Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 4897-84-1, formula is C5H9BrO2, The most pervasive is the naturally produced bromomethane. Category: bromides-buliding-blocks
Stachel, Shawn J.;Egbertson, Melissa S.;Wai, Jenny;Machacek, Michelle;Toolan, Dawn M.;Swestock, John;Eddins, Donnie M.;Puri, Vanita;McGaughey, Georgia;Su, Hua-Poo;Perlow, Debbie;Wang, Deping;Ma, Lei;Parthasarathy, Gopal;Reid, John C.;Abeywickrema, Pravien D.;Smith, Sean M.;Uslaner, Jason M. research published 《 Indole acids as a novel PDE2 inhibitor chemotype that demonstrate pro-cognitive activity in multiple species》, the research content is summarized as follows. An internal HTS effort identified a novel PDE2 inhibitor series that was subsequently optimized for improved PDE2 activity and off-target selectivity. The optimized lead, compound 4, improved cognitive performance in a rodent novel object recognition task as well as a non-human primate object retrieval task. In addition, co-crystallization studies of close analog of 4 in the PDE2 active site revealed unique binding interactions influencing the high PDE isoform selectivity.
Category: bromides-buliding-blocks, Methyl 4-bromobutyrate,also as known as 4-Bromobutyric acid methyl ester, is a useful research compound. Its molecular formula is C5H9BrO2 and its molecular weight is 181.03 g/mol. The purity is usually 95%.
4-Bromobutyric acid methyl ester is a synthetic compound that can be used to inhibit the activity of the G1 phase cyclin-dependent kinases. It has been shown to inhibit protein synthesis by alkylating the amino groups of proteins and fatty acids. 4-Bromobutyric acid methyl ester also inhibits the growth of cancer cell lines, such as renal carcinoma cells. The mechanism of action for this drug is not well understood, but it may be due to its ability to bind with monoclonal antibodies and enter kidney cells by passive diffusion., 4897-84-1.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary