Organic compounds having carbon bonded to bromine are called organic bromides. 1575-37-7, formula is C6H7BrN2, Name is 4-Bromobenzene-1,2-diamine. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Recommanded Product: 4-Bromobenzene-1,2-diamine.
Komuraiah, Buduma;Ren, Yichang;Xue, Mingming;Cheng, Binbin;Liu, Jin;Liu, Yao;Chen, Jianjun research published 《 Design, synthesis and biological evaluation of benz-fused five-membered heterocyclic compounds as tubulin polymerization inhibitors with anticancer activities》, the research content is summarized as follows. A series of benz-fused five-membered heterocyclic compounds such as I [R1 = H, Me, Br, etc.; R2 = H, Br, NH2, etc; X = O, S] were designed and synthesized as novel tubulin inhibitors targeting the colchicine binding site. Among them, compound I [R1 = Br, R2 = H, X = S] displayed the highest antiproliferative activity against four cancer cell lines. Compound I [R1 = Br, R2 = H, X = S] effectively inhibited tubulin polymerization in vitro. Further, compound I [R1 = Br, R2 = H, X = S] induced cell cycle arrest in G2/M phase. Finally, compound I [R1 = Br, R2 = H, X = S] inhibited the migration of cancer cells in a dose-dependent manner. In summary, these results suggested that compound I [R1 = Br, R2 = H, X = S] represented a new class of tubulin inhibitors deserving further investigation.
1575-37-7, 4-Bromo-1,2-diaminobenzene can be obtained from 1,2-diaminobenzene via acetylation followed by bromination and alkaline hydrolysis.
4-Bromobenzene-1,2-diamine, also known as 4-Bromobenzene-1,2-diamine, is a useful research compound. Its molecular formula is C6H7BrN2 and its molecular weight is 187.04 g/mol. The purity is usually 95%.
4-Bromo-1,2-diaminobenzene is a dye that is used in diagnostic
procedures to detect the presence of amide groups. 4-Bromo-1,2-diaminobenzene can be used as an inhibitor for cationic polymerization reactions. It also has tuberculostatic activity and inhibits the growth of Mycobacterium tuberculosis. This compound reacts with aniline to form a benzimidazole derivative that contains a reactive amine group. The reaction between this amine group and different electrophiles generates benzimidazole compounds with different properties that are useful in nucleophilic attack reactions. The reaction between 4-bromo-1,2-diaminobenzene and methyl ethyl sulfide produces a luminescent probe that can be used to detect hydrogen bonds., Recommanded Product: 4-Bromobenzene-1,2-diamine
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary