Organic compounds having carbon bonded to bromine are called organic bromides. 585-76-2, formula is C7H5BrO2, Name is 3-Bromobenzoic acid. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Application of C7H5BrO2.
Li, Peng;Liu, Ying;Yang, Hua;Liu, Hong-Min research published 《 Design, synthesis, biological evaluation and structure-activity relationship study of quinazolin-4(3H)-one derivatives as novel USP7 inhibitors》, the research content is summarized as follows. The design, synthesis and biol. evaluation of novel I [R1 = pyrrolyl, Ph, pyridinyl, etc.] and II [R2 = Et, furanyl, dimethylaminomethylene, etc.;R3 = H, methyl] as potent USP7 inhibitors was reported. This results indicated that the compounds II [R2 = pyrrolidinylmethylene, dimethylaminomethylene;R3 = H, methyl] exhibited the greatest potency against the USP7 catalytic domain, with IC50 values of 4.86μM and 1.537μM, resp. Ub-AMC assays further confirmed IC50 values of 5.048μM and 0.595μM for II [R2 = pyrrolidinylmethylene, dimethylaminomethylene; R3 = H, methyl] resp. MTT assays indicated that gastric cancer MGC-803 cells were more sensitive to these compounds than BGC-823 cells. Flow cytometry anal. revealed that II [R2 = pyrrolidinylmethylene; R3 = H ] restricted cancer cell growth at the G0/G1 and S phases and inhibited the proliferation and clone formation of MGC-803 cells. Further biochem. experiments indicated that II [R2 = pyrrolidinylmethylene; R3 = H ] decreased the MDM2 protein level and increased the levels of the tumor suppressors p53 and p21 in a dose-dependent manner. Docking studies predicted that solvent exposure of the side chains of II [R2 = pyrrolidinylmethylene, dimethylaminomethylene; R3 = H, methyl] would uniquely form hydrogen bonds with Met407 of USP7. Addnl., II [R2 = pyrrolidinylmethylene; R3 = H ] exhibited a remarkable anticancer effect in a zebrafish gastric cancer MGC-803 cell model. Results demonstrated that I [R1 = pyrrolyl, Ph, pyridinyl, etc.] and II [R2 = Et, furanyl, dimethylaminomethylene etc.; R3 = H, methyl] were suitable as leads for the development of novel USP7 inhibitors and especially for anti-gastric cancer drugs.
585-76-2, 3-bromobenzoic acid is a bromobenzoic acid carrying a single bromo subsituent at the 3-position.
3-Bromobenzoic acid, also known as 3-Bromobenzoic acid, is a useful research compound. Its molecular formula is C7H5BrO2 and its molecular weight is 201.02 g/mol. The purity is usually 95%.
3-bromobenzoic acid is used as a reagent in the synthesis of deoxypodophyllotoxin derivatives with insecticidal activity. Also used as a reagent in the synthesis of thiazole derivatives with antibacterial activity.
3-bromobenzoic acid is a molecule that is classified as a Group P2. It has an electronegativity of 1.3 and an acidity of 0.8, which are both in the middle range of values for this group. 3-Bromobenzoic acid is soluble in water and is soluble in ethanol, acetone, and ether. The chemical structure of 3-bromobenzoic acid can be determined by its monoclonal antibody binding sites, electrochemical impedance spectroscopy data, and Langmuir adsorption isotherm data. 3-Bromobenzoic acid reacts with hydrochloric acid to form benzoate and HCl gas. Chronic exposure to 3-bromobenzoic acid has been shown to cause glutamate dehydrogenase inhibition, leading to an accumulation of p-hydroxybenzoic acid in the body. , Application of C7H5BrO2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary