Month: October 2022

Organic compounds having carbon bonded to bromine are called organic bromides. 6911-87-1, formula is C7H8BrN, Name is 4-Bromo-N-methylaniline. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Application of C7H8BrN.

Duarte de Almeida, Leandro;Bourriquen, Florian;Junge, Kathrin;Beller, Matthias research published 《 Catalytic Formal Hydroamination of Allylic Alcohols Using Manganese PNP-Pincer Complexes》, the research content is summarized as follows. Several manganese-PNP pincer catalysts for the formal hydroamination of allylic alcs. were presented. The resulting γ-amino alcs. were selectively obtained in high yields applying compound I in a tandem process under mild conditions.

Application of C7H8BrN, 4-Bromo-N-methylaniline is a aniline based compound known to exhibit mutagenic properties.
4-Bromo-N-methylaniline is a useful research compound. Its molecular formula is C7H8BrN and its molecular weight is 186.05 g/mol. The purity is usually 95%.
4-Bromophenylmethylamine is an organic compound that has anti-inflammatory properties and is used as a pharmaceutical. It belongs to the group of amines. The hydrolysis of 4-bromophenylmethylamine by hydrochloric acid produces phenol and bromamine (NHBr). The reaction system can be used to synthesize a number of compounds, including anilines, benzofurans, and other aromatic compounds. 4-Bromophenylmethylamine reacts with muscle tissue in a similar manner as acetaminophen does. This drug also has been shown to have significant effects on the energy metabolism in the muscles of rats that are given carbon source., 6911-87-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 20469-65-2, formula is C8H9BrO2, Name is 1-Bromo-3,5-dimethoxybenzene. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Computed Properties of 20469-65-2.

Duan, Wenwen;Sun, Ying;Wu, Meng;Zhang, Zhiyuan;Zhang, Taotao;Wang, Huan;Li, Fei;Yang, Lingyun;Xu, Yueming;Liu, Zhi-Jie;Hua, Tian;Nie, Hong;Cheng, Jianjun research published 《 Carbon-silicon switch led to the discovery of novel synthetic cannabinoids with therapeutic effects in a mouse model of multiple sclerosis》, the research content is summarized as follows. Designed and synthesized a variety of novel cannabinoids based on the structural backbones of THC and CBD using the carbon-silicon switch strategy. A di-Me silyl group were introduced as the tail group and two series of novel compounds were designed and synthesized, which showed a wide range of binding affinity for CB1 and CB2 receptors. Among them, compound I were identified as a non-selective CB1 and CB2 agonist and II as a selective agonist for the CB2 receptor. Preliminary screening showed that both compounds I and II was improved metabolic stability than their carbon analogs and good in-vivo pharmacokinetic profiles. Furthermore, both I and II significantly alleviated the phenotype of exptl. autoimmune encephalomyelitis (EAE) in mice.

Computed Properties of 20469-65-2, 1-Bromo-3,5-dimethoxybenzene, also known as 1-Bromo-3,5-dimethoxybenzene, is a useful research compound. Its molecular formula is C8H9BrO2 and its molecular weight is 217.06 g/mol. The purity is usually 95%.
1-Bromo-3,5-dimethoxybenzene is used as an intermediate in the synthetic preparation of pharmaceutical inhibitors via cross-coupling reactions.
1-Bromo-3,5-dimethoxybenzene can be synthesized by using 1,3-dimethoxybenzene via iridium-catalyzed arene borylation.
1-Bromo-3,5-dimethoxybenzene (1BDMB) is a synthetic molecule that can be used as an electron acceptor in organic photovoltaic cells. 1BDMB is a salt of the sodium salt of resorcylic acid and 1,3-dibromo-5,5-dimethoxybenzene. It has been shown to have a radical mechanism for the generation of free radicals. The radical mechanism is initiated by light absorption by the ruthenium complex at the center of the molecule which induces photoinduced electron transfer from the ruthenium to 1BDMB. This process results in electron transfer from the donor to an acceptor molecule, such as oxygen or nitrogen. The pharmacokinetic properties of this compound are not well known; however, it has been demonstrated that it can be synthesized through a cross-coupling reaction with other aromatic compounds such as stemofuran., 20469-65-2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 6911-87-1, formula is C7H8BrN, Name is 4-Bromo-N-methylaniline, Computed Properties of 6911-87-1

Duan, Peng;Zhao, He;Yang, Jian;Cao, Liang;Jiang, Huanfeng;Zhang, Min research published 《 Construction of Fluorinated Amino Acid Derivatives via Cobalt-Catalyzed Oxidative Difunctionalization of Cyclic Ethers》, the research content is summarized as follows. A new synthetic method for the efficient construction of novel fluorinated γ-amino acid esters I (n = 1, 2; R = H, Me; R¹ = methyl(phenyl)aminyl, 1,2,3,4-tetrahydroquinolin-1-yl, 1H,2H,3H-pyrrolo[2,3-b]pyridin-1-yl, etc.) via difunctionalization of the α- and β-sites of cyclic ethers such as THF, tetrahydropyran, 2-methyloxolane and 2,3-dihydrofuran, by employing a CoBr₂/m-CPBA catalyst system was demonstrated. Several cyclic ethers were transformed in combination with a vast range of amines such as 4-methylaniline, thiomorpholine, tetrahydroquinoline, etc. and Et trifluoropyruvate into the desired products I under mild conditions, making this method a practical platform to enrich the library of fluorinated amino acid derivatives from cost-effective and readily available feedstocks.

Computed Properties of 6911-87-1, 4-Bromo-N-methylaniline is a aniline based compound known to exhibit mutagenic properties.
4-Bromo-N-methylaniline is a useful research compound. Its molecular formula is C7H8BrN and its molecular weight is 186.05 g/mol. The purity is usually 95%.
4-Bromophenylmethylamine is an organic compound that has anti-inflammatory properties and is used as a pharmaceutical. It belongs to the group of amines. The hydrolysis of 4-bromophenylmethylamine by hydrochloric acid produces phenol and bromamine (NHBr). The reaction system can be used to synthesize a number of compounds, including anilines, benzofurans, and other aromatic compounds. 4-Bromophenylmethylamine reacts with muscle tissue in a similar manner as acetaminophen does. This drug also has been shown to have significant effects on the energy metabolism in the muscles of rats that are given carbon source., 6911-87-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 19111-87-6, formula is C18H11Br, Name is 2-Bromotriphenylene. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Application In Synthesis of 19111-87-6.

Duan, Lu-meng;Chen, Ting;Li, Zhong-qing;Li, Ji-xiang;Ma, Ze-qun;Liang, Xian-li;Hang, De-yu research published 《 Synthesis of high purified 2-bromobenzo[9,10]phenanthrene》, the research content is summarized as follows. The target compound is an important intermediate in some fields such as organic luminescence, disk liquid crystal and biomedicine. The synthesis method of high purity target compound is rarely reported in literatures. 2-Biphenylboronic acid was prepared from the starting material 2-bromobiphenyl by lithiation reaction at ultra-low temperature, and then (2-nitro-4-bromophenyl)-1-1′-biphenyl was obtained from 2-biphenylboronic acid and 2,5-dibromonitrobenzene by Suzuki coupling reaction, which was reduced by iron powder to obtain (2-amino-4-bromophenyl)-1-1′-biphenyl, finally the title compound (I, CAS Number 19111-87-6) was prepared by ring closure with isoamyl nitrite. Synthetic route of the compound was easy to operate, and the raw materials were easy to obtain. The target compound was suitable for industrialization and market high standard quality demand because of high purity. The structures of the each step compound were confirmed by ¹HNMR and ¹³CNMR, the purity was determined by HPLC, and the performance of target compound was tested by DSC and TGA.

Application In Synthesis of 19111-87-6, 2-Bromotriphenylene is a useful research compound. Its molecular formula is C18H11Br and its molecular weight is 307.2 g/mol. The purity is usually 95%.
2-Bromotriphenylene is a brominating agent that has the ability to react with sodium carbonate and emit light. The luminescence of 2-bromotriphenylene can be used as an indicator of the degree of dilution, or how much water is present in a solution. It also emits light when it reacts with chloride ions in a reaction solution. 2-Bromotriphenylene can be used as a polymer matrix to form polymeric films, which are then used as catalysts for organic reactions. The luminescence properties of 2-bromotriphenylene make it suitable for use in functional theory experiments. This chemical compound is relatively low cost, and has been shown to have high yield in catalysis., 19111-87-6.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 4224-70-8, formula is C6H11BrO2, Name is 6-Bromohexanoic acid, Formula: C6H11BrO2

Duan, Jicheng;Wang, Yuquan;Qi, Liangliang;Guo, Peng;Pang, Xiaobo;Shu, Xing-Zhong research published 《 Nickel-Catalyzed Cross-Electrophile C(sp³)-Si Coupling of Unactivated Alkyl Bromides with Vinyl Chlorosilanes》, the research content is summarized as follows. Cross-electrophile C-Si coupling has emerged as a promising tool for the construction of organosilanes, but the potential of this method remains largely unexplored. Herein, we report a C(sp³)-Si coupling of unactivated alkyl bromides with vinyl chlorosilanes. The reaction proceeds under mild conditions, and it offers a new approach to alkylsilanes. Functionalities such as Grignard-sensitive groups (e.g., acid, amide, alc., ketone, and ester), acid-sensitive groups (e.g., ketal and THP protection), alkyl fluoride and chloride, aryl bromide, alkyl tosylate and mesylate, silyl ether, and amine were tolerated. Incorporation of the -Si(vinyl)R₂ moiety into complex mols. and the immobilization of a glass surface by formed organosilanes were demonstrated.

Formula: C6H11BrO2, 6-bromohexanoic acid is an organobromine compound comprising hexanoic acid having a bromo substituent at the 6-position. It derives from a hexanoic acid.
6-Bromohexanoic acid is a useful research compound. Its molecular formula is C6H11BrO2 and its molecular weight is 195.05 g/mol. The purity is usually 95%.
6-Bromohexanoic acid is useful for the preparation of anti-CTLA4 compounds as antitumor agents.
6-Bromohexanoic acid is a fatty acid that has been shown to be an effective agent for the treatment of cancer. It is used in gene therapy to inhibit the growth of cancer cells by binding to and then activating transcription factors. 6-Bromohexanoic acid can also be used as a chemotherapeutic agent and has been shown to cause apoptosis in monoclonal antibody-treated cells. 6-Bromohexanoic acid has pharmacokinetic properties that are similar to those of other fatty acids. The reaction solution was found to have high chemical stability, which may be due to the presence of nitrogen atoms. This reaction solution was found to adsorb onto the surface of monoclonal antibodies and cell culture, altering their properties., 4224-70-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 244205-40-1, formula is C6H6BBrO2, Name is (2-Bromophenyl)boronic acid. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Quality Control of 244205-40-1.

Du, Zhonglin;Li, Fenrui;Li, Li;Li, Ran research published 《 Microwave-assisted one-pot quick synthesis of monosubstituted 1,2,3-triazoles from arylboronic acids, sodium azide and 3-butyn-2-ols》, the research content is summarized as follows. Microwave-assisted one-pot quick synthesis of monosubstituted 1,2,3-triazoles were achieved with good to excellent yields using the widely available arylboronic acids, sodium azide and 3-butyn-2-ols within 15 min. This method featured high efficient and facile as organic azides, acetylene gas and harsh conditions were avoided.

Quality Control of 244205-40-1, 2-Bromophenylboronic Acid is used as an inhibitor of the hormone sensitive lipase.
2-Bromophenylboronic acid, also known as 2-Bromophenylboronic acid, is a useful research compound. Its molecular formula is C6H6BBrO2 and its molecular weight is 200.83 g/mol. The purity is usually 95%.
2-Bromophenylboronic acid is a glucose monitoring agent that has a ruthenium complex with an acidic environment. The nitro group and the amines are in close proximity to the boron center, and this proximity leads to a high nucleophilic character of the molecule. This reactivity allows 2-bromophenylboronic acid to be used as a fluorescence probe for acidic environments. 2-Bromophenylboronic acid also inhibits secretase enzymes, which are involved in Alzheimer’s disease and other neurodegenerative disorders. It is an inhibitor of γ-secretase, which is responsible for cleaving the amyloid precursor protein (APP), and it has shown efficacy against biphenyl, an anticancer drug that binds to benzodiazepine receptors. 2-Bromophenylboronic acid is also an enantiopure compound because all four substituents are different from each other., 244205-40-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 4224-70-8, formula is C6H11BrO2, Name is 6-Bromohexanoic acid. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Product Details of C6H11BrO2.

Du, Zaizhi;Liu, Han;Huang, Xie;Li, Yang;Wang, Liting;Liu, Jing;Long, Shuang;Li, Rong;Xiang, Qiang;Luo, Shenglin research published 《 Design and Synthesis of a Mitochondria-Targeting Radioprotectant for Promoting Skin Wound Healing Combined with Ionizing Radiation Injury》, the research content is summarized as follows. Wound healing is seriously retarded when combined with ionizing radiation injury, because radiation-induced excessive reactive oxygen species (ROS) profoundly affect cell growth and wound healing. Mitochondria play vital roles not only as cellular energy factories but also as the main source of endogenous ROS, and in this work a mitochondria-targeting radioprotectant (CY-TMP1) is reported for radiation injury-combined wound repair. It was designed, synthesized and screened out from different conjugates between mitochondria-targeting heptamethine cyanine dyes and a peroxidation inhibitor 2,2,6,6-tetramethylpiperidinyloxy (TEMPO). CY-TMP1 specifically accumulated in mitochondria, efficiently mitigated mitochondrial ROS and total intracellular ROS induced by 6 Gy of X-ray ionizing irradiation, thereby exhibiting a notable radioprotective effect. The mechanism study further demonstrated that CY-TMP1 protected mitochondria from radiation-induced injury, including maintaining mitochondrial membrane potential (MMP) and ATP generation, thereby reducing the ratio of cell apoptotic death. Particularly, an in vivo experiment showed that CY-TMP1 could effectively accelerate wound closure of mice after 6 Gy of whole-body ionizing radiation. Immunohistochem. staining further indicated that CY-TMP1 may improve wound repair through angiogenesis and re-epithelialization. Therefore, mitochondria-targeting ROS scavengers may present a feasible strategy to conquer refractory wound combined with radiation injury.

4224-70-8, 6-bromohexanoic acid is an organobromine compound comprising hexanoic acid having a bromo substituent at the 6-position. It derives from a hexanoic acid.
6-Bromohexanoic acid is a useful research compound. Its molecular formula is C6H11BrO2 and its molecular weight is 195.05 g/mol. The purity is usually 95%.
6-Bromohexanoic acid is useful for the preparation of anti-CTLA4 compounds as antitumor agents.
6-Bromohexanoic acid is a fatty acid that has been shown to be an effective agent for the treatment of cancer. It is used in gene therapy to inhibit the growth of cancer cells by binding to and then activating transcription factors. 6-Bromohexanoic acid can also be used as a chemotherapeutic agent and has been shown to cause apoptosis in monoclonal antibody-treated cells. 6-Bromohexanoic acid has pharmacokinetic properties that are similar to those of other fatty acids. The reaction solution was found to have high chemical stability, which may be due to the presence of nitrogen atoms. This reaction solution was found to adsorb onto the surface of monoclonal antibodies and cell culture, altering their properties., Product Details of C6H11BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 2576-47-8, formula is C2H7Br2N, The most pervasive is the naturally produced bromomethane. Related Products of 2576-47-8

Du, Yi-Ran;Yang, Xin;Wang, Yao-Feng;Guan, Peng-Xin;Wang, Rui;Xu, Bao-Hua research published 《 Immobilization poly(ionic liquid)s into hierarchical porous covalent organic frameworks as heterogeneous catalyst for cycloaddition of CO₂ with epoxides》, the research content is summarized as follows. The chem. fixation of CO₂ into high value-added chems. is of significant potential and sustainability to address the energy and ecol. issues. To achieve great catalytic performance on the transformation of CO₂, it is pivotal to strategically integrating several multifunctional and synergetic functionalities into the catalyst design and catalytic system construction. Herein, the poly(ionic liquid)-hierarchical porous covalent organic framework (PIL-HPCOF) hybrids were successfully synthesized via the formation of HPCOF through hard-template method, followed by in-situ polymerization of mono-vinyl decorated ionic liquids (ILs). The resultant PIL-HPCOF hybrids possess excellent versatility, with micropores providing high surface area to enhance CO₂ uptake capacity and macropores supplying sufficient pore volume to promote mass transport of substrates. As a proof of concept, the conversion of CO₂ with epoxides to produce cyclic carbonates was selected as a model reaction, which catalytic performance was obviously promoted by using PIL-HPCOF hybrids as the catalyst as compared to those of independent PIL and the PIL-COF hybrids with only micropores. Thus, it enables such a metal-free catalysis proceeds under much mild conditions (CO₂ (1 MPa), 90°C) and with broad substrates tolerance. These results supply the basis to design efficient and stable catalysts for CO₂ conversion.

Related Products of 2576-47-8, 2-Bromoethylamine hydrobromide is a useful building block for proteomics research.
2-Bromoethylamine hydrobromide is used in the synthesis of analogs of 5,​10,​15,​20-​tetrakis(1-​methylpyridinium-​4-​yl)​porphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist. It is used to construct C2-symmetric imidazolidinylidene ligands with a dioxolane backbone.
2-Bromoethylamine Hydrobromide is used in the synthesis of analogs of 5,​10,​15,​20-​tetrakis(1-​methylpyridinium-​4-​yl)​porphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist.
2-Bromoethylamine hydrobromide is a nonsteroidal anti-inflammatory drug that is used to treat inflammation and pain. It is a prodrug that is hydrolyzed in vivo to its active form, 2-Bromoethylamine hydrobromide. The bound form of this drug has been shown to inhibit the development of cell nuclei in the nucleus of cells. This drug also inhibits the production of nitric oxide, which leads to cell death by necrosis. 2-Bromoethylamine hydrobromide has been shown to have an inhibitory effect on the activity of glycol ethers, which are used as solvents for resins in coatings and adhesives., 2576-47-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 2576-47-8, formula is C2H7Br2N, Name is 2-Bromoethylamine hydrobromide. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Name: 2-Bromoethylamine hydrobromide.

Du, Yi-Ran;Ding, Guang-Rong;Wang, Yao-Feng;Xu, Bao-Hua;Zhang, Suo-Jiang research published 《 Construction of a PPIL@COF core-shell composite with enhanced catalytic activity for CO₂ conversion》, the research content is summarized as follows. Converting CO₂ into high value-added chems. is a promising approach for CO₂ utilization. It is imperative to develop novel catalysts for both selective and high adsorption of CO₂ and thereafter efficient chem. transformation. Herein, bromide-based porous poly(ionic liquid)s (PPILs) were covalently integrated with mesoporous covalent organic frameworks (COFs) to provide a kind of core-shell hybrid for the first time. The resultant PPIL@COF hybrids fabricated by anchoring a specific ratio of PPIL to COF have a bromide per unit mass value which corresponds to the requisite CO₂ uptake capacity, thereby facilitating the storage of enough CO₂ around the catalytic active sites. As a proof of concept, the cyclization of epoxides with CO₂ to form cyclic carbonates was selected as the benchmark reaction, the reactivity of which was significantly improved in the presence of hydroxyl group decorated PPIL@COFA compared to that of individual PPIL and the hydroxyl-free PPIL@COFB counterpart. The hydroxyl groups at the interfacial layer, functioning as the hydrogen bond donors, cooperate with the bromides from the PPIL core to facilitate the rate-limiting step of the ring opening of the epoxides. These findings provide the basis of a novel design concept for achieving both efficient and stable catalysts in the CO₂ transformation.

2576-47-8, 2-Bromoethylamine hydrobromide is a useful building block for proteomics research.
2-Bromoethylamine hydrobromide is used in the synthesis of analogs of 5,​10,​15,​20-​tetrakis(1-​methylpyridinium-​4-​yl)​porphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist. It is used to construct C2-symmetric imidazolidinylidene ligands with a dioxolane backbone.
2-Bromoethylamine Hydrobromide is used in the synthesis of analogs of 5,​10,​15,​20-​tetrakis(1-​methylpyridinium-​4-​yl)​porphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist.
2-Bromoethylamine hydrobromide is a nonsteroidal anti-inflammatory drug that is used to treat inflammation and pain. It is a prodrug that is hydrolyzed in vivo to its active form, 2-Bromoethylamine hydrobromide. The bound form of this drug has been shown to inhibit the development of cell nuclei in the nucleus of cells. This drug also inhibits the production of nitric oxide, which leads to cell death by necrosis. 2-Bromoethylamine hydrobromide has been shown to have an inhibitory effect on the activity of glycol ethers, which are used as solvents for resins in coatings and adhesives., Name: 2-Bromoethylamine hydrobromide

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 244205-40-1, formula is C6H6BBrO2, Name is (2-Bromophenyl)boronic acid, Computed Properties of 244205-40-1

Du, Xin;Zhao, Huan;Li, Xinling;Zhang, Lizhi;Dong, Yunhui;Wang, Ping;Zhang, Daopeng;Liu, Qing;Liu, Hui research published 《 Ligand-Regulated Palladium-Catalyzed Regiodivergent Hydroarylation of the Distal Double Bond of Allenamides with Aryl Boronic Acid》, the research content is summarized as follows. The ligand-regulated regiodivergent hydroarylation of the distal double bond of allenamides with aryl boronic acid was achieved in the presence of Pd(II) catalysts, delivering a variety of functionalized enamide with excellent E selectivity and Markovnikov/anti-Markovnikov selectivity. Two possible coordination intermediates probably are responsible for the regiodivergent hydroarylation: (1) The coordination Intermediate I, which probably is formed through the coordination of MeCN, distal double bond, Ph to Pd, led to the aryl group away from the Intermediate I, inducing excellent E selectivity and anti-Markovnikov selectivity. (2) A switch of regioselectivity to 1,2-Markovnikov hydroarylation was obtained using bidentate phosphine ligand (dppf or Xantphos). The formed coordination Intermediate II led to the N-tether away from the Intermediate II and at the trans position of aryl, resulting in excellent E selectivity and Markovnikov selectivity. Meanwhile, tentative study on the mechanism proved that the hydron source of this hydroarylation is more likely to be boronic acid. The transmetalation between aryl boronic acid and Pd catalyst was the initial step of this transformation.

Computed Properties of 244205-40-1, 2-Bromophenylboronic Acid is used as an inhibitor of the hormone sensitive lipase.
2-Bromophenylboronic acid, also known as 2-Bromophenylboronic acid, is a useful research compound. Its molecular formula is C6H6BBrO2 and its molecular weight is 200.83 g/mol. The purity is usually 95%.
2-Bromophenylboronic acid is a glucose monitoring agent that has a ruthenium complex with an acidic environment. The nitro group and the amines are in close proximity to the boron center, and this proximity leads to a high nucleophilic character of the molecule. This reactivity allows 2-bromophenylboronic acid to be used as a fluorescence probe for acidic environments. 2-Bromophenylboronic acid also inhibits secretase enzymes, which are involved in Alzheimer’s disease and other neurodegenerative disorders. It is an inhibitor of γ-secretase, which is responsible for cleaving the amyloid precursor protein (APP), and it has shown efficacy against biphenyl, an anticancer drug that binds to benzodiazepine receptors. 2-Bromophenylboronic acid is also an enantiopure compound because all four substituents are different from each other., 244205-40-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary