Month: October 2022

《Synthesis of Betulin Bromobenzoate, Dicinnamate, and Disuccinate in Melts of the Corresponding Acids》 was published in Chemistry of Natural Compounds in 2020. These research results belong to Levdansky, V. A.; Kondrasenko, A. A.; Levdansky, A. V.; Kuznetsov, B. N.. Related Products of 586-76-5 The article mentions the following:

The goal of the research was to develop synthetic methods for betulin 28-p-bromobenzoate, 3,28-dicinnamate and 3,28-disuccinate I [R1 = H, R2 = (4-bromophenyl)carbonyl; R1 = R2 = 3-phenylprop-2-enoyl; R1 = R2 = 3-carboxypropanoyl] via esterification of betulin in melts of corresponding acids R2OH. After reading the article, we found that the author used 4-Bromobenzoic acid(cas: 586-76-5Related Products of 586-76-5)

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography.Related Products of 586-76-5 It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《fac-Bis(phenoxatellurine) tricarbonyl manganese(I) bromide》 was written by Mostaghimi, Farzin; Lork, Enno; Beckmann, Jens. Electric Literature of C5BrMnO5 And the article was included in Main Group Metal Chemistry in 2020. The article conveys some information:

The reaction of (CO)5MnBr with phenoxatellurine (PT) provided the octahedral complex fac-(CO)3(PT)2MnBr in which the two PT ligands are situated in cis-position. The experimental part of the paper was very detailed, including the reaction process of Bromopentacarbonylmanganese(I)(cas: 14516-54-2Electric Literature of C5BrMnO5)

Bromopentacarbonylmanganese(I)(cas: 14516-54-2) has many other uses. It is used in the formation of (eta6-arene)tricarbonylmanganese(I) by reacting with arene (arene= hexamethyl benzene, 1,2,4,5-tetramethyl benzene, mesitylene, p-xylene and toluene) in the presence silver salt.Electric Literature of C5BrMnO5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Design, sustainable synthesis, characterization, antimicrobial evaluation and in silico ADMET prediction of new functionalized imidazolium based ionic liquids》 was written by Al Johani, Anas R.; Almutairi, Saud M.; El-Sayed, Wael S.; Sahu, Pramod K.; Sahu, Praveen K.; Messali, Mouslim. Related Products of 14660-52-7 And the article was included in Asian Journal of Chemistry in 2020. The article conveys some information:

A series of sixteen new ionic liquids (ILs) bearing imidazolium moiety I (R = 2-chlorobenzyl, 3-cyanopropyl, 4-acetoxybutyl, etc.; X = Cl, Br) were designed and synthesized under sustainable and green conditions which were confirmed by anal. and spectral techniques using 1H- & 13C-NMR, FT-IR, mass and elemental anal. A panel of clin. isolated strains was used for in vitro inhibitory antimicrobial activities screening of synthesized ionic liquids I. The results of antimicrobial assay showed that some of synthesized ionic liquids I showed moderate to good activity. Among these ILs, ionic liquids (bearing alkyl chain with a Ph group) I [R = (2-chlorophenyl)methyl, X = Cl; R = 2-phenoxyethyl, X = Br; R = 3-phenoxypropyl, X = Br] significantly inhibited cell growth of strains. In this regard, these ionic liquids I considered as promising antibacterial agents when compared with standard antibiotics. By encouraging in vitro antimicrobial screening, in silico ADMET evaluation has been performed and found excellent pharmacokinetic, bioavailability and toxicity profiles. Synthesized ionic liquids have found to be safe and non-toxic according to calculated in vivo computed LD50 values (2.49-2.80 mg/kg) for rat acute toxicity. In the part of experimental materials, we found many familiar compounds, such as Ethyl 5-bromovalerate(cas: 14660-52-7Related Products of 14660-52-7)

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Related Products of 14660-52-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Control over the Aspect Ratio of Supramolecular Nanosheets by Molecular Design》 was written by Sasaki, Norihiko; Yuan, Jennifer; Fukui, Tomoya; Takeuchi, Masayuki; Sugiyasu, Kazunori. Formula: C6H12Br2 And the article was included in Chemistry – A European Journal in 2020. The article conveys some information:

Recent developments in kinetically controlled supramol. polymerization permit control of the size (i.e., length and area) of self-assembled nanostructures. However, control of mol. self-assembly at a level comparable with organic synthetic chem. and the achievement of structural complexity at a hierarchy larger than the mol. level remain challenging. This study focuses on controlling the aspect ratio of supramol. nanosheets. A systematic understanding of the relationship between the monomer structure and the self-assembly energy landscape has derived a new monomer capable of forming supramol. nanosheets. With this monomer in hand, the aspect ratio of a supramol. nanosheet is demonstrated that it can be controlled by modulating intermol. interactions in two dimensions. The results came from multiple reactions, including the reaction of 1,6-Dibromohexane(cas: 629-03-8Formula: C6H12Br2)

1,6-Dibromohexane(cas: 629-03-8) is generally used to introduce C6 spacer in the molecular architecture. Some of the examples are: synthesis of solvent processable and conductive polyfluorene ionomers for alkaline fuel cell applications; synthesis of cross-linkable regioregular poly(3-(5-hexenyl)thiophene) (P3HNT) for stabilizing the film morphology in polymer photovoltaic cells.Formula: C6H12Br2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Palladium Catalyzed C-O Coupling of Amino Alcohols for the Synthesis of Aryl Ethers》 was written by Mikus, Malte S.; Sanchez, Carina; Fridrich, Cary; Larrow, Jay F.. Application of 7073-94-1 And the article was included in Advanced Synthesis & Catalysis in 2020. The article conveys some information:

Amine containing aryl ethers are common pharmacophore motifs that continue to emerge from drug discovery efforts. As amino alcs. are readily available building blocks, practical methodologies for incorporating them into more complex structures are highly desirable. We report our efforts to explore the application of Pd-catalyzed C-O coupling methods to the arylation of 1,2- and 1,3-amino alcs. [e.g., 1-bromo-4-(trifluoromethyl)benzene + amino alc. I → II (82%, 68% isolated)]. We established general and reliable conditions, under which we explored the scope and limitations of the transformation. The insights gained have been valuable in employing this methodol. within a fast-moving drug discovery environment, which we anticipate will be of general interest to the synthesis and catalysis communities. After reading the article, we found that the author used 1-Bromo-2-isopropylbenzene(cas: 7073-94-1Application of 7073-94-1)

1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. The most pervasive is the naturally produced bromomethane.Application of 7073-94-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Perfluoroalkylated anthracene endoperoxide: Synthesis, characterization, crystal structure analysis, and computational insights》 was written by Putta, Anjaneyulu; Sykes, Andrew G.; Sun, Haoran. Formula: C14H8Br2 And the article was included in Journal of Fluorine Chemistry in 2020. The article conveys some information:

Aromatic endoperoxides serve as important intermediate species toward generating singlet state oxygen, which is key to photodynamic therapy applications. Gaining insights for fine-tuning endoperoxide stability and degree of oxygen-oxygen bond activation is of fundamental and practical interest for the chem. and medicinal communities. We report here that 9,10-bisperfluorooctyl-anthracene, upon exposing to light and air, is almost quant. converted to 9,10-bisperfluorooctyl-anthracene endoperoxide (compound 1) at room temperature 1H NMR spectra and the X-ray crystal structure revealed that the resulting compound 1 is stable at room temperature without further decomposition The crystal structure anal. showed that the compound 1 is stabilized by F···O intramol. interactions along with F···F, F···H and F···C intermol. interactions. DFT calculations further indicate that the degree of oxygen-oxygen bond activation in anthracene endoperoxides, reflected as changes of O-O, C-O bond distances, may not solely depend on the electronic effect of substituents at the 9,10- positions. This uncertainty warrants further investigation both exptl. and computationally. The experimental part of the paper was very detailed, including the reaction process of 9,10-Dibromoanthracene(cas: 523-27-3Formula: C14H8Br2)

9,10-Dibromoanthracene(cas: 523-27-3) is a dibrominated polycyclic aromatic hydrocarbon (PAH). 9,10-Dibromoanthracene is often used as an energy acceptor and activator in reactions that produce chemiluminescence.Formula: C14H8Br2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Novel phenethylimidazolium based ionic liquids: Design, microwave synthesis, in-silico, modeling and biological evaluation studies》 was written by Titi, Abderrahim; Almutairi, Saud M.; Alrefaei, Abdulwahed F.; Manoharadas, Salim; Alqurashy, Bakheet A.; Sahu, Pramod K.; Hammouti, Belkheir; Touzani, Rachid; Messali, Mouslim; Ali, Imran. Synthetic Route of C7H13BrO2 And the article was included in Journal of Molecular Liquids in 2020. The article conveys some information:

An eco-friendly preparation method for the novel bioactive imidazolium ionic liquids halides (ILs) was developed under microwave-assisted conditions. Synthesized ILs were characterized by spectroscopic techniques. Selected ILs were investigated for their antimicrobial activity against highly resistant Gram-pos. and Gram-neg. bacterial strains. Overall, 3-(2-chlorobenzyl)-1-phenethyl-1H-imidazol-3-iumchloride (4) showed high antimicrobial activity against the Staphylococcus aureus strain in the inhibition zone tests and displayed low MIC and MBC levels against almost all tested bacteria. Furthermore, the ILs were screened in vitro against human hepatocellular carcinoma (HepG-2), human breast adenocarcinoma (MCF-7), and human colon carcinoma (Caco-2) cell lines. The screening results showed excellent to moderate anticancer activity across the ILs. Among the synthesized ILs, Overall, 3-(2-chlorobenzyl)-1-phenethyl-1H-imidazol-3-ium chloride (4) and 1-phenethyl-3-(3-phenoxypropyl)-1H-imidazol-3-ium bromide (7) were found to exhibit the most promising ant proliferative effects and had the lowest IC50 values. The docking study suggested strong interaction of ILs with DNA with binding energy ranging from -4.9 to -4.1 kcal/mol. ILs 4 and 7 were most strongly bonded with -4.9 and -4.8 kcal/mol binding energy; confirming in vitro anticancer results. In the part of experimental materials, we found many familiar compounds, such as Ethyl 5-bromovalerate(cas: 14660-52-7Synthetic Route of C7H13BrO2)

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Synthetic Route of C7H13BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Palladium-Catalyzed Olefination of N-Tosylhydrazones as β-Diazo Phosphonate Precursors with Arylhalides》 was written by He, Jing; Feng, Yijiao; Yang, Fang; Dai, Bin; Liu, Ping. Product Details of 2675-79-8 And the article was included in European Journal of Organic Chemistry in 2020. The article conveys some information:

Palladium-catalyzed reaction of β-ketophosphonate hydrazones R1C(:NNTs)CH2P(O)R22 with halides RX (R1, R = aryl, alkyl; X = halo) affording vinylphosphonates R1RC:CHP(O)R22 as a (Z/E)-mixtures An efficient palladium-catalyzed olefination of N-tosylhydrazones as β-diazo phosphonate precursors with aryl halides has been developed. 2,2-Disubstituted vinylphosphonates bearing versatile functional groups were easily accessed in moderate to excellent yields. Various aryl halides could be employed as the coupling partners, such as (hetero)aryl bromides, aryl iodides, and even aryl chlorides. Moreover, with a similar strategy (2,2-diphenylvinyl)diarylphosphine oxides can also be attained by the reaction of N-tosylhydrazones and aryl bromides. This protocol features easily available raw materials, simple reaction conditions, broad substrate scope as well as scale-up ability. Moreover, the potential application of this product was exemplified by further transformations. After reading the article, we found that the author used 1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8Product Details of 2675-79-8)

1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.Product Details of 2675-79-81-Bromo-3,4,5-trimethoxybenzene can be used to synthesize analogs of HA14-1, which shows promising anticancer properties.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wang, Chengdong; Guo, Yingjie; Wang, Xiaoming; Wang, Zheng; Ding, Kuiling published their research in Chemistry – A European Journal in 2021. The article was titled 《Ni-Catalyzed Regioselective Hydroarylation of 1-Aryl-1,3-Butadienes with Aryl Halides》.Related Products of 2635-13-4 The article contains the following contents:

An efficient nickel-catalyzed regioselective hydroarylation of 1,3-dienes with aryl halides and a silane has been developed, affording a range of allylic arenes in good to excellent yields under mild conditions. This method exhibits broad substrate scope, and excellent functional group tolerance. Late-stage modification of complex architectures was demonstrated.5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4Related Products of 2635-13-4) was used in this study.

Furthermore, the coupling of 5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4) with β-methallyl alcohol was catalyzed by Pd(OAc)2 in combination with P(t-Bu)3.Related Products of 2635-13-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Hussain, Waseem A.; Plunkett, Kyle N. published their research in Journal of Organic Chemistry in 2021. The article was titled 《Benzodithiophene-Fused Cyclopentannulated Aromatics via a Palladium-Catalyzed Cyclopentannulation and Scholl Cyclodehydrogenation Strategy》.Reference of 9,10-Dibromoanthracene The article contains the following contents:

The synthesis of a new class of cyclopenta-fused polyaromatic hydrocarbon (CP-PAH) incorporating fused benzodithiophene subunits was reported. These CP-PAHs were prepared utilizing a two-step process involving a palladium catalyzed cyclopentannulation followed by a Scholl cyclodehydrogenation. This work broadens the scope of annulation chem. by employing 1,2-bis(5-hexylthiophen-3-yl)ethyne and dibromoaryl derivatives based on 9,10-dibromoanthracene, 3,8-dibromopyrene, and 3,9-dibromoperylene. Scholl cyclodehydrogenation of the pendant thiophene units provided access to the π-extended polyaromatic systems that possess helicene-like fragments. The anthracene-based CP-PAH was contorted owing to [5]helicene-like arrangements, while the pyrene- and perylene-based systems were essentially planar. The fully conjugated small mols. give low optical gaps (1.7-2.1 eV) with broad light absorption. The HOMO and LUMO energies of the CP-PAHs were found to be in the range of -5.48 to -5.05 eV and -3.48 to -3.14 eV. Finally, the anthracene-based CP-PAH was found to be a p-type semiconductor when tested in an organic field effect transistor.9,10-Dibromoanthracene(cas: 523-27-3Reference of 9,10-Dibromoanthracene) was used in this study.

9,10-Dibromoanthracene(cas: 523-27-3) can be sublimated and oxidized to generate anthraquinone. Soluble in hot benzene and hot toluene, slightly soluble in alcohol, ether and cold benzene, insoluble in water.Reference of 9,10-Dibromoanthracene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary