Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 402-49-3, formula is C8H6BrF3, Name is 1-(Bromomethyl)-4-(trifluoromethyl)benzene. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Application of C8H6BrF3.
Saint-Jacques, Kevin;Ladd, Carolyn L.;Charette, Andre B. research published 《 Access to hexahydroazepinone heterocycles via palladium-catalysed C(sp3)-H alkenylation/ring-opening of cyclopropanes》, the research content is summarized as follows. Synthesis of novel hexahydroazepinone derivatives I [R = H, 8-tert-Bu, 8-Ph, etc.; R1 = Me, Bn, 2-BrC6H4CH2, etc.; n = 1,2,3] starting from N-cyclopropyl-N-methylcycloalkene-carboxamides in presence of a readily available palladium catalyst was repored. The reaction proceeded through a selective C(sp3)-H alkenylation/ring-opening process to obtain the seven-membered ring products I in good to excellent yields on a wide variety of substrates under batch, microwave and continuous flow conditions.
Application of C8H6BrF3, 4-Trifluoromethylbenzyl bromide is a useful research compound. Its molecular formula is C8H6BrF3 and its molecular weight is 239.03 g/mol. The purity is usually 95%.
4-Trifluoromethylbenzyl bromide is a choline derivative that acts as an anticancer agent. It is structurally similar to the anticancer drug doxorubicin, which has been shown to be effective against breast cancer and leukemia. 4-Trifluoromethylbenzyl bromide interacts with cellular proteins, including choline kinase, and inhibits the mitochondrial pathway. This leads to cell death through apoptosis. The molecule also interacts with nucleotide bases such as thymine and cytosine in DNA, inhibiting transcription and replication. 4-Trifluoromethylbenzyl bromide binds strongly to the hydroxyl group of cholesterol by an electrophilic substitution mechanism to form a covalent bond with its hydroxy group. The molecule can also bind to chloride ions by an ionic bond., 402-49-3.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary