Month: October 2022

The author of 《Investigation around the Oxadiazole Core in the Discovery of a New Chemotype of Potent and Selective FXR Antagonists》 were Festa, Carmen; Finamore, Claudia; Marchiano, Silvia; Di Leva, Francesco Saverio; Carino, Adriana; Monti, Maria Chiara; del Gaudio, Federica; Ceccacci, Sara; Limongelli, Vittorio; Zampella, Angela; Fiorucci, Stefano; De Marino, Simona. And the article was published in ACS Medicinal Chemistry Letters in 2019. Related Products of 3395-91-3 The author mentioned the following in the article:

Recent findings have shown that Farnesoid X Receptor (FXR) antagonists might be useful in the treatment of cholestasis and related metabolic disorders. In this paper, we report the discovery of a new chemotype of FXR antagonists featured by a 3,5-disubstituted oxadiazole core. In total, 35 new derivatives were designed and synthesized, and notably, compounds I and II, containing a piperidine ring, displayed the best antagonistic activity against FXR with promising cellular potency (IC50 = 0.58 ± 0.27 and 0.127 ± 0.02 μM, resp.). The excellent pharmacokinetic properties make compound I the most promising lead identified in this study. After reading the article, we found that the author used Methyl 3-bromopropanoate(cas: 3395-91-3Related Products of 3395-91-3)

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Related Products of 3395-91-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《New Series of Potent Allosteric Inhibitors of Deoxyhypusine Synthase》 was published in ACS Medicinal Chemistry Letters in 2020. These research results belong to Tanaka, Yuta; Kurasawa, Osamu; Yokota, Akihiro; Klein, Michael G.; Saito, Bunnai; Matsumoto, Shigemitsu; Okaniwa, Masanori; Ambrus-Aikelin, Geza; Uchiyama, Noriko; Morishita, Daisuke; Kimura, Hiromichi; Imamura, Shinichi. HPLC of Formula: 76006-33-2 The article mentions the following:

In this work, a new chem. series possessing fused ring scaffolds designed from high-throughput screening hit compounds was synthesized, discovering a 5,6-dihydrothieno[2,3-c]pyridine derivative I [R = (R)-i-Bu] with potent inhibitory activity. Furthermore, the X-ray crystallog. anal. of the DHPS complex with I [R = (R)-i-Bu] demonstrated a distinct allosteric binding mode compared to a previously reported inhibitor. These findings could be significantly useful in the functional anal. of conformational changes in DHPS as well as the structure-based design of allosteric inhibitors. In the part of experimental materials, we found many familiar compounds, such as 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2HPLC of Formula: 76006-33-2)

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.Organobromine chemicals are produced naturally by an array of biological and other chemical processes in our environment. HPLC of Formula: 76006-33-2Some of these compounds are identical to man-made organobromine compounds, such as methyl bromide, bromoform, and bromophenols, but many others are entirely new moleclar entities, often possessing extraordinary and important biological properties.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Organic Polymer Nanoparticles with Primary Ammonium Salt as Potent Antibacterial Nanomaterials》 was published in ACS Applied Materials & Interfaces in 2020. These research results belong to Guo, Lixia; Wang, Haoping; Wang, Yunxia; Liu, Feng; Feng, Liheng. Reference of Tris(4-bromophenyl)amine The article mentions the following:

Bacterial infections induced by drug-resistant strains have become a global crisis. A membrane-disrupted mechanism is considered as an effective way to kill bacteria with little chance to trigger drug resistance. It is necessary to explore and develop new materials based on the membrane-disrupted mechanism to combat bacterial resistance. Here we report the design of organic nanoparticles based on a polymer (PDCP) as highly effective inhibition and bactericidal reagents. The PDCP is devised to have a hydrophobic skeleton and hydrophilic side chain modified with protonated primary amines, which could self-assemble to form organic nanoparticles (PDCP-NPs). By taking advantage of the large surface to volume ratio of nanoparticles, the synthesized PDCP-NPs have enriched pos. charges and multiple membrane-binding sites. Research results display that PDCP-NPs have highly potent antibacterial activity in vitro and vivo, especially for Gram-neg. bacteria with low toxicity against mammalian cells. This work design will inspire researchers to develop more membrane-disrupted bactericide and advance the applications of organic nanoparticles in the antibacterial area. After reading the article, we found that the author used Tris(4-bromophenyl)amine(cas: 4316-58-9Reference of Tris(4-bromophenyl)amine)

In other references, Tris(4-bromophenyl)amine(cas: 4316-58-9) is often used in the synthesis of porous luminescent covalent–organic polymers (COPs)Reference of Tris(4-bromophenyl)amine

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Binuclear manganese-iron complexes containing ferrocenyl thiosemicarbazones: Biological activity and carbon monoxide-releasing properties》 was published in Inorganica Chimica Acta in 2020. These research results belong to Lawrence, Madelyn L.; Shell, Steven M.; Beckford, Floyd A.. Name: Bromopentacarbonylmanganese(I) The article mentions the following:

This research aimed to pair a ferrocenyl TSC ligand with a {Mn(CO)3} subunit to create a photoactive complex. Six complexes were synthesized, characterized, and tested for their biol. activities as well as their propensity to act as photoCORMs. The results suggest that while the complexes release CO only slowly and likely to a small extent, good toxicity profiles were observed for the CORMs against bacteria and human cells, suggesting a broad mechanism of action. The CORM compounds represent a potential vehicle for future development of targeted antibiotic and antitumor compounds In the experimental materials used by the author, we found Bromopentacarbonylmanganese(I)(cas: 14516-54-2Name: Bromopentacarbonylmanganese(I))

Bromopentacarbonylmanganese(I)(cas: 14516-54-2) has many other uses. It is used in the formation of (eta6-arene)tricarbonylmanganese(I) by reacting with arene (arene= hexamethyl benzene, 1,2,4,5-tetramethyl benzene, mesitylene, p-xylene and toluene) in the presence silver salt.Name: Bromopentacarbonylmanganese(I)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Water-soluble UV/visible light activated Mn-CO-releasing molecules: Synthesis, structure, CO releasing and biological activities evaluation》 was published in Inorganic Chemistry Communications in 2020. These research results belong to Hu, Mixia; Zhu, Baohua; Zhou, Haofei; Qiao, Lu; Fan, Jianming; Du, Yanqing; Chang, Fei; Yu, Shiyong. Safety of Bromopentacarbonylmanganese(I) The article mentions the following:

By reactions of MnBr(CO)5 with 2,2′-bipyridyl-4,4′-dicarboxylic acid and 2,5-pyridinedicarboxylic acid, resp., authors obtained two new Mn-CORMs, [Mn(CO)3(H2O)(HBPDC)] (1) and [Mn(CO)3(CH3CN)(HPYDC)]·CH3CN (2). Complexes 1 and 2 are stable in the absence of light, but they exhibit good CO release ability upon exposure to UV and visible light (blue and green). The CO releasing rate depends on the wavelength of irradiation light, i.e., UV > blue > green, which may make them act as visible light regulated CORMs. It is noteworthy that complexes 1 and 2 possess high water-solubility TD-DFT studies of complexes 1 and 2 reveal that the metal-to-ligand charge-transfer (MLCT) may be responsible for their CO releasing behaviors triggered by UV and visible light. The cellular viability and anti-inflammatory activities evaluation show that complexes 1 and 2 can inhibit the secretion of NO and TNF-α in LPS-stimulated RAW264.7 macrophages with fine biol. compatibility and without apparent cytotoxicity. Furthermore, during the synthesis of complexes 1 and 2, when the pH of solution is hinger than 7, complexes {[Mn(BPDC)]}n (1A) and [Mn(H2O)2(HPYDC)2] (2A) are obtained. Complex 1A is a new 3D Mn-MOF and complex 2A is a zero-dimensional mononuclear compound, which are all without -CO ligand. In the experimental materials used by the author, we found Bromopentacarbonylmanganese(I)(cas: 14516-54-2Safety of Bromopentacarbonylmanganese(I))

Bromopentacarbonylmanganese(I)(cas: 14516-54-2) has many other uses. It is used in the formation of (eta6-arene)tricarbonylmanganese(I) by reacting with arene (arene= hexamethyl benzene, 1,2,4,5-tetramethyl benzene, mesitylene, p-xylene and toluene) in the presence silver salt.Safety of Bromopentacarbonylmanganese(I)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Role of Substituents at 3-position of Thienylethynyl Spacer on Electronic Properties in Diruthenium(II) Organometallic Wire-like Complexes》 was written by Roy, Sourav Saha; Chowdhury, Sabyasachi Roy; Mishra, Sabyashachi; Patra, Sanjib K.. Synthetic Route of C4H2Br2S And the article was included in Chemistry – An Asian Journal in 2020. The article conveys some information:

Organometallic complexes [Cl(dppe)2Ru-C C-(3-R-C4H2S)-C C-Ru(dppe)2Cl] (3-R-C4H2S = 3-substituted thienyl moiety; R = -H, -C2H5, -Pr, -Bu, -C6H13, -OMe, -CN in 5a-5g, resp.) were synthesized by systematic variation of 3-substituents at the thienylethynyl bridging unit. The diruthenium(II) wire-like complexes (5a-5g) were achieved by the reaction of thienylethynyl bridging units, Hc C-(3-R-C4H2S)-C CH (4 a-4 g) with cis-[Ru(dppe)2Cl2]. The wire-like diruthenium(II) complexes undergo two consecutive electrochem. oxidation processes in the potential range of 0.0-0.8 V. The wave separation between the two redox waves is greatly influenced by the substituents at the 3-position of the thienylethynyl. Thus, the substitution on 3-position of the thienylethynyl bridging unit plays a pivotal role for tuning the electronic properties. To understand the electronic behavior, d. functional theory (DFT) calculations of the selected diruthenium wire-like complexes (5a-5e) with different alkyl appendages were performed. The theor. data demonstrate that incorporation of alkyl groups to the thienylethynyl entity leaves unsym. spin densities, thus affecting the electronic properties. The voltammetric features of the other two Ru(II) alkynyl complexes 5f and 5g (with -OMe and -CN group, resp.) show an apparent dependence on the electronic properties. The electronic properties in the redox conjugate, (5a+) with Kc of 3.9 × 106 are further examined by UV-visible-NIR and FTIR studies, showing optical responses in NIR region along with changes in -Ru-C C- vibrational stretching frequency. The origin of the observed electronic transition was assigned based on time-dependent DFT (TDDFT) calculations In the part of experimental materials, we found many familiar compounds, such as 2,5-Dibromothiophene(cas: 3141-27-3Synthetic Route of C4H2Br2S)

2,5-Dibromothiophene(cas: 3141-27-3) , is mainly used as pharmaceutical intermediate and synthesis intermediate. 2,5-Dibromothiophene may be used as starting reagent for the synthesis of α,α′-didecylquater-, -quinque- and -sexi-thiophenes.Synthetic Route of C4H2Br2S

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《The design of a novel near-infrared fluorescent HDAC inhibitor and image of tumor cells》 was written by Huang, Ying; Ru, Hong-bo; Bao, Bin; Yu, Jia-hui; Li, Jia; Zang, Yi; Lu, Wei. SDS of cas: 17696-11-6 And the article was included in Bioorganic & Medicinal Chemistry in 2020. The article conveys some information:

Histone deacetylases (HDACs) have been found to be biomarkers of cancers and the corresponding inhibitors have attracted much attention these years. Herein we reported a near-IR fluorescent HDAC inhibitor based on vorinostat (SAHA) and a NIR fluorophore. This newly designed inhibitor showed similar inhibitory activity to SAHA against three HDAC isoforms (HDAC1, 3, 6). The western blot assay showed significant difference in compared with the neg. group. When used as probe for further kinematic imaging, Probe 1 showed enhanced retention in tumor cells and the potential of HDAC inhibitors in drug delivery was firstly brought out. The cytotoxicity assay showed Probe 1 had some anti-proliferation activities with corresponding IC50 values of 9.20 ± 0.96μM on Hela cells and 5.91 ± 0.57μM on MDA-MB-231 cells. These results indicated that Probe 1 could be used as a potential NIR fluorescent in the study of HDAC inhibitors and lead compound for the development of visible drugs. In addition to this study using 8-Bromooctanoic acid, there are many other studies that have used 8-Bromooctanoic acid(cas: 17696-11-6SDS of cas: 17696-11-6) was used in this study.

8-Bromooctanoic acid(cas: 17696-11-6) acid is used in the synthesis of 8-(N-Methyl-4,4′-bipyridinyl)- octanoic acid. 8-Mercaptooctanoic acid was prepared from 8-bromooctanoic acid.SDS of cas: 17696-11-6

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Fe Single Atoms and Fe2O3 Clusters Liberated from N-Doped Polyhedral Carbon for Chemoselective Hydrogenation under Mild Conditions》 was written by Yun, Ruirui; Zhan, Feiyang; Li, Na; Zhang, Beibei; Ma, Wanjiao; Hong, Lirui; Sheng, Tian; Du, Liting; Zheng, Baishu; Liu, Shoujie. HPLC of Formula: 626-40-4 And the article was included in ACS Applied Materials & Interfaces in 2020. The article conveys some information:

Fe-based catalyst FeSAs/Fe2O3ACs/N-doped polyhedral carbon (NPC) was designed and synthesized. As we expected, compared with FeSAs and FeNPs, FeSAs/Fe2O3ACs/NPC showed excellent catalytic performance (turnover frequency up to 1923 h-1, calculated with nitrobenzene), chemoselectivity, and tolerance during the hydrogenation reaction of nitro compounds under room temperature because of the synergistic effects between FeSAs and Fe2O3ACs. The theor. calculations show that FeSAs prefers to undergo hydrazine decomposition to generate hydrogen and the Fe2O3ACs surface is more active toward the nitrobenzene reduction to aniline. The experimental process involved the reaction of 3,5-Dibromoaniline(cas: 626-40-4HPLC of Formula: 626-40-4)

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.HPLC of Formula: 626-40-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Discovery and Optimization of α-Mangostin Derivatives as Novel PDE4 Inhibitors for the Treatment of Vascular Dementia》 was written by Liang, Jinhao; Huang, Yi-You; Zhou, Qian; Gao, Yuqi; Li, Zhe; Wu, Deyan; Yu, Si; Guo, Lei; Chen, Zhen; Huang, Ling; Liang, Steven H.; He, Xixin; Wu, Ruibo; Luo, Hai-Bin. Category: bromides-buliding-blocks And the article was included in Journal of Medicinal Chemistry in 2020. The article conveys some information:

To validate PDE4 inhibitors as novel therapeutic agents against vascular dementia (VaD), 25 derivatives were discovered from the natural inhibitor α-mangostin (IC50 = 1.31μM). Hit-to-lead optimization identified a novel and selective PDE4 inhibitor 4e (IC50 = 17 nM), which adopted a different binding pattern from PDE4 inhibitors roflumilast and rolipram. Oral administration of 4e at a dose of 10 mg/kg exhibited remarkable therapeutic effects in a VaD model and did not cause emesis to beagle dogs, indicating its potential as a novel anti-VaD agent. In the experiment, the researchers used many compounds, for example, Ethyl 5-bromovalerate(cas: 14660-52-7Category: bromides-buliding-blocks)

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Applying Gewald reaction for the preparation of some novel aminothieno derivatives featuring noroxymorphone skeletal backbone》 was written by Bagherpour, Saeed; Mojtahedi, Mohammad M.; Abaee, M. Saeed. Application In Synthesis of (Bromomethyl)cyclopropane And the article was included in Journal of Sulfur Chemistry in 2020. The article conveys some information:

Synthesis of several novel semisynthetic aminothieno derivatives containing the noroxymorphone skeletal backbone using a one-pot Gewald reaction conditions was reported. The Gewald reaction conditions involved reaction of elemental sulfur and malononitrile under refluxing piperidine/ethanol. In the experimental materials used by the author, we found (Bromomethyl)cyclopropane(cas: 7051-34-5Application In Synthesis of (Bromomethyl)cyclopropane)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Application In Synthesis of (Bromomethyl)cyclopropane

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary