Month: October 2022

In 2022,Li, Yue; Ouyang, Yifan; Wu, Han; Wang, Peng; Huang, Yu; Li, Xue; Chen, Hongtong; Sun, Yu; Hu, Xinxin; Wang, Xiukun; Li, Guoqing; Lu, Yun; Li, Congran; Lu, Xi; Pang, Jing; Nie, Tongying; Sang, Xiaohong; Dong, Luyao; Dong, Wenting; Jiang, Jiandong; Paterson, Ian C.; Yang, Xinyi; Hong, Wei; Wang, Hao; You, Xuefu published an article in European Journal of Medicinal Chemistry. The title of the article was 《The discovery of 1, 3-diamino-7H-pyrrol[3, 2-f]quinazoline compounds as potent antimicrobial antifolates》.Application of 1129-28-8 The author mentioned the following in the article:

The shortage of new antibiotics makes infections caused by gram-neg. (G-) bacteria a significant clin. problem. The key enzymes involved in folate biosynthesis represent important targets for drug discovery, and new antifolates with novel mechanisms are urgently needed. By targeting to dihydrofolate reductase (DHFR), a series of 1,3-diamino-7H-pyrrol[3,2-f]quinazoline (PQZ) compounds were designed, and exhibited potent antibacterial activities in vitro, especially against multi-drug resistant G- strains. Multiple experiments indicated that PQZ compounds contain a different mol. mechanism against the typical DHFR inhibitor, trimethoprim (TMP), and the thymidylate synthase (TS) was identified as another potential but a relatively weak target. A significant synergism between the representative compound, OYYF-175, and sulfamethoxazole (SMZ) was observed with a strong cumulative and significantly bactericidal effect at extremely low concentrations (2 μg/mL for SMZ and 0.03 pg/mL for OYYF-175), which could be resulted from the simultaneous inhibition of dihydropteroate synthase (DHPS), DHFR and TS. PQZ compounds exhibited therapeutic effects in a mouse model of i.p. infections caused by Escherichia coli (E. coli). The co-crystal structure of OYYF-175-DHFR was solved and the detailed interactions were provided. The inhibitors reported represent innovative chem. structures with novel mol. mechanism of action, which will benefit the generation of new, efficacious bactericidal compounds In addition to this study using Methyl 3-(bromomethyl)benzoate, there are many other studies that have used Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Application of 1129-28-8) was used in this study.

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Moreover, several studies demonstrate that the average proportion of bromine in drugs is significantly higher than that in natural products. Application of 1129-28-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Tajammal, Affifa; Siddiqa, Aysha; Irfan, Ahmad; Azam, Muhammad; Hafeez, Huma; Munawar, Munawar Ali; Basra, Muhammad Asim Raza published an article in Journal of Molecular Structure. The title of the article was 《Antioxidant, molecular docking and computational investigation of new flavonoids》.Application of 6630-33-7 The author mentioned the following in the article:

Flavonoids are a group of polyphenolic compounds diverse in structure, biol. and pharmacol. functions possessing antioxidant potential. New flavonoids I (R = 2-Br, 4-Br), II (R = 3-Br, 4-Br), 2,5-(OH)2C6H3C(O)CH=CHC6H4R (III) (R = 2-Br, 3-Br), were synthesized by acid catalyzed condensation of bromo-benzaldehydes RC6H4CHO and 2,5-dihydroxyacetophenone. In vitro antioxidant potential of synthesized compounds was evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging, 2,2′-azinobis-(3-ethylbenzthiazoline-6-sulfonate) cation (ABTS+) radical scavenging, iron chelating, iron reducing and phosphomolybdenum activity. The results revealed that DPPH radical scavenging and ABTS+scavenging activity of compounds III were better than reference compounds i.e., trolox and ascorbic acid. Furthermore, mol. docking was performed to check the affinity of flavonoids with Keap1 for the activation of antioxidant defense system of body and computational study was carried out by DFT approach using B3LYP functional and 6-31G** basis set. All the compounds showed better results compared to the reference compounds and mol. docking studies supported the computational results. In the experimental materials used by the author, we found o-Bromobenzaldehyde(cas: 6630-33-7Application of 6630-33-7)

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Application of 6630-33-7Synthetic applications of o-Bromobenzaldehyde include: synthesis of aza-fused polycyclic quinolines through copper-catalyzed cascade reaction, preparation of 1-substituted indazoles by CuI-catalyzed coupling with N-aryl hydrazides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Recommanded Product: Methyltriphenylphosphonium bromideIn 2022 ,《A Simple and Feasible Synthetic Strategy towards Poly(4-thiostyrene)》 appeared in Macromolecular Chemistry and Physics. The author of the article were Li, Jincai; Richardson, Joseph J.; Ejima, Hirotaka. The article conveys some information:

Poly(4-thiostyrene), a historically challenging to synthesize polymer, is synthesized herein via a feasible three-step protocol. Based on the newly developed protection-deprotection strategy, the precursor polymer containing thiomethyl groups is deprotected using Li/naphthalene to yield poly(4-thiostyrene) after acidification. This newly developed procedure is crucial for preventing crosslinking of the thiol groups and therefore the resulting polymer is soluble in common organic solvents (e.g., chloroform, tetrahydrofuran) and can be stored long-term, which has been challenging to accomplish over the past 60 years. The successful synthesis is confirmed by various characterization techniques including NMR, Fourier-transform IR spectroscopy, and Raman anal., which collectively are new and useful data that have generally been unavailable in previous reports. This work provides a robust approach for synthesizing this promising polymer and offers a new route to investigate thiol-containing polymers. In the experiment, the researchers used many compounds, for example, Methyltriphenylphosphonium bromide(cas: 1779-49-3Recommanded Product: Methyltriphenylphosphonium bromide)

Methyltriphenylphosphonium bromide(cas: 1779-49-3) is a lipophilic molecule with a cation allowing for it to be used to deliver molecules to specific cell components. Also considered an antineoplastic agent.Recommanded Product: Methyltriphenylphosphonium bromide

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of C9H9BrO2In 2016 ,《Synthesis and SAR assessment of novel Tubathian analogs in the pursuit of potent and selective HDAC6 inhibitors》 appeared in Organic & Biomolecular Chemistry. The author of the article were De Vreese, Rob; Depetter, Yves; Verhaeghe, Tom; Desmet, Tom; Benoy, Veronick; Haeck, Wanda; Van Den Bosch, Ludo; D’hooghe, Matthias. The article conveys some information:

The synthesis of novel isoform-selective HDAC inhibitors is considered to be an important, emerging field in medicinal chem. In this paper, the preparation and assessment of thirteen selective HDAC6 inhibitors is disclosed, elaborating on a previously developed thiaheterocyclic Tubathian series. All compounds were evaluated in vitro for their ability to inhibit HDAC6, and a selection of five potent compounds was further screened toward all HDAC isoforms (HDAC1-11). The capability of these Tubathian analogs to inhibit α-tubulin deacetylation was assessed as well, and ADME/Tox data were collected. This thorough SAR evaluation revealed that the oxidized, para-substituted hydroxamic acids can be recognized as valuable lead structures in the pursuit of novel potent and selective HDAC6 inhibitors. The results came from multiple reactions, including the reaction of Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Electric Literature of C9H9BrO2)

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.Organobromine chemicals are produced naturally by an array of biological and other chemical processes in our environment. Electric Literature of C9H9BrO2Some of these compounds are identical to man-made organobromine compounds, such as methyl bromide, bromoform, and bromophenols, but many others are entirely new moleclar entities, often possessing extraordinary and important biological properties.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

HPLC of Formula: 4316-58-9In 2020 ,《High-Yield Synthesis of Pyridyl Conjugated Microporous Polymer Networks with Large Surface Areas: From Molecular Iodine Capture to Metal-Free Heterogeneous Catalysis》 appeared in Macromolecular Rapid Communications. The author of the article were Zuo, Hongyu; Wei, Lyu; Zhang, Weiyi; Li, Ying; Liao, Yaozu. The article conveys some information:

Capturing volatile radioactive nuclides including iodine (I129 or I131) is one of the major problems to be solved for environmental sustainability. Multiple types of functional microporous materials such as metal organic frameworks and covalent organic frameworks have been constructed for iodine emission control. However, most of the microporous materials are limited by their weak binding force with iodine and low stability, leading to low capture efficiencies. Herein, the synthesis of pyridyl conjugated microporous polymer networks with large surface areas (PCMP-Y) up to 1304 m2 g-1 and high yields up to 95% via a simple Yamamoto cross-coupling reaction, is reported. The PCMP-Y carries amine and pyridine N groups which have stronger interactions with iodine mols. The high sp. surface areas and porosities of PCMP-Y facilitate iodine capture, delivering a maximum adsorption capacity of 4.75 g g-1 in a short time (3 h), which is superior to a majority of porous materials reported. Moreover, the reversible desorption nature of PCMP-Y capturing iodine imparts a platform for metal-free heterogeneous catalyst, which can be applied to synthesize aminobenzothiazole medicines via O2-promoted cascade reactions. The experimental part of the paper was very detailed, including the reaction process of Tris(4-bromophenyl)amine(cas: 4316-58-9HPLC of Formula: 4316-58-9)

In general, Tris(4-bromophenyl)amine(cas: 4316-58-9) is often used in the synthesis of porous luminescent covalent–organic polymers (COPs)HPLC of Formula: 4316-58-9

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

SDS of cas: 3141-27-3In 2022 ,《Silver salt enabled H/D exchange at the β-position of thiophene rings: synthesis of fully deuterated thiophene derivatives》 was published in Organic & Biomolecular Chemistry. The article was written by Sheng, Fei-Fei; Li, En-Ci; Bai, Jing-Wen; Wang, Cai-Xia; Hu, Guang-Qi; Liu, Kai-Hui; Sun, Zheng-Yi; Shen, Kang; Zhang, Hong-Hai. The article contains the following contents:

We disclose a silver catalyzed H/D exchange reaction, which can introduce the deuterium atom at the β position of thiophene rings without the assistance of any coordinating groups. The advantages of this reaction include operation in open air, usage of D2O as the deuterium source, good tolerance to a range of functional groups and obtaining high atom% deuterium incorporation. In addition, this H/D exchange reaction is employed for direct deuteration of a thiophene based monomer, which is usually prepared by multistep synthesis from expensive deuterated starting materials. In addition to this study using 2,5-Dibromothiophene, there are many other studies that have used 2,5-Dibromothiophene(cas: 3141-27-3SDS of cas: 3141-27-3) was used in this study.

2,5-Dibromothiophene(cas: 3141-27-3) , is mainly used as pharmaceutical intermediate and synthesis intermediate. 2,5-Dibromothiophene polymerizes by debromination with magnesium catalyzed by nickel compounds to form poly(2,5- thienylene) .SDS of cas: 3141-27-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Quality Control of Methyl 3-(bromomethyl)benzoateIn 2017 ,《Stilbene Boronic Acids Form a Covalent Bond with Human Transthyretin and Inhibit Its Aggregation》 was published in Journal of Medicinal Chemistry. The article was written by Smith, Thomas P.; Windsor, Ian W.; Forest, Katrina T.; Raines, Ronald T.. The article contains the following contents:

Transthyretin (TTR) is a homotetrameric protein. Its dissociation into monomers leads to the formation of fibrils that underlie human amyloidogenic diseases. The binding of small mols. to the thyroxin-binding sites in TTR stabilizes the homotetramer and attenuates TTR amyloidosis. Herein, we report on boronic acid-substituted stilbenes that limit TTR amyloidosis in vitro. Assays of affinity for TTR and inhibition of its tendency to form fibrils were coupled with X-ray crystallog. anal. of nine TTR·ligand complexes. The ensuing structure-function data led to a sym. diboronic acid that forms a boronic ester reversibly with serine 117. This diboronic acid inhibits fibril formation by both wild-type TTR and a common disease-related variant, V30M TTR, as effectively as does tafamidis, a small-mol. drug used to treat TTR-related amyloidosis in the clinic. These findings establish a new modality for covalent inhibition of fibril formation and illuminate a path for future optimization. In the part of experimental materials, we found many familiar compounds, such as Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Quality Control of Methyl 3-(bromomethyl)benzoate)

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Quality Control of Methyl 3-(bromomethyl)benzoate Due to the reactivity of bromide, they are used as potential precursors or important intermediates in organic synthesis.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of C14H8Br2In 2020 ,《Switchable Conformational Isomerization of an Overcrowded Tristricyclic Aromatic Ene》 was published in Journal of Organic Chemistry. The article was written by Nishiuchi, Tomohiko; Ito, Ryuoh; Stratmann, Erik; Kubo, Takashi. The article contains the following contents:

We have prepared a new overcrowded tristricyclic aromatic ene (TAE) and investigated its external stimuli-responsive behavior for the interconversion between a closed-shell folded form and an open-shell twisted form. Upon photoirradiation, the folded form transforms into the biradical twisted form, whereas by keeping the twisted form in the dark, the reverse reaction gradually occurs at room temperature This switchable conformational change is analyzed by means of UV-Vis and ESR spectroscopies, cyclic voltammetry, d. functional theory (DFT) calculations, and kinetic studies. In the experimental materials used by the author, we found 9,10-Dibromoanthracene(cas: 523-27-3Synthetic Route of C14H8Br2)

9,10-Dibromoanthracene(cas: 523-27-3) is a dibrominated polycyclic aromatic hydrocarbon (PAH). 9,10-Dibromoanthracene is often used as an energy acceptor and activator in reactions that produce chemiluminescence.Synthetic Route of C14H8Br2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Recommanded Product: 586-76-5In 2021 ,《Synthesis and Acidity of 5-(m-Terphenyl-2′-yl)-1H-tetrazoles: Evidence for an Enhanced Polar-π Effect Compared to Carboxylic Acids》 was published in Journal of Medicinal Chemistry. The article was written by Bookser, Brett C.; Do, Quyen-Quyen; Sritana-Anant, Yongsak; Baldridge, Kim K.; Siegel, Jay S.. The article contains the following contents:

The polar-π effect on tetrazoles, medicinal chem. isosteres of carboxylate, is tested by a Hammett pKa (microtitration) anal. over a series of 5-(m-terphenyl-2′-yl)-1H-tetrazoles. A comparison with m-terphenyl-2′-yl-carboxylic acids supports the isostere analogy also in response to environmental changes. Computational (B97D/def2TZVPPD) extension of the series plus a scan of solvents (vacuum to water) demonstrates the trend with the dielec. constant The effect is energetically small but may make statistically significant contributions to the tetrazole pharmacol. profile. The experimental part of the paper was very detailed, including the reaction process of 4-Bromobenzoic acid(cas: 586-76-5Recommanded Product: 586-76-5)

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography. It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.Recommanded Product: 586-76-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Discovery and structure activity relationships of 7-benzyl triazolopyridines as stable, selective, and reversible inhibitors of myeloperoxidase》 was written by Shaw, Scott A.; Vokits, Benjamin P.; Dilger, Andrew K.; Viet, Andrew; Clark, Charles G.; Abell, Lynn M.; Locke, Gregory A.; Duke, Gerald; Kopcho, Lisa M.; Dongre, Ashok; Gao, Ji; Krishnakumar, Arathi; Jusuf, Sutjano; Khan, Javed; Spronk, Steven A.; Basso, Michael D.; Zhao, Lei; Cantor, Glenn H.; Onorato, Joelle M.; Wexler, Ruth R.; Duclos, Franck; Kick, Ellen K.. Synthetic Route of C9H9BrO2This research focused ontriazolopyridine preparation myeloperoxidase inhibitor; structure arylmethyl aminophenylpropyl triazolopyridine inhibition myeloperoxidase selectivity; Atherosclerosis; Myeloperoxidase; Triazolopyridine. The article conveys some information:

Myeloperoxidase (MPO) is a heme peroxidase found in neutrophils, monocytes and macrophages that efficiently catalyzes the oxidation of endogenous chloride into hypochlorous acid for antimicrobial activity. Chronic MPO activation can lead to indiscriminate protein modification causing tissue damage, and has been associated with chronic inflammatory diseases, atherosclerosis, and acute cardiovascular events. A previously-known benzyloxy triazolopyrimidine was a reversible MPO inhibitor; however it suffered from poor stability in acid, and is an irreversible inhibitor of the DNA repair protein Me guanine Me transferase (MGMT). Structure-based drug design was employed to discover benzyl triazolopyridines such as I with improved MPO potency, as well as acid stability, no reactivity with MGMT, and selectivity against thyroid peroxidase (TPO). Structure-activity relationships, a crystal structure of the MPO-inhibitor complex, and acute in vivo pharmacodynamic data are described herein. In addition to this study using Methyl 3-(bromomethyl)benzoate, there are many other studies that have used Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Synthetic Route of C9H9BrO2) was used in this study.

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Synthetic Route of C9H9BrO2 Moreover, several studies demonstrate that the average proportion of bromine in drugs is significantly higher than that in natural products.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary