A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 90-59-5, formula is C7H4Br2O2, Name is 3,5-Dibromo-2-hydroxybenzaldehyde. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Synthetic Route of 90-59-5.
Mishra, Nilima Priyadarsini;Mohapatra, Seetaram;Sahoo, Chita Ranjan;Raiguru, Bishnu Prasad;Nayak, Sabita;Jena, Subhrakant;Padhy, Rabindra Nath research published 《 Design, one-pot synthesis, molecular docking study, and antibacterial evaluation of novel 2H-chromene based imidazo[1,2-a]pyridine derivatives as potent peptide deformylase inhibitors》, the research content is summarized as follows. An efficient, environmentally friendly, one-pot three-component synthesis of a series of 2H-chromene-based imidazo[1,2-a]pyridines I [R = H, Ph; R1 = H, Cl, Br, MeO; R2 = H, MeO; R3 = H, Cl, Br, MeO, EtO] was designed and were synthesized. This protocol was developed by the reaction of substituted 2H-chromene aldehydes and 2-aminopyridine in a mixture of nitroalkane and DMF under microwave irradiation at 60W, 100°C in 15 min with the presence of FeCl3 as the catalyst. The products were obtained in excellent yields with high functional group tolerance. All these compounds had been investigated further in vitro for evaluation of antibacterial potency by agar-well diffusion method against human pathogenic Gram-pos. and Gram-neg. bacteria, with the determination of min. inhibitory concentration (MIC) values. Indeed, compound 2-(3H-benzo[f]chromen-2-yl)imidazo[1,2-a]pyridine strongly inhibited peptide deformylase (MIC = 16μg/mL) in the Gram-neg. Escherichia coli, in silico. From structure-activity relationships based on the biol. and mol. docking results and the potent antibacterial activities, it could be stated that the selected synthetic compounds could be used as potent drugable antibacterial agents.
Synthetic Route of 90-59-5, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.
3,5-Dibromosalicylaldehyde, also known as 3,5-Dibromosalicylaldehyde, is a useful research compound. Its molecular formula is C7H4Br2O2 and its molecular weight is 279.91 g/mol. The purity is usually 95%.
3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes. 3,5-Dibromosalicylaldehyde can be used in the synthesis of Schiff base and can be used as reactant for synthesis of Schiff base ligands which forms mononuclear complexes with copper(II), nickel(II), zinc(II) and cobalt(II).
3,5-Dibromosalicylaldehyde is a copper complex that has been synthesized from 3,5-dibromosalicylaldehyde and copper chloride. FTIR spectroscopy revealed that the coordination geometry of the copper complex is octahedral with two nitrogen atoms in the equatorial plane. The presence of hydrogen bonding interactions was confirmed by homologous protein adsorption experiments. This chemical structure was determined using X-ray crystallography and fluorescence probe experiments. The copper complex showed high affinity for malonic acid, which is an ester hydrochloride. The molecular mechanism of this interaction is based on adsorption, which occurs through hydrogen bonding interactions and hydrophobic interactions. Structural analysis revealed that the polymeric matrix consists of a three-dimensional network of crosslinked chains, while FTIR analysis indicated a possible disulfide bond between two cysteine residues., 90-59-5.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary