Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 2576-47-8, formula is C2H7Br2N, Name is 2-Bromoethylamine hydrobromide. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Reference of 2576-47-8.
Miyaji, Akimitsu;Amao, Yutaka research published 《 Visible-Light Driven CO2 Reduction to Formate with Electron Mediated Nicotinamide-Modified Viologen in the System of Water-Soluble Zinc Porphyrin and Formate Dehydrogenase》, the research content is summarized as follows. Visible-light driven CO2 reduction to formate with the system consisting of water-soluble zinc tetraphneylporphyrin tetrasulfonate (ZnTPPS), formate dehydrogenase from Candida boidinii (CbFDH) and 1-nicotinamidethy-1′-methyl-4,4′- bipyridinium salt (NEMBP) in the presence of triethanolamine (TEOA) as an electron donor was investigated. NEMBP was prepared as the 4,4′-BP with the nicotinamide-group to promote the improvement of affinity with CbFDH. The properties of NEMBP were characterized by photochem. and electrochem. methods. In order to evaluate the affinity between cation radical of NEMBP (NEMBP+.), as a co-enzyme and CbFDH, the energy level based on simple docking simulation and d. functional theory were estimated It was speculated that NEMBP+. could bind near the substrate binding pocket of CbFDH as well as NAD+ by docking simulation. In the visible-light driven NEMBP reduction with the sensitization of ZnTPPS in the presence of TEOA, the yield for reduction of NEMBP to NEMBP+. was estimated to be 80%. In the CO2 reduction to formate with the system consisting of TEOA, ZnTPPS, NEMBP and CbFDH, the turnover numbers of NEMBP and CbFDH were estimated to be 0.14 and 1.53 h-1, resp.
2576-47-8, 2-Bromoethylamine hydrobromide is a useful building block for proteomics research.
2-Bromoethylamine hydrobromide is used in the synthesis of analogs of 5,10,15,20-tetrakis(1-methylpyridinium-4-yl)porphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist. It is used to construct C2-symmetric imidazolidinylidene ligands with a dioxolane backbone.
2-Bromoethylamine Hydrobromide is used in the synthesis of analogs of 5,10,15,20-tetrakis(1-methylpyridinium-4-yl)porphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist.
2-Bromoethylamine hydrobromide is a nonsteroidal anti-inflammatory drug that is used to treat inflammation and pain. It is a prodrug that is hydrolyzed in vivo to its active form, 2-Bromoethylamine hydrobromide. The bound form of this drug has been shown to inhibit the development of cell nuclei in the nucleus of cells. This drug also inhibits the production of nitric oxide, which leads to cell death by necrosis. 2-Bromoethylamine hydrobromide has been shown to have an inhibitory effect on the activity of glycol ethers, which are used as solvents for resins in coatings and adhesives., Reference of 2576-47-8
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary