Month: October 2022

In 2017,Li, Zheng; Liu, Chunxia; Xu, Xue; Qiu, Qianqian; Su, Xin; Dai, Yuxuan; Yang, Jianyong; Li, Huilan; Shi, Wei; Liao, Chen; Pan, Miaobo; Huang, Wenlong; Qian, Hai published 《Discovery of phenylsulfonyl acetic acid derivatives with improved efficacy and safety as potent free fatty acid receptor 1 agonists for the treatment of type 2 diabetes》.European Journal of Medicinal Chemistry published the findings.Name: 1-Bromo-2-isopropylbenzene The information in the text is summarized as follows:

The free fatty acid receptor 1 (FFA1) has emerged as an attractive anti-diabetic target that mediates glucose-stimulated insulin secretion. Several FFA1 agonists have been reported, but many of them possessed somewhat high lipophilicity and/or mol. weight Herein, the authors describe the identification of sulfone-carboxylic acid moiety with the multiple advantages of reducing lipophilicity, cytotoxicity and β-oxidation associated with compound 2 (I). Further structure-activity relationship study based on the privileged scaffolds led to the discovery of 2-{(4-[(2′-chloro-[1,1′-biphenyl]-3-yl)methoxy]phenyl)sulfonyl}acetic acid (compound 20), which showed a better balance than compound 2 in terms of physicochem. properties, cytotoxicity profiles and pharmacokinetic properties. Subsequent in vivo studies demonstrated that compound 20 robustly improves the glucose tolerance both in normal and type 2 diabetic models without the risk of hypoglycemia. Compared to the high risk of TAK-875 induced liver toxicity, there was no significant adverse effects such as hepatic and renal toxicity were observed in the chronic toxicity studies of compound 20 even at the higher dose. The experimental part of the paper was very detailed, including the reaction process of 1-Bromo-2-isopropylbenzene(cas: 7073-94-1Name: 1-Bromo-2-isopropylbenzene)

1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. Name: 1-Bromo-2-isopropylbenzene The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2017,Greulich, Tobias W.; Yamaguchi, Eriko; Doerenkamp, Carsten; Luebbesmeyer, Maximilian; Daniliuc, Constantin G.; Fukazawa, Aiko; Eckert, Hellmut; Yamaguchi, Shigehiro; Studer, Armido published 《Synthesis and Physical Properties of Strained Doubly Phosphorus-Bridged Biaryls and Viologens》.Chemistry – A European Journal published the findings.Electric Literature of C6H5Br2N The information in the text is summarized as follows:

New P/N-containing π-electron systems comprising fully planar biaryl arrays are synthesized by multiple radical phosphanylation. The biaryl moiety in these highly strained planar π-systems is rigidified by double P-bridging. The electronic properties of the core biaryl entity are varied by introducing N-donor substituents or by installing N-atoms within the π-system, thereby moving to the viologen core structure. The electrochem. and photophys. properties of these compounds are discussed and compared with those of related systems.3,5-Dibromoaniline(cas: 626-40-4Electric Literature of C6H5Br2N) was used in this study.

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Electric Literature of C6H5Br2N

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Journal of the American Chemical Society included an article by Li, Yang; Liang, Yujie; Dong, Junchao; Deng, Yi; Zhao, Chunyang; Su, Zhongmin; Guan, Wei; Bi, Xihe; Liu, Qun; Fu, Junkai. Application of 7051-34-5. The article was titled 《Directed Copper-Catalyzed Intermolecular Aminative Difunctionalization of Unactivated Alkenes》. The information in the text is summarized as follows:

A diverse collection of copper-catalyzed intermol. aminative difunctionalizations of unactivated alkenes with N-halodialkylamines as the terminal dialkylamino source is reported. A bidentate auxiliary tethered on the alkene substrates is crucial, which can promote the migratory insertion of nonactivated alkenes into the aminyl radical-metal complex and stabilize the resultant high-valent copper intermediate to allow for further transformations. By employing this strategy, the intermol. aminohalogenation reactions and a three-component aminoazidation reaction of unactivated alkenes with dialkylamino source were successively achieved in a remarkable regio- and stereoselective manner. These reactions were performed under neutral conditions and maintained excellent functional group tolerance toward a wide range of N-halodialkylamines and unactivated alkenes. Further mechanistic studies and DFT calculations supported a concerted migratory insertion of the C-C double bond into the aminyl radical-metal complex to form a Cu(III) intermediate. The results came from multiple reactions, including the reaction of (Bromomethyl)cyclopropane(cas: 7051-34-5Application of 7051-34-5)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Application of 7051-34-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Angewandte Chemie, International Edition included an article by Yi, Hong; Mao, Wenbin; Oestreich, Martin. Recommanded Product: 2969-81-5. The article was titled 《Enantioselective Construction of α-Chiral Silanes by Nickel-Catalyzed C(sp3)-C(sp3) Cross-Coupling》. The information in the text is summarized as follows:

An enantioselective C(sp3)-C(sp3) cross-coupling of racemic α-silylated alkyl iodides and alkylzinc reagents is reported. The reaction is catalyzed by NiCl2/(S,S)-Bn-Pybox and yields α-chiral silanes with high enantiocontrol. The catalyst system does not promote the cross-coupling of the corresponding carbon analog, corroborating the stabilizing effect of the silyl group on the alkyl radical intermediate (α-silicon effect). Both coupling partners can be, but do not need to be, functionalized, and hence, even α-chiral silanes with no functional group in direct proximity of the asym. substituted carbon atom become accessible. This distinguishes the new method from established approaches for the synthesis of α-chiral silanes. In the experimental materials used by the author, we found Ethyl 4-bromobutyrate(cas: 2969-81-5Recommanded Product: 2969-81-5)

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Recommanded Product: 2969-81-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Russian Journal of General Chemistry included an article by Yakantham, T.; Sreenivasulu, R.; Raju, R. R.. Formula: C7H5BrO2. The article was titled 《Design, Synthesis, and Anticancer Evaluation of 2-{3-{4-[(5-Aryl-1,2,4-oxadiazol-3-yl)methoxy]phenyl}isoxazol-5-yl}-N-(3,4,5-trimethylphenyl)thiazol-4-amine Derivatives》. The information in the text is summarized as follows:

A series of new 2-(3-(4-[(5-aryl-1,2,4-oxadiazol-3-yl)methoxy]phenyl)isoxazol-5-yl)-N-(3,4,5-tri-methylphenyl)thiazol-4-amine derivatives I (R = H, MeO, NO2; R1 = H, MeO, Br, Cl, Me, NO2; R2 = H, MeO, NO2) is synthesized, and the structures of products are confirmed by 1H and 13C NMR, and mass spectra. The new compounds I are tested for their anticancer activity against human cancer cell lines: MCF-7 (breast), A549 (lung), Du-145 (prostate), and MDA MB-231 (breast) by using MTT assay and etoposide as a standard reference All compounds I demonstrate good to moderate activity on all cell lines.4-Bromobenzoic acid(cas: 586-76-5Formula: C7H5BrO2) was used in this study.

4-Bromobenzoic acid(cas: 586-76-5) has been used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.Formula: C7H5BrO2 It was used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,European Journal of Medicinal Chemistry included an article by Li, Zheng; Liu, Chunxia; Yang, Jianyong; Zhou, Jiaqi; Ye, Zhiwen; Feng, Dazhi; Yue, Na; Tong, Jiayi; Huang, Wenlong; Qian, Hai. Reference of 1-Bromo-2-isopropylbenzene. The article was titled 《Design, synthesis and biological evaluation of novel FFA1/GPR40 agonists: New breakthrough in an old scaffold》. The information in the text is summarized as follows:

Based on an old phenoxyacetic acid scaffold, CPU014 (compound 14) has been identified as a superior agonist by comprehensive exploration of structure-activity relationship. In vitro toxicity study suggested that CPU014 has lower risk of hepatotoxicity than TAK-875. During acute toxicity study (5-500 mg/kg), a favorable therapeutic window of CPU014 was observed by evaluation of plasma profiles and liver slices. Moreover, CPU014 promotes insulin secretion in a glucose-dependent manner, while no GLP-1 secretion has been enhanced. Other than good pharmacokinetic properties, CPU014 significantly improved glucose tolerance both in normal and diabetic models without the risk of hypoglycemia. These subversive findings provided a safer candidate CPU014, which is currently in preclin. study to assess its potential for the treatment of diabetes. The experimental part of the paper was very detailed, including the reaction process of 1-Bromo-2-isopropylbenzene(cas: 7073-94-1Reference of 1-Bromo-2-isopropylbenzene)

1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides. Reference of 1-Bromo-2-isopropylbenzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Effect of aromatic spacer groups and counterions on aqueous micellar and thermal properties of the synthesized quaternary ammonium gemini surfactants》 were Shakil Hussain, S. M.; Kamal, Muhammad Shahzad; Murtaza, Mobeen. And the article was published in Journal of Molecular Liquids in 2019. HPLC of Formula: 623-24-5 The author mentioned the following in the article:

One of the major challenges for the oil industry in the 21st century is to get the desired surfactants that are soluble in high saline water (220, 000 ppm) and stable at high temperature (100°C). Most com. surfactants suffering due to hydrolysis at high temperature and the monovalent and divalent reservoir ions leads to surfactant precipitation In order to address these issues, a new series of cationic gemini surfactants with a different number of aromatic rings in the spacer group as well as different counter ions were synthesized and characterized with the aid of MALDI-TOF MS, FTIR, 1H NMR, and 13C NMR spectroscopy. The effect of number of Ph aromatic rings in the spacer and counterions on thermal and surface properties was determined Thermogravimetric results showed the decomposition temperature of all the gemini surfactant near to 300°C which is larger than the existing oilfield temperature (≥100°C). The insertion of ethoxy units between the lipophilic tail and lipophobic headgroup resulted in good solubility of cationic gemini surfactants in high saline and normal water without cloudiness or precipitation The critical micelle concentration and the corresponding surface tension were lower for gemini surfactants containing bromide counterions compared to the surfactants containing chloride counterions. The gemini surfactants containing two aromatic Ph rings in the spacer have lower critical micelle concentration compared to the gemini surfactants with one Ph ring. The properties of the synthesized cationic gemini surfactants mark them a material of choice for high salinity/temperature reservoirs. In the experimental materials used by the author, we found 1,4-Bis(bromomethyl)benzene(cas: 623-24-5HPLC of Formula: 623-24-5)

1,4-Bis(bromomethyl)benzene(cas: 623-24-5) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. HPLC of Formula: 623-24-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Ruthenium-Catalyzed Alternating Ring-Opening Metathesis Copolymerization of Norborn-2-ene with Cyclic Olefins》 were Paradiso, Veronica; Grisi, Fabia. And the article was published in Advanced Synthesis & Catalysis in 2019. Safety of 1-Bromo-2-isopropylbenzene The author mentioned the following in the article:

A Grubbs-type olefin metathesis catalyst bearing a backbone-substituted unsym. N-heterocyclic carbene (NHC) ligand has been prepared from readily available reagents using a four-step synthetic protocol. This catalyst was found able to promote the alternating ring-opening metathesis copolymerization of norborn-2-ene (NBE) with cis-cyclooctene (COE) or cyclopentene (CPE) with a high degree of chemoselectivity (98% and 95% of alternating diads, resp.) at low comonomers ratios. The results came from multiple reactions, including the reaction of 1-Bromo-2-isopropylbenzene(cas: 7073-94-1Safety of 1-Bromo-2-isopropylbenzene)

1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals.Safety of 1-Bromo-2-isopropylbenzene The most pervasive is the naturally produced bromomethane.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《A water soluble light activated hydrogen sulfide donor induced by an excited state meta effect》 were Bera, Manoranjan; Maji, Somnath; Paul, Amrita; Ray, Souvik; Maiti, Tapas Kumar; Singh, N. D. Pradeep. And the article was published in Organic & Biomolecular Chemistry in 2019. COA of Formula: C4H7BrO2 The author mentioned the following in the article:

We have utilized an m-amino benzyl based photoremovable protecting group (PRPG) to develop a new water soluble H2S donor. It efficiently releases H2S on demand in a spatio-temporally controlled fashion by an excited state “”meta effect”” with good chem. and photochem. quantum yield in an aqueous environment. The efficient photorelease of H2S under physiol. conditions was also demonstrated by in vitro studies.4-Bromobutanoic acid(cas: 2623-87-2COA of Formula: C4H7BrO2) was used in this study.

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).COA of Formula: C4H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Novel hapten design, antibody recognition mechanism study, and a highly sensitive immunoassay for diethylstilbestrol in shrimp》 were Mi, Jiafei; Dong, Xiaoyun; Zhang, Xiya; Li, Chenglong; Wang, Jianyi; Mujtaba, Mari Ghulam; Zhang, Suxia; Wen, Kai; Yu, Xuezhi; Wang, Zhanhui. And the article was published in Analytical and Bioanalytical Chemistry in 2019. Category: bromides-buliding-blocks The author mentioned the following in the article:

Over the past few years, there has been a lack of progress in the quality of diethylstilbestrol (DES) antibodies used in immunoassay. In this study, a new immunizing hapten was designed for remarkably sensitive and specific antibody generation against diethylstilbestrol. By introducing a benzene ring instead of the traditional linear chain alkane as the hapten spacer, a more specific immune reaction was induced in the process of immunization. The developed polyclonal antibodies were characterized using the indirect competitive ELISA (icELISA). Under optimized conditions, the half maximal inhibitory concentration (IC50) of the best polyclonal antibody was 0.14 ng/mL and it displayed low cross-reactions (CRs) with the structural analogs such as hexestrol (HEX) and dienestrol (DI). The mol. modeling and quantum chem. computation revealed that the lowest CR of the DES antibody to DI was mainly due to the huge three-dimensional conformational difference between DES and DI. Finally, a highly sensitive icELISA method based on the polyclonal antibody was developed for the determination of DES in shrimp tissue. The limit of detection (LOD) was as low as 0.2μg/kg in shrimp and the recoveries in the spiked samples ranged from 83.4 to 90.8% with the coefficient of variation less than 13.8%. These results indicated that the use of an aromatic ring as the immunizing hapten spacer arm could be a potential strategy for the enhancement of anti-DES antibody sensitivity, and the established icELISA was applicable to the trace detection of DES in shrimp. In addition to this study using Methyl 3-(bromomethyl)benzoate, there are many other studies that have used Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Category: bromides-buliding-blocks) was used in this study.

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.Organobromine chemicals are produced naturally by an array of biological and other chemical processes in our environment. Some of these compounds are identical to man-made organobromine compounds, such as methyl bromide, bromoform, and bromophenols, but many others are entirely new moleclar entities, often possessing extraordinary and important biological properties. Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary