Month: October 2022

Zhou, Guojun; Ren, Qiqiong; Molokeev, Maxim S.; Zhou, Yayun; Zhang, Jian; Zhang, Xian-Ming published an article in 2021. The article was titled 《Unraveling the Ultrafast Self-assembly and Photoluminescence in Zero-Dimensional Mn2+-Based Halides with Narrow-Band Green Emissions》, and you may find the article in ACS Applied Electronic Materials.Application of 1530-32-1 The information in the text is summarized as follows:

The discovery of narrow-band luminescent materials remains an immense challenge to optimize the performance of white light-emitting diodes (LEDs). So far, the zero-dimensional (0D) Mn2+-based halides with near-unity narrow-band emissions have emerged as a class of promising phosphors in solid-state displays, but the related large-scale synthesis strategies have not been proposed and evaluated. Herein, we report an in situ synthetic process of 0D Mn2+-based halides and utilize (C20H20P)2MnBr4 as a case to investigate the photoluminescence characteristics and the structural essence of ultrafast self-assembly. The bright green emission peak at 523 nm with a full width at half maximum of 48 nm for (C20H20P)2MnBr4 is attributed to the d-d transition (4T1-6A1) of tetrahedrally coordinated [MnBr4]2- centers, and the fabricated white LED device shows a wide color gamut of 103.7% National Television System Committee (NTSC) standard Remarkably, the exptl. and theor. results indicate that there are hydrogen bonding of C-H···Br and weak van der Waals interactions between [C20H20P]+ and [MnBr4]2-, resulting in the root for the realization of ultrafast self-assembly in 0D Mn2+-based halides. This work reveals a feasible and general synthesis method for preparing 0D Mn2+-based halides, thereby providing a possibility for their industrial application in solid-state displays. The experimental part of the paper was very detailed, including the reaction process of Ethyltriphenylphosphonium bromide(cas: 1530-32-1Application of 1530-32-1)

Ethyltriphenylphosphonium bromide(cas: 1530-32-1) is a phase transfer catalyst, used to accelerate the cure of phenolic-based epoxy resins, certain fluoroelastomer resins and thermosetting powder coatings. CatOnium ETPB is also used as catalysts in the synthesis of certain organic compounds.Application of 1530-32-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wang, Guowei; Jiang, Timing; Li, Sen; Hou, Huijie; Xiao, Keke; Hu, Jingping; Liang, Sha; Liu, Bingchuan; Yang, Jiakuan published an article in 2021. The article was titled 《Occurrence and exposure risk evaluation of polyhalogenated carbazoles (PHCZs) in drinking water》, and you may find the article in Science of the Total Environment.Related Products of 6825-20-3 The information in the text is summarized as follows:

Although polyhalogenated carbazoles (PHCZs) can be generated and detected in drinking water, their occurrence and potential health risks to humans via drinking water ingestion are not well known. In this study, 11 PHCZs were screened in drinking water samples from Wuhan, the most populous city in central China. The total concentration of PHCZs could be up to 53.48 ng/L with a median level of 8.19 ng/L, which was comparable to polychlorinated biphenyls and poly- and perfluoroalkyl substances reported in the literatures for drinking water. Composition profiles revealed that 3,6-dichlorocarbazole, 3-chlorocarbazole, 3-bromocarbazole and 3,6-dibromocarbazole were the predominant PHCZ congeners in the tested samples. Regional differences in the levels and patterns of PHCZs suggested that anthropogenic releases should be the dominant source compared to natural generation. Potential health risks associated to the levels of PHCZs in drinking water were assessed using the toxic equivalent (TEQs) method. The estimated daily intake of PHCZs via drinking water ingestion is up to 0.38 pg-TEQ/kg body weight/day for infants, nearly 4.5 times higher than that for adults, and appears to reach the maximum permissible concentration set by certain authority agencies. Overall, drinking water ingestion represents an important exposure pathway for PHCZs. This is the first comprehensive study on the abundance and health risks of PHCZs in drinking water. In the experiment, the researchers used 3,6-Dibromo-9H-carbazole(cas: 6825-20-3Related Products of 6825-20-3)

3,6-Dibromo-9H-carbazole(cas: 6825-20-3) is used as a pharmaceutical intermediate, and also an important intermediate of synthesizing optoelectronic materials. It has been used in the preparation of N-(2-hydroxyethyl)-3,6-dibromocarbazole.Related Products of 6825-20-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Liu, Mingkai; Jia, Yuxi; Cui, Zilong; Lu, Zhichao; Zhang, Weikun; Liu, Kezhong; Shuai, Li; Shi, Lei; Ke, Runhui; Lou, Yinghua published an article in 2021. The article was titled 《Occurrence and potential sources of polyhalogenated carbazoles in farmland soils from the Three Northeast Provinces, China》, and you may find the article in Science of the Total Environment.Application In Synthesis of 3,6-Dibromo-9H-carbazole The information in the text is summarized as follows:

Polyhalogenated carbazoles (PHCZs) have been detected in various environments frequently and have attracted increasing attention for their multiple toxicities. However, only a few reports record the occurrence of PHCZs in farmland soils, and the sources of which were not yet been implemented. In this study, 12 PHCZs and carbazole (CZ) were screened in farmland soil samples from the Three Northeast Provinces, and the ∑PHCZs were in the range of 18.16-219.67 ng/g dw. 36-CCZ was the dominant congener (40.67%) in farmland soils, followed by 3-CCZ (14.51%), and average percentages of other congeners were lower than 10%. A concrete anal. of the sources of PHCZs in the soil was conducted, revealing the diversity of PHCZs sources. Potential toxic effects associated with the levels of PHCZs were evaluated via the toxic equivalency (TEQ) approach, and the TEQs of PHCZs (TEQPHCZs) were in the range of 2.24-14.06 pg TEQ/g dw. Notwithstanding the 1368-CCZ with a low concentration level, the mean contribution to TEQPHCZs was up to 24.24%, preceded only by 36-CCZ (39.69%), showing the congeners with low concentration also may pose potential risks to the environment. Partial PHCZs congeners (2-BCZ, 3-BCZ, 36-CCZ, 136-BCZ, and 2367-BCZ) showed significant correlations (r = 0.45-0.63, p < 0.05) with the total organic carbon (TOC). Significant correlations were shown between PHCZ congeners replaced by halogens of the same species and quantity (r = 0.40-0.99, p < 0.01). In view of the fact that the high concentration level of PHCZs in the soil and their source diversity, more environmental monitoring and risk assessments of PHCZs should be of particular concern. The experimental part of the paper was very detailed, including the reaction process of 3,6-Dibromo-9H-carbazole(cas: 6825-20-3Application In Synthesis of 3,6-Dibromo-9H-carbazole)

3,6-Dibromo-9H-carbazole(cas: 6825-20-3) is used as a pharmaceutical intermediate, and also an important intermediate of synthesizing optoelectronic materials. It has been used in the preparation of N-(2-hydroxyethyl)-3,6-dibromocarbazole.Application In Synthesis of 3,6-Dibromo-9H-carbazole

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhang, Kezhuo; Huang, Jiaxin; Zhao, Wanxiang published an article in 2022. The article was titled 《Rh-Catalyzed Coupling of Aldehydes with Allylboronates Enables Facile Access to Ketones》, and you may find the article in Chemistry – A European Journal.SDS of cas: 14660-52-7 The information in the text is summarized as follows:

A novel strategy for the preparation of ketones R1C(O)CHR2CH2CH2R3 (R1 = n-pentyl, cyclohexyl, Ph, 2-thienyl, 4-pyridinyl, etc., R2 = R3 = H; R1 = Ph, R2 = Ph, 4-MeC6H4, 2-naphthyl, 3-furyl, etc., R3 = H; R1 = Ph, R2 = H, R3 = Et, Ph; etc.) from aldehydes R1CHO and allylic boronic esters R2CH:CHCHR3Bpin is presented. This reaction involves the allylation of aldehydes with allylic boronic esters and the Rh-catalyzed chain-walking of homoallylic alcs. The key to this successful development is the protodeboronation of alkenyl boryl ether intermediate via a tetravalent borate anion species in the presence of KHF2 and MeOH. This approach features mild reaction conditions, broad substrate scope, and excellent functional group tolerance. Mechanistic studies also supported that the tandem allylation and chain-walking process are involved.Ethyl 5-bromovalerate(cas: 14660-52-7SDS of cas: 14660-52-7) was used in this study.

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.SDS of cas: 14660-52-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Hasegawa, Yoko; Cantin, Thomas; Decaens, Jonathan; Couve-Bonnaire, Samuel; Charette, Andre B.; Poisson, Thomas; Jubault, Philippe published an article in 2022. The article was titled 《Catalytic Asymmetric Syntheses of Alkylidenecyclopropanes from Allenoates with Donor-Acceptor and Diacceptor Diazo Reagents》, and you may find the article in Chemistry – A European Journal.Safety of Benzyl 2-bromoacetate The information in the text is summarized as follows:

The first diastereo- and enantioselective cyclopropanation reactions of electron-deficient allenes with donor-acceptor and diacceptor diazo reagents was described. The desired enantioenriched alkylidenecyclopropanes (ACPs) were obtained in high yields with high diastereo- and enantioselectivities in the presence of Rh2((S)-TCPTAD)4 or Rh2((R)-BTPCP)4 catalysts (up to 95% yield, >95 : 5 d.r. and 99 : 1 e.r.). This methodol. gave a direct access to ACPs bearing multiple electron-deficient substituents and allows to further expand the availability of ACPs chem. Interestingly, during the examination of the scope of this reaction, the asym. intramol. C-H insertion reaction into tert-Bu group was observed as a side reaction with up to 94 : 6 e.r. In the experimental materials used by the author, we found Benzyl 2-bromoacetate(cas: 5437-45-6Safety of Benzyl 2-bromoacetate)

Benzyl 2-bromoacetate(cas: 5437-45-6) belongs to benzyl acetate. Benzyl acetate is a synthetic chemical produced for industry from benzyl alcohol and acetic acid, but is also naturally present in the essential oils of many plants, including jasmine and ylang ylang.Safety of Benzyl 2-bromoacetate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Kumar, Gautam; Bhattacharya, Debkanta; Chatterjee, Indranil published an article in 2022. The article was titled 《Lewis Acid-Assisted Transition Metal-Free Aminocyanation of Alkynes with Arylamines and N-Cyanosuccinimide》, and you may find the article in Advanced Synthesis & Catalysis.Category: bromides-buliding-blocks The information in the text is summarized as follows:

A transition-metal-free aminocyanation of aryl alkynes has been achieved using indium tribromide, InBr3 or B(C6F5)3 as a Lewis acid. This aminocyanation protocol features with non-toxic cyanide source, a good substrate scope and potentially valuable aminocyanation products. Mechanistic studies reveal the complex formation between Lewis acid and alkyne to produce in situ alkyne nitrile as a key intermediate. Further hydroamination of alkyne nitrile with arylamines affords the E-selective (E:Z = 70:30 to 90:10) β-aminoacrylonitrile derivatives The experimental process involved the reaction of Indium(III) bromide(cas: 13465-09-3Category: bromides-buliding-blocks)

Indium(III) bromide(cas: 13465-09-3) is used in organic synthesis as a water tolerant Lewis acid. It efficiently catalyzes the three-component coupling of β-keto esters, aldehydes and urea (or thiourea) to afford the corresponding dihydropyrimidinones.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Banerjee, Ankush; Saha, Shuvendu; Maji, Modhu Sudan published an article in Journal of Organic Chemistry. The title of the article was 《Cascade Benzannulation Approach for the Syntheses of Lipocarbazoles, Carbazomycins, and Related Alkaloids》.Category: bromides-buliding-blocks The author mentioned the following in the article:

Herein, a state-of-the-art one-pot cascade benzannulation technique for the efficacious synthesis of valuable 3-hydroxy-2-Me carbazoles, a linchpin of more than 25 carbazole-based alkaloids, is unveiled from readily affordable fundamental commodities. The key step of this strategy is gaining aromaticity by site-selective elimination of hydroxyl group controlled by nucleophilicity of the indole ring. The present strategy shows excellent functional group tolerance with a broad substrate scope. The utility of this convenient approach was appealingly exemplified via concise total syntheses of 10 carbazole-based alkaloids possessing significant biol. activities and thus of medicinal importance. In the experimental materials used by the author, we found Ethyltriphenylphosphonium bromide(cas: 1530-32-1Category: bromides-buliding-blocks)

Ethyltriphenylphosphonium bromide(cas: 1530-32-1) is a phase transfer catalyst, used to accelerate the cure of phenolic-based epoxy resins, certain fluoroelastomer resins and thermosetting powder coatings. It is also used as catalysts in the synthesis of certain organic compounds and as a pharmaceutical intermediate.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Khosravi, Hormoz; Mirzaei, Saber; Balalaie, Saeed published an article in Journal of Organic Chemistry. The title of the article was 《Decarboxylative Cyclization of Proline with o-Alkynylbenzaldehyde through an Unexploited 8π-Electrocyclization: A DFT Study》.Quality Control of o-Bromobenzaldehyde The author mentioned the following in the article:

We employed d. functional theory (DFT) methods to investigate the most plausible mechanism of cyclization/ring expansion of proline with o-alkynylbenzaldehyde. This one-pot reaction starts with the in situ formation of azomethine ylide, which can undergo three different reaction pathways to form the final product. Two mechanisms are based on nucleophilic addition and 4π-electrocyclization of the azomethine ylide, and our results indicate that the rate-determining step (RDS) of these two cyclizations are 40.1 and 40.2 kcal/mol, resp. The third novel pathway relies upon 8π-electrocyclization as the key step of this reaction; interestingly, the RDS of this cyclization is ~20.6 kcal/mol, which shows this route to be most feasible. Thus, we introduce a novel mechanism for the electrocyclization reaction of conjugated azomethine ylides that can help chemists to design and access a new series of compounds The experimental part of the paper was very detailed, including the reaction process of o-Bromobenzaldehyde(cas: 6630-33-7Quality Control of o-Bromobenzaldehyde)

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Quality Control of o-BromobenzaldehydeSynthetic applications of o-Bromobenzaldehyde include: synthesis of aza-fused polycyclic quinolines through copper-catalyzed cascade reaction, preparation of 1-substituted indazoles by CuI-catalyzed coupling with N-aryl hydrazides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Du, Zhongkun; Hou, Kaixuan; Zhou, Tongtong; Shi, Baihui; Zhang, Cheng; Zhu, Lusheng; Li, Bing; Wang, Jinhua; Wang, Jun published an article in Science of the Total Environment. The title of the article was 《Polyhalogenated carbazoles (PHCZs) induce cardiotoxicity and behavioral changes in zebrafish at early developmental stages》.Recommanded Product: 6825-20-3 The author mentioned the following in the article:

Polyhalogenated carbazoles (PHCZs) are widely present in the environment, and their health risks are of increasing concern. Available studies primarily confirm their dioxin-like toxicity mechanism based on biomarkers, such as aryl hydrocarbon receptor (AHR) and CYP1A1, while few studies have investigated their actual toxic effects at the level of individual organisms. In the present study, the developmental toxicity of two typical PHCZs with a high detection rate and high concentration in the environment (3,6-dichlorocarbazol (3,6-DCCZ) and 3,6-dibromocarbazole (3,6-DBCZ)) was investigated based on a fish embryo acute toxicity test (FET, zebrafish) and transcriptomics anal. The 96 h LC50 values of 3,6-DCCZ and 3,6-DBCZ were 0.636 mg/L and 1.167 mg/L, resp. Both tested PHCZs reduced the zebrafish heart rate and blocked heart looping at concentrations of 0.5 mg/L or higher. The swimming/escaping behavior of zebrafish larvae was more vulnerable to 3,6-DBCZ than 3,6-DCCZ. Transcriptomics assays showed that multiple pathways linked to organ development, immunization, metabolism and protein synthesis were disturbed in PHCZ-exposed fish, which might be the internal mechanism of the adverse effects. The present study provides evidence that PHCZs cause cardiac developmental toxicity and behavioral changes and improves our understanding of their health risks. In addition to this study using 3,6-Dibromo-9H-carbazole, there are many other studies that have used 3,6-Dibromo-9H-carbazole(cas: 6825-20-3Recommanded Product: 6825-20-3) was used in this study.

3,6-Dibromo-9H-carbazole(cas: 6825-20-3) is used as a pharmaceutical intermediate, and also an important intermediate of synthesizing optoelectronic materials. It has been used as a reagent in the synthesis of P7C3-A20 which is a potent neuroprotective agent.Recommanded Product: 6825-20-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Jiang, Ben-Jie; Zhang, Song-Lin published an article in Advanced Synthesis & Catalysis. The title of the article was 《Synthesis of Quinolines and 2-Functionalized Quinolines by Difluorocarbene Incorporation》.Computed Properties of C20H20BrP The author mentioned the following in the article:

A general method was developed to allow de novo construction of quinolines I [R = Me, cyclopropyl, Ph, etc.] and C2-functionalized quinolines II [R1 = Me, cyclopentyl, Ph; R2 = Ph, Bn, 1-naphthyl, etc.; R3 = H, Me] from ortho-alkenyl anilines in the presence of a difluorocarbene precursor. This method exploited a crucial reactivity of in-situ generation of isocyanides from condensation of primary aniline with difluorocarbene. Subsequent α-addition of isocyanide by neighboring alkenyl group constructs the quinoline ring. Furthermore, when a combination of difluorocarbene precursor and Se are present, selenoisocyanate intermediates were tentatively generated that upon nucleophilic addition by ortho-alkenyl produce 2-SeH quinolines. In the presence of a second nucleophile such as anilines, competing nucleophilic addition of anilines to the selenoisocyanate was preferred, generating selenourea intermediate. Further nucleophilic addition of the ortho-alkenyl to selenourea followed by elimination of H2Se produces 2-aminoquinolines. This allows one-step multi-component modular preparation of various C2-functionalized quinolines from readily available starting compounds This method showed good yields, scope and chemoselectivity. It was operationally convenient and friendly without manipulating unpleasant isocyanides. The difluorocarbene-enabled primary amine to isocyanide conversion may be exploited to develop other interesting reactions. In the experiment, the researchers used Ethyltriphenylphosphonium bromide(cas: 1530-32-1Computed Properties of C20H20BrP)

Ethyltriphenylphosphonium bromide(cas: 1530-32-1) is a phase transfer catalyst, used to accelerate the cure of phenolic-based epoxy resins, certain fluoroelastomer resins and thermosetting powder coatings. CatOnium ETPB is also used as catalysts in the synthesis of certain organic compounds.Computed Properties of C20H20BrP

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary