Month: October 2022

Quality Control of Methyl 3-(bromomethyl)benzoateIn 2021 ,《Visible-Light-Promoted Multistep Tandem Reaction of Vinyl Azides toward the Formation of 1-Tetralones》 was published in Journal of Organic Chemistry. The article was written by Jiao, Meng-Jie; Hu, Qiang; Hu, Xiu-Qin; Xu, Peng-Fei. The article contains the following contents:

A visible-light-driven multistep tandem reaction between vinyl azides 2-R-3-R1-4-R2-C6H2C(=CH2)N3 (R = H, Cl, Me; R1 = H, Me; R2 = H, Br, CN, Ph, etc.) and alkyl bromides R3CH(R4)C((C(O)OCH2CH3)2)Br (R3 = H, prop-1-yn-1-yl, Ph, naphthalen-1-yl, etc.; R4 = H, Me; R3R4 = -(CH2)4-) has been developed leading to the formation of tetralone skeletons I (R5 = H, Me) under mild conditions, which can be easily scaled up to the gram scale. Various 1-tetralone derivatives I are synthesized and transformed into desired products in good to high yields. In the experiment, the researchers used many compounds, for example, Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Quality Control of Methyl 3-(bromomethyl)benzoate)

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. Quality Control of Methyl 3-(bromomethyl)benzoate Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Recommanded Product: 17696-11-6In 2020 ,《Symmetrical-Tetramethyl-Cucurbit[6]uril-Driven Movement of Cucurbit[7]uril Gives Rise to Heterowheel [4]Pseudorotaxanes》 was published in Journal of Organic Chemistry. The article was written by Lin, Rui-Lian; Li, Ran; Shi, Hao; Zhang, Kun; Meng, Di; Sun, Wen-Qi; Chen, Kai; Liu, Jing-Xin. The article contains the following contents:

Two novel heterowheel [4]pseudorotaxanes consisting of cucurbit[7]uril (Q[7]) and sym.-tetramethyl-cucurbit[6]uril (TMeQ[6]) were constructed via the multirecognition mechanism, in which Q[7] can rotate freely around the horizontal axis, while TMeQ[6] cannot. In the construction process, due to strong repulsive forces between carbonyl portals of two neighboring wheels, the dethreading and movement of the wheels along the axle was observed The dissociation of the [4]pseudorotaxanes was also discussed. The experimental process involved the reaction of 8-Bromooctanoic acid(cas: 17696-11-6Recommanded Product: 17696-11-6)

8-Bromooctanoic acid(cas: 17696-11-6) acid is used in the synthesis of 8-(N-Methyl-4,4′-bipyridinyl)- octanoic acid. 8-Mercaptooctanoic acid was prepared from 8-bromooctanoic acid. And 8-Bromooctanoic Acid is a useful compound for sonodynamic therapy.Recommanded Product: 17696-11-6

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Safety of Ethyl 4-bromobutyrateIn 2019 ,《Tetraphenylporphyrin-based dual-functional medical agent for magnetic resonance and fluorescence imaging》 was published in Applied Organometallic Chemistry. The article was written by Jin, Manyu; Zhang, Yanqun; Gao, Ge; Xi, Qiaoyue; Tong, Jie; Zhao, Yongxia; Wu, Cunqi; Zhou, Hua; Yang, Qiuxia; Yang, Wei; Xu, Jingwei. The article contains the following contents:

A bimodal magnetic resonance imaging contrast agent, TPP-M-Gd, was developed by modifying tetraphenylporphyrin (TPP) with a small dendritic mol. as a ligand (M) to chelate gadolinium (Gd) ions. The ligand featured four carboxylate groups, which contributed to good water solubility and a strong combination with metal ions. The longitudinal relaxivity (R1) of the resulting agent is 12.45 mM-1s-1, which is much higher than that of DTPA-Gd (4.49 mM-1s-1). The magnetic resonance imaging experiments showed that the newly synthesized contrast agent could enhance T1-weighted magnetic resonance imaging quality both in vitro and in vivo. In addition, TPP-M-Gd exhibited good fluorescent property as shown in cell imaging experiments The cytotoxicity of TPP-M-Gd was even better than that of clin. approved DTPA-Gd, which makes it a promising dual-functional medical imaging agent to provide more detailed information about biol. and disease-related events. In the experiment, the researchers used Ethyl 4-bromobutyrate(cas: 2969-81-5Safety of Ethyl 4-bromobutyrate)

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Safety of Ethyl 4-bromobutyrate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Recommanded Product: 6825-20-3In 2021 ,《Thin-Film Luminescent Solar Concentrator Based on Intramolecular Charge Transfer Fluorophore and Effect of Polymer Matrix on Device Efficiency》 was published in Polymers (Basel, Switzerland). The article was written by Mateen, Fahad; Lee, Namcheol; Lee, Sae Youn; Taj Ud Din, Syed; Yang, Woochul; Shahzad, Asif; Kaliamurthy, Ashok Kumar; Lee, Jae-Joon; Hong, Sung-Kyu. The article contains the following contents:

Luminescent solar concentrators (LSCs) provide a transformative approach to integrating photovoltaics into a built environment. In this paper, we report thin-film LSCs composed of intramol. charge transfer fluorophore (DACT-II) and discuss the effect of two polymers, polymethyl methacrylate (PMMA), and poly (benzyl methacrylate) (PBzMA) on the performance of large-area LSCs. As observed exptl., DACT-II with the charge-donating diphenylaminocarbazole and charge-accepting triphenyltriazine moieties shows a large Stokes shift and limited re-absorption losses in both polymers. Our results show that thin-film LSC (10 x 10 x 0.3 cm3) with optimized concentration (0.9 wt%) of DACT-II in PBzMA gives better performance than that in the PMMA matrix. In particular, optical conversion efficiency (ηopt) and power-conversion efficiency (ηPCE) of DACT-II/PBzMA LSC are 2.32% and 0.33%, resp., almost 1.2 times higher than for DACT-II/PMMA LSC. In the experiment, the researchers used 3,6-Dibromo-9H-carbazole(cas: 6825-20-3Recommanded Product: 6825-20-3)

3,6-Dibromo-9H-carbazole(cas: 6825-20-3) is used as a pharmaceutical intermediate, and also an important intermediate of synthesizing optoelectronic materials. It has been used in the preparation of N-(2-hydroxyethyl)-3,6-dibromocarbazole.Recommanded Product: 6825-20-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《A New Biscarbazole-Based Metal-Organic Framework for Efficient Host-Guest Energy Transfer》 was written by Mu, Qianqian; Liu, Jingjuan; Chen, Weiben; Song, Xiaoyu; Liu, Xiaoting; Zhang, Xiaotao; Chang, Ze; Chen, Long. Reference of 3,6-Dibromo-9H-carbazoleThis research focused onzinc bicarbazoletetracarboxylate MOF host guest energy transfer fluorescent dye; crystal structure zinc bicarbazoletetracarboxylate MOF preparation fluorescence energy transfer; energy transfer; fluorescence; host-guest systems; in situ encapsulation; metal-organic frameworks. The article conveys some information:

A new metal-organic framework (MOF), [Zn6L4(Me2NH2+)4·H2O] (1) was constructed based on [9,9′-biscarbazole]-3,3′,6,6′-tetracarboxylic acid (H4L) and Zn2+ ions. The porous framework and intense blue fluorescence of the MOF based on the biscarbazole moiety of the ligand could facilitate efficient host to guest energy transfer, which makes it an ideal platform for the tuning of luminescence. The results came from multiple reactions, including the reaction of 3,6-Dibromo-9H-carbazole(cas: 6825-20-3Reference of 3,6-Dibromo-9H-carbazole)

3,6-Dibromo-9H-carbazole(cas: 6825-20-3) is used as a pharmaceutical intermediate, and also an important intermediate of synthesizing optoelectronic materials. It has been used in the preparation of N-(2-hydroxyethyl)-3,6-dibromocarbazole.Reference of 3,6-Dibromo-9H-carbazole

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Click-based conjugated microporous polymers as efficient heterogeneous photocatalysts for organic transformations》 was written by Gan, Shaolin; Zeng, Yan; Liu, Jiaxin; Nie, Junqi; Lu, Cuifen; Ma, Chao; Wang, Feiyi; Yang, Guichun. Synthetic Route of C4H2Br2SThis research focused ontriazole thiophene conjugated polymer catalyst preparation optical band gap; dimethylaniline aryl iso isocyanide triazolethiophene catalyst ugi reaction; methyl arylamino phenylacetanmide preparation; tetrahydroisoquinoline triazolethiophene catalyst oxidation; tetrahydroisoquinolinone preparation. The article conveys some information:

In this study, the design and synthesis of three 1,2,3-triazole-thiophene based CMP (Ta-Th) photocatalysts through the click reaction was described. Compared with the corresponding thienyl- and bithienyl-bridged Ta-Th-4 and Ta-Th-5, the terthiophene based Ta-Th-6 shows a stronger light-harvesting ability, a narrower optical energy gap, and a better charge separation efficiency for facilitated charge transfer, which make Ta-Th-6 a promising candidate for photoredox reactions. Indeed, Ta-Th-6 presents superior photocatalytic activity in the Ugi multicomponent reaction and α-oxidation of N-substituted tetrahydroisoquinolines. Furthermore, the catalyst exhibits a considerable activity after recycling five times, demonstrating its high stability and excellent reusability. The experimental part of the paper was very detailed, including the reaction process of 2,5-Dibromothiophene(cas: 3141-27-3Synthetic Route of C4H2Br2S)

2,5-Dibromothiophene(cas: 3141-27-3) , is mainly used as pharmaceutical intermediate and synthesis intermediate. 2,5-Dibromothiophene polymerizes by debromination with magnesium catalyzed by nickel compounds to form poly(2,5- thienylene) .Synthetic Route of C4H2Br2S

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Deoxofluorination of Aliphatic Carboxylic Acids: A Route to Trifluoromethyl-Substituted Derivatives》 was written by Bugera, Maksym; Trofymchuk, Serhii; Tarasenko, Karen; Zaporozhets, Olga; Pustovit, Yurii; Mykhailiuk, Pavel K.. Application of 2623-87-2This research focused ontrifluoromethyl substituted derivative preparation; aliphatic carboxylic acid deoxofluorination sulfur tetrafluoride water additive. The article conveys some information:

A practical method for the synthesis of functionalized aliphatic trifluoromethyl-substituted derivatives from aliphatic acids was developed. The transformation proceeds with sulfur tetrafluoride in the presence of water as a key additive. Compared to previous methods, the reaction gives products with full retention of stereo- and absolute configuration of chiral centers. After reading the article, we found that the author used 4-Bromobutanoic acid(cas: 2623-87-2Application of 2623-87-2)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Application of 2623-87-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Discovery of an Orally Bioavailable Gonadotropin-Releasing Hormone Receptor Antagonist》 was written by Kim, Seon-Mi; Lee, Minhee; Lee, So Young; Park, Euisun; Lee, Soo-Min; Kim, Eun Jeong; Han, Min Young; Yoo, Taekyung; Ann, Jihyae; Yoon, Suyoung; Lee, Jiyoun; Lee, Jeewoo. Application In Synthesis of Methyl 3-(bromomethyl)benzoateThis research focused onuracil derivative SKI2496 preparation GnRH receptor antagonist pharmacokinetics. The article conveys some information:

The authors developed a compound library for orally available gonadotropin-releasing hormone (GnRH) receptor antagonists that were based on a uracil scaffold. Based on in vitro activity and CYP inhibition profile, the authors selected 18a ((R)-4-((2-(3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-5-(4-((5-(trifluoromethyl)-furan-2-yl)methyl)-piperazin-1-yl)-2,3-dihydropyrimidin-1(6H)-yl)-1-phenylethyl)-amino)-butanoic acid, SKI2496) for further in vivo studies. Compound 18a exhibited more selective antagonistic activity toward the human GnRH receptors over the GnRHRs in monkeys and rats, and this compound also showed inhibitory effects on GnRH-mediated signaling pathways. Pharmacokinetic and pharmacodynamic evaluations of 18a revealed improved bioavailability and superior gonadotropic suppression activity compared with Elagolix, the most clin. advanced compound Considering that 18a exhibited highly potent and selective antagonistic activity toward the hGnRHRs along with favorable pharmacokinetic profiles, the authors believe that 18a may represent a promising candidate for an orally available hormonal therapy. The experimental process involved the reaction of Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Application In Synthesis of Methyl 3-(bromomethyl)benzoate)

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Due to the reactivity of bromide, they are used as potential precursors or important intermediates in organic synthesis. Application In Synthesis of Methyl 3-(bromomethyl)benzoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary