Month: October 2022

《A green and highly effective protocol for the synthesis of N,N’-alkylidene bisamides using saccharin-N-sulfonic acid》 was published in Iranian Chemical Communication in 2020. These research results belong to Zare, Abdolkarim; Dianat, Manije; Pishahang, Nasrin; Khanivar, Roghayyeh; Kaman-Torki, Soheila; Fakhraei, Fatemeh; Kordrostami, Zahra; Sadeghi-Takallo, Masoud. COA of Formula: C7H5BrO The article mentions the following:

A green and highly effective solvent-free protocol has been reported for the synthesis of N,N’-alkylidene bisamides RC(O)NHCH(Ar)NHC(O)R (R = Me, Ph; Ar = Ph, 3-O2NC6H4, 4-BrC6H4, etc.) via the reaction of arylaldehydes (1 equivalent) with primary amides (2 equivalent) in the presence of saccharin-N-sulfonic acid (SaSA) as a solid-acid catalyst. The mentioned compounds have been obtained in high yields and short reaction times. In the part of experimental materials, we found many familiar compounds, such as o-Bromobenzaldehyde(cas: 6630-33-7COA of Formula: C7H5BrO)

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.COA of Formula: C7H5BrOIt is a key starting material in the total synthesis of an anticancer agent, (-)-taxol.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Off-on fluorogenic substrate harnessing ESIPT and AIE features for in situ and long-term tracking of β-glucuronidase in Escherichia coli》 was published in Sensors and Actuators, B: Chemical in 2020. These research results belong to Wei, Xianhu; Wu, Qingping; Feng, Ying; Chen, Minling; Zhang, Shuhong; Chen, Moutong; Zhang, Jumei; Yang, Guangzhu; Ding, Yu; Yang, Xiaojuan; Ye, Qinghua; Zhang, Youxiong; Gu, Qihui; Wang, Juan; Wu, Shi; Pang, Rui; Li, Ying. Quality Control of (2R,3R,4S,5S,6S)-2-Bromo-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate The article mentions the following:

Detection and isolation of both O157:H7 and non-O157:H7 Escherichia coli are essential for the evaluation and surveillance of the associated foodborne disease risk. However, the development of a chromogenic/fluorogenic culture medium for detection and isolation is challenging yet urgent. β-Glucuronidase (GUS) serves as an important biomarker in E. coli. A novel and simple off-on fluorogenic substrate (BTBP-Gluc) was developed, based on a solid-state fluorophore (BTBP) with excited-state intramol. proton transfer (ESIPT) and aggregation-induced emission (AIE) effects. BTBP-Gluc could be well-suited for visually detecting GUS activity under acidic conditions. It was successfully applied for detection of endogenous intracellular GUS activity in living E. coli and could produce the in situ and long-term localization of the target colonies and cell imaging of living E. coli. Addnl., it showed high selectivity, little toxicity, excellent cell permeability and sensitivity. BTBP-Gluc was combined with two tightly localizing chromogenic substrates, Magenta-Gal and X-Glu. These combinations were applied to the development of a new chromogenic-fluorogenic culture medium. On this new agar simultaneous visual detection and isolation of O157:H7 and non-O157:H7 E. coli with relatively high accuracy was achieved. C-F E. coli agar shows potential in serving as a simple sensitive tool for detecting and isolating O157:H7 and non-O157:H7 E. coli in food samples such as milk. In the experiment, the researchers used (2R,3R,4S,5S,6S)-2-Bromo-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate(cas: 21085-72-3Quality Control of (2R,3R,4S,5S,6S)-2-Bromo-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate)

(2R,3R,4S,5S,6S)-2-Bromo-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate(cas: 21085-72-3) may be used for the synthesis of HMR1098-S-Glucuronide Methyl Ester, a new K-ATP-blocking agent being developed as a drug for prevention of sudden cardiac death.Quality Control of (2R,3R,4S,5S,6S)-2-Bromo-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Efficient Oral Delivery of Poorly Water-Soluble Drugs Using Carnitine/Organic Cation Transporter 2-Mediated Polymeric Micelles》 was published in ACS Biomaterials Science & Engineering in 2020. These research results belong to He, Chuyu; Jin, Yao; Deng, Yunqiang; Zou, Yang; Han, Shidi; Zhou, Chuhang; Zhou, Yuanhang; Liu, Yan. HPLC of Formula: 539-74-2 The article mentions the following:

The intestine epithelium is considered to be the most critical obstacle for nanoparticles for oral delivery of water-insoluble and poorly absorbed drugs. Based on the specific transporters located on the apical membrane of the intestinal epithelium, the carnitine-conjugated polymeric micelles targeting to the carnitine/organic cation transporter 2 (OCTN2) were developed by combining carnitine-conjugated poly(2-ethyl-2-oxazoline)-poly(D,L-lactide) with monomethoxy poly(ethylene-glycol)-poly(D,L-lactide). The carnitine-conjugated micelles with favorable stability in gastrointestinal fluid were validated to remarkably increase the cellular internalization and transcellular transport, while these were not the cases in the presence of free carnitine. These were further confirmed by more distribution of the micelles within epithelial cells, on the apical and basolateral side of the epithelium in mice. Addnl., identification of the carnitine-conjugated micelles by OCTN2 was detected to facilitate cellular uptake of the micelles via fluorescence immunoassay. Both clathrin and caveolae/lipid rafts pathways mediated endocytosis and transcellular transport of the carnitine-conjugated micelles, implying the enrichment of endocytic and transcellular transport pathway compared with that of carnitine-unconjugated micelles. Further, the intracellular trafficking process of the carnitine-conjugated micelles was tracked under confocal laser scanning microscopy, which involved in intracellular compartments such as late endosomes, lysosomes, endoplasmic reticulum, and Golgi apparatus as well. In conclusion, the current study provided an efficient strategy to facilitate the oral absorption of water-insoluble and poorly absorbed agents using intestinal transporter-mediated polymeric micelles. After reading the article, we found that the author used Ethyl 3-bromopropanoate(cas: 539-74-2HPLC of Formula: 539-74-2)

Ethyl 3-bromopropanoate(cas: 539-74-2) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides. HPLC of Formula: 539-74-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Configurationally Random Polythiophene for Improved Polymer Ordering and Charge-Transporting Ability》 was published in ACS Applied Materials & Interfaces in 2020. These research results belong to Opoku, Henry; Lee, Ji Hyeon; Nketia-Yawson, Benjamin; Bae, Seunghwan; Lee, Jae-Joon; Ahn, Hyungju; Jo, Jea Woong. COA of Formula: C4H2Br2S The article mentions the following:

Random polythiophene polymers are characterized by the arbitrary sequence of monomeric units along polymer backbones. These untailored orientations generally results in the twisting of thiophene rings out of the conjugation planarity in addition to steric repulsions experienced among substituted alkyl chains. These tendencies have limited close polymer packing which has been detrimental to charge transport in these moieties. To ameliorate charge transport in these class of polymers, we make use of simple Stille coupling polymerization to synthesize highly random polythiophene polymers. We induced a pos. microstructural change between polymer chains by attuning the ratio between alkyl substituted and non-alkyl substituted monomer units along the backbones. The optimized random polythiophene was found to have enhanced intermol. interaction, increased size of crystallites, and stronger tendency to take edge-orientation compared to both regiorandom and regioregular poly(3-hexylthiophene) polymers. Incorporation of the optimized random polythiophene as an active material in a solid-state electrolyte gate insulator-gated organic field-effect transistors exhibited better performance than control device using regioregular poly(3-hexylthiophene), with a high hole mobility up to 4.52 cm2 V-1 s-1 in ambient condition. The results came from multiple reactions, including the reaction of 2,5-Dibromothiophene(cas: 3141-27-3COA of Formula: C4H2Br2S)

2,5-Dibromothiophene(cas: 3141-27-3) , is mainly used as pharmaceutical intermediate and synthesis intermediate. 2,5-Dibromothiophene may be used in the preparation of soluble α,ω-diformyl-a-oligothiophenes.COA of Formula: C4H2Br2S

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Ultra-Low Power Electrochromic Heat Shutters Through Tailoring Diffusion-Controlled Behaviors》 was written by In, Ye Ryeong; Kim, Yong Min; Lee, Yujeong; Choi, Won Young; Kim, Se Hyun; Lee, Seung Woo; Moon, Hong Chul. Category: bromides-buliding-blocks And the article was included in ACS Applied Materials & Interfaces in 2020. The article conveys some information:

In this study, we propose low power consumption, all-in-one type electrochromic devices (ECDs) for effective heat shutters. Considering diffusion-controlled device operation, polymeric viologens (poly-viologens) are synthesized to lower the diffusivity of EC chromophores and to minimize self-bleaching. In comparison with devices based on mono-viologens corresponding to the monomer of poly-viologens, poly-viologen-containing ECDs exhibit advantages of lower coloration voltage (ca, -0.55 V) and higher coloration/bleaching cyclic stability (>1500 cycles). In particular, poly-viologen ECDs show remarkably reduced self-bleaching as designed, resulting in extremely low power consumption (~8.3μW/cm2) to maintain the colored state. Moreover, we successfully demonstrate solar heat shutters that suppress the increment of indoor temperature by taking the advantage of low-power operation and near-IR absorption of the colored poly-viologen-based ECDs. Overall, these results imply that the control of the diffusivity of EC chromophores is an effective methodol. for achieving single-layered, low-power electrochem. heat shutters that can save indoor cooling energy when applied as smart windows for buildings or vehicles.1,4-Bis(bromomethyl)benzene(cas: 623-24-5Category: bromides-buliding-blocks) was used in this study.

1,4-Bis(bromomethyl)benzene(cas: 623-24-5) belongs to organobromine compounds.Organobromine chemicals are produced naturally by an array of biological and other chemical processes in our environment. Some of these compounds are identical to man-made organobromine compounds, such as methyl bromide, bromoform, and bromophenols, but many others are entirely new moleclar entities, often possessing extraordinary and important biological properties. Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Discovery of SHP2-D26 as a First, Potent, and Effective PROTAC Degrader of SHP2 Protein》 was written by Wang, Mingliang; Lu, Jianfeng; Wang, Mi; Yang, Chao-Yie; Wang, Shaomeng. Application of 14660-52-7 And the article was included in Journal of Medicinal Chemistry in 2020. The article conveys some information:

Src homol. 2 domain-containing phosphatase 2 (SHP2) is an attractive therapeutic target for human cancers and other human diseases. Herein, we report our discovery of potent small-mol. SHP2 degraders whose design is based upon the proteolysis-targeting chimera (PROTAC) concept. This work has led to the discovery of potent and effective SHP2 degraders, exemplified by SHP2-D26. SHP2-D26(I) achieves DC50 values of 6.0 and 2.6 nM in esophageal cancer KYSE520 and acute myeloid leukemia MV4;11 cells, resp., and is capable of reducing SHP2 protein levels by >95% in cancer cells. SHP2-D26 is >30-times more potent in inhibition of phosphorylation of extracellular signal-regulated kinase (ERK) and of cell growth than SHP099, a potent SHP2 inhibitor, in KYSE520 and MV4;11 cancer cell lines. This study demonstrates that induced SHP2 degradation is a very effective approach to inhibit the function of SHP2. Further optimization of these SHP2 degraders may lead to the development of a new class of therapies for cancers and other human diseases. The experimental process involved the reaction of Ethyl 5-bromovalerate(cas: 14660-52-7Application of 14660-52-7)

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Application of 14660-52-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Fusaric acid and derivatives as novel antimicrobial agents》 was written by Thanh, Tung Truong; Quoc, Thang Nguyen; Xuan, Huy Luong. Formula: C4H7Br And the article was included in Medicinal Chemistry Research in 2020. The article conveys some information:

Abstract: The synthesis and screening of several fusaric acid (FA) and analogs against five common clin. pathogens (gram-pos. and gram-neg.) and in vitro hemolytic activity assay in human red blood cells, for the first time, were reported. The biol. results reveal that FA and its analogs exhibited moderate antimicrobial activities. Compounds 2-5 and 7 showed growth inhibitory activity in gram-pos. bacteria. Compounds 6 and 9 showed growth inhibitory activity in both gram-pos. and gram-neg. bacteria. None of the compounds induce hemolysis, which is potent for future drug development on this template. In addition, the structure-activity relationship and docking studies are discussed. After reading the article, we found that the author used (Bromomethyl)cyclopropane(cas: 7051-34-5Formula: C4H7Br)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Formula: C4H7Br

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Supramolecular Energetic and Topological Study of Halogenated Aryl Carboxylic Acids》 was written by Teixeira Campos, Patrick; Cunha da Rosa, Bruno Felipe; Saija Hilsinger, Henrique; Auler Milani, Marceo; Uecker Kruger, Vanessa. HPLC of Formula: 586-76-5 And the article was included in Crystal Growth & Design in 2020. The article conveys some information:

A supramol. energetic and topol. study of 12 monohalogenated aryl carboxylic acids (F, Cl, Br, I) in the ortho, meta, and para positions was performed. The energy of intermol. interactions was determined from long-range corrected hybrid d. functional theor. computational calculations, using the ωB97X-D3 method. The surface of contact between the mols. and the mol. coordination numbers were determined From these data, all intermol. interactions were classified, and the robustness of the interactions was evaluated. Thus, the mol. (Mn) allocations around a central mol. (M1) are proposed. In addition, the energy from the intermol. interactions present in the first coordination sphere, which involves the central mol., the energy resulting from the interactions between the peripheral mols. and the total energy of the cluster provided by all interactions, was determined The role of hydrogen bonding (O-H···O, C-H···O, and C-H···X), π···π interactions, and halogen bonding (X···X) were evaluated, in the formation of the first coordination sphere and in the nucleation process. Information from the first coordination sphere helps one to understand the crystal. There is a proposal for nucleation initiation from hydrogen bonds forming dimers and subsequent π···π interactions forming a block. The approximation of these blocks results in the interactions C-H···O, C-H···Cl, and halogen bonds, which lead to three-dimensional supramol. growth until the formation of the crystal. After reading the article, we found that the author used 4-Bromobenzoic acid(cas: 586-76-5HPLC of Formula: 586-76-5)

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography.HPLC of Formula: 586-76-5 It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Synthesis of Ionic Ultramicroporous Polymers for Selective Separation of Acetylene from Ethylene》 was written by Suo, Xian; Cui, Xili; Yang, Lifeng; Xu, Nan; Huang, Yuqi; He, Yi; Dai, Sheng; Xing, Huabin. Quality Control of 1,4-Bis(bromomethyl)benzene And the article was included in Advanced Materials (Weinheim, Germany) in 2020. The article conveys some information:

The design of highly stable and efficient porous materials is essential for developing breakthrough hydrocarbon separation methods based on physisorption to replace currently used energy-intensive distillation/absorption technologies. Efforts to develop advanced porous materials such as zeolites, coordination frameworks, and organic polymers have met with limited success. Here, a new class of ionic ultramicroporous polymers (IUPs) with high-d. inorganic anions and narrowly distributed ultramicroporosity is reported, which are synthesized by a facile free-radical polymerization using branched and amphiphilic ionic compounds as reactive monomers. A covalent and ionic dual-crosslinking strategy is proposed to manipulate the pore structure of amorphous polymers at the ultramicroporous scale. The IUPs exhibit exceptional selectivity (286.1-474.4) for separating acetylene from ethylene along with high thermal and water stability, collaboratively demonstrated by gas adsorption isotherms and exptl. breakthrough curves. Modeling studies unveil the specific binding sites for acetylene capture as well as the interconnected ultramicroporosity for size sieving. The porosity-engineering protocol used in this work can also be extended to the design of other ultramicroporous materials for the challenging separation of other key gas constituents. The results came from multiple reactions, including the reaction of 1,4-Bis(bromomethyl)benzene(cas: 623-24-5Quality Control of 1,4-Bis(bromomethyl)benzene)

1,4-Bis(bromomethyl)benzene(cas: 623-24-5) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Alkyl bromides are mainly used as alkylating agents and also find application as a solvent to extract oil from seeds and wool. Quality Control of 1,4-Bis(bromomethyl)benzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Isomechanical Groups in Molecular Crystals and Role of Aromatic Interactions》 was written by Gabriele, Benjamin P. A.; Williams, Craig J.; Lauer, Matthias Eckhard; Derby, Brian; Cruz-Cabeza, Aurora J.. Application of 586-76-5 And the article was included in Crystal Growth & Design in 2020. The article conveys some information:

We have measured mech. properties in mol. crystals of a series of para-substituted benzoic acids using nanoindentation. Two linear correlations were found for these materials: first between the Young’s modulus and the m.p. per unit of volume, and second between the hardness and the crystal cohesive energy d. These correlations, however, were found to only hold within isomech. groups. These are groups of materials with similar interaction strengths and dimensionalities. A close anal. of the intermol. interactions present in these crystals revealed that structures with aromatic rings interacting through t-type interactions may achieve higher interaction dimensionalities and thus result in harder crystals than those with rings interacting through aromatic stacking. In these systems, thus, the dimensionality of the aromatic interactions in the crystals appears to play the major role in their mech. behavior. We correlate mech. properties measured in mol. crystals of a series of para-substituted benzoic acids, first with their m.p. per unit of volume and second with the crystals’ cohesive energy d. Structures with aromatic rings interacting through t-type interactions may achieve higher interaction dimensionalities and thus result in harder crystals than those with rings interacting through aromatic stacking. The experimental process involved the reaction of 4-Bromobenzoic acid(cas: 586-76-5Application of 586-76-5)

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography. It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.Application of 586-76-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary