Month: October 2022

In 2016,Zhang, Zongyao; Zheng, Kunyi; Xia, Tianlong; Xu, Lijin; Cao, Rui published 《Ni3 versus Ni30: A Truncated Octahedron Metal-Organic Cage Constructed with [Ni5(CN)4]6+ Squares and Tripodal Tris-tacn Ligands That are Large and Flexible》.Chemistry – A European Journal published the findings.Related Products of 1129-28-8 The information in the text is summarized as follows:

Reactions of trinickel complex of tripodal tris-tacn ligand N(CH2-m-C6H4-CH2tacn)3 (L, tacn = 1,4,7-triazacyclononane) in acetonitrile-methanol solution with and without phosphate led to two complexes of distinct nuclearities, [(NiIICl)3(CH3OH)3(HPO4)L](PF6) (Ni3, 1) and [(NiII5(CN)4(H2O)8Cl)6L8]Cl30 (Ni30, 2). Ligand L takes upward and downward conformation in the structure of 1 and 2, resp. It is proposed that phosphate directs the upward conformation of Ni3L to form 1. In the absence of phosphate, Ni3L assembles with cyanide ions, which are formed by Ni-catalyzed C-CN bond cleavage of acetonitrile, to give a nano-sized Ni30 cage. Complex 2 represents a discrete truncated octahedron cage assembled with [Ni5(CN)4]6+ squares and large and flexible triangular ligands, which is scarcely observed for self-assembled metal-organic cages. The magnetic properties of 1 and 2 were examined, showing intriguing magnetic properties.Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Related Products of 1129-28-8) was used in this study.

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Moreover, several studies demonstrate that the average proportion of bromine in drugs is significantly higher than that in natural products. Related Products of 1129-28-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2016,Schmidt, Andrea; Molano, Viviana; Hollering, Manuela; Poethig, Alexander; Casini, Angela; Kuehn, Fritz E. published 《Evaluation of New Palladium Cages as Potential Delivery Systems for the Anticancer Drug Cisplatin》.Chemistry – A European Journal published the findings.Name: 3,5-Dibromoaniline The information in the text is summarized as follows:

Self-assembled metallocages are very promising drug-delivery systems among supramol. complexes. Thus, exo-functionalized Pd2L4 (L=ligand) cages were synthesized and characterized, and the encapsulation of the anticancer drug cisplatin in their cavity has been documented. The antiproliferative effects of the metallocages and their combination with cisplatin were examined in vitro in cancer cell lines, while fluorescence microscopy was used to monitor their uptake. Notably, the hydroxymethyl-functionalized PdII cage encapsulating cisplatin showed improved cytotoxic effect against human ovarian cancer cells compared to free cisplatin. The toxicity of Pd2L4 cages was evaluated for the first time ex vivo in healthy rat-liver tissues using the precision cut-tissue slices technol., demonstrating in some cases scarce effects on liver viability. These results further highlight the potential of self-assembled Pd2L4 cages for biol. applications. In the experimental materials used by the author, we found 3,5-Dibromoaniline(cas: 626-40-4Name: 3,5-Dibromoaniline)

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Name: 3,5-Dibromoaniline

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2017,Walker, Ann L.; Ancellin, Nicolas; Beaufils, Benjamin; Bergeal, Marylise; Binnie, Margaret; Clapham, David; Haslam, Carl P.; Holmes, Duncan S.; Hutchinson, Jonathan P.; Liddle, John; McBride, Andrew; Mirguet, Olivier; Mowat, Christopher G.; Rowland, Paul; Tiberghien, Nathalie; Trottet, Lionel; Uings, Iain; Webster, Scott P.; Zheng, Xiaozhong; Mole, Damian J. published 《Development of a Series of Kynurenine 3-Monooxygenase Inhibitors Leading to a Clinical Candidate for the Treatment of Acute Pancreatitis》.Journal of Medicinal Chemistry published the findings.Application of 3395-91-3 The information in the text is summarized as follows:

Recently, we reported a novel role for KMO in the pathogenesis of acute pancreatitis (AP). A number of inhibitors of kynurenine 3-monooxygenase (KMO) have previously been described as potential treatments for neurodegenerative conditions and particularly for Huntington’s disease. However the inhibitors reported to date have insufficient aqueous solubility relative to their cellular potency to be compatible with the i.v. (i.v.) dosing route required in AP. We have identified and optimized a novel series of high affinity KMO inhibitors with favorable physicochem. properties. The leading example is exquisitely selective, has low clearance in two species, prevents lung and kidney damage in a rat model of acute pancreatitis and is progressing into preclin. development. In the experimental materials used by the author, we found Methyl 3-bromopropanoate(cas: 3395-91-3Application of 3395-91-3)

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Application of 3395-91-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2017,Chu, Shidong; Zhou, Guangyan; Gochin, Miriam published 《Evaluation of ligand-based NMR screening methods to characterize small molecule binding to HIV-1 glycoprotein-41》.Organic & Biomolecular Chemistry published the findings.Formula: C9H9BrO2 The information in the text is summarized as follows:

Small mol. inhibitors of glycoprotein-41 (gp41) are able to prevent HIV infection by binding to a hydrophobic pocket (HP) contained within the gp41 ectodomain, and preventing progression of fusion. There is little structural information on gp41-ligand complexes, owing to hydrophobicity of the ligands, occlusion of the HP in folded gp41 ectodomain, and failure to form crystals of complexes. Here the authors used an engineered gp41 ectodomain protein containing an exposed HP and a small mol. designed to bind with weak affinity to the HP. The authors evaluated NMR methods, including WaterLOGSY, Saturation Transfer Difference spectroscopy (STD-NMR) and 1H relaxation rate difference spectroscopy with and without target irradiation (DIRECTION) for their ability to probe complex formation and structure. WaterLOGSY was the most sensitive technique for monitoring formation of the complex. STD-NMR and DIRECTION experiments gave similar pharmacophore mapping profiles, although the low dynamic range of the DIRECTION experiment limited its discrimination and sensitivity. A unique binding pose was identified from the STD data and provided clues for future optimization. Advantages and disadvantages of the techniques are discussed. This is the first example of the use of STD for structural anal. of a gp41-small mol. complex. After reading the article, we found that the author used Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Formula: C9H9BrO2)

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Formula: C9H9BrO2 In contrast, terrestrial plants account only for a few bromine-containing compounds.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2017,Yoon, Dong-Oh; Zhao, Xiaodi; Son, Dohyun; Han, Jung Tae; Yun, Jaesook; Shin, Dongyun; Park, Hyun-Ju published 《SAR Studies of Indole-5-propanoic Acid Derivatives To Develop Novel GPR40 Agonists》.ACS Medicinal Chemistry Letters published the findings.Name: 1-Bromo-2-isopropylbenzene The information in the text is summarized as follows:

G-protein coupled receptor 40 (GPR40) has been considered to be an attractive drug target for the treatment of type 2 diabetes because of its role in free fatty acids-mediated enhancement of glucose-stimulated insulin secretion (GSIS) from pancreatic β-cells. A series of indole-5-propanoic acid compounds were synthesized, and their GPR40 agonistic activities were evaluated by nuclear factor of activated T-cells reporter assay and GSIS assay in the MIN-6 insulinoma cells. Three compounds, 8h (3-(2-(2-chlorophenyl)-1H-indol-5-yl)propanoic acid) (EC50 = 58.6 nM), 8i (3-(2-(3-chlorophenyl)-1H-indol-5-yl)propanoic acid) (EC50 = 37.8 nM), and 8o (3-(2-(2-bromophenyl)-1H-indol-5-yl)propanoic acid) (EC50 = 9.4 nM), were identified as potent GPR40 agonists with good GSIS effects. In the part of experimental materials, we found many familiar compounds, such as 1-Bromo-2-isopropylbenzene(cas: 7073-94-1Name: 1-Bromo-2-isopropylbenzene)

1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Name: 1-Bromo-2-isopropylbenzene Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2018,Advanced Synthesis & Catalysis included an article by Han, Wen-Jing; Pu, Fan; Li, Chao-Jun; Liu, Zhong-Wen; Fan, Juan; Shi, Xian-Ying. SDS of cas: 76006-33-2. The article was titled 《Carboxyl-Directed Conjugate Addition of C-H Bonds to α,β-Unsaturated Ketones in Air and Water》. The information in the text is summarized as follows:

A simple ruthenium-catalyzed conjugate addition of C-H bonds to α,β-unsaturated ketones directed by a removable carboxyl group was developed as an effective protocol to synthesize ortho-alkylated benzoic acids in a greener manner. Without any additives, satisfactory to excellent yields of the targeted products were achieved in neat water, and the process characterizes in mild reaction conditions (in air and water), simple operations, and broad substrate scope. Noteworthy features of this method include mild reaction conditions (in air and water), operational simplicity and broad substrate scope. The versatility and utility of the addition products were demonstrated through further transformation into commonly inaccessible but highly useful motifs of meta-substituted alkylbenzenes and 3-substituted isochromanones. The results came from multiple reactions, including the reaction of 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2SDS of cas: 76006-33-2)

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.Organobromine chemicals are produced naturally by an array of biological and other chemical processes in our environment. SDS of cas: 76006-33-2Some of these compounds are identical to man-made organobromine compounds, such as methyl bromide, bromoform, and bromophenols, but many others are entirely new moleclar entities, often possessing extraordinary and important biological properties.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Journal of Solid State Chemistry included an article by Liu, Jian-Jun; Yu, Li-Mei; Han, Fu-Xu; Chen, Fu-Yu; Cheng, Fei-Xiang. Category: bromides-buliding-blocks. The article was titled 《A thioether-containing luminescent metal-organic framework for highly selective and sensitive detection of Ag(I) ion》. The information in the text is summarized as follows:

A stable three-dimensional coordination polymer, [Eu2(pbbp)(pbsd)3] (1) (H2pbsd = 2,2′-((1,4-phenylenebis(methylene))bis(sulfanediyl))dinicotinic acid, H2pbbp·2Cl = 1,1′-(1,4-phenylene-bis(methylene))-bis(3-carboxy pyridinium) dichloride), was prepared by the solvothermal reaction of Eu(NO3)3·6H2O, H2pbbp·2Cl and H2pbsd in mixed solvent of DMF and H2O, which was characterized by single-crystal X-ray diffraction, powder X-ray diffraction, IR spectroscopy, and thermogravimetric analyses. 1 exhibits a 3D 6-connected sqcl network decorated by uncoordinated Lewis basic thioether groups. In particular, 1 shows excellent application as luminescent sensor for sensing Ag+ ions in ethylene glycol solution with high sensitivity and selectivity based on luminescence quenching effect. The experimental part of the paper was very detailed, including the reaction process of 1,4-Bis(bromomethyl)benzene(cas: 623-24-5Category: bromides-buliding-blocks)

1,4-Bis(bromomethyl)benzene(cas: 623-24-5) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Due to the reactivity of bromide, they are used as potential precursors or important intermediates in organic synthesis. Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Dual-Functionalized Fluorescent Cationic Organic Network: Highly Efficient Detection and Removal of Dichromate from Water》 were Li, Zhi-Jun; Xue, Hua-Dong; Ma, Yun-Xiang; Zhang, Qi; Li, Yan-Chun; Xie, Miao; Qi, Hui-Li; Zheng, Xu-Dong. And the article was published in ACS Applied Materials & Interfaces in 2019. Formula: C8H8Br2 The author mentioned the following in the article:

Dichromate is one of widespread contaminants in wastewater, it has threatened the health of human and other organisms. Therefore, effective detection and removal of dichromate from water is of great significance. Herein, a tetraphenylethylene functionalized cationic organic network (CON-LDU2) was constructed via a facile quaternization reaction. CON-LDU2 was successfully integrated with both detection and removal functionalities towards dichromate. On the one hand, benefitting from the strong fluorescence, CON-LDU2 was employed as a chemosensor, it could efficiently and selectively probe Cr2O72- in water with “”turn-off”” fluorescent response. On the other hand, the cationic skeleton and free anions inside framework make CON-LDU2 an excellent adsorbent for Cr2O72-, it could capture Cr2O72- from water with rapid kinetic and high capacity. The kinetic constant for adsorption of Cr2O72- can reach up to 1.784 g mg-1 min-1, while the capacity is determined as 325 mg g-1. Furthermore, CON-LDU2 displayed good recyclability and can be reused at least for 5 cycles. Therefore, CON-LDU2 can serve as an ideal candidate not only in detection but also in removal of Cr2O72- in water medium. After reading the article, we found that the author used 1,4-Bis(bromomethyl)benzene(cas: 623-24-5Formula: C8H8Br2)

1,4-Bis(bromomethyl)benzene(cas: 623-24-5) belongs to organobromine compounds.Organobromine chemicals are produced naturally by an array of biological and other chemical processes in our environment. Some of these compounds are identical to man-made organobromine compounds, such as methyl bromide, bromoform, and bromophenols, but many others are entirely new moleclar entities, often possessing extraordinary and important biological properties. Formula: C8H8Br2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Microwave assisted synthesis and antibacterial activities of some N-Benzylideneaniline halogen derivatives》 were Celik, Hulya. And the article was published in Fresenius Environmental Bulletin in 2019. SDS of cas: 6630-33-7 The author mentioned the following in the article:

In this study a series of Schiff base N-benzylideneaniline halogen derivatives were synthesized by microwave-irradiation method the 4-fluoroaniline was condensed with various aromatic aldehydes to give Schiff base. The present work involved condensation of various benzaldehyde with aromatic amine in under microwave irradiation The microwave irradiation method offered advantages such as reduction of reaction time, increase in conversion, reduced wastes and good quality. The chem. structure of the compound was characterized using Mass Spectrometry, 1H-NMR and 13C-NMR techniques. The prepared compounds were tested for their in-vitro antibacterial activity. The agar well diffusion assay method was used for the assessment of in vitro antibacterial activity compounds against Escherichia coli (ATCC 10536), Pseudomonas aeruginosa (ATCC 15442), Staphylococcus aureus (ATCC 6538) and Bacillus subtilis (ATCC 6633). In the experimental materials used by the author, we found o-Bromobenzaldehyde(cas: 6630-33-7SDS of cas: 6630-33-7)

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.SDS of cas: 6630-33-7Synthetic applications of o-Bromobenzaldehyde include: synthesis of aza-fused polycyclic quinolines through copper-catalyzed cascade reaction, preparation of 1-substituted indazoles by CuI-catalyzed coupling with N-aryl hydrazides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Reconfigurable Flow Platform for Automated Reagent Screening and Autonomous Optimization for Bioinspired Lignans Synthesis》 were Aka, Ehu Camille; Wimmer, Eric; Barre, Elvina; Vasudevan, Natarajan; Cortes-Borda, Daniel; Ekou, Tchirioua; Ekou, Lynda; Rodriguez-Zubiri, Mireia; Felpin, Francois-Xavier. And the article was published in Journal of Organic Chemistry in 2019. Quality Control of Ethyltriphenylphosphonium bromide The author mentioned the following in the article:

Naturally occurring benzoxanthenones, which belong to the vast family of lignans, are promising biol. relevant targets. They are biosynthetically produced by the oxidative dimerization of 2-propenyl phenols. In this manuscript, we disclose a powerful automated flow-based strategy for identifying and optimizing a cobalt-catalyzed oxidizing system for the bioinspired dimerization of 2-propenyl phenols. We designed a reconfigurable flow reactor associating online monitoring and process control instrumentation. Our machine was first configured as an automated screening platform to evaluate a matrix of 4 catalysts (plus the blank) and 5 oxidants (plus the blank) at two different temperatures, resulting in an array of 50 reactions. The automated screening was conducted on micromole scale at a rate of one fully characterized reaction every 26 min. After having identified the most promising cobalt-catalyzed oxidizing system, the automated screening platform was straightforwardly reconfigured to an autonomous self-optimizing flow reactor by implementation of an optimization algorithm in the closed-loop system. The optimization campaign allowed the determination of very effective exptl. conditions in a limited number of experiments, which allowed us to prepare the natural products carpanone and polemannone B as well as synthetic analogs. The experimental part of the paper was very detailed, including the reaction process of Ethyltriphenylphosphonium bromide(cas: 1530-32-1Quality Control of Ethyltriphenylphosphonium bromide)

Ethyltriphenylphosphonium bromide(cas: 1530-32-1) is a phase transfer catalyst, used to accelerate the cure of phenolic-based epoxy resins, certain fluoroelastomer resins and thermosetting powder coatings. CatOnium ETPB is also used as catalysts in the synthesis of certain organic compounds.Quality Control of Ethyltriphenylphosphonium bromide

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary