Month: October 2022

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 244205-40-1, formula is C6H6BBrO2, Name is (2-Bromophenyl)boronic acid. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. COA of Formula: C6H6BBrO2.

Feuerstein, Wolfram;Holzer, Christof;Gui, Xin;Neumeier, Lilly;Klopper, Wim;Breher, Frank research published 《 Synthesis of New Donor-Substituted Biphenyls: Pre-ligands for Highly Luminescent (CĈD̂) Gold(III) Pincer Complexes》, the research content is summarized as follows. The authors herein report on new synthetic strategies for the preparation of pyridine and imidazole substituted 2,2′-dihalo biphenyls. These structures are pre-ligands suitable for the preparation of resp. stannoles. The latter can successfully be transmetalated to K[AuCl₄] forming nonpalindromic [(CĈD̂)Au(III)] pincer complexes featuring a lateral pyridine (D = N) or N-heterocyclic carbene (NHC, D = C’) donor. The latter is the 1st report on a pincer complex with two formally anionic sp² and one carbenic C donor. The [(CĈD̂)Au(III)] complexes show intense phosphorescence in solution at room temperature The developed multistep strategy and touch upon synthetic challenges are discussed. The prepared complexes were fully characterized including x-ray diffraction anal. The Au(III) complexes’ photophys. properties were studied by absorption and emission spectroscopy as well as quantum chem. calculations on the quasi-relativistic two-component TD-DFT and GW/Bethe-Salpeter level including spin-orbit coupling. Thus, the authors shed light on the electronic influence of the nonpalindromic pincer ligand and reveal nonradiative relaxation pathways of the different ligands employed.

COA of Formula: C6H6BBrO2, 2-Bromophenylboronic Acid is used as an inhibitor of the hormone sensitive lipase.
2-Bromophenylboronic acid, also known as 2-Bromophenylboronic acid, is a useful research compound. Its molecular formula is C6H6BBrO2 and its molecular weight is 200.83 g/mol. The purity is usually 95%.
2-Bromophenylboronic acid is a glucose monitoring agent that has a ruthenium complex with an acidic environment. The nitro group and the amines are in close proximity to the boron center, and this proximity leads to a high nucleophilic character of the molecule. This reactivity allows 2-bromophenylboronic acid to be used as a fluorescence probe for acidic environments. 2-Bromophenylboronic acid also inhibits secretase enzymes, which are involved in Alzheimer’s disease and other neurodegenerative disorders. It is an inhibitor of γ-secretase, which is responsible for cleaving the amyloid precursor protein (APP), and it has shown efficacy against biphenyl, an anticancer drug that binds to benzodiazepine receptors. 2-Bromophenylboronic acid is also an enantiopure compound because all four substituents are different from each other., 244205-40-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 4897-84-1, formula is C5H9BrO2, Name is Methyl 4-bromobutanoate, Category: bromides-buliding-blocks

Festa, Carmen;Finamore, Claudia;Marchiano, Silvia;Di Leva, Francesco Saverio;Carino, Adriana;Monti, Maria Chiara;del Gaudio, Federica;Ceccacci, Sara;Limongelli, Vittorio;Zampella, Angela;Fiorucci, Stefano;De Marino, Simona research published 《 Investigation around the Oxadiazole Core in the Discovery of a New Chemotype of Potent and Selective FXR Antagonists》, the research content is summarized as follows. Recent findings have shown that Farnesoid X Receptor (FXR) antagonists might be useful in the treatment of cholestasis and related metabolic disorders. In this paper, we report the discovery of a new chemotype of FXR antagonists featured by a 3,5-disubstituted oxadiazole core. In total, 35 new derivatives were designed and synthesized, and notably, compounds I and II, containing a piperidine ring, displayed the best antagonistic activity against FXR with promising cellular potency (IC₅₀ = 0.58 ± 0.27 and 0.127 ± 0.02 μM, resp.). The excellent pharmacokinetic properties make compound I the most promising lead identified in this study.

Category: bromides-buliding-blocks, Methyl 4-bromobutyrate,also as known as 4-Bromobutyric acid methyl ester, is a useful research compound. Its molecular formula is C5H9BrO2 and its molecular weight is 181.03 g/mol. The purity is usually 95%.
4-Bromobutyric acid methyl ester is a synthetic compound that can be used to inhibit the activity of the G1 phase cyclin-dependent kinases. It has been shown to inhibit protein synthesis by alkylating the amino groups of proteins and fatty acids. 4-Bromobutyric acid methyl ester also inhibits the growth of cancer cell lines, such as renal carcinoma cells. The mechanism of action for this drug is not well understood, but it may be due to its ability to bind with monoclonal antibodies and enter kidney cells by passive diffusion., 4897-84-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 2576-47-8, formula is C2H7Br2N, Name is 2-Bromoethylamine hydrobromide. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Computed Properties of 2576-47-8.

Feng, Yuxi;Peng, Huawen;Zhao, Qiang research published 《 Fabrication of high performance Mg²⁺/Li⁺ nanofiltration membranes by surface grafting of quaternized bipyridine》, the research content is summarized as follows. A new monomer (quaternized bipyridine, QBPD) was synthesized to modify the interfacially polymerized polyethyleneimine (PEI) membranes. The QBPD monomer, containing binary charge sites and amine groups (NH₂), was anchored to the pristine PEI membrane through the “amine ∼ acyl chloride” amidation reaction. Pure water flux of the QBPD membrane is ∼ 96.6 L m^-2h^-1 while the MgCl₂ rejection is maintained at 92%±3. Noteworthy, the flux is ∼ 2.8 times as high as that of the pristine PEI membrane (∼34.0 L m^-2h^-1 at 0.6 MPa). Meanwhile, separation performance of the QBPD membrane remains stable in 162 h operation time at 0.6 MPa. When filtrating 50:1 Mg²⁺/Li⁺ mixture, the flux of the QBPD membrane is 81.6 L m^-2h^-1, and the Mg/Li ratio in the permeate was reduced to 8.5:1. Collectively, the QBPD membrane shows good performance compared with recent nanofiltration membranes for Mg²⁺/Li⁺ separation, exhibiting considerable potential for lithium extraction from salt lakes with high Mg²⁺/Li⁺ ratio.

Computed Properties of 2576-47-8, 2-Bromoethylamine hydrobromide is a useful building block for proteomics research.
2-Bromoethylamine hydrobromide is used in the synthesis of analogs of 5,​10,​15,​20-​tetrakis(1-​methylpyridinium-​4-​yl)​porphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist. It is used to construct C2-symmetric imidazolidinylidene ligands with a dioxolane backbone.
2-Bromoethylamine Hydrobromide is used in the synthesis of analogs of 5,​10,​15,​20-​tetrakis(1-​methylpyridinium-​4-​yl)​porphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist.
2-Bromoethylamine hydrobromide is a nonsteroidal anti-inflammatory drug that is used to treat inflammation and pain. It is a prodrug that is hydrolyzed in vivo to its active form, 2-Bromoethylamine hydrobromide. The bound form of this drug has been shown to inhibit the development of cell nuclei in the nucleus of cells. This drug also inhibits the production of nitric oxide, which leads to cell death by necrosis. 2-Bromoethylamine hydrobromide has been shown to have an inhibitory effect on the activity of glycol ethers, which are used as solvents for resins in coatings and adhesives., 2576-47-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides. 6911-87-1, formula is C7H8BrN, Name is 4-Bromo-N-methylaniline. Organic compounds having carbon bonded to bromine are called organic bromides. HPLC of Formula: 6911-87-1.

Feng, Xinshu;Huang, Ming research published 《 Effect of the ancillary ligand in N-heterocyclic carbene iridium(III) catalyzed N-alkylation of amines with alcohols》, the research content is summarized as follows. A series of air-stable N-heterocyclic carbene (NHC) Ir(III) complexes (Ir1-Ir6), bearing various combinations of chlorine, pyridine and NHC ligands, were assayed for the N-alkylation of amines with alcs. It was found that Ir3, with two monodentate 1,3-bis-methyl-imidazolylidene (IMe) ligands, emerged as the most active complex. A large variety of amines and primary alcs. were efficiently converted into mono-N-alkylated amines in 53-96% yields. As a special highlight, for the challenging MeOH, selective N-monomethylation could be achieved using KOH as a base under an air atm. Moreover, this catalytic system was successfully applied to the gram-scale synthesis of some valuable compounds

HPLC of Formula: 6911-87-1, 4-Bromo-N-methylaniline is a aniline based compound known to exhibit mutagenic properties.
4-Bromo-N-methylaniline is a useful research compound. Its molecular formula is C7H8BrN and its molecular weight is 186.05 g/mol. The purity is usually 95%.
4-Bromophenylmethylamine is an organic compound that has anti-inflammatory properties and is used as a pharmaceutical. It belongs to the group of amines. The hydrolysis of 4-bromophenylmethylamine by hydrochloric acid produces phenol and bromamine (NHBr). The reaction system can be used to synthesize a number of compounds, including anilines, benzofurans, and other aromatic compounds. 4-Bromophenylmethylamine reacts with muscle tissue in a similar manner as acetaminophen does. This drug also has been shown to have significant effects on the energy metabolism in the muscles of rats that are given carbon source., 6911-87-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 1575-37-7, formula is C6H7BrN2, Name is 4-Bromobenzene-1,2-diamine. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Recommanded Product: 4-Bromobenzene-1,2-diamine.

Fayed, Eman a.;Ammar, Yousry a.;Saleh, Marwa a.;Bayoumi, Ashraf h.;Belal, Amany;Mehany, Ahmed b. m.;Ragab, Ahmed research published 《 Design, synthesis, antiproliferative evaluation, and molecular docking study of new quinoxaline derivatives as apoptotic inducers and EGFR inhibitors》, the research content is summarized as follows. A new series of quinoxaline derivatives I (R = 6-Br, 6-Cl, 7-PhCO; X = MeO, H₂NNH) and II [R = H, 6-Br-6-Cl-7-PhCO; X = HO, MeO, EtO, H₂NNH, PhC(O)NHNH, 4-MeC₆H₄CH:NNH, etc.] were synthesized and pharmacol. evaluated against HepG-2, HCT-116, and MCF-7 cell lines. Seven compounds I (R = 6-Cl, 6-Br; X = H₂NNH), II (R = 6-Cl, 6-Br, 7-PhCO, X = MeO; R = 6-Cl, X = EtO) and 3,4-dihydro-2H-pyrano[2,3-b]quinoxalin-2-one were found to possess the highest activities against the examined cell lines with IC₅₀ values ranging from (7.57 to 28.44μM). These compounds were further selected to analyze their apoptotic potential in MCF-7 cells. Interestingly, it was found that the Bcl-2 level decreased by 1.95-3.99 times and the BAX level increased by 7.2-10.6 times relative to the control. These compounds also increased the active Caspase-3 level by 5.77-10.69 folds compared to untreated cells. WI-38 cells were treated with these compounds to estimate the cytotoxicity level of in non-tumorigenic cells, and these compounds displayed higher IC₅₀ values (142.21-335.03μM). Further studies on the mechanism of the most promising compounds I (R = 6-Br; X = H₂NNH), II (R = 6-Cl, 6-Br; X = MeO) and 3,4-dihydro-2H-pyrano[2,3-b]quinoxalin-2-one, revealed that they increase apoptotic cells and induce cell cycle arrest at pre-G1 and G2/M phases. Besides, evaluation of both wild EGFRWT and mutant EGFRL858R-TK inhibitory activity for these derivatives showed IC₅₀ values ranging from 0.075-1.547μM vs. wild EGFRWT and 63.70-87.34 nM vs. the mutant type. Erlotinib was used as a standard reference with IC₅₀ values of 0.0656μM and 59.56 nM vs. both types. Finally, the mol. docking study of most potent quinoxaline derivatives exhibited a good binding inside the active site of EGFR (1M17), with binding energy ranged between (-15.86 to -16.97) compared to Erlotinib (-17.84) kcal/mol. Also, by applying Lipinski’s parameters, it was found that these derivatives showed no violations and indicated possibility to formulate orally.

1575-37-7, 4-Bromo-1,2-diaminobenzene can be obtained from 1,2-diaminobenzene via acetylation followed by bromination and alkaline hydrolysis.
4-Bromobenzene-1,2-diamine, also known as 4-Bromobenzene-1,2-diamine, is a useful research compound. Its molecular formula is C6H7BrN2 and its molecular weight is 187.04 g/mol. The purity is usually 95%.
4-Bromo-1,2-diaminobenzene is a dye that is used in diagnostic
procedures to detect the presence of amide groups. 4-Bromo-1,2-diaminobenzene can be used as an inhibitor for cationic polymerization reactions. It also has tuberculostatic activity and inhibits the growth of Mycobacterium tuberculosis. This compound reacts with aniline to form a benzimidazole derivative that contains a reactive amine group. The reaction between this amine group and different electrophiles generates benzimidazole compounds with different properties that are useful in nucleophilic attack reactions. The reaction between 4-bromo-1,2-diaminobenzene and methyl ethyl sulfide produces a luminescent probe that can be used to detect hydrogen bonds., Recommanded Product: 4-Bromobenzene-1,2-diamine

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 1575-37-7, formula is C6H7BrN2, Name is 4-Bromobenzene-1,2-diamine, Quality Control of 1575-37-7

Fasiuddin, G. S.;Liakath Ali Khan, F.;Sakthivel, S.;Muthu, S.;Irfan, Ahmad research published 《 Synthesis, Spectroscopic, Molecular Docking and inhibitory activity of 6-Bromo-2-(4-chlorophenyl)-1H-benzimidazole- a DFT approach》, the research content is summarized as follows. A novel compound 6-bromo-2-(4-chlorophenyl)-1H-benzimidazole was synthesized to treat antimicrobial infections and characterized by FT-IR, FT-Raman, 1H-NMR, UV-Vis. The stable conformer and structural optimization were carried out using the DFT-B3LYP (6-311 ++ G (d, p)) method in Gaussian 16 W. FT-IR and FT-Raman exptl. and theor. wavenumbers with the complete vibrational assignment were reported. NMR of 1H -13C and UV-Vis is calculated at different solvents using the IEF-PCM method. The conductivity, reactivity and stability of the title compound are determined by HOMO-LUMO values. The antibacterial activity was tested against S. aureus and A. niger to indicate a significant zone of inhibition than the reference drug ciprofloxacin at the concentration of 25μg/mL, and protein and ligand interaction site in docking was determined by MEP. Finally, the mol. docking between the title and the reference compound ligand with the A. niger / 3EQA was studied and compared the binding energy of the compound at the active sites.

1575-37-7, 4-Bromo-1,2-diaminobenzene can be obtained from 1,2-diaminobenzene via acetylation followed by bromination and alkaline hydrolysis.
4-Bromobenzene-1,2-diamine, also known as 4-Bromobenzene-1,2-diamine, is a useful research compound. Its molecular formula is C6H7BrN2 and its molecular weight is 187.04 g/mol. The purity is usually 95%.
4-Bromo-1,2-diaminobenzene is a dye that is used in diagnostic
procedures to detect the presence of amide groups. 4-Bromo-1,2-diaminobenzene can be used as an inhibitor for cationic polymerization reactions. It also has tuberculostatic activity and inhibits the growth of Mycobacterium tuberculosis. This compound reacts with aniline to form a benzimidazole derivative that contains a reactive amine group. The reaction between this amine group and different electrophiles generates benzimidazole compounds with different properties that are useful in nucleophilic attack reactions. The reaction between 4-bromo-1,2-diaminobenzene and methyl ethyl sulfide produces a luminescent probe that can be used to detect hydrogen bonds., Quality Control of 1575-37-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 823-78-9, formula is C7H6Br2, Name is 1-Bromo-3-(bromomethyl)benzene. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Recommanded Product: 1-Bromo-3-(bromomethyl)benzene.

Fanourakis, Alexander;Williams, Benjamin D.;Paterson, Kieran J.;Phipps, Robert J. research published 《 Enantioselective Intermolecular C-H Amination Directed by a Chiral Cation》, the research content is summarized as follows. A family of anionic variants of the best-in-class catalyst for Rh-catalyzed C-H amination, Rh₂(esp)₂, with which the chiral cations are associated And derived from quaternized cinchona alkaloids, has been described. These ion-paired catalysts enable high levels of enantioselectivity to be achieved in the benzylic C-H amination of substrates R(CH₂)₄OH (R = Ph, 1-naphthyl, 3-methylthiophen-2-yl, etc.) bearing pentyl hydroxyl groups. Addnl., the quinoline of the chiral cation appears to engage in axial ligation to the rhodium complex, providing improved yields of products RCH(NHS(O)₂OCH₂R¹)(CH₂)₃OH (R¹ = (CF₂)₂CF₃) vs. Rh₂(esp)₂ and highlighting the dual role that the cation is playing. These results underline the potential of using chiral cations to control enantioselectivity in challenging transition-metal-catalyzed transformations.

823-78-9, 3-Bromobenzyl bromide undergoes reduction with diethylzinc in the presence of Pd(PPh3)4 to yield corresponding hydrocarbon.

3-Bromobenzyl bromide is a useful research compound. Its molecular formula is C7H6Br2 and its molecular weight is 249.93 g/mol. The purity is usually 95%.

3-Bromobenzyl bromide is a molecule that has been synthesized and shown to have anticancer activity. It inhibits the activity of cancer cells by binding to amines in these cells and preventing the formation of hydrogen bonds between these molecules. 3-Bromobenzyl bromide has also been shown to selectively inhibit the activity of NS5B polymerase, an enzyme that is important in the replication of the hepatitis C virus. The synthetic nature of this molecule makes it an attractive target for analytical methods such as nuclear magnetic resonance spectroscopy. This molecule also shows significant cytotoxicity against cancer cell lines in vitro, as well as inducing tumor necrosis factor-alpha (TNF-α) production in lps-stimulated murine macrophages., Recommanded Product: 1-Bromo-3-(bromomethyl)benzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 585-76-2, formula is C7H5BrO2, Name is 3-Bromobenzoic acid. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Category: bromides-buliding-blocks.

Fang, Ze-Yu;Zhang, Yi-Heng;Chen, Chong-Hao;Zheng, Qi;Lv, Peng-Cheng;Ni, Lei-Qiang;Sun, Juan;Wu, Yuan-Feng research published 《 Design, Synthesis and Molecular Docking of Novel Quinazolinone Hydrazide Derivatives as EGFR Inhibitors》, the research content is summarized as follows. A series of novel quinazolinone hydrazide derivatives were designed and synthesized as EGFR inhibitors. The results indicated that most of the aimed compounds had potential anti-tumor cell proliferation and EGFR inhibitory activities. In the comprehensive anal. of all the tested compounds, the target compound 9c showed the best anti-tumor cell proliferation activity, (IC50=1.31 μM for MCF-7, IC50=1.89 μM for HepG2, IC50=2.10 μM for SGC), and IC50=0.59 μM for the EGFR inhibitory activity. Docking results showed that compound 9c could ideally insert the active site and interact with the critical amino acid residues (Val702, Lys721, Met769, Asp831) in the active site.

585-76-2, 3-bromobenzoic acid is a bromobenzoic acid carrying a single bromo subsituent at the 3-position.
3-Bromobenzoic acid, also known as 3-Bromobenzoic acid, is a useful research compound. Its molecular formula is C7H5BrO2 and its molecular weight is 201.02 g/mol. The purity is usually 95%.
3-bromobenzoic acid is used as a reagent in the synthesis of deoxypodophyllotoxin derivatives with insecticidal activity. Also used as a reagent in the synthesis of thiazole derivatives with antibacterial activity.
3-bromobenzoic acid is a molecule that is classified as a Group P2. It has an electronegativity of 1.3 and an acidity of 0.8, which are both in the middle range of values for this group. 3-Bromobenzoic acid is soluble in water and is soluble in ethanol, acetone, and ether. The chemical structure of 3-bromobenzoic acid can be determined by its monoclonal antibody binding sites, electrochemical impedance spectroscopy data, and Langmuir adsorption isotherm data. 3-Bromobenzoic acid reacts with hydrochloric acid to form benzoate and HCl gas. Chronic exposure to 3-bromobenzoic acid has been shown to cause glutamate dehydrogenase inhibition, leading to an accumulation of p-hydroxybenzoic acid in the body. , Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 4224-70-8, formula is C6H11BrO2, Name is 6-Bromohexanoic acid. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Electric Literature of 4224-70-8.

Fang, Xiong;Meng, Qian;Zhang, Huijun;Fang, Xiao;Huang, Lina S.;Zhang, Xingquan;Schooley, Robert T.;Ciechanover, Aaron;An, Jing;Xu, Yan;Huang, Ziwei research published 《 A fragment integrational approach to GPCR inhibition: Identification of a high affinity small molecule CXCR4 antagonist》, the research content is summarized as follows. Here, employed a fragment integrational approached, designed and synthesized a new and potent small mol. CXCR4 antagonist (named as HF51116 I), as well as a fluorescent (FITC)-labeled HF51116 I (FITC-HF51116 I). I exhibited very high CXCR4 binding affinity with IC₅₀ of 12 nM in competitive binding with a CXCR4 specific antibody 12G5, which was comparable to the wild type chemokines or synthetic peptides of much larger mol. sizes. Direct binding measurement using FITC-HF51116 I further revealed the compound’s high CXCR4 affinity. HF51116 I strongly antagonized SDF-1α-induced cell migration, calcium mobilization, and CXCR4 internalization. Furthermore, HF51116 I inhibited HIV-1 infection via CXCR4, demonstrating its antiviral therapeutic potential. The mechanism of HF51116 I-CXCR4 interaction was analyzed by site-directed mutagenesis and mol. modeling which suggested that the compound recognized the minor and major subpockets of CXCR4. Its binding to CXCR4 was found to block G protein-dependent downstream signal pathways as detected by luciferase reporter assays. With its potent bioactivities and asym. structure amenable to chem. diversification, HF51116 I may serve as a prototype for developing a new class of CXCR4-targeted therapeutics and proof of the concept of similar strategies for studying other GPCRs.

Electric Literature of 4224-70-8, 6-bromohexanoic acid is an organobromine compound comprising hexanoic acid having a bromo substituent at the 6-position. It derives from a hexanoic acid.
6-Bromohexanoic acid is a useful research compound. Its molecular formula is C6H11BrO2 and its molecular weight is 195.05 g/mol. The purity is usually 95%.
6-Bromohexanoic acid is useful for the preparation of anti-CTLA4 compounds as antitumor agents.
6-Bromohexanoic acid is a fatty acid that has been shown to be an effective agent for the treatment of cancer. It is used in gene therapy to inhibit the growth of cancer cells by binding to and then activating transcription factors. 6-Bromohexanoic acid can also be used as a chemotherapeutic agent and has been shown to cause apoptosis in monoclonal antibody-treated cells. 6-Bromohexanoic acid has pharmacokinetic properties that are similar to those of other fatty acids. The reaction solution was found to have high chemical stability, which may be due to the presence of nitrogen atoms. This reaction solution was found to adsorb onto the surface of monoclonal antibodies and cell culture, altering their properties., 4224-70-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic compounds having carbon bonded to bromine are called organic bromides. 70-23-5, formula is C5H7BrO3, Name is Ethyl 3-bromo-2-oxopropanoate. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Recommanded Product: Ethyl 3-bromo-2-oxopropanoate.

Fang, Lincheng;Hu, Zhaoxue;Yang, Yifei;Chen, Pan;Zhou, Jinpei;Zhang, Huibin research published 《 Discovery of 3,5-dimethylisoxazole derivatives as novel, potent inhibitors for bromodomain and extraterminal domain (BET) family》, the research content is summarized as follows. Bromodomain and extra-terminal (BET) is a promising therapeutic target for various hematol. cancers. We used the BRD4 inhibitor compound 13 (I) as a lead compound to develop a variety of compounds, and we introduced diverse groups into the position of the compound 13 orienting toward the ZA channel. A series of compounds bearing triazolopyridazine motif exhibited remarkable BRD4 protein inhibitory activities. Among them, compound 39 (II) inhibited BRD4(BD1) protein with an IC₅₀ of 0.003μM which was superior to lead compound 13. Meanwhile, compound 39 possess activity, IC₅₀ = 2.1μM, in antiproliferation activity against U266 cancer cells. On the other hand, compound 39 could arrest tumor cells into the G0/G1 phase and induce apoptosis, which was consistent with its results in inhibiting cell proliferation. Biol. and biochem. data suggest that BRD4 protein might be a therapeutic target and that compound 39 is an excellent lead compound for further development.

Recommanded Product: Ethyl 3-bromo-2-oxopropanoate, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., 70-23-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary