One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 823-78-9, formula is C7H6Br2, Name is 1-Bromo-3-(bromomethyl)benzene, Safety of 1-Bromo-3-(bromomethyl)benzene
Stefanucci, Azzurra;Iobbi, Valeria;Della Valle, Alice;Scioli, Giuseppe;Pieretti, Stefano;Minosi, Paola;Mirzaie, Sako;Novellino, Ettore;Mollica, Adriano research published 《 In Silico Identification of Tripeptides as Lead Compounds for the Design of KOR Ligands》, the research content is summarized as follows. The kappa opioid receptor (KOR) represents an attractive target for the development of drugs as potential antidepressants, anxiolytics and analgesics. A robust computational approach may guarantee a reduction in costs in the initial stages of drug discovery, novelty and accurate results. In this work, a virtual screening workflow of a library consisting of ∼6 million mols. was set up, with the aim to find potential lead compounds that could manifest activity on the KOR. This in silico study provides a significant contribution in the identification of compounds capable of interacting with a specific mol. target. The main computational techniques adopted in this exptl. work include: (i) virtual screening; (ii) drug design and leads optimization; (iii) mol. dynamics. The best hits are tripeptides prepared via solution phase peptide synthesis. These were tested in vivo, revealing a good antinociceptive effect after s.c. administration. However, further work is due to delineate their full pharmacol. profile, in order to verify the features predicted by the in silico outcomes.
823-78-9, 3-Bromobenzyl bromide undergoes reduction with diethylzinc in the presence of Pd(PPh3)4 to yield corresponding hydrocarbon.
3-Bromobenzyl bromide is a useful research compound. Its molecular formula is C7H6Br2 and its molecular weight is 249.93 g/mol. The purity is usually 95%.
3-Bromobenzyl bromide is a molecule that has been synthesized and shown to have anticancer activity. It inhibits the activity of cancer cells by binding to amines in these cells and preventing the formation of hydrogen bonds between these molecules. 3-Bromobenzyl bromide has also been shown to selectively inhibit the activity of NS5B polymerase, an enzyme that is important in the replication of the hepatitis C virus. The synthetic nature of this molecule makes it an attractive target for analytical methods such as nuclear magnetic resonance spectroscopy. This molecule also shows significant cytotoxicity against cancer cell lines in vitro, as well as inducing tumor necrosis factor-alpha (TNF-α) production in lps-stimulated murine macrophages., Safety of 1-Bromo-3-(bromomethyl)benzene
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary