Month: October 2022

Application of 4316-58-9In 2021 ,《Tunable pyridyl-based conjugated microporous polymers for visible light-driven hydrogen evolution》 appeared in ACS Applied Energy Materials. The author of the article were Kotp, Mohammed G.; Elewa, Ahmed M.; El-Mahdy, Ahmed F. M.; Chou, Ho-Hsiu; Kuo, Shiao-Wei. The article conveys some information:

Conjugated microporous polymers (CMPs) are promising light harvesters for photocatalytic H2 evolution because they are simple to prepare with various band gaps. To achieve CMPs displaying high photocatalytic performance, appropriate building blocks must be chosen. We prepared four kinds of triphenylpyridine-based CMPs (TPP-CMPs) through reactions with multibrominated monomers having different geometries [1,3,6,8-tetrabromopyrene (pyrene-4Br), tris(4-bromophenyl)amine (TPA-3Br), 2,4,6-tris(4-bromrophenyl)pyridine (TPP-3Br), and 1,2,4,5-tetrabromobenzene (BZ-4Br), forming the TPP-pyrene (Py), TPP-triphenylamine (TPA), TPP-TPP, and TPP-benzene (BZ) CMPs, resp.]. This strategy allowed effective synthetic regulation of electron enrichment, porosities, and optoelectronic properties of the TPP-CMPs. The surface areas of the TPP-CMPs were high, up to 1370 m2 g-1, and had a high thermal stability. TPP-Py CMP displayed the highest photocatalytic performance with a H2 production rate of 18 100 μmol g-1 h-1 under irradiation with visible light. Moreover, we achieved apparent quantum yields as high as 22.97% at 420 nm, comparable with those of most other CMPs reported previously. The experimental process involved the reaction of Tris(4-bromophenyl)amine(cas: 4316-58-9Application of 4316-58-9)

In general, Tris(4-bromophenyl)amine(cas: 4316-58-9) is often used in the synthesis of porous luminescent covalent–organic polymers (COPs)Application of 4316-58-9

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

SDS of cas: 76006-33-2In 2018 ,《Regioselective C-H Alkylation via Carboxylate-Directed Hydroarylation in Water》 appeared in Chemistry – A European Journal. The author of the article were Zhang, Guodong; Jia, Fan; Goossen, Lukas J.. The article conveys some information:

In the presence of catalytic [RuCl2(p-cym)]2 and using Li3PO4 as the base, benzoic acids react with olefins in water to afford the corresponding 2-alkylbenzoic acids in moderate to excellent yields. This C-H alkylation process is generally applicable to diversely substituted electron-rich and electron-deficient benzoic acids, along with α,β-unsaturated olefins including unprotected acrylic acid. The widely available carboxylate directing group can be removed or used for further derivatization. Mechanistic studies revealed that the transformation proceeds via a ruthenacycle intermediate. In the experiment, the researchers used 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2SDS of cas: 76006-33-2)

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Due to the reactivity of bromide, they are used as potential precursors or important intermediates in organic synthesis. SDS of cas: 76006-33-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

COA of Formula: C9H9BrO2In 2020 ,《On the electron withdrawing nature of ethers in glycosylation chemistry》 appeared in Carbohydrate Research. The author of the article were Marqvorsen, Mikkel H. S.; Brinkoe, Anne; Jensen, Henrik H.. The article conveys some information:

The present review paper is a commentary on the electronic effects that protecting groups exert on glycosylation chem (with new data). Specifically, its purpose is to rectify the misguided use of the term electron donating benzyl groups, which hardly makes sense in the context of protecting groups on alcs. in saturated systems such as carbohydrates. It is argued that benzyl ethers (OBn) should rightfully be referred to as being inductively electron withdrawing, even if they are less so than benzoyl esters (OBz). In the experimental materials used by the author, we found Benzyl 2-bromoacetate(cas: 5437-45-6COA of Formula: C9H9BrO2)

Benzyl 2-bromoacetate(cas: 5437-45-6) has been used in the alkylation of (-)-2,3-O-isopropylidene-D-threitol that afforded lipopeptide, 2-[(4R,5R)-5-({[(9H-fluoren-9-yl)methoxy]carbonylaminomethyl}-2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]acetic acid.COA of Formula: C9H9BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Quality Control of Ethyl 4-bromobutyrateIn 2019 ,《A Scalable Total Synthesis of Halofuginone》 was published in Organic Process Research & Development. The article was written by Xu, Hua; Yin, Wenhao; Liang, Haoqiang; Nan, Yanbo; Qiu, Fayang; Jin, Yehua. The article contains the following contents:

A scalable total synthesis of halofuginone (I) has been accomplished. This synthetic route features a total of 12 steps of highly efficient reactions, without any chromatog. purification Halofuginone was obtained in 17% overall yield and over 98.5% HPLC purity. All the reaction conditions are mild and reliable. In addition, no hazardous materials are used or produced. All reagents are com. available and inexpensive. This route is safe, robust, scalable, cost-effective, and environmentally benign.Ethyl 4-bromobutyrate(cas: 2969-81-5Quality Control of Ethyl 4-bromobutyrate) was used in this study.

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Quality Control of Ethyl 4-bromobutyrate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of C4H7BrO2In 2016 ,《Bacterial versus human sphingosine-1-phosphate lyase (S1PL) in the design of potential S1PL inhibitors》 was published in Bioorganic & Medicinal Chemistry. The article was written by Sanllehi, Pol; Abad, Jose-Luis; Casas, Josefina; Bujons, Jordi; Delgado, Antonio. The article contains the following contents:

A series of potential active-site sphingosine-1-phosphate lyase (S1PL) inhibitors have been designed from scaffolds 1 and 2, arising from virtual screening using the X-ray structures of the bacterial (StS1PL) and the human (hS1PL) enzymes. Both enzymes are very similar at the active site, as confirmed by the similar exptl. kinetic constants shown by the fluorogenic substrate RBM13 in both cases. However, the docking scoring functions used probably overestimated the weight of electrostatic interactions between the ligands and key active-site residues in the protein environment, which may account for the modest activity found for the designed inhibitors. In addition, the possibility that the inhibitors do not reach the enzyme active site should not be overlooked. Finally, since both enzymes show remarkable structural differences at the access channel and in the proximity to the active site cavity, caution should be taken when designing inhibitors acting around that area, as evidenced by the much lower activity found in StS1PL for the potent hS1PL inhibitor D. In the experiment, the researchers used Methyl 3-bromopropanoate(cas: 3395-91-3Synthetic Route of C4H7BrO2)

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Synthetic Route of C4H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Formula: C8H8Br2In 2020 ,《Triblock Copolymer/Polyoxometalate Nanocomposite Electrolytes with Inverse Hexagonal Cylindrical Nanostructures》 was published in Macromolecular Rapid Communications. The article was written by Zhai, Liang; Chai, Shengchao; Wang, Gang; Zhang, Wei; He, Haibo; Li, Haolong. The article contains the following contents:

The primary issue of polymer electrolytes is to achieve high ion conductivity while retaining mech. properties. A nanocomposite electrolyte with the inverse hexagonal cylindrical phase (three-dimensionally continuous domains for ion conduction and embedded domains for mech. support) is prepared through the electrostatic self-assembly of a polyoxometalate (H3PW12O40, PW) and a triblock copolymer poly(N-vinyl pyrrolidone)-block-polystyrene-block-poly(N-vinyl pyrrolidone) (PSP). The cylindrical nanocomposite exhibits a conductivity of 1.32 mS cm-1 and a storage modulus of 4.6 × 107 Pa at room temperature These two values are higher than those of pristine PSP by two orders of magnitudes and a factor of six, resp. PW clusters are used as multifunctional nano-additives (morphol. inducer, proton conductor, and nano-enhancer) and their incorporation achieves the simultaneous improvement in both conductive and mech. performance. In the experimental materials used by the author, we found 1,4-Bis(bromomethyl)benzene(cas: 623-24-5Formula: C8H8Br2)

1,4-Bis(bromomethyl)benzene(cas: 623-24-5) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. In contrast, terrestrial plants account only for a few bromine-containing compounds.Formula: C8H8Br2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Application of 626-40-4In 2022 ,《Development of Sulfamoylated 4-(1-Phenyl-1H-1,2,3-triazol-4-yl)phenol Derivatives as Potent Steroid Sulfatase Inhibitors for Efficient Treatment of Breast Cancer》 was published in Journal of Medicinal Chemistry. The article was written by Biernacki, Karol; Ciupak, Olga; Dasko, Mateusz; Rachon, Janusz; Kozak, Witold; Rak, Janusz; Kubinski, Konrad; Maslyk, Maciej; Martyna, Aleksandra; Sliwka-Kaszynska, Magdalena; Wietrzyk, Joanna; Switalska, Marta; Nocentini, Alessio; Supuran, Claudiu T.; Demkowicz, Sebastian. The article contains the following contents:

Here development of new sulfamoylated 4-(1-phenyl-1H-1,2,3-triazol-4-yl)phenol derivatives I [R = 3-Cl, 3-Br, 3-Et, etc.; X = H, SO2NH2] via sulfamoylation reaction of 4-(1-phenyl1H-1,2,3-triazol-4-yl)phenol derivatives with sulfamoyl chloride as potent steroid sulfatase (STS) inhibitors for the treatment of breast cancer was presented. Prompted by promising biol. results and in silico anal., the initial series of similar compounds were extended, appending a variety of m-substituents at the outer Ph ring. The inhibition profiles of the newly synthesized compounds were evaluated using a radioisotope enzymic assay and, together with the preceding reported derivatives, using a radioisotope assay in MCF-7 cells. The most active compound, I [R = 3,5-di-F, X = SO2NH2], demonstrated an extraordinary STS inhibitory potency in MCF-7 cells with an IC50 value improved 5-fold compared to that of the reference Irosustat (0.21 vs 1.06 nM). The five most potent compounds were assessed in vivo in a 67NR mouse mammary gland cancer model, with I [R = 3,5-di-Cl, X = SO2NH2] measured to induce up to 51% tumor growth inhibition at 50 mg/kg with no evidence of side effects and toxicity. In addition to this study using 3,5-Dibromoaniline, there are many other studies that have used 3,5-Dibromoaniline(cas: 626-40-4Application of 626-40-4) was used in this study.

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.Application of 626-40-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of C6H12Br2In 2022 ,《Thermosensitive Microgels Containing AIEgens: Enhanced Luminescence and Distinctive Photochromism for Dynamic Anticounterfeiting》 was published in ACS Applied Materials & Interfaces. The article was written by Dong, Shunni; Zang, Qiguang; Ma, Zhao-Yu; Tang, Meiqi; Xu, Zhi-Kang; Nie, Jingjing; Du, Binyang; Sun, Jing Zhi; Tang, Ben Zhong. The article contains the following contents:

The proposal of the aggregation-induced emission (AIE) effect shines a light on the practical application of luminescent materials. The AIE-active luminescence microgels (TPEC MGs) with photo-induced color-changing behavior were developed by integrating pos. charged AIE luminogens (AIEgens) into the anionic network of microgels, where AIEgens of TPEC were obtained from the quaternization reaction between tetra-(4-pyridylphenyl)ethylene (TPE-4Py) and 7-(6-bromohexyloxy)-coumarin. The aqueous suspensions of TPEC MGs exhibit a significant AIE effect following the enhancement of quantum yield. In addition, further increase in fluorescence intensity and blueshift occur at elevated temperatures due to the collapse of microgels. The distinctive photochromic behavior of TPEC MGs was observed, which presents as the transition from orange-yellow to blue-green color under UV irradiation, which is different from TPEC in good organic solvents. The phenomenon of color changing can be ascribed to the competition between photodimerization of the coumarin part and photocyclization of TPE-4Py in TPEC. The photochromic TPEC MG aqueous suspensions can be conducted as aqueous microgel inks for information display, encryption, and dynamic anticounterfeiting. In the experimental materials used by the author, we found 1,6-Dibromohexane(cas: 629-03-8Synthetic Route of C6H12Br2)

1,6-Dibromohexane(cas: 629-03-8) is generally used to introduce C6 spacer in the molecular architecture. Some of the examples are: synthesis of solvent processable and conductive polyfluorene ionomers for alkaline fuel cell applications; synthesis of cross-linkable regioregular poly(3-(5-hexenyl)thiophene) (P3HNT) for stabilizing the film morphology in polymer photovoltaic cells.Synthetic Route of C6H12Br2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Application of 3395-91-3In 2018 ,《Metal-Free Thiolation of Imidazopyridines with Functionalized Haloalkanes Using Elemental Sulfur》 was published in Advanced Synthesis & Catalysis. The article was written by Zhang, Jun-Rong; Zhan, Ling-Zhi; Wei, Liang; Ning, Yun-Yun; Zhong, Xiao-Lin; Lai, Jing-Xiong; Xu, Li; Tang, Ri-Yuan. The article contains the following contents:

The assembly of two functional mols. via a sulfur linking atom allowed an access to a diverse array of thioether-containing compounds I [R = Et, CH2CN, n-Bu, etc., R1 = Ph, 4-MeC6H4, 4-FC6H4, etc., R2 = H, Me, F]. This method disclosed a metal-free thiolation of imidazopyridines with a variety of functionalized haloalkanes using elemental sulfur to gave thiolated imidazopyridines I. In addition to this study using Methyl 3-bromopropanoate, there are many other studies that have used Methyl 3-bromopropanoate(cas: 3395-91-3Application of 3395-91-3) was used in this study.

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Application of 3395-91-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Oxidation of Substituted Toluenes by Nitric Acid》 was written by Kazakov, P. V.; Gorelenko, S. V.; Derevyagina, I. D.; Lukashov, O. I.; Mirzabekova, N. S.. Electric Literature of C7H5BrO2This research focused ontoluene nitric acid oxidation; benzoic acid preparation. The article conveys some information:

Oxidation by HNO3 at atm. pressure of toluenes with electroneg. substituents on the benzene ring was studied. A method enabling the corresponding benzoic acids to be obtained in high yields with minimal wastes was developed. The method could be used in the laboratory and in production of medicines. The results came from multiple reactions, including the reaction of 4-Bromobenzoic acid(cas: 586-76-5Electric Literature of C7H5BrO2)

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography. It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.Electric Literature of C7H5BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary