Month: October 2022

Application In Synthesis of 3,6-Dibromo-9H-carbazoleIn 2021 ,《Occurrence and distribution of polyhalogenated carbazoles (PHCs) in sediments from the northern South China Sea》 appeared in Science of the Total Environment. The author of the article were Zhou, Wenxiu; Chen, Weifang; Li, Peng; Gu, Zhaoyang; Peng, Jinghe; Lin, Kunde. The article conveys some information:

Polyhalogenated carbazoles (PHCs) have been frequently detected in various environments and have gained increasing attention due to their dioxin-like toxicity. In this study, 28 surface sediments and three sediment cores were collected from the northern South China Sea (SCS) to investigate the spatial and temporal distribution trends of PHCs. The total concentrations of PHCs in the surface sediments ranged from 0.25 ng/g to 3.10 ng/g, with a median concentration of 1.50 ng/g. The composition profiles of PHCs in the surface sediments were dominated by 3,6-dichlorocarbazole (36-CCZ), 3,6-dibromocarbazole (36-BCZ), and 1,3,6,8-tetrabromocarbazole (1368-BCZ). The total organic carbon (TOC) based concentrations of 36-CCZ, 1-bromo-3,6-dichlorocarbazole, 1,3,6,8-tetrachlorocarbazole, and 1368-BCZ showed significant pos. correlation with water depth (r = 0.58-0.88, p values < 0.01). On the contrary, the TOC based concentration of 2,3,6,7-tetrachlorocarbazole displayed a significant neg. correlation with the water depth (r = -0.52, p < 0.01). However, no significant correlation was observed for 3-chlorocarbazole, 36-BCZ, and 1,3,6-tribromocarbazole (p values > 0.05). PHCs in sediment cores showed that congener profiles and concentrations of PHCs remained largely stable throughout the 1890s and 2010s. In addition, all the detected PHCs displayed a significant pos. correlation with TOC content of the sediments. These unique spatial and temporal distribution patterns suggest that both terrigenous and natural marine sources contributed the observed PHCs in sediments of the northern SCS. In the experimental materials used by the author, we found 3,6-Dibromo-9H-carbazole(cas: 6825-20-3Application In Synthesis of 3,6-Dibromo-9H-carbazole)

3,6-Dibromo-9H-carbazole(cas: 6825-20-3) is used as a pharmaceutical intermediate, and also an important intermediate of synthesizing optoelectronic materials. It has been used in the preparation of N-(2-hydroxyethyl)-3,6-dibromocarbazole.Application In Synthesis of 3,6-Dibromo-9H-carbazole

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

COA of Formula: C4H7BrO2In 2019 ,《Preparation of a series of photoresponsive polymersomes bearing photocleavable a 2-nitrobenzyl group at the hydrophobic/hydrophilic interfaces and their payload releasing behaviors》 appeared in Polymers (Basel, Switzerland). The author of the article were Yamamoto, Shota; Yamada, Takafumi; Kubo, Genki; Sakurai, Kazuo; Yamaguchi, Kazuo; Nakanishi, Jun. The article conveys some information:

In this study, the structure-function relationships of a series of polymersomes composed of well-defined amphiphilic diblock copolymers were investigated. The building blocks were synthesized by clicking hydrophobic polymers, synthesized beforehand, and com. available poly(ethylene glycol) with photocleavable 2-nitrobenzyl compounds bearing alkyne and maleimide functionalities. All of the tested polymersomes preserved their hollow structures even after sufficient photoirradiation Nevertheless, the release rate of an entrapped anionic fluorophore was highly dependent on the mol. weight and the type of hydrophobic polymer, as well as on the presence or absence of the charged end groups. Moreover, the polymersomes with a 2-nitrosobenzyl photolysis residue within the hydrophobic shells exhibited photo-induced payload release after complete photolysis. It was concluded that the payload release was mediated by photo-induced permeability changes of the hydrophobic shells rather than the decomposition of their overall structures. In the experiment, the researchers used 4-Bromobutanoic acid(cas: 2623-87-2COA of Formula: C4H7BrO2)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).COA of Formula: C4H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

HPLC of Formula: 629-03-8In 2022 ,《Effect of the Crosslinking Degree on Self-Healing Poly(1,2,3-Triazolium) Adhesive》 appeared in Macromolecular Rapid Communications. The author of the article were Zhang, Jun; Shang, Chengyuan; Yu, Zhuoer; Wang, Linxiao; Tang, Junkun; Huang, Farong. The article conveys some information:

Dynamic covalent materials are a class of polymer that could be stress-relaxation, reprocessable, and self-healing due to dynamic crosslinks in network. Dynamic crosslinks play an important role in the typical characteristic of self-healing polymers. It is meaningful to understand the effect of crosslinking degree on the properties of poly(1,2,3-triazolium) (PTAM). In this article, the dynamic covalent network of PTAM adhesive was used to study the effect of crosslinking degree. PTAM adhesive with different crosslinking degrees were obtained by changing the amount of crosslinker. Adhesion property can rise then fall down with the increase of crosslinking degree and the best lap-shear strength is >20 MPa. Creep resistance and solvent resistance can be enhanced with the increase of crosslinking degree. Self-healing studies showed that crosslinking degree can enhance the ability of self-healing, but too high crosslinking degree raises the temperature of self-healing and causes side reaction which reduces the self-healing efficiency. These results provide some insights for the influence of the crosslinking degree on the self-healing and the structural design of dynamic covalent materials. After reading the article, we found that the author used 1,6-Dibromohexane(cas: 629-03-8HPLC of Formula: 629-03-8)

1,6-Dibromohexane(cas: 629-03-8) is generally used to introduce C6 spacer in the molecular architecture. Some of the examples are: synthesis of pyrrolo-tetrathiafulvalene molecular bridge (6PTTF6) to study redox switching behavior of single molecules; synthesis of water-soluble thermoresponsive polylactides.HPLC of Formula: 629-03-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

HPLC of Formula: 14660-52-7In 2021 ,《Novel Nonsecosteroidal Vitamin D Receptor Modulator Combined with Gemcitabine Enhances Pancreatic Cancer Therapy through Remodeling of the Tumor Microenvironment》 appeared in Journal of Medicinal Chemistry. The author of the article were Kang, Zisheng; Wang, Cong; Tong, Yu; Li, Yanyi; Gao, Yi; Hou, Siyuan; Hao, Meixi; Han, Xiaolin; Wang, Bin; Wang, Qianqian; Zhang, Can. The article conveys some information:

In a pancreatic tumor microenvironment, activated pancreatic stellate cells (PSCs) produce extracellular matrix (ECM) to form a barrier to drug penetration. Moreover, the interaction between cancer cells and activated PSCs promotes the tumor growth. Vitamin D receptor (VDR), as a key regulator to promote the recovery of PSCs to the resting state, is an attractive therapeutic target for pancreatic cancer. Herein, we reported the design and synthesis of 57 nonsecosteroidal VDR modulators based on the skeleton of phenyl-pyrrolyl pentane. Among them, compounds C4, I5, and I8 exhibited excellent VDR affinity and effective inhibition of the activation of PSCs, as well as potent suppression of the interaction between cancer cells and PSCs in vitro. In vivo, compound I5 combined with gemcitabine achieved efficacious antitumor activity without causing hypercalcemia. In conclusion, the compounds designed in our study can remodel the tumor microenvironment and are expected to be candidates for the treatment of pancreatic cancer. The experimental process involved the reaction of Ethyl 5-bromovalerate(cas: 14660-52-7HPLC of Formula: 14660-52-7)

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.HPLC of Formula: 14660-52-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Application of 2675-79-8In 2020 ,《Tellurides Bearing Sulfonamides as Novel Inhibitors of Leishmanial Carbonic Anhydrase with Potent Antileishmanial Activity》 appeared in Journal of Medicinal Chemistry. The author of the article were Angeli, Andrea; Etxebeste-Mitxeltorena, Mikel; Sanmartin, Carmen; Espuelas, Socorro; Moreno, Esther; Azqueta, Amaya; Parkkila, Seppo; Carta, Fabrizio; Supuran, Claudiu T.. The article conveys some information:

A novel series of tellurides bearing sulfonamide has been reported for the first time as selective and potent inhibitors of the β-class carbonic anhydrase (CA; EC 4.2.1.1) enzyme expressed in Leishmania donovani protozoa. Such derivatives showed high activity against axenic amastigotes, and among them, 4-(((3,4,5-trimethoxyphenyl)tellanyl)methyl)benzenesulfonamide showed an IC50 of 0.02μM being highly selective for the parasites over THP-1 cells with a selectivity index of 300. The in vitro and in vivo toxicity experiments showed this compound to possess a safe profile thus paving the way for tellurium-containing compounds as novel drug entities.1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8Application of 2675-79-8) was used in this study.

1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.Application of 2675-79-81-Bromo-3,4,5-trimethoxybenzene can be used to synthesize analogs of HA14-1, which shows promising anticancer properties.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of C8H8Br2In 2021 ,《Static Retention of Dynamic Chiral Arrangements for Achiral Shear Thinning Metal-Organic Colloids》 appeared in Chemistry – A European Journal. The author of the article were Huang, Jian-Cai; Xiao, Hui; Chen, Zhixin; Zheng, Wenxu; Huang, Chang-Cang; Wu, Shu-Ting; Xie, Zenghong; Zhuang, Naifeng. The article conveys some information:

Chiral compounds are known to be important not only because they are the fundamental components of living organisms, but also for their unique chiroptical properties. In recent years, scientists have fabricated several chiral organic supramol. aggregates by using chiral phys. fields, such as vortex flow. Herein, the relationship between dynamic chiroptical properties and rheol. nature is discussed, suggesting the shear thinning properties of non-Newtonian fluids might help colloidal particles adopt a chiral arrangement in vortices. Furthermore, the storage modulus of colloids could be increased by adding a linking agent, which successfully kept the dynamic chiroptical properties in the static state. Moreover, the salt effect on the host-guest interaction involved in the colloids was studied, the results suggested a significant enhancement of the transferred dynamic CD for the achiral guest mol. In the experiment, the researchers used 1,4-Bis(bromomethyl)benzene(cas: 623-24-5Electric Literature of C8H8Br2)

1,4-Bis(bromomethyl)benzene(cas: 623-24-5) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. Electric Literature of C8H8Br2 Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Recommanded Product: 76006-33-2In 2014 ,《Pyridyl Benzamides as a Novel Class of Potent Inhibitors for the Kinetoplastid Trypanosoma brucei》 appeared in Journal of Medicinal Chemistry. The author of the article were Ferrins, Lori; Gazdik, Michelle; Rahmani, Raphael; Varghese, Swapna; Sykes, Melissa L.; Jones, Amy J.; Avery, Vicky M.; White, Karen L.; Ryan, Eileen; Charman, Susan A.; Kaiser, Marcel; Bergstrom, Christel A. S.; Baell, Jonathan B.. The article conveys some information:

A whole-organism screen of approx. 87000 compounds against Trypanosoma brucei identified a number of promising compounds for medicinal chem. optimization. One of these classes of compounds the authors termed the pyridyl benzamides. While the initial hit had an IC50 of 12 μM, it was small enough to be attractive for further optimization, and the authors utilized three parallel approaches to develop the structure-activity relationships. The authors determined that the physicochem. properties for this class are generally favorable with particular positions identified that appear to block metabolism when substituted and others that modulate solubility The most active compound is 79, which has an IC50 of 0.045 μM against the human pathogenic strain Trypanosoma brucei rhodesiense and is more than 4000 times less active against the mammalian L6 cell line. In the experiment, the researchers used 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Recommanded Product: 76006-33-2)

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.Organobromine chemicals are produced naturally by an array of biological and other chemical processes in our environment. Recommanded Product: 76006-33-2Some of these compounds are identical to man-made organobromine compounds, such as methyl bromide, bromoform, and bromophenols, but many others are entirely new moleclar entities, often possessing extraordinary and important biological properties.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Computed Properties of C4H2Br2SIn 2022 ,《Microwave-Assisted Synthesis of 2-Aryl and 2,5-Diarylthiophene Derivatives via Suzuki-Miyaura Cross-Coupling Using Novel Palladium Complex as a Catalyst》 appeared in Polycyclic Aromatic Compounds. The author of the article were Khormi, Afaf Y.; Farghaly, Thoraya. A.; Shaaban, Mohamed R.. The article conveys some information:

A novel phosphine-free pyrimidine-based palladium(II) complex was synthesized from easily accessible starting materials and its ability to be a catalyst for cross-coupling reactions namely, Suzuki-Miyaura (SMC) was investigated. The structure of the new formamidinyl pyrimidine-based complex was elucidated by using spectroscopic as well as phys. characterization techniques. The novel palladium(II) complex showed its applicability as a catalyst for SMC of 2-bromothiophene and 2,5-dibromothiophene with arylboronic acids under conventional and microwaves irradiation conditions. The developed catalytic system exhibited reasonable catalytic activity to obtain 2-aryl and 2,5-diarylthiophene derivatives using mild reaction conditions. The results came from multiple reactions, including the reaction of 2,5-Dibromothiophene(cas: 3141-27-3Computed Properties of C4H2Br2S)

2,5-Dibromothiophene(cas: 3141-27-3) , is mainly used as pharmaceutical intermediate and synthesis intermediate. 2,5-Dibromothiophene polymerizes by debromination with magnesium catalyzed by nickel compounds to form poly(2,5- thienylene) .Computed Properties of C4H2Br2S

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Product Details of 17696-11-6In 2022 ,《Discovery of Potent PROTACs Targeting EGFR Mutants through the Optimization of Covalent EGFR Ligands》 appeared in Journal of Medicinal Chemistry. The author of the article were Zhao, Hong-Yi; Wang, Hai-Peng; Mao, Yu-Ze; Zhang, Hao; Xin, Minhang; Xi, Xiao-Xiao; Lei, Hao; Mao, Shuai; Li, Dong-Hui; Zhang, San-Qi. The article conveys some information:

To overcome the intractable problem of drug resistance, proteolysis targeting chimeras (PROTACs) targeting EGFR mutants were developed by optimizing covalent EGFR ligands. Covalent or reversible covalent pyrimidine- or purine-containing PROTACs were designed, synthesized, and evaluated. As a consequence, covalent PROTAC I, with a novel purine-containing EGFR ligand, was discovered as a highly potent degrader against EGFRL858R/T790M and EGFRdel19, reaching the lowest DC50 values among all reported EGFR-targeting PROTACs. Furthermore, I exhibited excellent cellular activity against the H1975 and HCC827 cell lines with high selectivity. Mechanism investigation indicated that the lysosome was involved in the degradation process. Importantly, the covalent binding strategy was proven to be an effective approach for the design of PROTACs targeting EGFRL858R/T790M, which laid the practical foundation for further development of potent EGFR-targeting PROTACs. After reading the article, we found that the author used 8-Bromooctanoic acid(cas: 17696-11-6Product Details of 17696-11-6)

8-Bromooctanoic acid(cas: 17696-11-6) acid is used in the synthesis of 8-(N-Methyl-4,4′-bipyridinyl)- octanoic acid. 8-Mercaptooctanoic acid was prepared from 8-bromooctanoic acid. And 8-Bromooctanoic Acid is a useful compound for sonodynamic therapy.Product Details of 17696-11-6

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

SDS of cas: 626-40-4In 2018 ,《Species-Selective Pyrimidineamine Inhibitors of Trypanosoma brucei S-Adenosylmethionine Decarboxylase》 appeared in Journal of Medicinal Chemistry. The author of the article were Volkov, Oleg A.; Brockway, Anthony J.; Wring, Stephen A.; Peel, Michael; Chen, Zhe; Phillips, Margaret A.; De Brabander, Jef K.. The article conveys some information:

New therapeutic options are needed for treatment of human African trypanosomiasis (HAT) caused by protozoan parasite Trypanosoma brucei. S-Adenosylmethionine decarboxylase (AdoMetDC) is an essential enzyme in the polyamine pathway of T. brucei. Previous attempts to target this enzyme were thwarted by the lack of brain penetration of the most advanced series. Herein, the authors describe a T. brucei AdoMetDC inhibitor series based on a pyrimidineamine pharmacophore that the authors identified by target-based high-throughput screening. The pyrimidineamines showed selectivity for T. brucei AdoMetDC over the human enzyme, inhibited parasite growth in whole-cell assay, and had good predicted blood-brain barrier penetration. The medicinal chem. program elucidated structure-activity relationships within the series. Features of the series that were required for binding were revealed by determining the x-ray crystal structure of TbAdoMetDC bound to one analog. The pyrimidineamine series provides a novel starting point for an anti-HAT lead optimization. In the part of experimental materials, we found many familiar compounds, such as 3,5-Dibromoaniline(cas: 626-40-4SDS of cas: 626-40-4)

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.SDS of cas: 626-40-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary