anke;Buckpesch, Rainer;Schmutzler, Dirk;Machettira, Anu B.;Dietrich, Hansjorg;Asmus, Elisabeth;Bierer, Donald;McLeod, Michael C. research published 《 Flexible Synthesis and Herbicidal Activity of Fully Substituted 3-Hydroxypyrazoles》, the research content is summarized as follows. The synthesis and herbicidal efficacy of a novel library of fully substituted 3-hydroxypyrazoles I (R1 = H, Me, Et, i-Pr, 2-methoxyethyl; R2 = H, 2,4-F2, 3,4-F2, 3-Cl, etc.; A = O, S, CH2, etc.) is reported. An efficient, divergent approach to introduce Ph, phenoxy, phenylsulfanyl, anilino and benzyl substituents in the 4-position of the pyrazole, alongside a flexible synthesis of N1-alkyl analogs I is described via final step diversification of key intermediates. Herbicidal screening of the prepared compounds against key weed species identified the lead compound I (R1 = Me; R2 = H, 2,4-F2; A = O), which was prepared on a multi-gram scale using an optimized synthetic route.
402-49-3, 4-Trifluoromethylbenzyl bromide is a useful research compound. Its molecular formula is C8H6BrF3 and its molecular weight is 239.03 g/mol. The purity is usually 95%.
4-Trifluoromethylbenzyl bromide is a choline derivative that acts as an anticancer agent. It is structurally similar to the anticancer drug doxorubicin, which has been shown to be effective against breast cancer and leukemia. 4-Trifluoromethylbenzyl bromide interacts with cellular proteins, including choline kinase, and inhibits the mitochondrial pathway. This leads to cell death through apoptosis. The molecule also interacts with nucleotide bases such as thymine and cytosine in DNA, inhibiting transcription and replication. 4-Trifluoromethylbenzyl bromide binds strongly to the hydroxyl group of cholesterol by an electrophilic substitution mechanism to form a covalent bond with its hydroxy group. The molecule can also bind to chloride ions by an ionic bond., Recommanded Product: 1-(Bromomethyl)-4-(trifluoromethyl)benzene
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary