Month: October 2022

Anselmi, Michele; Borbely, Adina; Figueras, Eduard; Michalek, Carmela; Kemker, Isabell; Gentilucci, Luca; Sewald, Norbert published an article in 2021. The article was titled 《Linker hydrophilicity modulates the anticancer activity of RGD-cryptophycin conjugates》, and you may find the article in Chemistry – A European Journal.SDS of cas: 21085-72-3 The information in the text is summarized as follows:

Most anticancer agents are hydrophobic and can easily penetrate the tumor cell membrane by passive diffusion. This may impede the development of highly effective and tumor-selective treatment options. A hydrophilic β-glucuronidase-cleavable linker was used to connect the highly potent antimitotic agent cryptophycin-55 glycinate with the αvβ3 integrin ligand c(RGDfK). Incorporation of the self-immolative linker containing glucuronic acid results in lower cytotoxicity than that of the free payload, suggesting that hydrophilic sugar linkers can preclude passive cellular uptake. In vitro drug-release studies and cytotoxicity assays demonstrated the potential of this small mol.-drug conjugate, providing guidance for the development of therapeutics containing hydrophobic anticancer drugs. The experimental part of the paper was very detailed, including the reaction process of (2R,3R,4S,5S,6S)-2-Bromo-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate(cas: 21085-72-3SDS of cas: 21085-72-3)

(2R,3R,4S,5S,6S)-2-Bromo-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate(cas: 21085-72-3) may be used for the synthesis of HMR1098-S-Glucuronide Methyl Ester, a new K-ATP-blocking agent being developed as a drug for prevention of sudden cardiac death.SDS of cas: 21085-72-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Li, Yan; Liu, Deguang; Wan, Lei; Zhang, Jun-Yang; Lu, Xi; Fu, Yao published an article in 2022. The article was titled 《Ligand-Controlled Cobalt-Catalyzed Regiodivergent Alkyne Hydroalkylation》, and you may find the article in Journal of the American Chemical Society.Electric Literature of C4H7Br The information in the text is summarized as follows:

Herein, a ligand-controlled cobalt-catalyzed regiodivergent alkyne hydroalkylation was reported. The sensible selection of bisoxazoline and pyridine-oxazoline ligands led to reliable and predictable protocols that provided (E)-1,2-disubstituted and 1,1-disubstituted alkenes with high E/Z stereoselectivity and regioisomeric ratio starting from identical terminal alkyne and alkyl halide substrates and produced trisubstituted alkenes in the case of internal alkynes. This method exhibited a broad scope for terminal and internal alkynes with a wide range of activated and unactivated alkyl halides and shows excellent functional group compatibility. In the experiment, the researchers used many compounds, for example, (Bromomethyl)cyclopropane(cas: 7051-34-5Electric Literature of C4H7Br)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Electric Literature of C4H7Br

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Hu, Rong; Wang, Wan-Li; Yang, Ying-Yue; Hu, Xia-Tong; Wang, Qi-Wei; Zuo, Wei-Qiong; Xu, Ying; Feng, Qiang; Wang, Ning-Yu published an article in 2022. The article was titled 《Identification of a selective BRD4 PROTAC with potent antiproliferative effects in AR-positive prostate cancer based on a dual BET/PLK1 inhibitor》, and you may find the article in European Journal of Medicinal Chemistry.Electric Literature of C4H7BrO2 The information in the text is summarized as follows:

BRD4-targeted proteolysis targeting chimera (PROTAC) have exhibited promising in vitro and in vivo anticancer activity in a number of cancer models. However, the clin. development of current reported BRD4-PROTACs have stagnated, largely due to the safety risks caused by their poor degradation selectivity. In this study, we designed and synthesized a series of PROTACs based on our recently reported dual BET/PLK1 inhibitor WNY0824, which led to the discovery of an isoform-selective and potent BRD4-PROTAC 12a (WWL0245). WWL0245 exhibited excellent selective cytotoxicity in the BETi sensitive cancer cell lines, including AR-pos. prostate cancer cell lines. It could also efficiently induce ubiquitin-proteasomal degradation of BRD4 in AR-pos. prostate cancer cell lines, with sub-nanomolar half-maximal degrading concentration (DC50) and maximum degradation (Dmax) > 99%. Moreover, WWL0245 induced cell cycle arrest at the G0/G1 phase and apoptosis in AR-pos. prostate cancer by downregulation of the protein levels of AR, PSA and c-Myc as well as transcriptionally suppressed AR-regulated genes. WWL0245 was thus expected to be developed as a promising drug candidate for AR-pos. prostate cancer and a valuable tool compound to study the biol. function of BRD4. In addition to this study using 4-Bromobutanoic acid, there are many other studies that have used 4-Bromobutanoic acid(cas: 2623-87-2Electric Literature of C4H7BrO2) was used in this study.

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Electric Literature of C4H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Liu, Yuxiang; Wu, Jun; Wang, Feng published an article in Applied Catalysis, B: Environmental. The title of the article was 《Dibenzothiophene-S,S-dioxide-containing conjugated polymer with hydrogen evolution rate up to 147 mmol g-1 h-1》.HPLC of Formula: 3141-27-3 The author mentioned the following in the article:

Mol. engineering in donor-acceptor conjugated polymers is currently one of the most successful and popular strategy to prepare high performance photocatalysts for hydrogen evolution. In this contribution, we have designed and synthesized two novel conjugated polymers with tailored donor-acceptor structures based on dibenzothiophene-S,S-dioxide and thiophene derivatives, which exhibited tunable band gaps and adjustable charge separation efficiencies. As a result, PDBTSO-T showed an outstanding hydrogen evolution rate (HER) of 1.47 mmol h-1 by DMF exfoliation under UV-vis region with Pt cocatalyst in ascorbic acid aqueous solution at 10 mg level, which is among the top performance for photocatalysis conversion reported so far. Very excitingly, when the photocatalysis tests were subjected to natural sunlight irradiation, an impressive HER of ∼27 mL (107 mmol g-1 h-1) was achieved after 0.5 h of illumination (12:30 pm – 13:00 pm) on a consistently sunny day under identical reaction conditions. The experimental process involved the reaction of 2,5-Dibromothiophene(cas: 3141-27-3HPLC of Formula: 3141-27-3)

2,5-Dibromothiophene(cas: 3141-27-3) , is mainly used as pharmaceutical intermediate and synthesis intermediate. 2,5-Dibromothiophene may be used in the preparation of soluble α,ω-diformyl-a-oligothiophenes.HPLC of Formula: 3141-27-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Hayyan, Adeeb; Hizaddin, Hanee F.; Abed, Khalid M.; Mjalli, Farouq S.; Hashim, Mohd Ali; Abo-Hamad, Ali; Saleh, Jehad; Aljohani, Abdullah S. M.; Alharbi, Yousef M.; Alhumaydhi, Fahad A.; Ahmad, Abdul Aziz; Yeow, Andrew T. H.; Aldeehani, Ahmaad Kadmouse; Alajmi, Falah D. H.; Al Nashef, Inas published an article in Biomass Conversion and Biorefinery. The title of the article was 《Encapsulated deep eutectic solvent for esterification of free fatty acid》.Recommanded Product: 1779-49-3 The author mentioned the following in the article:

Abstract: A novel encapsulated deep eutectic solvent (DES) was introduced for biodiesel production via a two-step process. The DES was encapsulated in medical capsules and were used to reduce the free fatty acid (FFA) content of acidic crude palm oil (ACPO) to the min. acceptable level (< 1). The DES was synthesized from methyltriphenylphosphonium bromide (MTPB) and p-toluenesulfonic acid (PTSA). The effects pertaining to different operating conditions such as capsule dosage, reaction time, molar ratio, and reaction temperature were optimized. The FFA content of ACPO was reduced from existing 9.61to less than 1under optimum operating conditions. This indicated that encapsulated MTPB-DES performed high catalytic activity in FFA esterification reaction and showed considerable activity even after four consecutive recycling runs. The produced biodiesel after acid esterification and alk. transesterification met the EN14214 international biodiesel standard specifications. To our best knowledge, this is the first study to introduce an acidic catalyst in capsule form. This method presents a new route for the safe storage of new materials to be used for biofuel production Conductor-like screening model for real solvents (COSMO-RS) representation of the DES using σ-profile and σ-potential graphs indicated that MTPB and PTSA is a compatible combination due to the balanced presence and affinity towards hydrogen bond donor and hydrogen bond acceptor in each constituent.Methyltriphenylphosphonium bromide(cas: 1779-49-3Recommanded Product: 1779-49-3) was used in this study.

Methyltriphenylphosphonium bromide(cas: 1779-49-3) is an organophosphorus compound, with potential use as a precursor and a solvent in organic synthesis. And it is used widely for methylenation via the Wittig reaction.Recommanded Product: 1779-49-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Sun, Bin; Najarian, Amin Morteza; Sagar, Laxmi Kishore; Biondi, Margherita; Choi, Min-Jae; Li, Xiyan; Levina, Larissa; Baek, Se-Woong; Zheng, Chao; Lee, Seungjin; Kirmani, Ahmad R.; Sabatini, Randy; Abed, Jehad; Liu, Mengxia; Vafaie, Maral; Li, Peicheng; Richter, Lee J.; Voznyy, Oleksandr; Chekini, Mahshid; Lu, Zheng-Hong; Garcia de Arquer, F. Pelayo; Sargent, Edward H. published an article in Advanced Materials (Weinheim, Germany). The title of the article was 《Fast Near-Infrared Photodetection Using III-V Colloidal Quantum Dots》.Name: Indium(III) bromide The author mentioned the following in the article:

Colloidal quantum dots (CQDs) are promising materials for IR (IR) light detection due to their tunable bandgap and their solution processing; however, to date, the time response of CQD IR photodiodes is inferior to that provided by Si and InGaAs. It is reasoned that the high permittivity of II-VI CQDs leads to slow charge extraction due to screening and capacitance, whereas III-Vs-if their surface chem. can be mastered-offer a low permittivity and thus increase potential for high-speed operation. In initial studies, it is found that the covalent character in indium arsenide (InAs) leads to imbalanced charge transport, the result of unpassivated surfaces, and uncontrolled heavy doping. Surface management using amphoteric ligand coordination is reported, and it is found that the approach addresses simultaneously the In and As surface dangling bonds. The new InAs CQD solids combine high mobility (0.04 cm2 V-1 s-1) with a 4x reduction in permittivity compared to PbS CQDs. The resulting photodiodes achieve a response time faster than 2 ns-the fastest photodiode among previously reported CQD photodiodes-combined with an external quantum efficiency (EQE) of 30% at 940 nm. In the experiment, the researchers used Indium(III) bromide(cas: 13465-09-3Name: Indium(III) bromide)

Indium(III) bromide(cas: 13465-09-3) is used as a catalyst to produce dithioacetals when unactivated alkynes react with thiols and fields such as optics and microelectronics that utilize semiconductor technology have wide uses for indium in high-performing solar cells.Name: Indium(III) bromide

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Chen, Xiaodong; Chen, Qian; He, Dan; Yang, Sanxiu; Yang, Yunfei; Qian, Jing; Long, Lingliang; Wang, Kun published an article in Sensors and Actuators, B: Chemical. The title of the article was 《Mitochondria targeted and immobilized ratiometric NIR fluorescent probe for investigating SO2 phytotoxicity in plant mitochondria》.Application In Synthesis of 1,4-Bis(bromomethyl)benzene The author mentioned the following in the article:

Exposure to excessive SO2 will induce severe phytotoxicity to plants. Dissecting mechanisms of SO2 phytotoxicity is vital for preventing adverse effect of SO2. But unfortunately, the mechanisms of SO2 phytotoxicity remain elusive. We speculated that interaction of SO2 derivatives with mitochondria might be an important mechanism for SO2 phytotoxicity. To authenticate this speculation, it is urgently need to detect SO2 derivatives in plant mitochondria when it is suffering from SO2 phytotoxicity. Herein, we presented a novel ratiometric NIR fluorescent probe for highly sensitive and selective detection of SO2 derivatives in plant mitochondria. Notably, the probe not only could target into the mitochondria, but also can immobilize in the mitochondria to continue detecting SO2 derivatives even when the mitochondrial membrane potential was collapsed by high concentration of SO2 derivatives Importantly, the probe has been successfully employed for monitoring high concentration of SO2 derivatives in the plant mitochondria when the plant is suffering from SO2 phytotoxicity. The results demonstrated that the SO2 derivatives level in plant mitochondria is strictly associated with SO2 phytotoxicity. Thus, the interaction of SO2 derivatives with plant mitochondria could be considered as an important mechanism for SO2 phytotoxicity. In the experimental materials used by the author, we found 1,4-Bis(bromomethyl)benzene(cas: 623-24-5Application In Synthesis of 1,4-Bis(bromomethyl)benzene)

1,4-Bis(bromomethyl)benzene(cas: 623-24-5) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals.Application In Synthesis of 1,4-Bis(bromomethyl)benzene The most pervasive is the naturally produced bromomethane.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Staerz, Sophia D.; Jones, Corey L.; Tepe, Jetze J. published an article in Journal of Medicinal Chemistry. The title of the article was 《Design, Synthesis, and Biological Evaluation of Potent 20S Proteasome Activators for the Potential Treatment of α-Synucleinopathies》.Quality Control of Methyl 3-(bromomethyl)benzoate The author mentioned the following in the article:

While neurodegenerative diseases affect millions of patients worldwide, there are insufficient available therapeutics to halt or slow down the progression of these diseases. A key pathol. feature of several neurodegenerative diseases is the oligomerization and aggregation of specific intrinsically disordered proteins (IDPs) creating neuronal deposits, such as Lewy bodies in Parkinson’s disease. Clearance of these pathogenic, aggregation-prone IDPs is mediated by the 20S isoform of the human proteasome. Thus, enhancing the 20S proteasome-mediated proteolysis could be a very useful therapeutic pathway to prevent neurotoxicity. Here, authors report the successful development of sub-microM 20S proteasome activators based on a phenothiazine scaffold. This class of compounds prevented the accumulation of pathol. relevant IDPs, such as the pathogenic A53T mutated α-synuclein, in vitro and in mammalian cell lines. After reading the article, we found that the author used Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Quality Control of Methyl 3-(bromomethyl)benzoate)

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Quality Control of Methyl 3-(bromomethyl)benzoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 1779-49-3In 2019 ,《A quantitative prediction of the viscosity of amine based DESs using Sσ-profile molecular descriptors》 appeared in Journal of Molecular Structure. The author of the article were Benguerba, Yacine; Alnashef, Inas M.; Erto, Alessandro; Balsamo, Marco; Ernst, Barbara. The article conveys some information:

In recent years, the preparation of deep eutectic solvents (DESs) using amines as H bond donors (HBD) was reported by several research groups. One of the potential use of this type of DESs is in the field of CO2 capture, where the viscosity of the solvent before and after the absorption is of paramount importance. Since the number of possible combinations of DESs is huge, a math. model for the predicting of the viscosity of DESs at different temperatures is very important. A new math. model for the prediction of amine-based DESs viscosities using the quant. structure property relations (QSPR) approach is presented. A combination of multilinear regression (MLR) and artificial neural networks (ANN) methods is used for the development of the model. A data set of 108 exptl. measurements of viscosity of 5 amines-based DESs, taken from the literature, is used for the development and subsequent verification of the model. The more appropriate model is determined by a dedicated statistical anal., in which the most significant descriptors are preliminary determined The proposed models are able to predict the DESs viscosities with very high accuracy, i.e. with a R2 value of 0.9975 in training and 0.9863 for validation using the ANN model and R2 value of 0.9305 for the MLR model. The retrieved model can be considered as a very reliable tool for the prediction of DESs viscosity when exptl. data are absent. In turn, this can provide useful guidelines for the synthesis of low-viscosity DESs able to minimize energy requirements associated to their processing (e.g. power required for pumps), thus fostering their industrial-scale implementation. In the experiment, the researchers used many compounds, for example, Methyltriphenylphosphonium bromide(cas: 1779-49-3Related Products of 1779-49-3)

Methyltriphenylphosphonium bromide(cas: 1779-49-3) is a lipophilic molecule with a cation allowing for it to be used to deliver molecules to specific cell components. Also considered an antineoplastic agent.Related Products of 1779-49-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Product Details of 21085-72-3In 2019 ,《Extended scaffold glucuronides: en route to the universal synthesis of O-aryl glucuronide prodrugs》 appeared in Organic & Biomolecular Chemistry. The author of the article were Walther, Raoul; Jarlstad Olesen, Morten T.; Zelikin, Alexander N.. The article conveys some information:

We demonstrate that an extended scaffold based on a self-immolative linker (SIL) enables the universal production of O-aryl glucuronide prodrugs: high yield glucuronidation is performed on a precursor substrate (SIL) and the subsequent drug conjugation proceeds via less challenging chem. reactions. The results came from multiple reactions, including the reaction of (2R,3R,4S,5S,6S)-2-Bromo-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate(cas: 21085-72-3Product Details of 21085-72-3)

(2R,3R,4S,5S,6S)-2-Bromo-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate(cas: 21085-72-3) may be used for the synthesis of HMR1098-S-Glucuronide Methyl Ester, a new K-ATP-blocking agent being developed as a drug for prevention of sudden cardiac death.Product Details of 21085-72-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary