Month: October 2022

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 6911-87-1, formula is C7H8BrN, Name is 4-Bromo-N-methylaniline. Organobromine compounds have fallen under increased scrutiny for their environmental impact., SDS of cas: 6911-87-1.

Guo, Zhiqiang;Pang, Tengfei;Yan, Leilei;Wei, Xuehong;Chao, Jianbin;Xi, Chanjuan research published 《 CO₂-tuned highly selective reduction of formamides to the corresponding methylamines》, the research content is summarized as follows. Herein an efficient, CO₂-tuned and highly selective C-O bond cleavage of N-methylated formanilides is described. With easy-to-handle and com. available NaBH₄ as the reductant, a variety of formanilides could be turned into the desired tertiary amines in moderate to excellent yields. The role of CO₂ has been investigated in detail, and the mechanism is proposed on the basis of experiments

SDS of cas: 6911-87-1, 4-Bromo-N-methylaniline is a aniline based compound known to exhibit mutagenic properties.
4-Bromo-N-methylaniline is a useful research compound. Its molecular formula is C7H8BrN and its molecular weight is 186.05 g/mol. The purity is usually 95%.
4-Bromophenylmethylamine is an organic compound that has anti-inflammatory properties and is used as a pharmaceutical. It belongs to the group of amines. The hydrolysis of 4-bromophenylmethylamine by hydrochloric acid produces phenol and bromamine (NHBr). The reaction system can be used to synthesize a number of compounds, including anilines, benzofurans, and other aromatic compounds. 4-Bromophenylmethylamine reacts with muscle tissue in a similar manner as acetaminophen does. This drug also has been shown to have significant effects on the energy metabolism in the muscles of rats that are given carbon source., 6911-87-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 402-49-3, formula is C8H6BrF3, Name is 1-(Bromomethyl)-4-(trifluoromethyl)benzene. Organobromine compounds have fallen under increased scrutiny for their environmental impact., COA of Formula: C8H6BrF3.

Guo, Yating;Jiang, Xiaoding;Chang, Qi;Xiao, Zhihong;Chen, Zhuo;Jiang, Dejian;Hu, Gaoyun;Li, Qianbin research published 《 Novel pyrazolo[3,4-b]pyridine derivatives: Synthesis, structure-activity relationship studies, and regulation of the AMPK/70S6K pathway》, the research content is summarized as follows. A series of novel pyrazolo[3,4-b]pyridine derivatives were designed, synthesized, and biol. evaluated for anti-lung cancer activity. Structure-activity relationship and AutoGPA models were constructed based on the in vitro antiproliferative potency of the compounds against a human lung adenocarcinoma cell line (A549). Compound 9d exhibits improved potency for A549 cell growth inhibition (3.06 ± 0.05 μM) compared with A-769662 (45.29 ± 2.14 μM). Compound 9d can elevate the phosphorylation levels of adenosine monophosphate-activated protein kinase (AMPK) and its substrate acetyl-CoA carboxylase and reduce the level of phosphorylated ribosomal S6 kinase (p-70S6K) at 1 μM, which is comparable to the activity of A-769662 at 20 μM. 9d induced G2/M cell cycle arrest, which was rescued when co-incubated with “Compound C,” a potent AMPK inhibitor. Taken together, compound 9d showed potential anti-lung cancer activity via inducing cell cycle arrest by regulation of the AMPK/70S6K pathway in A549 cells, which could provide a new lead for the discovery of anti-lung cancer agents.

COA of Formula: C8H6BrF3, 4-Trifluoromethylbenzyl bromide is a useful research compound. Its molecular formula is C8H6BrF3 and its molecular weight is 239.03 g/mol. The purity is usually 95%.
4-Trifluoromethylbenzyl bromide is a choline derivative that acts as an anticancer agent. It is structurally similar to the anticancer drug doxorubicin, which has been shown to be effective against breast cancer and leukemia. 4-Trifluoromethylbenzyl bromide interacts with cellular proteins, including choline kinase, and inhibits the mitochondrial pathway. This leads to cell death through apoptosis. The molecule also interacts with nucleotide bases such as thymine and cytosine in DNA, inhibiting transcription and replication. 4-Trifluoromethylbenzyl bromide binds strongly to the hydroxyl group of cholesterol by an electrophilic substitution mechanism to form a covalent bond with its hydroxy group. The molecule can also bind to chloride ions by an ionic bond., 402-49-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 5445-17-0, formula is C4H7BrO2, Name is Methyl 2-bromopropanoate, COA of Formula: C4H7BrO2

Guo, Wengang;Luo, Yuzheng;Sung, Herman H.-Y.;Williams, Ian D.;Li, Pingfan;Sun, Jianwei research published 《 Chiral Phosphoric Acid Catalyzed Enantioselective Synthesis of α-Tertiary Amino Ketones from Sulfonium Ylides》, the research content is summarized as follows. Herein we disclose a new catalytic asym. approach for the synthesis of chiral α-amino ketones, which is particularly useful for the less accessible acyclic α-tertiary cases. By a protonation-amination sequence, our approach represents a rare asym. H-heteroatom bond insertion by α-carbonyl sulfonium ylides, an attractive surrogate of diazocarbonyls. The mild intermol. C-N bond formation was catalyzed by chiral phosphoric acids with excellent efficiency and enantioselectivity. The products are precursors to other important chiral amine derivatives, including drug mols. and chiral ligands. The enantioselectivity was controlled by dynamic kinetic resolution in the amination step, rather than the initial protonation. This process opens up a new platform for the development of other related insertion reactions.

COA of Formula: C4H7BrO2, Methyl 2-bromopropionate, also known as Methyl 2-bromopropionate, is a useful research compound. Its molecular formula is C4H7BrO2 and its molecular weight is 167 g/mol. The purity is usually 95%.
Methyl 2-bromopropionate is used in the synthesis of poly(ADP-Ribose)polymerase inhibitors derived from benzoxazin-3-one. Also used in the synthesis of 5-HT2C antagonists affecting serotonin levels.
Methyl 2-bromopropanoate is a chemical compound that can be synthesized in an asymmetric manner. The reaction of methyl 2-bromopropanoate with hydrochloric acid gives the corresponding carboxylic acid, methyl propanoate, and hydrogen bromide in a 1:1 ratio. It has been shown that methyl 2-bromopropanoate is a potential catalyst for the reduction of chloride to chloride ion via the borohydride reduction method. Methyl 2-bromopropanoate has also been used as a model system for studying halides and copper complexes. Magnetic resonance spectroscopy studies have revealed that this chemical compound has a high redox potential and kinetic properties., 5445-17-0.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 6911-87-1, formula is C7H8BrN, The most pervasive is the naturally produced bromomethane. HPLC of Formula: 6911-87-1

Guo, Wei;Cai, Liuhuan;Xie, Zhen;Mei, Weijie;Liu, Gongping;Deng, Ling;Zhuo, Xiaoya;Zhong, Yumei;Zou, Xiaoying;Zheng, Lvyin;Fan, Xiaolin research published 《 Photocatalyzed intermolecular amination for the synthesis of hydrazonamides》, the research content is summarized as follows. A sequential multi-component reaction of β-ketonitriles with N,N-disubstituted hydrazines is designed and developed through a photocatalyzed intermol. amination process to afford hydrazonamides I [R = Et, Ph, 2-furyl, etc.; R¹ = Me, Et, n-Pr, etc.; R² = Ph, 3-MeC₆H₄, 4-ClC₆H₄, etc.]. This work reported the first example of the use of N,N-disubstituted hydrazines as two different “amine” sources, characterized by isotope labeling experiments The C-CN/N-N bonds were cleaved and new C-N/C=N bonds were constructed in a one-pot reaction. This protocol could be carried out without the addition of any external metals, ligands, bases, oxidants and reductants, and possessed the advantages of operational simplicity, mild reaction conditions, and good functional group tolerance. Furthermore, this approach enabled late-stage modifications of structurally complex bioactive mols., natural products and drugs, thus showing potential applications in the field of organo-pharmaceutical chem.

HPLC of Formula: 6911-87-1, 4-Bromo-N-methylaniline is a aniline based compound known to exhibit mutagenic properties.
4-Bromo-N-methylaniline is a useful research compound. Its molecular formula is C7H8BrN and its molecular weight is 186.05 g/mol. The purity is usually 95%.
4-Bromophenylmethylamine is an organic compound that has anti-inflammatory properties and is used as a pharmaceutical. It belongs to the group of amines. The hydrolysis of 4-bromophenylmethylamine by hydrochloric acid produces phenol and bromamine (NHBr). The reaction system can be used to synthesize a number of compounds, including anilines, benzofurans, and other aromatic compounds. 4-Bromophenylmethylamine reacts with muscle tissue in a similar manner as acetaminophen does. This drug also has been shown to have significant effects on the energy metabolism in the muscles of rats that are given carbon source., 6911-87-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 1575-37-7, formula is C6H7BrN2, The most pervasive is the naturally produced bromomethane. Category: bromides-buliding-blocks

Guo, Tao;Liu, Tianwei;He, Jianghua;Zhang, Yuetao research published 《 One-Pot Transformation of Lignin and Lignin Model Compounds into Benzimidazoles》, the research content is summarized as follows. It is a challenging task to simultaneously achieve selective depolymerization and valorization of lignin due to their complex structure and relatively stable bonds. We herein report an efficient depolymerization strategy that employs 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) as oxidant/catalyst to selectively convert different oxidized lignin models to a wide variety of 2-phenylbenzimidazole-based compounds in up to 94% yields, by reacting with o-phenylenediamines with varied substituents. This method could take full advantage of both C_β and/or C_γ atom in lignin structure to furnish the desirable products instead of forming byproducts, thus exhibiting high atom economy. Furthermore, this strategy can effectively transform both the oxidized hardwood (birch) and softwood (pine) lignin into the corresponding degradation products in up to 45 wt% and 30 wt%, resp. Through a “one-pot” process, we have successfully realized the oxidation/depolymerization/valorization of natural birch lignin at the same time and produced the benzimidazole derivatives in up to 67 wt% total yields.

Category: bromides-buliding-blocks, 4-Bromo-1,2-diaminobenzene can be obtained from 1,2-diaminobenzene via acetylation followed by bromination and alkaline hydrolysis.
4-Bromobenzene-1,2-diamine, also known as 4-Bromobenzene-1,2-diamine, is a useful research compound. Its molecular formula is C6H7BrN2 and its molecular weight is 187.04 g/mol. The purity is usually 95%.
4-Bromo-1,2-diaminobenzene is a dye that is used in diagnostic
procedures to detect the presence of amide groups. 4-Bromo-1,2-diaminobenzene can be used as an inhibitor for cationic polymerization reactions. It also has tuberculostatic activity and inhibits the growth of Mycobacterium tuberculosis. This compound reacts with aniline to form a benzimidazole derivative that contains a reactive amine group. The reaction between this amine group and different electrophiles generates benzimidazole compounds with different properties that are useful in nucleophilic attack reactions. The reaction between 4-bromo-1,2-diaminobenzene and methyl ethyl sulfide produces a luminescent probe that can be used to detect hydrogen bonds., 1575-37-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 402-49-3, formula is C8H6BrF3, Name is 1-(Bromomethyl)-4-(trifluoromethyl)benzene. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Related Products of 402-49-3.

Guo, Rui;Sang, Jiale;Xiao, Haijing;Li, Junxia;Zhang, Guozhu research published 《 Development of Novel Phosphino-Oxazoline Ligands and Their Application in Asymmetric Alkynlylation of Benzylic Halides》, the research content is summarized as follows. A new set of stereochem. diverse phosphino-oxazoline ligands derived from simple L-amino acids and 2-(diphenylphosphanyl)benzoic acid were developed. Those mono anionic tridentated N,N,P-ligands promote the Cu-catalyzed enantioselective radical coupling of terminal alkynes with a broad range of benzylic halides including benzo-fused cyclic α-halides and α-silyl benzyl halides in high yield and excellent enantioselectivity under mild reaction conditions. With multi distinct sites for structural modification, a diverse pool of chiral N,N,P-ligands is readily accessed, allowing for rapid optimization of the ligand structure for a specific substrate. Notably, the enantioselective alkynlylation of benzylic halides bonds in benzo-cyclic mols. has also been realized for the first time.

Related Products of 402-49-3, 4-Trifluoromethylbenzyl bromide is a useful research compound. Its molecular formula is C8H6BrF3 and its molecular weight is 239.03 g/mol. The purity is usually 95%.
4-Trifluoromethylbenzyl bromide is a choline derivative that acts as an anticancer agent. It is structurally similar to the anticancer drug doxorubicin, which has been shown to be effective against breast cancer and leukemia. 4-Trifluoromethylbenzyl bromide interacts with cellular proteins, including choline kinase, and inhibits the mitochondrial pathway. This leads to cell death through apoptosis. The molecule also interacts with nucleotide bases such as thymine and cytosine in DNA, inhibiting transcription and replication. 4-Trifluoromethylbenzyl bromide binds strongly to the hydroxyl group of cholesterol by an electrophilic substitution mechanism to form a covalent bond with its hydroxy group. The molecule can also bind to chloride ions by an ionic bond., 402-49-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic compounds having carbon bonded to bromine are called organic bromides. 4224-70-8, formula is C6H11BrO2, Name is 6-Bromohexanoic acid. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Category: bromides-buliding-blocks.

Guo, Peng;Pang, Xiaobo;Wang, Ke;Su, Pei-Feng;Pan, Qiu-Quan;Han, Guan-Yu;Shen, Qian;Zhao, Zhen-Zhen;Zhang, Wenhua;Shu, Xing-Zhong research published 《 Nickel-Catalyzed Reductive Csp³-Ge Coupling of Alkyl Bromides with Chlorogermanes》, the research content is summarized as follows. Reductive cross-coupling provides facile access to organogermanes, but it remains largely unexplored. Herein the authors report a Ni-catalyzed reductive Csp³-Ge coupling of alkyl bromides with chlorogermanes. This work established a new method for producing alkylgermanes. The reaction proceeds under very mild conditions and tolerates various functionalities including ether, alc., alkene, nitrile, amine, ester, phosphonates, amides, ketone, and aldehyde. The application of this method to the modification of bioactive mols. is demonstrated.

Category: bromides-buliding-blocks, 6-bromohexanoic acid is an organobromine compound comprising hexanoic acid having a bromo substituent at the 6-position. It derives from a hexanoic acid.
6-Bromohexanoic acid is a useful research compound. Its molecular formula is C6H11BrO2 and its molecular weight is 195.05 g/mol. The purity is usually 95%.
6-Bromohexanoic acid is useful for the preparation of anti-CTLA4 compounds as antitumor agents.
6-Bromohexanoic acid is a fatty acid that has been shown to be an effective agent for the treatment of cancer. It is used in gene therapy to inhibit the growth of cancer cells by binding to and then activating transcription factors. 6-Bromohexanoic acid can also be used as a chemotherapeutic agent and has been shown to cause apoptosis in monoclonal antibody-treated cells. 6-Bromohexanoic acid has pharmacokinetic properties that are similar to those of other fatty acids. The reaction solution was found to have high chemical stability, which may be due to the presence of nitrogen atoms. This reaction solution was found to adsorb onto the surface of monoclonal antibodies and cell culture, altering their properties., 4224-70-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 4897-84-1, formula is C5H9BrO2, Name is Methyl 4-bromobutanoate. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Application of C5H9BrO2.

Guo, Menglu;He, Shipeng;Cheng, Junfei;Li, Yu;Dong, Guoqiang;Sheng, Chunquan research published 《 Hydrophobic Tagging-Induced Degradation of PDEδ in Colon Cancer Cells》, the research content is summarized as follows. The development of KRAS-PDEδ protein-protein interaction (PPI) inhibitors is generally hampered by limited antitumor activity. Herein, the first hydrophobic tagging (HyT)-based PDEδ degraders were designed. Compound 17c (I) efficiently bound to PDEδ and induced degradation of PDEδ in SW480 colon cancer cells. As compared with PDEδ inhibitor deltazinone, HyT-based degrader 17c exhibited improved antitumor activity toward KRAS mutant cancer cells. This study highlighted the potential of HyT as a valuable chem. tool for tumorigenic PDEδ knockdown, which could be developed into a promising strategy for antitumor drug discovery.

Application of C5H9BrO2, Methyl 4-bromobutyrate,also as known as 4-Bromobutyric acid methyl ester, is a useful research compound. Its molecular formula is C5H9BrO2 and its molecular weight is 181.03 g/mol. The purity is usually 95%.
4-Bromobutyric acid methyl ester is a synthetic compound that can be used to inhibit the activity of the G1 phase cyclin-dependent kinases. It has been shown to inhibit protein synthesis by alkylating the amino groups of proteins and fatty acids. 4-Bromobutyric acid methyl ester also inhibits the growth of cancer cell lines, such as renal carcinoma cells. The mechanism of action for this drug is not well understood, but it may be due to its ability to bind with monoclonal antibodies and enter kidney cells by passive diffusion., 4897-84-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides. 6911-87-1, formula is C7H8BrN, Name is 4-Bromo-N-methylaniline. Organic compounds having carbon bonded to bromine are called organic bromides. SDS of cas: 6911-87-1.

Guo, Luxia;Ye, Meng;Vaccaro, Luigi;Li, Minghao;Gu, Yanlong research published 《 Two-Step Access to β-Substituted o-Hydroxyphenyl Ethyl Ketones from 4-Chromanone and its Application in Preparation of a Silica-Supported Cobalt(II) Salen Complex》, the research content is summarized as follows. A base-mediated ring opening of 4-chromanone was used to introduce the β-ethoxyl o-hydroxyphenyl Et ketone intermediary, followed by nucleophile substitution under BF₃·Et₂O assisted conditions to give the desired β-carbon, nitrogen, or thiol substituted o-hydroxyphenyl Et ketones I [R = p-tolyl-thiol, 1H-indol-3-yl, 2,4,5-(OMe)₃C₆H₂, etc.; R¹ = H, 5-Me, 4-OMe, etc.]. With the aid of this protocol, a silica-supported cobalt(II) salen complex was successfully prepared and its structure was confirmed by FTIR, ¹³C MAS NMR, UV-Vis absorption and XPS spectra. The immobilized cobalt(II) salen catalyst displayed comparable catalytic activity in the synthesis of several heterocycles including 1,3-oxazolidines II [R² = H, F; R³ = H, Me, Cl, etc.], benzimidazole and benzoxazole as compared with their homogeneous counterparts and also could be recycled for several times without obvious loss of its catalytic activity.

SDS of cas: 6911-87-1, 4-Bromo-N-methylaniline is a aniline based compound known to exhibit mutagenic properties.
4-Bromo-N-methylaniline is a useful research compound. Its molecular formula is C7H8BrN and its molecular weight is 186.05 g/mol. The purity is usually 95%.
4-Bromophenylmethylamine is an organic compound that has anti-inflammatory properties and is used as a pharmaceutical. It belongs to the group of amines. The hydrolysis of 4-bromophenylmethylamine by hydrochloric acid produces phenol and bromamine (NHBr). The reaction system can be used to synthesize a number of compounds, including anilines, benzofurans, and other aromatic compounds. 4-Bromophenylmethylamine reacts with muscle tissue in a similar manner as acetaminophen does. This drug also has been shown to have significant effects on the energy metabolism in the muscles of rats that are given carbon source., 6911-87-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 1575-37-7, formula is C6H7BrN2, The most pervasive is the naturally produced bromomethane. Recommanded Product: 4-Bromobenzene-1,2-diamine

Guo, Jingwen;Zhang, Lina;Du, Xinyue;Zhang, Liting;Cai, Yuepiao;Xia, Qinqin research published 《 Metal-Free Direct Oxidative C-N Bond Coupling of Quinoxalin-2(1H)-ones with Azoles under Mild Conditions》, the research content is summarized as follows. Direct C3-H amination of quinoxalin-2(1H)-ones with azoles under mild conditions promoted by PIFA has been achieved in good yield in a very fast manner. Mechanistic study revealed that the reaction proceeds through a radical process. In addition, this method could be applied to gram-scale reaction.

1575-37-7, 4-Bromo-1,2-diaminobenzene can be obtained from 1,2-diaminobenzene via acetylation followed by bromination and alkaline hydrolysis.
4-Bromobenzene-1,2-diamine, also known as 4-Bromobenzene-1,2-diamine, is a useful research compound. Its molecular formula is C6H7BrN2 and its molecular weight is 187.04 g/mol. The purity is usually 95%.
4-Bromo-1,2-diaminobenzene is a dye that is used in diagnostic
procedures to detect the presence of amide groups. 4-Bromo-1,2-diaminobenzene can be used as an inhibitor for cationic polymerization reactions. It also has tuberculostatic activity and inhibits the growth of Mycobacterium tuberculosis. This compound reacts with aniline to form a benzimidazole derivative that contains a reactive amine group. The reaction between this amine group and different electrophiles generates benzimidazole compounds with different properties that are useful in nucleophilic attack reactions. The reaction between 4-bromo-1,2-diaminobenzene and methyl ethyl sulfide produces a luminescent probe that can be used to detect hydrogen bonds., Recommanded Product: 4-Bromobenzene-1,2-diamine

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary