Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 402-49-3, formula is C8H6BrF3, Name is 1-(Bromomethyl)-4-(trifluoromethyl)benzene. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Related Products of 402-49-3.
Ravu, Ranga Rao;Jacob, Melissa R.;Khan, Shabana I.;Wang, Mei;Cao, Liang;Agarwal, Ameeta K.;Clark, Alice M.;Li, Xing-Cong research published 《 Synthesis and Antifungal Activity Evaluation of Phloeodictine Analogues》, the research content is summarized as follows. The phloeodictine-based 6-hydroxy-2,3,4,6-tetrahydropyrrolo[1,2-a]pyrimidinium structural moiety with an n-tetradecyl side chain at C-6 has been demonstrated to be a new antifungal template. Thirty-four new synthetic analogs with modifications of the bicyclic tetrahydropyrrolopyrimidinium skeleton and the N-1 side chain have been prepared and evaluated for in vitro antifungal activities against the clin. important fungal pathogens including Cryptococcus neoformans ATCC 90113, Candida albicans ATCC 90028, Candida glabrata ATCC 90030, Candida krusei ATCC 6258, and Aspergillus fumigatus ATCC 90906. Nineteen compounds showed antifungal activities against the aforementioned five fungal pathogens with min. inhibitory concentrations (MICs) in the range 0.88-10μM, and all were fungicidal with min. fungicidal concentrations (MFCs) similar to the resp. MIC values. Three compounds were especially active against C. neoformans ATCC 90113 with MIC/MFC values of 1.0/1.0, 1.6/1.6, and 1.3/2.0μM but exhibited low cytotoxicity with an IC50 > 40μM against the mammalian Vero cells. The structure and antifungal activity relationship indicates that synthetic modifications of the phloeodictines can afford analogs with potent antifungal activity and reduced cytotoxicity, necessitating further preclin. studies of this new class of antifungal compounds
402-49-3, 4-Trifluoromethylbenzyl bromide is a useful research compound. Its molecular formula is C8H6BrF3 and its molecular weight is 239.03 g/mol. The purity is usually 95%.
4-Trifluoromethylbenzyl bromide is a choline derivative that acts as an anticancer agent. It is structurally similar to the anticancer drug doxorubicin, which has been shown to be effective against breast cancer and leukemia. 4-Trifluoromethylbenzyl bromide interacts with cellular proteins, including choline kinase, and inhibits the mitochondrial pathway. This leads to cell death through apoptosis. The molecule also interacts with nucleotide bases such as thymine and cytosine in DNA, inhibiting transcription and replication. 4-Trifluoromethylbenzyl bromide binds strongly to the hydroxyl group of cholesterol by an electrophilic substitution mechanism to form a covalent bond with its hydroxy group. The molecule can also bind to chloride ions by an ionic bond., Related Products of 402-49-3
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary