Month: October 2022

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 70-23-5, formula is C5H7BrO3, Name is Ethyl 3-bromo-2-oxopropanoate. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. HPLC of Formula: 70-23-5.

Ertas, Merve;Biltekin, Sevde Nur;Berk, Barkin;Yurttas, Leyla;Demirayak, Seref research published 《 Synthesis of some 5,6-diaryl-1,2,4-triazine derivatives and investigation of their cyclooxygenase (COX) inhibitory activity》, the research content is summarized as follows. Within this study, [(diaryltriazinyl)thio]-N-(benzo/thiazolyl)acetamide derivatives (I [R = H,Me, Cl, etc.; R¹ = H, Me, COOEt; R² = H, Me; R¹R² = (CH₂)₃]) were synthesized and COX inhibitory activities of the compounds were investigated. Compounds I [R = MeO; R¹ = H, Me, COOEt;R² = H; R¹ = R² = Me; R¹R² = (CH₂)₄] , which have a 4-methoxyphenyl group within their structures, showed strong inhibitory activity on COX-2 enzyme, even compound I [R = MeO; R¹ = R² = H] namely 2-{[5,6-bis(4-methoxyphenyl)-1,2,4-triazin-3-yl]thio}-N-(thiazol-2-yl)acetamide exhibited higher selectivity on this enzyme (IC₅₀:3.06 μM). Mol. docking studies were performed for compound I [R = MeO; R¹ = R² = H] on COX-1 and COX-2 enzymes and the results were found to support the mol.′s COX-2 selectivity.

HPLC of Formula: 70-23-5, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., 70-23-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 70-23-5, formula is C5H7BrO3, Name is Ethyl 3-bromo-2-oxopropanoate. Organobromine compounds have fallen under increased scrutiny for their environmental impact., SDS of cas: 70-23-5.

Erigur, Esra Caner;Altug, Cevher;Angeli, Andrea;Supuran, Claudiu T. research published 《 Design, synthesis and human carbonic anhydrase I, II, IX and XII inhibitory properties of 1,3-thiazole sulfonamides》, the research content is summarized as follows. A series of novel 1,3-thiazole sulfonamides I [R = i-Pr, n-Bu, HOCH₂CH₂, Ph(CH₂)₄, etc.] has been designed, synthesized and studied their carbonic anhydrase (CA) inhibitory properties. The inhibition property of four human CA isoforms was investigated: hCA I, II, IX, and XII using the standard drug acetazolamide (AAZ) for comparison. The compounds I showed a wide range of inhibition potency towards the cytosolic enzyme hCA I. Nevertheless, the compounds I (R = n-Pr, i-Pr, HOCH₂CHMe, HOCHMeCH₂, MeOCH₂CH₂) have shown higher inhibition potential as compared to acetazolamide (KI = 250 nM). The abundant human cytosolic isoform, hCA II, was strongly inhibited by the most compounds in low nanomolar range (KI < 12.1 nM). On the other hand, almost all novel synthesized compounds have shown weaker inhibition potential as compared to acetazolamide against the tumor membrane- associated isoform hCA IX. Finally, the second tumor membrane-associated isoform, hCA XII, showed a wide range of potency that spanned from 9.3 to 729.6 nM.

SDS of cas: 70-23-5, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., 70-23-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 402-49-3, formula is C8H6BrF3, Name is 1-(Bromomethyl)-4-(trifluoromethyl)benzene, Recommanded Product: 1-(Bromomethyl)-4-(trifluoromethyl)benzene

Erasmus, Chane;Aucamp, Janine;Smit, Frans J.;Seldon, Ronnett;Jordaan, Audrey;Warner, Digby F.;N’Da, David D. research published 《 Synthesis and comparison of in vitro dual anti-infective activities of novel naphthoquinone hybrids and atovaquone》, the research content is summarized as follows. A principal factor that contributes towards the failure to eradicate leishmaniasis and tuberculosis infections is the reduced efficacy of existing chemotherapies, owing to a continuous increase in multidrug-resistant strains of the causative pathogens. This accentuates the dire need to develop new and effective drugs against both plights. A series of naphthoquinone-triazole hybrids was synthesized and evaluated in vitro against Leishmania (L.) and Mycobacterium tuberculosis (Mtb) strains. Their cytotoxicities were also evaluated, using the human embryonic kidney cell line (HEK-293). The hybrids were found to be non-toxic towards human cells and had demonstrated micromolar cellular antileishmanial and antimycobacterial potencies. Hybrid 13, i.e. 2-{[1-(4-methylbenzyl)-1H-1,2,3-triazol-4-yl]methoxy}naphthalene-1,4-dione was the most active of all. It was found with MIC₉₀ 0.5μM potency against Mtb in a protein free medium, and with half-maxima inhibitory concentrations (IC₅₀) of 0.81μM and 1.48μM against the infective promastigote parasites of L. donavani and L. major, resp., with good selectivity towards these pathogens (SI 22 – 65). Comparatively, the clin. naphthoquinone, atovaquone, although less cytotoxic, was found to be two-fold less antimycobacterial potent, and six- to twelve-fold less active against leishmania. Hybrid 13 may therefore stand as a potential anti-infective hit for further development in the search for new antitubercular and antileishmanial drugs. Elucidation of its exact mechanism of action and mol. targets will constitute future endeavour.

402-49-3, 4-Trifluoromethylbenzyl bromide is a useful research compound. Its molecular formula is C8H6BrF3 and its molecular weight is 239.03 g/mol. The purity is usually 95%.
4-Trifluoromethylbenzyl bromide is a choline derivative that acts as an anticancer agent. It is structurally similar to the anticancer drug doxorubicin, which has been shown to be effective against breast cancer and leukemia. 4-Trifluoromethylbenzyl bromide interacts with cellular proteins, including choline kinase, and inhibits the mitochondrial pathway. This leads to cell death through apoptosis. The molecule also interacts with nucleotide bases such as thymine and cytosine in DNA, inhibiting transcription and replication. 4-Trifluoromethylbenzyl bromide binds strongly to the hydroxyl group of cholesterol by an electrophilic substitution mechanism to form a covalent bond with its hydroxy group. The molecule can also bind to chloride ions by an ionic bond., Recommanded Product: 1-(Bromomethyl)-4-(trifluoromethyl)benzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic compounds having carbon bonded to bromine are called organic bromides. 585-76-2, formula is C7H5BrO2, Name is 3-Bromobenzoic acid. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Safety of 3-Bromobenzoic acid.

Empel, Claire;Nguyen, Thanh Vinh;Koenigs, Rene M. research published 《 Tropylium-Catalyzed O-H Insertion Reactions of Diazoalkanes with Carboxylic Acids》, the research content is summarized as follows. Herein, the application of a nonbenzenoid aromatic carbocation, namely tropylium, as an organic Lewis acid catalyst in O-H functionalization reactions of diazoalkanes with benzoic acids is described. The newly developed protocol is applicable to a wide range of diazoalkane and carboxylic acid substrates with excellent efficiency (43 examples, up to 99% yield).

Safety of 3-Bromobenzoic acid, 3-bromobenzoic acid is a bromobenzoic acid carrying a single bromo subsituent at the 3-position.
3-Bromobenzoic acid, also known as 3-Bromobenzoic acid, is a useful research compound. Its molecular formula is C7H5BrO2 and its molecular weight is 201.02 g/mol. The purity is usually 95%.
3-bromobenzoic acid is used as a reagent in the synthesis of deoxypodophyllotoxin derivatives with insecticidal activity. Also used as a reagent in the synthesis of thiazole derivatives with antibacterial activity.
3-bromobenzoic acid is a molecule that is classified as a Group P2. It has an electronegativity of 1.3 and an acidity of 0.8, which are both in the middle range of values for this group. 3-Bromobenzoic acid is soluble in water and is soluble in ethanol, acetone, and ether. The chemical structure of 3-bromobenzoic acid can be determined by its monoclonal antibody binding sites, electrochemical impedance spectroscopy data, and Langmuir adsorption isotherm data. 3-Bromobenzoic acid reacts with hydrochloric acid to form benzoate and HCl gas. Chronic exposure to 3-bromobenzoic acid has been shown to cause glutamate dehydrogenase inhibition, leading to an accumulation of p-hydroxybenzoic acid in the body. , 585-76-2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 1575-37-7, formula is C6H7BrN2, The most pervasive is the naturally produced bromomethane. Electric Literature of 1575-37-7

Elumalai, Vijayaragavan;Hansen, Joern H. research published 《 A Green, Scalable, and Catalyst-Free One-Minute Synthesis of Quinoxalines》, the research content is summarized as follows. A highly efficient and catalyst-free protocol was reported for the synthesis of quinoxalines via the classical cyclocondensation reaction between aryldiamines and dicarbonyl compounds Remarkably simple and green reaction conditions employed methanol as solvent afforded medium to excellent yield of quinoxalines after only one-minute reaction time at ambient temperature The conditions allow at least 10 g scale synthesis of quinoxalines and preferred starting point for optimization and method of choice for applications in the synthetic community.

1575-37-7, 4-Bromo-1,2-diaminobenzene can be obtained from 1,2-diaminobenzene via acetylation followed by bromination and alkaline hydrolysis.
4-Bromobenzene-1,2-diamine, also known as 4-Bromobenzene-1,2-diamine, is a useful research compound. Its molecular formula is C6H7BrN2 and its molecular weight is 187.04 g/mol. The purity is usually 95%.
4-Bromo-1,2-diaminobenzene is a dye that is used in diagnostic
procedures to detect the presence of amide groups. 4-Bromo-1,2-diaminobenzene can be used as an inhibitor for cationic polymerization reactions. It also has tuberculostatic activity and inhibits the growth of Mycobacterium tuberculosis. This compound reacts with aniline to form a benzimidazole derivative that contains a reactive amine group. The reaction between this amine group and different electrophiles generates benzimidazole compounds with different properties that are useful in nucleophilic attack reactions. The reaction between 4-bromo-1,2-diaminobenzene and methyl ethyl sulfide produces a luminescent probe that can be used to detect hydrogen bonds., Electric Literature of 1575-37-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic compounds having carbon bonded to bromine are called organic bromides. 402-49-3, formula is C8H6BrF3, Name is 1-(Bromomethyl)-4-(trifluoromethyl)benzene. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Name: 1-(Bromomethyl)-4-(trifluoromethyl)benzene.

Elkamhawy, Ahmed;Paik, Sora;Park, Jong-Hyun;Kim, Hyeon Jeong;Hassan, Ahmed H. E.;Lee, Kyeong;Park, Ki Duk;Roh, Eun Joo research published 《 Discovery of novel and potent safinamide-based derivatives as highly selective hMAO-B inhibitors for treatment of Parkinson’s disease (PD): Design, synthesis, in vitro, in vivo and in silico biological studies》, the research content is summarized as follows. Up to date, the current clin. practice employs only symptomatic treatments for management of Parkinson’s disease (PD) but unable to stop disease progression. The discovery of new chem. entities endowed with potent and selective human monoamine oxidase B (hMAO-B) inhibitory activity is a clin. relevant subject. Herein, a structural optimization strategy for safinamide (a well-known second generation hMAO-B inhibitor) afforded a series of thirty-six safinamide-derived new analogs (4aa-bj). Most compounds showed promising inhibitory activities against hMAO-B (>70% inhibition at a single dose concentration of 10μM), with no apparent effect on hMAO-A at 100μM. Moreover, while six compounds (4ak, 4as, 4az, 4be, 4bg, and 4bi) exhibited potent double-digit nanomolar activities over hMAO-B with IC₅₀ values of 29.5, 42.2, 22.3, 18.8, 42.2, and 33.9 nM, resp., three derivatives (4aq, 4at, and 4bf), possessing the same carboxamide moiety (2-pyrazinyl), showed the most potent single-digit nanomolar activities (IC₅₀ = 9.7, 5.1, and 3.9 nM, resp.). Compound 4bf revealed an excellent selectivity index (SI > 25641) with a 29-fold increase compared to safinamide (SI > 892). A structure activity relationship along with mol. docking simulations provided insights into enzyme – inhibitor interactions and a rational for the observed activity. In an in vivo MPTP-induced mouse model of PD, oral administration of compound 4bf significantly protected nigrostriatal dopaminergic neurons as revealed by tyrosine hydroxylase staining and prevented MPTP-induced Parkinsonism as revealed by motor behavioral assays. Accordingly, we present compound 4bf as a novel, highly potent, and selective hMAO-B inhibitor with an effective therapeutic profile for relieving PD.

Name: 1-(Bromomethyl)-4-(trifluoromethyl)benzene, 4-Trifluoromethylbenzyl bromide is a useful research compound. Its molecular formula is C8H6BrF3 and its molecular weight is 239.03 g/mol. The purity is usually 95%.
4-Trifluoromethylbenzyl bromide is a choline derivative that acts as an anticancer agent. It is structurally similar to the anticancer drug doxorubicin, which has been shown to be effective against breast cancer and leukemia. 4-Trifluoromethylbenzyl bromide interacts with cellular proteins, including choline kinase, and inhibits the mitochondrial pathway. This leads to cell death through apoptosis. The molecule also interacts with nucleotide bases such as thymine and cytosine in DNA, inhibiting transcription and replication. 4-Trifluoromethylbenzyl bromide binds strongly to the hydroxyl group of cholesterol by an electrophilic substitution mechanism to form a covalent bond with its hydroxy group. The molecule can also bind to chloride ions by an ionic bond., 402-49-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 4897-84-1, formula is C5H9BrO2, Name is Methyl 4-bromobutanoate. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Recommanded Product: Methyl 4-bromobutanoate.

Elhaj, Elrasheed;Wang, Huajun;Gu, Yanlong research published 《 Functionalized quaternary ammonium salt ionic liquids (FQAILs) as an economic and efficient catalyst for synthesis of glycerol carbonate from glycerol and dimethyl carbonate》, the research content is summarized as follows. A series of functionalized quaternary ammonium salt ionic liquids (FQAILs) with different functional groups, such as hydroxyl, carboxyl, ether group, and amino, were prepared and used as a catalyst for the synthesis of glycerol carbonate from transesterification of glycerol and di-Me carbonate without any addnl. organic solvent and co-catalyst. The effects of functional groups, anions (Cl^–, Br^–, I^–, OH^–), and reaction parameters were investigated in detail. It is found that both the cation and anion of FQAILs display an important effect on its catalytic activity. Among these FQAILs, hydroxyl functionalized ionic liquid, [HPTPA]OH possesses the highest activity because there are the strong interactions between hydroxyl and di-Me carbonate mol. and between anion OH- and glycerol mol., which were shown by FTIR spectra. The glycerol conversion of 96.2% and glycerol carbonate yield of 87.6% can be obtained over [HPTPA]OH under moderate conditions of reaction temperature of 80 °C, reaction time of 90 min, di-Me carbonate/glycerol molar ratio of 3, and catalyst amount of 0.9 mol% based on glycerol amount The [HPTPA]OH catalyst can be reused at least three cycles without significant reduction in its catalytic activity. Finally, a possible reaction mechanism for the synthesis of glycerol carbonate is also proposed.

Recommanded Product: Methyl 4-bromobutanoate, Methyl 4-bromobutyrate,also as known as 4-Bromobutyric acid methyl ester, is a useful research compound. Its molecular formula is C5H9BrO2 and its molecular weight is 181.03 g/mol. The purity is usually 95%.
4-Bromobutyric acid methyl ester is a synthetic compound that can be used to inhibit the activity of the G1 phase cyclin-dependent kinases. It has been shown to inhibit protein synthesis by alkylating the amino groups of proteins and fatty acids. 4-Bromobutyric acid methyl ester also inhibits the growth of cancer cell lines, such as renal carcinoma cells. The mechanism of action for this drug is not well understood, but it may be due to its ability to bind with monoclonal antibodies and enter kidney cells by passive diffusion., 4897-84-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 823-78-9, formula is C7H6Br2, Name is 1-Bromo-3-(bromomethyl)benzene. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Synthetic Route of 823-78-9.

Elgendy, Bahaa;Griffett, Kristine;Hegazy, Lamees;Di Fruscia, Paolo;Sample, Kirby;Schoepke, Emmalie;Kamenecka, Theodore M.;Burris, Thomas P. research published 《 Synthesis and structure activity relationship of the first class of LXR inverse agonists》, the research content is summarized as follows. Liver X Receptors (LXRs) are members of the nuclear receptor family, and they play significant role in lipid and cholesterol metabolism Moreover, they are key regulators of several inflammatory pathways. Pharmacol. modulation of LXRs holds great potential in treatment of metabolic diseases, neurodegenerative diseases, and cancer. We were the first group to identify LXR inverse agonists SR9238 and SR9243 and demonstrate their potential utility in treating liver diseases and cancer. Here, we present the results of structure-activity relationship (SAR) studies, based around SR9238 and SR9243. This study led to identification of I, II, III and IV which were more potent inverse agonists than SR9238 and SR9243 and inhibited expression of the fatty acid synthase gene in DU145 cells. We previously demonstrated that inhibition of FASN is correlated to the anticancer activity of SR9243 and this suggests that new inverse agonists have great potential as anticancer agents. We identified compounds with distinct selectivity toward both LXR isoforms, which can be excellent tools to study the pharmacol. of both isoforms. We employed mol. dynamic (MD) simulations to better understand the mol. mechanism underlying inverse agonist activity and to guide our future design.

823-78-9, 3-Bromobenzyl bromide undergoes reduction with diethylzinc in the presence of Pd(PPh3)4 to yield corresponding hydrocarbon.

3-Bromobenzyl bromide is a useful research compound. Its molecular formula is C7H6Br2 and its molecular weight is 249.93 g/mol. The purity is usually 95%.

3-Bromobenzyl bromide is a molecule that has been synthesized and shown to have anticancer activity. It inhibits the activity of cancer cells by binding to amines in these cells and preventing the formation of hydrogen bonds between these molecules. 3-Bromobenzyl bromide has also been shown to selectively inhibit the activity of NS5B polymerase, an enzyme that is important in the replication of the hepatitis C virus. The synthetic nature of this molecule makes it an attractive target for analytical methods such as nuclear magnetic resonance spectroscopy. This molecule also shows significant cytotoxicity against cancer cell lines in vitro, as well as inducing tumor necrosis factor-alpha (TNF-α) production in lps-stimulated murine macrophages., Synthetic Route of 823-78-9

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 90-59-5, formula is C7H4Br2O2, Name is 3,5-Dibromo-2-hydroxybenzaldehyde. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Synthetic Route of 90-59-5.

El-Attar, Mona;Aazam, Elham research published 《 Redox behavior, spectroscopic investigations, theoretical interpretation and biological effectiveness of some novel prepared bis-azomethine derivatives and their copper(II) complexes》, the research content is summarized as follows. Three new bis-azomethine derivatives were synthesized in a good yield, along with their copper(II) complexes and confirmed by IR, ¹³C-NMR, ¹H-NMR, MS, ESR, powder XRD and UV-visible spectroscopy. The spectral studies indicated that the ligands in all complexes act as dibasic tetradentate, coordinated through two azomethine nitrogen and two deprotonated phenolic oxygen atoms. Square planar geometries were assigned for Cu(II) complexes in monomeric structures. Also, quantum chem. calculations using DFT were conducted to elucidate the effect of quantum chem. parameters on the mol. and electronic structures of the mols. under consideration, and then confirming their electrochem. behavior and biol. effectiveness. There were good correlations between practical and theor. studies. The redox pathway of bis-azomethine derivatives and their Cu(II) complexes was elucidated and confirmed based on exptl. and theor. calculations In vitro antimicrobial effectiveness of the synthesized three ligands and their Cu(II) complexes exhibited varying degrees of inhibitory effect on the growth of the test pathogenic microorganisms, confirming that antimicrobial efficiency is dependent on the mol. structure of the prepared compounds and their liposoly. The MIC was also determined for the compound H₂L_c which exhibited the highest antimicrobial activity against each of Pseudomonas aeruginosa (G-) and Candida albicans.

Synthetic Route of 90-59-5, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

3,5-Dibromosalicylaldehyde, also known as 3,5-Dibromosalicylaldehyde, is a useful research compound. Its molecular formula is C7H4Br2O2 and its molecular weight is 279.91 g/mol. The purity is usually 95%.

3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes. 3,5-Dibromosalicylaldehyde can be used in the synthesis of Schiff base and can be used as reactant for synthesis of Schiff base ligands which forms mononuclear complexes with copper(II), nickel(II), zinc(II) and cobalt(II).

3,5-Dibromosalicylaldehyde is a copper complex that has been synthesized from 3,5-dibromosalicylaldehyde and copper chloride. FTIR spectroscopy revealed that the coordination geometry of the copper complex is octahedral with two nitrogen atoms in the equatorial plane. The presence of hydrogen bonding interactions was confirmed by homologous protein adsorption experiments. This chemical structure was determined using X-ray crystallography and fluorescence probe experiments. The copper complex showed high affinity for malonic acid, which is an ester hydrochloride. The molecular mechanism of this interaction is based on adsorption, which occurs through hydrogen bonding interactions and hydrophobic interactions. Structural analysis revealed that the polymeric matrix consists of a three-dimensional network of crosslinked chains, while FTIR analysis indicated a possible disulfide bond between two cysteine residues., 90-59-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 2576-47-8, formula is C2H7Br2N, Name is 2-Bromoethylamine hydrobromide. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Electric Literature of 2576-47-8.

Dub, Pavel A.;Batrice, Rami J.;Gordon, John C.;Scott, Brian L.;Minko, Yury;Schmidt, Jurgen G.;Williams, Robert F. research published 《 Engineering Catalysts for Selective Ester Hydrogenation》, the research content is summarized as follows. The development of efficient catalysts and processes for synthesizing functionalized (olefinic and/or chiral) primary alcs. and fluoral hemiacetals is currently needed. These are valuable building blocks for pharmaceuticals, agrochems., perfumes, and so forth. From an economic standpoint, bench-stable Takasago Int. Corp.’s Ru-PNP, more commonly known as Ru-MACHO, and Gusev’s Ru-SNS complexes are arguably the most appealing mol. catalysts to access primary alcs. from esters and H₂ (Waser, M. et al. Organic Proc. Res. Dev. 2018,22, 862). This work introduces economically competitive Ru-SNP(O)_z complexes (z = 0, 1), which combine key structural elements of both of these catalysts. In particular, the incorporation of SNP heteroatoms into the ligand skeleton is crucial for the design of a more product-selective catalyst in the synthesis of fluoral hemiacetals under kinetically controlled conditions. Based on exptl. observations and computational anal., this paper further extends the current state-of-the-art understanding of the accelerative role of KO-t-Bu in ester hydrogenation. It attempts to explain why a maximum turnover occurs starting at ∼25 mol % base, in contrast to only ∼10 mol % with ketones as substrates.

Electric Literature of 2576-47-8, 2-Bromoethylamine hydrobromide is a useful building block for proteomics research.
2-Bromoethylamine hydrobromide is used in the synthesis of analogs of 5,​10,​15,​20-​tetrakis(1-​methylpyridinium-​4-​yl)​porphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist. It is used to construct C2-symmetric imidazolidinylidene ligands with a dioxolane backbone.
2-Bromoethylamine Hydrobromide is used in the synthesis of analogs of 5,​10,​15,​20-​tetrakis(1-​methylpyridinium-​4-​yl)​porphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist.
2-Bromoethylamine hydrobromide is a nonsteroidal anti-inflammatory drug that is used to treat inflammation and pain. It is a prodrug that is hydrolyzed in vivo to its active form, 2-Bromoethylamine hydrobromide. The bound form of this drug has been shown to inhibit the development of cell nuclei in the nucleus of cells. This drug also inhibits the production of nitric oxide, which leads to cell death by necrosis. 2-Bromoethylamine hydrobromide has been shown to have an inhibitory effect on the activity of glycol ethers, which are used as solvents for resins in coatings and adhesives., 2576-47-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary