Month: October 2022

In 2018,Tanini, Damiano; Tiberi, Caterina; Gellini, Cristina; Salvi, Pier Remigio; Capperucci, Antonella published 《A Straightforward Access to Stable β-Functionalized Alkyl Selenols》.Advanced Synthesis & Catalysis published the findings.Recommanded Product: 3395-91-3 The information in the text is summarized as follows:

Treatment of epoxides with bis(trimethylsilyl)-selenide under strictly controlled conditions allowed to isolate β-hydroxy selenols which evidence an unexpected stability, taking into account their known propensity to afford diselenides. Also thiiranes and aziridines lead to functionalized selenols bearing a thiol and a N-Ts- or N-Boc-protected amino moiety on β-position. These selenols were stable enough to react with different electrophiles. Ab-initio DF calculations on two suitable model systems, Pr selenol and β-hydroxy derivative, allow to ascribe the observed low tendency to oxidation to noncovalent interactions between the selenol moiety and the -OH group.Methyl 3-bromopropanoate(cas: 3395-91-3Recommanded Product: 3395-91-3) was used in this study.

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Recommanded Product: 3395-91-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2018,Tria, George S.; Abrams, Tinya; Baird, Jason; Burks, Heather E.; Firestone, Brant; Gaither, L. Alex; Hamann, Lawrence G.; He, Guo; Kirby, Christina A.; Kim, Sunkyu; Lombardo, Franco; Macchi, Kaitlin J.; McDonnell, Donald P.; Mishina, Yuji; Norris, John D.; Nunez, Jill; Springer, Clayton; Sun, Yingchuan; Thomsen, Noel M.; Wang, Chunrong; Wang, Jianling; Yu, Bing; Tiong-Yip, Choi-Lai; Peukert, Stefan published 《Discovery of LSZ102, a Potent, Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen Receptor Positive Breast Cancer》.Journal of Medicinal Chemistry published the findings.Reference of 1-Bromo-2-isopropylbenzene The information in the text is summarized as follows:

In breast cancer, estrogen receptor alpha (ERα) pos. cancer accounts for approx. 74% of all diagnoses, and in these settings, it is a primary driver of cell proliferation. Treatment of ERα pos. breast cancer has long relied on endocrine therapies such as selective estrogen receptor modulators, aromatase inhibitors, and selective estrogen receptor degraders (SERDs). The steroid-based anti-estrogen fulvestrant, the only approved SERD, is effective in patients who have not previously been treated with endocrine therapy as well as in patients who have progressed after receiving other endocrine therapies. Its efficacy, however, may be limited due to its poor physicochem. properties. THe authors describe the design and synthesis of a series of potent benzothiophene-containing compounds that exhibit oral bioavailability and preclin. activity as SERDs. This article culminates in the identification of LSZ102 (I), a compound in clin. development for the treatment of ERα pos. breast cancer. In the part of experimental materials, we found many familiar compounds, such as 1-Bromo-2-isopropylbenzene(cas: 7073-94-1Reference of 1-Bromo-2-isopropylbenzene)

1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Reference of 1-Bromo-2-isopropylbenzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2018,Knerr, Laurent; Giordanetto, Fabrizio; Nordberg, Peter; Pettersen, Daniel; Selmi, Nidhal; Beisel, Hans-Georg; de la Motte, Hannah; Olsson, Thomas; Perkins, Tim D. J.; Hersloef, Margareta; Maansson, Aasa; Dahlstroem, Mikael; Starke, Ingemar; Broddefalk, Johan; Saarinen, Gabrielle; Klingegaard, Fredrik; Hurt-Camejo, Eva; Rosengren, Birgitta; Brengdahl, Johan; Jansen, Frank; Rohman, Mattias; Sandmark, Jenny; Hallberg, Kenth; Aakerud, Tomas; Roth, Robert G.; Ahlqvist, Marie published 《Discovery of a Series of Indole-2 Carboxamides as Selective Secreted Phospholipase A2 Type X (sPLA2-X) Inhibitors》.ACS Medicinal Chemistry Letters published the findings.Safety of Methyl 3-(bromomethyl)benzoate The information in the text is summarized as follows:

In order to assess the potential of sPLA2-X as a therapeutic target for atherosclerosis, novel sPLA2 inhibitors with improved type X selectivity are required. To achieve the objective of identifying such compounds, we embarked on a lead generation effort that resulted in the identification of a novel series of indole-2-carboxamides as selective sPLA2-X inhibitors with excellent potential for further optimization. In the part of experimental materials, we found many familiar compounds, such as Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Safety of Methyl 3-(bromomethyl)benzoate)

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Moreover, several studies demonstrate that the average proportion of bromine in drugs is significantly higher than that in natural products. Safety of Methyl 3-(bromomethyl)benzoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Chemistry – A European Journal included an article by Walker, Rebecca; Pociecha, Damian; Storey, John M. D.; Gorecka, Ewa; Imrie, Corrie T.. HPLC of Formula: 2623-87-2. The article was titled 《The Chiral Twist-Bend Nematic Phase (N*TB)》. The information in the text is summarized as follows:

The twist-bend nematic, NTB, phase has been observed for chiral materials in which chirality is introduced through a branched 2-methylbutyl terminal tail. The chiral twist-bend nematic phase, N*TB, is completely miscible with the NTB phase of the standard achiral material, CB6OCB. The N*TB phase exhibits optical textures with lower birefringence than those observed for the achiral NTB phase, suggesting an addnl. mechanism of averaging mol. orientations. The N*-N*TB transition temperatures for the chiral materials are higher than the NTB-N transition temperatures seen for the corresponding racemic materials. This suggests the double degeneracy of helical twist sense in the NTB* phase is removed by the intrinsic mol. chirality. A square lattice pattern is observed in the N* phase over a temperature range of several degrees above the N*TB-N phase transition, which may be attributed to a non-monotonic dependence of the bend elastic constant In the part of experimental materials, we found many familiar compounds, such as 4-Bromobutanoic acid(cas: 2623-87-2HPLC of Formula: 2623-87-2)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).HPLC of Formula: 2623-87-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Pharmacia (Sofia, Bulgaria) included an article by Severina, Hanna I.; Skupa, Olha O.; Voloshchuk, Natalya I.; Suleiman, Marharyta M.; Georgiyants, Victoriya A.. Recommanded Product: Benzyl 2-bromoacetate. The article was titled 《Synthesis and anticonvulsant activity of 6-methyl-2-((2-oxo-2-arylethyl)thio) pyrimidin-4(3H)-one derivatives and products of their cyclization》. The information in the text is summarized as follows:

The alkylation of 6-methyl-2-thioxo-2,3-dihydro-1H-pyrimidine-4-one with phenacyl bromides RC6H4C(O)CH2Br (R = H, 4-Br, 3-OMe, 4-OMe, 4-F, 4-NO2), bromo-acetic acid benzyl ester under different conditions was investigated. It was found that during the reaction in the medium of DMF/K2CO3, a mixture of 2-(2-aryl-2-oxoethyl)thio-6-methyl-pyrimidine-4(3H)-ones I and 3-hydroxy-3-aryl-7-methyl-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidine-5-ones II was formed. The holding of the resulting mixture in the concentrated sulfuric acid leads to the formation of cyclization products III with high yields. Individual S-alkylated derivatives I, benzyl [(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)thio]acetate were obtained by reacting in methanol in the presence of sodium methoxide. Pharmacol. screening of synthesized compounds I (R = H, 4-Br, 3-OMe, 4-OMe), III, benzyl [(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)thio]acetate for anticonvulsant activity on the model of pentylenetetrazole seizures in rats was carried out and some regularity “”structure-activity”” was established. The experimental part of the paper was very detailed, including the reaction process of Benzyl 2-bromoacetate(cas: 5437-45-6Recommanded Product: Benzyl 2-bromoacetate)

Benzyl 2-bromoacetate(cas: 5437-45-6) belongs to benzyl acetate. Benzyl acetate is a synthetic chemical produced for industry from benzyl alcohol and acetic acid, but is also naturally present in the essential oils of many plants, including jasmine and ylang ylang.Recommanded Product: Benzyl 2-bromoacetate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Journal of Physical Chemistry C included an article by Chen, Shanbao; Huang, Chengxi; Sun, Huasheng; Ding, Junfei; Jena, Puru; Kan, Erjun. Category: bromides-buliding-blocks. The article was titled 《Boosting the Curie temperature of two-dimensional semiconducting CrI3 monolayer through van der Waals heterostructures》. The information in the text is summarized as follows:

The integration of ferromagnetic and semiconducting properties in a single 2-dimensional (2D) material has been recognized as a fertile ground for fundamental science as well as for practical applications in information processing and storage. CrI3 monolayer has recently drawn much attention due to its 2D long-range ferromagnetic (FM) order. However, its Curie temperature (TC) is too low (∼45 K) for practical spintronic applications. Here, the authors show that the in-plane FM coupling of CrI3 can be remarkably enhanced by constructing a 2D heterostructure where CrI3 monolayer is supported on a nonmagnetic normal semiconductor/insulator substrate. Choosing MoTe2 monolayer as a substrate, the authors find that the CrI3/MoTe2 2D heterostructure is an intrinsic semiconducting ferromagnet with TC of ∼60 K. The TC can be further increased to ∼85 K by applying an out-of-plane pressure of ∼4.2 GPa. The doubling of the TC in this 2D heterostructure comes from the introduction of extra spin superexchange (Cr-Te-Cr) paths. These findings provide a promising pathway to improve ferromagnetism in 2D semiconductors, which can stimulate further theor. and exptl. interest. In the experimental materials used by the author, we found Indium(III) bromide(cas: 13465-09-3Category: bromides-buliding-blocks)

Indium(III) bromide(cas: 13465-09-3) is used as a catalyst to produce dithioacetals when unactivated alkynes react with thiols and fields such as optics and microelectronics that utilize semiconductor technology have wide uses for indium in high-performing solar cells.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Energies (Basel, Switzerland) included an article by Ghodrat, Maryam; Samali, Bijan; Rhamdhani, Muhammad Akbar; Brooks, Geoffrey. Application of 13465-09-3. The article was titled 《Thermodynamic-based exergy analysis of precious metal recovery out of waste printed circuit board through black copper smelting process》. The information in the text is summarized as follows:

Exergy anal. is one of the useful decision-support tools in assessing the environmental impact related to waste emissions from fossil fuel. This paper proposes a thermodn.-based design to estimate the exergy quantity and losses during the recycling of copper and other valuable metals out of electronic waste (e-waste) through a secondary copper recycling process. The losses related to recycling, as well as the quality losses linked to metal and oxide dust, can be used as an index of the resource loss and the effectiveness of the selected recycling route. Process-based results are presented for the emission exergy of the major equipment used, which are namely a reduction furnace, an oxidation furnace, and fire-refining, electrorefining, and precious metal-refining (PMR) processes for two scenarios (secondary copper recycling with 50% and 30% waste printed circuit boards in the feed). The results of the work reveal that increasing the percentage of waste printed circuit boards (PCBs) in the feed will lead to an increase in the exergy emission of CO2. The variation of the exergy loss for all of the process units involved in the e-waste treatment process illustrated that the oxidation stage is the key contributor to exergy loss, followed by reduction and fire refining. The results also suggest that a fundamental variation of the emission refining through a secondary copper recycling process is necessary for e-waste treatment. The results came from multiple reactions, including the reaction of Indium(III) bromide(cas: 13465-09-3Application of 13465-09-3)

Indium(III) bromide(cas: 13465-09-3) is used in organic synthesis as a water tolerant Lewis acid. It efficiently catalyzes the three-component coupling of β-keto esters, aldehydes and urea (or thiourea) to afford the corresponding dihydropyrimidinones.Application of 13465-09-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Physiochemical Properties and Molecular Dynamics Simulations of Phosphonium and Ammonium Based Deep Eutectic Solvents》 were Naik, Papu Kumar; Paul, Sandip; Banerjee, Tamal. And the article was published in Journal of Solution Chemistry in 2019. HPLC of Formula: 1779-49-3 The author mentioned the following in the article:

Deep eutectic solvents (DES) are considered as second-generation ionic liquids and are used in many applications such as separation, extraction and electrochem. In the current work, a set of four DES is synthesized by mixing a hydrogen bond donor (HBD) (ethylene glycol/glycerol) with a quaternary ammonium or phosphonium salt or the hydrogen bond acceptor (HBA). Here the HBA, namely methyltriphenylphosphonium bromide and tetrabutylammonium bromide (TBAB), were mixed with the HBD in a molar ratio of 1:4. Fourier transform IR and thermogravimetric anal. anal. were then carried out to understand the functional groups along with their thermal stability. NMR anal. was also used to validate the molar ratio of 1:4 in solution Thereafter, the four DESs were simulated with mol. dynamics simulations to evaluate and measure the pure component properties of these solvents at room temperature Thermodn. insights such as non-bonded interaction energies, hydrogen bonds, coordination number and radial distribution functions were also discussed to understand their atomistic interactions involved in the eutectic mixtures In addition to this study using Methyltriphenylphosphonium bromide, there are many other studies that have used Methyltriphenylphosphonium bromide(cas: 1779-49-3HPLC of Formula: 1779-49-3) was used in this study.

Methyltriphenylphosphonium bromide(cas: 1779-49-3) is a lipophilic molecule with a cation allowing for it to be used to deliver molecules to specific cell components. Also considered an antineoplastic agent.HPLC of Formula: 1779-49-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Clickable coupling of carboxylic acids and amines at room temperature mediated by SO2F2: A significant breakthrough for the construction of amides and peptide linkages》 were Wang, Shi-Meng; Zhao, Chuang; Zhang, Xu; Qin, Hua-Li. And the article was published in Organic & Biomolecular Chemistry in 2019. Electric Literature of C7H5BrO2 The author mentioned the following in the article:

A mild, simple, efficient and robust protocol was developed for the synthesis of amides RC(O)NR1R2 [R = Et, Ph, 2-furyl, 4-pyridyl, etc., R1 = H, Et, Bn, etc., R2 = Et, Ph, 3-pyridyl, etc.] via SO2F2-mediated clickable coupling of carboxylic acids with amines. Peptide linkages were also prepared using this methodol. The direct click reactions of acids and amines on gram scale were also demonstrated using an extremely easy work-up and purification process of washing with 1 M aqueous HCl to provide the desired amides in greater than 99% purity and excellent yields. In the experiment, the researchers used 4-Bromobenzoic acid(cas: 586-76-5Electric Literature of C7H5BrO2)

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography. It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.Electric Literature of C7H5BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Universal Antibacterial Surfaces Fabricated from Quaternary Ammonium Salt-Based PNIPAM Microgels》 was published in ACS Applied Materials & Interfaces in 2020. These research results belong to Zhao, Ziqing; Ma, Xiaoliang; Chen, Rui; Xue, Hui; Lei, Jiehua; Du, Hui; Zhang, Zexin; Chen, Hong. Name: 1,6-Dibromohexane The article mentions the following:

Because of the excellent film-forming ability of poly(N-isopropylacrylamide) (PNIPAM) microgel and high-efficient bactericidal property of quaternary ammonium salt (QAS), QAS-based PNIPAM (QAS-PNIPAM) microgels are synthesized and employed to modify the surface of a range of commonly used materials including metal, plastic, and elastomer. Bacterial culture is carried out on such QAS-PNIPAM microgel-modified surfaces to examine the viability of the attached bacteria. It is found that the bactericidal efficiency is nearly 100% on the modified surfaces of all the studied materials. We attribute the high-efficient bactericidal performance of QAS-PNIPAM microgel film to the QAS component rather than the topog. of the microgel film itself. In addition, the microgel film is robust and shows great integrity even after culture of the bacteria and repeated rinses, and the cell experiment demonstrates that this microgel film is cyto-compatible. Therefore, such a simple, versatile method of preparing antibacterial films paves the way for future bactericidal applications. In the experimental materials used by the author, we found 1,6-Dibromohexane(cas: 629-03-8Name: 1,6-Dibromohexane)

1,6-Dibromohexane(cas: 629-03-8) is generally used to introduce C6 spacer in the molecular architecture. Some of the examples are: synthesis of solvent processable and conductive polyfluorene ionomers for alkaline fuel cell applications; synthesis of cross-linkable regioregular poly(3-(5-hexenyl)thiophene) (P3HNT) for stabilizing the film morphology in polymer photovoltaic cells.Name: 1,6-Dibromohexane

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary