Month: October 2022

Saini, Parul; Krishnan, Anandhu; Yadav, Deepak; Hazra, Susanta; Elias, Anil J. published their research in Asian Journal of Organic Chemistry in 2021. The article was titled 《External Catalyst-Free Oxidation of Benzyl Halides to Benzoic Acids Using NaOH/TBHP in Water》.Recommanded Product: 586-76-5 The article contains the following contents:

An efficient and metal-free methodol. for the oxidation of benzyl halides to benzoic acids using an inexpensive and green oxidant (TBHP) in aqueous basic medium has been developed. This protocol offers an excellent way to avoid adding catalysts and involves the use of an in-situ generated halide ion as catalyst. It is also the first report on the oxidation of benzyl iodides to benzoic acids. A series of carboxylic acids were prepared from benzyl halides in high yields under mild reaction conditions by this method which does not require chromatog. purification Gram scale reactions for the synthesis of the carboxylic acids in good yields have been successfully carried out using benzyl chloride, bromide and iodide. As an industrial application, the synthesis of a key monomer used for the synthesis of polyethylene terephthalate (PET), i. e., terephthalic acid (PTA), has also been accomplished in good yields. In the experiment, the researchers used many compounds, for example, 4-Bromobenzoic acid(cas: 586-76-5Recommanded Product: 586-76-5)

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography.Recommanded Product: 586-76-5 It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Sterman, Andrej; Kosmrlj, Janez; Zigart, Nina; Gobec, Stanislav; Sosic, Izidor; Casar, Zdenko published their research in Advanced Synthesis & Catalysis in 2021. The article was titled 《Catalytic Approach to Diverse α-Aminoboronic Acid Derivatives by Iridium-Catalyzed Hydrogenation of Trifluoroborate-Iminiums》.Safety of 5-Bromobenzo[d][1,3]dioxole The article contains the following contents:

Structurally diverse benzyl protected trifluoroborate-ammoniums were prepared in good to high yields by an efficient hydrogenation of corresponding trifluoroborate-iminiums using Crabtree’s catalyst. Subsequent N- and B-deprotections were demonstrated on selected examples to provide several α-aminoboronic acids. Preliminary experiments on asym. version of the reaction indicated a correlation between E/Z-ratio in the trifluoroborate-iminium substrate and enantioselectivity. The broad scope, operational simplicity and efficiency of the presented method imply its high potential for a facile access to libraries of α-aminoboronic acid derivatives that can be used in medicinal chem. applications and beyond. In addition to this study using 5-Bromobenzo[d][1,3]dioxole, there are many other studies that have used 5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4Safety of 5-Bromobenzo[d][1,3]dioxole) was used in this study.

Furthermore, the coupling of 5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4) with β-methallyl alcohol was catalyzed by Pd(OAc)2 in combination with P(t-Bu)3.Safety of 5-Bromobenzo[d][1,3]dioxole

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Bobileva, Olga; Bobrovs, Raitis; Kanepe, Iveta; Patetko, Liene; Kalnins, Gints; Sisovs, Mihails; Bula, Anna L.; Grinberga, Solveiga; Boroduskis, Martins; Ramata-Stunda, Anna; Rostoks, Nils; Jirgensons, Aigars; Tars, Kaspars; Jaudzems, Kristaps published their research in ACS Medicinal Chemistry Letters in 2021. The article was titled 《Potent SARS-CoV-2 mRNA Cap Methyltransferase Inhibitors by Bioisosteric Replacement of Methionine in SAM Cosubstrate》.Related Products of 1129-28-8 The article contains the following contents:

Viral mRNA cap methyltransferases (MTases) are emerging targets for the development of broad-spectrum antiviral agents. In this work, we designed potential SARS-CoV-2 MTase Nsp14 and Nsp16 inhibitors by using bioisosteric substitution of the sulfonium and amino acid substructures of the cosubstrate S-adenosylmethionine (SAM), which serves as the Me donor in the enzymic reaction. The synthetically accessible target structures were prioritized using mol. docking. Testing of the inhibitory activity of the synthesized compounds showed nanomolar to submicromolar IC50 values for 5 compounds To evaluate selectivity, enzymic inhibition of the human glycine N-methyltransferase involved in cellular SAM/SAH ratio regulation was also determined, which indicated that the discovered compounds are nonselective inhibitors of the studied MTases with slight selectivity for Nsp16. No cytotoxic effects were observed; however, this is most likely a result of the poor cell permeability of all evaluated compounds The experimental part of the paper was very detailed, including the reaction process of Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Related Products of 1129-28-8)

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals.Related Products of 1129-28-8 Organobromine compounds have fallen under increased scrutiny for their environmental impact.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Chen, Yihan; Xu, Zhaoran; Hu, Wenrui; Li, Xiaojing; Cheng, Yixiang; Quan, Yiwu published their research in Macromolecular Rapid Communications in 2021. The article was titled 《Strong-Induced CPL Emission Promoted from Achiral Conjugated Polymer-Containing Emissive Nematic Liquid Crystals (P-N*-LCs)》.SDS of cas: 629-03-8 The article contains the following contents:

With the rapid development on 3D printing technol., more and more works have been devoted to 3D display. 3D display will really come true by using circularly polarized luminescence (CPL)-active materials with both high quantum yield and dissymmetry factor (gem) in organic light-emitting diode OLED or liquid crystals (LCs). But so far most of these CPL materials cannot meet the real application requirement because of the low gem values in the range of 10-5-10-2. In this paper, ternary chiral emissive LCs (P-N*-LCs) is designed by doping chiral binaphthyl-based enantiomers as chiral dopant I (Guest 1) and achiral conjugated polymer as induced CPL emitter II (Guest 2) into nematic liquid crystal (N-LCs) Host 5CB. Both Guest 1 and Guest 2 show excellent compatibility with Host 5CB. The obtained ternary P-N*-LCs can emit strong-induced CPL signal with gem up to 1.12 and ΦFL up to 66.1%. This work first develops a new strategy for the smart design of excellent CPL materials from versatile achiral conjugation fluorescence polymers. In the experiment, the researchers used many compounds, for example, 1,6-Dibromohexane(cas: 629-03-8SDS of cas: 629-03-8)

1,6-Dibromohexane(cas: 629-03-8) is generally used to introduce C6 spacer in the molecular architecture. Some of the examples are: synthesis of pyrrolo-tetrathiafulvalene molecular bridge (6PTTF6) to study redox switching behavior of single molecules; synthesis of water-soluble thermoresponsive polylactides.SDS of cas: 629-03-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhang, Yuqi; Zhao, Meng; Fang, Jing; Ye, Shuyue; Wang, Anna; Zhao, Yan; Cui, Chaoxiang; He, Lei; Shi, Haibin published an article in 2021. The article was titled 《Smart On-Site Immobilizable Near-Infrared II Fluorescent Nanoprobes for Ultra-Long-Term Imaging-Guided Tumor Surgery and Photothermal Therapy》, and you may find the article in ACS Applied Materials & Interfaces.Recommanded Product: Methyl 3-bromopropanoate The information in the text is summarized as follows:

Accurate diagnosis and efficient treatment of tumors are highly significant in battling cancer. Near-IR II (NIR-II) fluorescence imaging shows big promise for deep tumor visualization in living systems due to high temporal and spatial resolution and deep tissue penetration capability, whereas the development of efficient NIR-II probes for tumor theranostics still faces a huge challenge. Herein, we have designed and constructed intelligent mPEG5000-PCL3000-encapsulated NIR-II nanoprobe ZM1068-NPs that showed great chem. stability and excellent biocompatibility. With the merits of the strong fluorescence in the NIR-II region and prominent optical-thermal conversion efficiency, this probe was successfully used for NIR-II imaging-guided surgery and photothermal therapy of breast carcinoma in living mice. More notably, it was for the first time found that ZM1068 dyes could be covalently on-site-immobilized within tumors through the thiol-chlor nucleophilic substitution reaction, resulting in improved tumor accumulation and retention time. We thus envision that this probe may provide an attractive means for precise cancer diagnosis and treatment. The experimental process involved the reaction of Methyl 3-bromopropanoate(cas: 3395-91-3Recommanded Product: Methyl 3-bromopropanoate)

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Recommanded Product: Methyl 3-bromopropanoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Tang, Xuehang; Ning, Mengmeng; Ye, Yangliang; Gu, Yipei; Yan, Hongyi; Leng, Ying; Shen, Jianhua published an article in 2021. The article was titled 《Discovery of novel ketoxime ether derivatives with potent FXR agonistic activity, oral effectiveness and high liver/blood ratio》, and you may find the article in Bioorganic & Medicinal Chemistry.Related Products of 1129-28-8 The information in the text is summarized as follows:

The farnesoid X receptor (FXR) is a promising therapeutic target for nonalcoholic steatohepatitis (NASH) and other bile acid related diseases because it plays a critical role in fibrosis, inflammation and bile acid homeostasis. Obeticholic acid (OCA), a FXR agonist which was synthesized from chenodeoxycholic acid, showed desirable curative effects in clin. trials. However, the pruritus which was the main side effect of OCA limited its further applications in NASH. Although pruritus was also observed in the clin. trials of non-steroidal FXR agonists, the proportion of patients with pruritus was much smaller than that of OCA. Thus, we decided to develop non-steroidal FXR agonists and discovered a series of novel FXR agonists which were synthesized from GW4064 by replacing the stilbene group with ketoxime ether. Encouragingly, in the following biol. tests, our target compounds I and II not only showed potent FXR agonistic activities in vitro, but also effectively promoted the expression of target genes in vivo. More importantly, in the pharmacokinetic experiments, compounds I and II displayed high liver/blood ratio characteristics which were helpful to reduce the potential side effects which were caused by prolonged systemic activation of FXR. In summary, our compounds were good choices for the development of non-steroidal FXR agonists and were deserved further investigation. The experimental part of the paper was very detailed, including the reaction process of Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Related Products of 1129-28-8)

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. The most pervasive is the naturally produced bromomethane.Related Products of 1129-28-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Yang, Woojin; Yoon, Younggun; Lee, Yunjee; Oh, Hyeongyeol; Choi, Jieun; Shin, Sujin; Lee, Seongsoo; Lee, Hohjai; Lee, Yunho; Seo, Jiwon published an article in 2021. The article was titled 《Photosensitizer-peptoid conjugates for photoinactivation of Gram-negative bacteria: structure-activity relationship and mechanistic studies》, and you may find the article in Organic & Biomolecular Chemistry.Recommanded Product: Ethyl 5-bromovalerate The information in the text is summarized as follows:

Multitarget engagement is considered an effective strategy to overcome the threat of bacterial infection, and antimicrobials with multiple mechanisms of action have been successful as natural chem. weaponry. Here, we synthesized a library of photosensitizer-peptoid conjugates (PsPCs) as novel antimicrobial photodynamic therapy (aPDT) agents. The peptoids, linkers, and photosensitizers were varied, and their structure-antimicrobial activity relationships against Escherichia coli were evaluated; PsPC 9 was indicated to be the most promising photoresponsive antimicrobial agent among the synthesized PsPCs. Spectroscopic analyses indicated that 9 generated singlet oxygen upon absorption of visible light (420 nm) while maintaining the weakly helical conformation of the peptoid. Mechanistic studies suggested that damage to the bacterial membrane and cleavage of DNA upon light irradiation were the main causes of bactericidal activity, which was supported by flow cytometry and DNA gel electrophoresis experiments We demonstrated that the optimal combination of membrane-active peptoids and photosensitizers can generate an efficient aPDT agent that targets multiple sites of bacterial components and kills bacteria by membrane disruption and reactive oxygen species generation. The results came from multiple reactions, including the reaction of Ethyl 5-bromovalerate(cas: 14660-52-7Recommanded Product: Ethyl 5-bromovalerate)

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Recommanded Product: Ethyl 5-bromovalerate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Jayaprakash, Harikrishnan published an article in 2021. The article was titled 《Mn(I) phosphine-amino-phosphinites: a highly modular class of pincer complexes for enantioselective transfer hydrogenation of aryl-alkyl ketones》, and you may find the article in Dalton Transactions.Name: Bromopentacarbonylmanganese(I) The information in the text is summarized as follows:

A series of Mn(I) catalysts with readily accessible and more π-accepting phosphine-amino-phosphinite (P'(O)N(H)P) pincer ligands have been explored for the asym. transfer hydrogenation of aryl-alkyl ketones which led to good to high enantioselectivities (up to 98%) compared to other reported Mn-based catalysts for such reactions. The easy tunability of the chiral backbone and the phosphine moieties makes P'(O)N(H)P an alternative ligand framework to the well-known PNP-type pincers.Bromopentacarbonylmanganese(I)(cas: 14516-54-2Name: Bromopentacarbonylmanganese(I)) was used in this study.

Bromopentacarbonylmanganese(I)(cas: 14516-54-2) has many other uses. It is used in the formation of (eta6-arene)tricarbonylmanganese(I) by reacting with arene (arene= hexamethyl benzene, 1,2,4,5-tetramethyl benzene, mesitylene, p-xylene and toluene) in the presence silver salt.Name: Bromopentacarbonylmanganese(I)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Geniller, Lilian; Taillefer, Marc; Jaroschik, Florian; Prieto, Alexis published an article in 2022. The article was titled 《Photo-Induced Halogen-Atom Transfer: Generation of Halide Radicals for Selective Hydrohalogenation Reactions》, and you may find the article in Chemistry – A European Journal.Formula: C5H9BrO2 The information in the text is summarized as follows:

The first photo-mediated process enabling the generation of halide radicals by Halogen-Atom Transfer (XAT) is described. Contrary to radical transformations involving XAT reactivity, which exploit stable carbon radicals, this unique approach uses 1,2-dihaloethanes for the generation of unstable carbon radicals by XAT. These transient radicals then underwent β-scission with release of ethylene and formation of more stable halide radicals which have been used in selective hydrohalogenations of a large number of unsaturated hydrocarbons, including Michael acceptors, unactivated alkenes and alkynes. This hydrohalogenation is tolerant of a broad range of functionalities and is believed to proceed through a radical-chain manifold that propagates by the use of silane derivatives In addition to this study using Ethyl 3-bromopropanoate, there are many other studies that have used Ethyl 3-bromopropanoate(cas: 539-74-2Formula: C5H9BrO2) was used in this study.

Ethyl 3-bromopropanoate(cas: 539-74-2) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Formula: C5H9BrO2 In contrast, terrestrial plants account only for a few bromine-containing compounds.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Guan, Xianghong; Cheryala, Narsihmulu; Karim, Rezaul Md.; Chan, Alice; Berndt, Norbert; Qi, Jun; Georg, Gunda I.; Schonbrunn, Ernst published an article in Journal of Medicinal Chemistry. The title of the article was 《Bivalent BET Bromodomain Inhibitors Confer Increased Potency and Selectivity for BRDT via Protein Conformational Plasticity》.Application In Synthesis of Ethyl 4-bromobutyrate The author mentioned the following in the article:

Bromodomain and extraterminal domain (BET) proteins are important regulators of gene transcription and chromatin remodeling. BET family members BRD4 and BRDT are validated targets for cancer and male contraceptive drug development, resp. Due to the high structural similarity of the acetyl-lysine binding sites, most reported inhibitors lack intra-BET selectivity. We surmised that protein-protein interactions induced by bivalent inhibitors may differ between BRD4 and BRDT, conferring an altered selectivity profile. Starting from nonselective monovalent inhibitors, we developed cell-active bivalent BET inhibitors with increased activity and selectivity for BRDT. X-ray crystallog. and solution studies revealed unique structural states of BRDT and BRD4 upon interaction with bivalent inhibitors. Varying spacer lengths and sym. vs unsym. connections resulted in the same dimeric states, whereas different chemotypes induced different dimers. The findings indicate that the increased intra-BET selectivity of bivalent inhibitors is due to the differential plasticity of BET bromodomains upon inhibitor-induced dimerization. The results came from multiple reactions, including the reaction of Ethyl 4-bromobutyrate(cas: 2969-81-5Application In Synthesis of Ethyl 4-bromobutyrate)

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Application In Synthesis of Ethyl 4-bromobutyrate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary