Month: October 2022

《Interaction of ninhydrin with zinc(II) complex of tryptophan in the three dicationic gemini surfactants》 was written by Abdul Rub, Malik; Kumar, Dileep. Formula: C6H12Br2This research focused onzinc ninhydrin tryptophan gemini surfactant critical micellar concentration. The article conveys some information:

Present work concerns with the interaction of ninhydrin with zinc(II) complex of tryptophan ([Zn(II)-Trp]+) in the three dicationic gemini surfactant systems. To record critical micellar concentration (CMC) and absorbance, we have used Systronics conductivity meter and UV-visible spectrophotometer, resp. Experiment opens up the fractional- and first-order paths in ninhydrin and complex, resp. Gemini micellar medium is found more superior over aqueous medium. Rate constant (kψ) vs. [gemini] plot shows the unusual role of geminis on kψ. kψ increases with gemini concentration (at concentrations lower than the CMC, part I) and leveling-off regions obtain (concentration up to 400 × 10-5 mol dm-3, part II). Characteristics of part I and part II are just the same as that of conventional surfactant. Later, gemini produces a third region of increasing kψ at higher concentrations ([gemini] > 400 × 10-5 mol dm-3, part III). Detail and systematic elucidation about the effect of surfactants are mentioned and discussed in the text. Binding constants (KS for [Zn(II)-Trp]+ and KN for ninhydrin) and rate constant (km in geminis) were determined by nonlinear least squares regression technique. The kinetic results acquired can reasonably be interpreted by pseudo-phase model of surfactant micelles. In the experimental materials used by the author, we found 1,6-Dibromohexane(cas: 629-03-8Formula: C6H12Br2)

1,6-Dibromohexane(cas: 629-03-8) is generally used to introduce C6 spacer in the molecular architecture. Some of the examples are: synthesis of solvent processable and conductive polyfluorene ionomers for alkaline fuel cell applications; synthesis of cross-linkable regioregular poly(3-(5-hexenyl)thiophene) (P3HNT) for stabilizing the film morphology in polymer photovoltaic cells.Formula: C6H12Br2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Oxygen vacancy-induced donor-acceptor-conjugated microporous poly(triphenylamine-benzothiadiazole)/TiO2 as a Z-scheme heterojunction photocatalyst towards a visible-light-driven degradation of bisphenol A》 was written by Liu, Chenrui; Liu, Lulu; Liu, Yun; Dang, Zhi; Li, Chengcheng. Name: Tris(4-bromophenyl)amineThis research focused ontitanium dioxide heterojunction photocatalyst polycondensation structural morphol catalytic property. The article conveys some information:

Herein, a kind of donor-acceptor-conjugated microporous polymer (D-A CMP), poly(triphenylamine-benzothiadiazole) denoted as TPABT, was introduced to synthesize a novel organic-inorganic heterojunction photocatalyst with TiO2 by in situ polycondensation. Resultant TPABT/TiO2 composites were used to photodegrade bisphenol A (BPA) under visible light. Results indicated that the TPABT/TiO2 composite with a mass ratio of TPABT to TiO2 of 10 : 100 (labeled as 10-TPABT/TiO2) showed optimum photocatalytic activity, 8 and 4 times that of pure TiO2 and TPABT, resp. Systematic characterizations revealed that the incorporation of TPABT caused the generation of oxygen vacancies on TiO2, which improved the visible light responsiveness of TiO2. Moreover, EIS (electrochem. impedance spectroscopy), photocurrent response and PL emission spectra suggested that 10-TPABT/TiO2 composites exhibited optimum activity than TPABT and TiO2. Moreover, detailed investigations indicated that the improvement in the photoactivity of TPABT/TiO2 contributed to the formation of a Z-scheme heterojunction, which enhanced the charge transfer from TPABT to TiO2. This work provides some interesting ideas for enhancing the photocatalytic activity of TiO2 and exploiting efficient heterojunction photocatalysts based on CMPs for pollutant degradation The experimental part of the paper was very detailed, including the reaction process of Tris(4-bromophenyl)amine(cas: 4316-58-9Name: Tris(4-bromophenyl)amine)

In general, Tris(4-bromophenyl)amine(cas: 4316-58-9) is often used in the synthesis of porous luminescent covalent–organic polymers (COPs)Name: Tris(4-bromophenyl)amine

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Synthesis and in vitro Antitumor Effect of New Vindoline Derivatives Coupled with Triphenylphosphine》 was written by Keglevich, Andras; Szigetvari, Aron; Dekany, Miklos; Szantay, Csaba; Keglevich, Peter; Hazai, Laszlo. COA of Formula: C4H7BrO2This research focused onvindoline preparation antitumor activity. The article conveys some information:

An important approach to the development of new antitumor agents is the synthesis of conjugates containing two or more structural units. Taking this into consideration, vindoline derivatives I (n = 1, 3, 4) were coupled with triphenylphosphine, to afford the expected phosphonium salts II. The new hybrid entities were characterized by NMR spectroscopy, and their anticancer activity was also evaluated. In the part of experimental materials, we found many familiar compounds, such as 4-Bromobutanoic acid(cas: 2623-87-2COA of Formula: C4H7BrO2)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).COA of Formula: C4H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Triazole Bridged Flavonoid Dimers as Potent, Nontoxic, and Highly Selective Breast Cancer Resistance Protein (BCRP/ABCG2) Inhibitors》 was written by Zhu, Xuezhen; Wong, Iris L. K.; Chan, Kin-Fai; Cui, Jiahua; Law, Man Chun; Chong, Tsz Cheung; Hu, Xuesen; Chow, Larry M. C.; Chan, Tak Hang. Related Products of 1129-28-8This research focused ontriazole bridged flavonoid dimer breast cancer SAR docking. The article conveys some information:

The present work describes the syntheses of diverse triazole bridged flavonoid dimers and identifies potent, nontoxic, and highly selective BCRP inhibitors. A homodimer, Ac22(Az8)2, with m-methoxycarbonylbenzyloxy substitution at C-3 of the flavone moieties and a bis-triazole-containing linker (21 atoms between the two flavones) showed low toxicity (IC50 toward L929, 3T3, and HFF-1 > 100 μM), potent BCRP-inhibitory activity (EC50 = 1-2 nM), and high BCRP selectivity (BCRP selectivity over MRP1 and P-gp > 455-909). Ac22(Az8)2 inhibits BCRP-ATPase activity, blocks the drug efflux activity of BCRP, elevates the intracellular drug accumulation, and finally restores the drug sensitivity of BCRP-overexpressing cells. It does not down-regulate the surface BCRP protein expression to enhance the drug retention. Therefore, Ac22(Az8)2 and similar flavonoid dimers appear to be promising candidates for further development into combination therapy to overcome MDR cancers with BCRP overexpression. In the experimental materials used by the author, we found Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Related Products of 1129-28-8)

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Related Products of 1129-28-8 In contrast, terrestrial plants account only for a few bromine-containing compounds.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Two-dimensional zinc(II) and copper(I) coordination polymers for photoluminescence》 was written by Jeong, Ah Rim; Shin, Hye Jin; Jang, Yoon Jung; Min, Kil Sik. Recommanded Product: 623-24-5This research focused onzinc copper polypyridine coordination polymer preparation photoluminescence thermal stability; crystal structure zinc copper polypyridine coordination polymer. The article conveys some information:

Two-dimensional (2-D) coordination polymers [Zn2(bpab)(CH3CO2)4]·H2O (1), [Zn(bpab)(H2O)2](NO3)2 (2), [Cu2(bpab)I2]·CH3OH (3), and [Cu2(tpmd)I2] (4) have been synthesized by the reaction of zinc(II)/copper(I) ions and tetradentate polypyridine ligands (bpab = bis-1,4-(di-4-pyridylaminomethyl)benzene and tpmd = N,N,N’,N’-tetrakis(pyridine-4-yl)methanediamine). The zinc(II) ions of 1 and 2 have distorted tetrahedral and trigonal bipyramidal geometries, resp. By coordinating zinc(II) ions and bpab ligands, 1 and 2 formed a brick wall and puckered 2-D networks, resp. The copper(I) ions of 3 and 4 are both tetrahedral structures with Cu2I2 rhomboidal geometry. By linking the Cu2I2 cores and bpab/tpmd ligands, 3 and 4 exhibited interwoven and interconnected bilayered 2-D networks, resp. Compared to free bpab and tpmd ligands, polymers 1 and 2 show strongly blue-shifted emissions, whereas polymers 3 and 4 show strongly red-shifted emissions. Therefore, the shifts of emission wavelengths are strongly dependent on the zinc(II) and copper(I) ions that linked the bpab/tpmd tetradentate ligands, resp. In the experimental materials used by the author, we found 1,4-Bis(bromomethyl)benzene(cas: 623-24-5Recommanded Product: 623-24-5)

1,4-Bis(bromomethyl)benzene(cas: 623-24-5) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Recommanded Product: 623-24-5 In contrast, terrestrial plants account only for a few bromine-containing compounds.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Safety of 3-Bromo-2-nitrobenzoic acidOn June 4, 2004, Fatemi, M. H. published an article in Journal of Chromatography A. The article was 《Prediction of the electrophoretic mobilities of some carboxylic acids from theoretically derived descriptors》. The article mentions the following:

A 4-4-1 artificial neural network was constructed and trained for the prediction of the electrophoretic mobilities of some aliphatic and aromatic carboxylic acids based on quant. structure-property relations. The inputs of this network are theor. derived descriptors that were chosen by the stepwise variables selection techniques. These descriptors are: shape factor, mol. surface area, the maximum value of electron d. on atom in mol., and the sum of at. polarizability. To assess the accuracy and predictability of the proposed model, the cross-validation test was employed. The results obtained showed the ability of developed artificial neural network to prediction of electrophoretic mobilities of aliphatic and carboxylic acids. Also result reveals the superiority of the artificial neural network over the multiple linear regression models. The experimental process involved the reaction of 3-Bromo-2-nitrobenzoic acid(cas: 116529-61-4Safety of 3-Bromo-2-nitrobenzoic acid)

3-Bromo-2-nitrobenzoic acid(cas: 116529-61-4) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides.Safety of 3-Bromo-2-nitrobenzoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,ACS Medicinal Chemistry Letters included an article by Mori, Mattia; Dasso Lang, Maria Chiara; Saladini, Francesco; Palombi, Nastasja; Kovalenko, Lesia; De Forni, Davide; Poddesu, Barbara; Friggeri, Laura; Giannini, Alessia; Malancona, Savina; Summa, Vincenzo; Zazzi, Maurizio; Mely, Yves; Botta, Maurizio. Product Details of 1129-28-8. The article was titled 《Synthesis and Evaluation of Bifunctional Aminothiazoles as Antiretrovirals Targeting the HIV-1 Nucleocapsid Protein》. The information in the text is summarized as follows:

Small mol. inhibitors of the HIV-1 nucleocapsid protein (NC) are considered as promising agents in the treatment of HIV/AIDS. In an effort to exploit the privileged 2-amino-4-phenylthiazole moiety in NC inhibition, here we conceived, synthesized, and tested in vitro 18 NC inhibitors (NCIs) bearing a double functionalization. In these NCIs, one part of the mol. is designed to interact noncovalently with the NC hydrophobic pocket, while the second portion is designed to interact with the N-terminal domain of NC. This binding hypothesis was verified by mol. dynamics simulations, while the linkage between these two pharmacophores was found to enhance antiretroviral activity both on the wild-type virus and on HIV-1 strains with resistance to currently licensed drugs. The two most interesting compounds, I and II, showed no cytotoxicity, thus becoming valuable leads for further investigations. In the experimental materials used by the author, we found Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Product Details of 1129-28-8)

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Product Details of 1129-28-8 Alkyl bromides are mainly used as alkylating agents and also find application as a solvent to extract oil from seeds and wool.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Journal of Organic Chemistry included an article by Ding, Shao-Lei; Ji, Yang; Su, Yan; Li, Rui; Gu, Peiming. Synthetic Route of C7H13BrO2. The article was titled 《Schmidt Reaction of ω-Azido Valeryl Chlorides Followed by Intermolecular Trapping of the Rearrangement Ions: Synthesis of Assoanine and Related Pyrrolophenanthridine Alkaloids》. The information in the text is summarized as follows:

The Schmidt reaction of ω-azido valeryl chlorides in the presence of an addnl. nucleophile was explored. The arenes, alcs., and amines were demonstrated as the intermol. trapping reagents for isocyanate ion and N-acyliminium ion from the Schmidt rearrangement, affording the corresponding products with moderate to excellent yields. Two 2-oxoindoles from the reaction were successfully converted into four natural alkaloids, namely, assoanine, anhydrolycorine, oxoassoanine, and anhydrolycorinone. The results came from multiple reactions, including the reaction of Ethyl 5-bromovalerate(cas: 14660-52-7Synthetic Route of C7H13BrO2)

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Synthetic Route of C7H13BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Journal of Organic Chemistry included an article by Mallick, Sudesh; Maddala, Sudhakar; Kollimalayan, Kalidass; Venkatakrishnan, Parthasarathy. Product Details of 6825-20-3. The article was titled 《Oxidative Coupling of Carbazoles: A Substituent-Governed Regioselectivity Profile》. The information in the text is summarized as follows:

Oxidative C-C coupling of carbazoles possessing various substituents is demonstrated in the presence of organic (metal-free) recyclable oxidants, such as DDQ or CA/H+, for accessing bicarbazole regioisomers. Differently substituted carbazoles are examined to showcase regioselective discrimination (3,3′- vs. 1,3′-bicarbazoles) and preferences based on sterics and electronics in oxidative coupling. Finally, a mechanism that involves the carbazole radical cation has been traced (evidenced) and proposed on the basis of the UV-vis-NIR absorption and EPR spectroscopy results. This study underlines the strategic chem. preparation of a series of bicarbazoles in an efficient manner. The experimental part of the paper was very detailed, including the reaction process of 3,6-Dibromo-9H-carbazole(cas: 6825-20-3Product Details of 6825-20-3)

3,6-Dibromo-9H-carbazole(cas: 6825-20-3) is used as a pharmaceutical intermediate, and also an important intermediate of synthesizing optoelectronic materials. It has been used as a reagent in the synthesis of P7C3-A20 which is a potent neuroprotective agent.Product Details of 6825-20-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Journal of Organic Chemistry included an article by Baydoun, Orsola; De Rycke, Nicolas; Leonce, Estelle; Boutin, Celine; Berthault, Patrick; Jeanneau, Erwann; Brotin, Thierry. Safety of Benzyl 2-bromoacetate. The article was titled 《Synthesis of Cryptophane-223-Type Derivatives with Dual Functionalization》. The information in the text is summarized as follows:

The authors present the synthesis of new cryptophane-type hosts capable of binding xenon in aqueous media and that may be useful for the development of xenon-based magnetic resonance imaging derivatives The synthetic route proposed was chosen to facilitate both the introduction of water-solubilizing substituents and the functionalization of the host with a single arm showing recognition properties that constitute two crucial steps. This was made possible by preparing new cryptophane-223 derivatives bearing two different chem. functions that can be easily modified at a later stage. Thus, subsequent reactions allowed the design of a new cryptophane host able to bind zinc or nickel cations. The ability of this mol. to bind cationic species was assessed by calorimetric titration experiments and hyperpolarized 129Xe NMR. The advantages and disadvantages of this approach are discussed. The experimental process involved the reaction of Benzyl 2-bromoacetate(cas: 5437-45-6Safety of Benzyl 2-bromoacetate)

Benzyl 2-bromoacetate(cas: 5437-45-6) belongs to benzyl acetate. Benzyl acetate is an aromatic chemical, usually appearing as a clear liquid with a moderate sweet-jasmine fragrance. This compound appears as a component of some of our fragrance blends.Safety of Benzyl 2-bromoacetate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary