Month: October 2022

The author of 《Highly frustrated liquid crystal phases in optically active dimers: synthesis and rich phase transitional behavior》 were Nayak, Rashmi Ashwathama; Bhat, Sachin A.; Shanker, G.; Rao, D. S. Shankar; Yelamaggad, C. V.. And the article was published in New Journal of Chemistry in 2019. Product Details of 2623-87-2 The author mentioned the following in the article:

Herein the authors report on the synthesis and characterization of four new series of optically active, nonsym. dimers in which cholesterol is covalently linked to a Schiff base core through an ω-oxyalkanoyl spacer. While the Schiff base core is substituted with n-butyloxy, n-hexyloxy, n-octyloxy, n-decyloxy and n-dodecyloxy tails, three even-parity spacers, namely, 4-oxybutanoyl, 6-oxyhexanoyl, 8-oxyoctanoyl, and an odd-parity spacer, namely, 5-oxypentanoyl, were used to join the two cores. The length and parity of the spacer and the length of the terminal tail play a vital role in deciding the phase sequences of the dimers. In general, the dimers possessing an even-parity spacer display enantiotropic LC phases such as chiral nematic (N*), twist grain boundary (TGB), smectic A (SmA), chiral smectic C (SmC*) and twist grain boundary phase with SmC* slabs (TGBC*). Some of these dimers display TGBC* over a wide temperature range. The dimers with an odd-parity (5-oxypentanoyl) spacer display, unlike their even-membered counterparts, blue phases (BPIII/II/I); besides, they stabilize N* and/or unknown smectic (SmX) phases. The CD measurements were carried out as a function of temperature on the planar texture formed by three even-membered dimers and an odd-membered dimer. The occurrence of a strong neg. CD band in the N* phase of the even-membered dimers suggests a left-handed screw sense of the macroscopic helical structure, and the scenario is opposite in the case of an odd-membered dimer. In the experiment, the researchers used 4-Bromobutanoic acid(cas: 2623-87-2Product Details of 2623-87-2)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Product Details of 2623-87-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Thermo-sensitive Microgels Supported Gold Nanoparticles as Temperature-mediated Catalyst》 were Zhou, Xian-Jing; Lu, Hai-Peng; Kong, Ling-Li; Zhang, Dong; Zhang, Wei; Nie, Jing-Jing; Yuan, Jia-Yin; Du, Bin-Yang; Wang, Xin-Ping. And the article was published in Chinese Journal of Polymer Science in 2019. Related Products of 629-03-8 The author mentioned the following in the article:

Microgels with a thermo-sensitive poly(N-isopropylacrylamide) (polyNIPAm) backbone and bis-imidazolium (VIM) ionic cross-links, denoted as poly(NIPAm-co-VIM), were successfully prepared The as-synthesized ionic microgels were converted to nanoreactors, denoted as Au@PNI MGs, upon generation and immobilization of gold nanoparticles (Au NPs) of 5-8 nm in size into poly(NIPAm-co-VIM). The content of Au NPs in microgels could be regulated by controlling the 1,6-dibromohexane/vinylimidazole molar ratio in the quaternization reaction. The microgel-based nanoreactors were morphol. spherical and uniform in size, and presented reversible thermo-sensitive behavior with volume phase transition temperatures (VPTTs) at 39-40 °C. The Au@PNI MGs were used for the reduction of 4-nitrophenol, of which the catalytic activity could be modulated by temperature In the experiment, the researchers used 1,6-Dibromohexane(cas: 629-03-8Related Products of 629-03-8)

1,6-Dibromohexane(cas: 629-03-8) is generally used to introduce C6 spacer in the molecular architecture. Some of the examples are: synthesis of solvent processable and conductive polyfluorene ionomers for alkaline fuel cell applications; synthesis of cross-linkable regioregular poly(3-(5-hexenyl)thiophene) (P3HNT) for stabilizing the film morphology in polymer photovoltaic cells.Related Products of 629-03-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Design, synthesis, and evaluation of novel N-(4-phenoxybenzyl)aniline derivatives targeting acetylcholinesterase, β-amyloid aggregation and oxidative stress to treat Alzheimer’s disease》 were Srivastava, Pavan; Tripathi, Prabhash Nath; Sharma, Piyoosh; Shrivastava, Sushant Kumar. And the article was published in Bioorganic & Medicinal Chemistry in 2019. Electric Literature of C6H5Br2N The author mentioned the following in the article:

Novel hybrids N-(4-phenoxybenzyl)aniline were designed, synthesized, and evaluated for their potential AChE inhibitory activity along with antioxidant potential. The inhibitory potential (IC50) of synthesized analogs was evaluated against human cholinesterases (hAChE and hBChE) using Ellman’s method. Among all the tested compounds, 42 with trimethoxybenzene substituent showed maximum hAChE inhibition with the competitive type of enzyme inhibition (IC50 = 1.32 μM; Ki = 0.879 μM). Further, parallel artificial membrane permeation assay (PAMPA-BBB) showed favorable BBB permeability by most of the synthesized compounds Meanwhile, compound 42 also inhibited AChE-induced Aβ aggregation (39.5-66.9%) in thioflavin T assay. The in vivo behavioral studies showed dose-dependent improvement in learning and memory by compound 42. The ex vivo studies also affirmed the significant AChE inhibition and antioxidant potential of compound 42 in brain homogenates. In the experiment, the researchers used 3,5-Dibromoaniline(cas: 626-40-4Electric Literature of C6H5Br2N)

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.Electric Literature of C6H5Br2N

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Acceptorless dehydrogenative oxidation of primary alcohols to carboxylic acids and reduction of nitroarenes via hydrogen borrowing catalyzed by a novel nanomagnetic silver catalyst》 was published in Journal of Organometallic Chemistry in 2020. These research results belong to Yazdani, Elahe; Heydari, Akbar. COA of Formula: C7H5BrO2 The article mentions the following:

A novel silver nanomagnetic catalyst was devised for dehydrogenative oxidation of aromatic and aliphatic alcs. to the corresponding acid with water as the sole oxygen source and hydrogen gas as the only byproduct. The designed catalytic system advantages from easy recovery of magnetic materials i.e. magnetic decantation, being economically viable and environmentally friendly. Furthermore, the catalytic reaction is able to reduce aryl nitro compounds in the absence of any reducing agent. In the part of experimental materials, we found many familiar compounds, such as 4-Bromobenzoic acid(cas: 586-76-5COA of Formula: C7H5BrO2)

4-Bromobenzoic acid(cas: 586-76-5) has been used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.COA of Formula: C7H5BrO2 It was used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Investigation into the influence of an acrylic acid acceptor in organic D-π-A sensitizers against phototoxicity》 was published in Bioorganic & Medicinal Chemistry in 2020. These research results belong to Fuse, Shinichiro; Moriya, Wataru; Sato, Shinichi; Nakamura, Hiroyuki. Safety of 2,5-Dibromothiophene The article mentions the following:

Photodynamic therapy (PDT) is a non-invasive, selective, and cost-effective cancer therapy. We previously reported that thiophene-based organic D-π-A sensitizers consist of an electron-donating (D) moiety, a π-conjugated bridge (π) moiety, and an electron-accepting (A) moiety, and are readily accessible and stable templates for photosensitizers that could be used in PDT. In addition, acrylic acid acceptor-containing photosensitizers exert a high level of phototoxicity. This study was an investigation into 1) the possibility of increasing phototoxicity by introducing another carboxyl group or by replacing a carboxyl group with a pyridinium group, and 2) the importance of an alkene in the acrylic acid acceptor for phototoxicity. A review of the design, synthesis, and evaluation of sensitizers revealed that neither dicarboxylic acid nor pyridinium photosensitizers enhance phototoxicity. An evaluation of a photosensitizer without an alkene in the acrylic acid moiety revealed that the alkene was not indispensable in the pursuit of phototoxicity. The obtained results provided new insight into the design of ideal D-π-A photosensitizers for PDT. After reading the article, we found that the author used 2,5-Dibromothiophene(cas: 3141-27-3Safety of 2,5-Dibromothiophene)

2,5-Dibromothiophene(cas: 3141-27-3) , is mainly used as pharmaceutical intermediate and synthesis intermediate. 2,5-Dibromothiophene may be used in the preparation of soluble α,ω-diformyl-a-oligothiophenes.Safety of 2,5-Dibromothiophene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Regioselective Hydroformylation of Internal and Terminal Alkenes via Remote Supramolecular Control》 was published in Chemistry – A European Journal in 2020. These research results belong to Linnebank, Pim R.; Ferreira, Stephan Falcao; Kluwer, Alexander M.; Reek, Joost N. H.. Computed Properties of C8H15BrO2 The article mentions the following:

Herein, the redesign of a supramol. Rh-bisphosphite hydroformylation catalyst containing a neutral carboxylate receptor (DIM pocket) with a larger distance between the phosphite metal binding moieties and the DIM pocket was reported. For the first time regioselective hydroformylation of internal CH3(CH2)nCH:CH(CH2)7C(O)OH (n = 3, 5, 7), CH3CH:CH(CH2)nC(O)OH (n = 6, 7) and terminal CH2:CH(CH2)nC(O)OH (n = 2, 3, 4, etc.) alkenes containing a remote carboxylate directing group is demonstrated. For carboxylate substrates that possess an internal double bond at the Δ-9 position, regioselectivity was observed As such, the catalyst was used to hydroformylate natural monounsaturated fatty acids (MUFAs) in a regioselective fashion, forming of an excess of the 10-formyl product (10-formyl/9-formyl product ratio of 2.51), which is the first report of a regioselective hydroformylation reaction of such substrates. The experimental process involved the reaction of 8-Bromooctanoic acid(cas: 17696-11-6Computed Properties of C8H15BrO2)

8-Bromooctanoic acid(cas: 17696-11-6) acid is used in the synthesis of 8-(N-Methyl-4,4′-bipyridinyl)- octanoic acid. 8-Mercaptooctanoic acid was prepared from 8-bromooctanoic acid. And 8-Bromooctanoic Acid is a useful compound for sonodynamic therapy.Computed Properties of C8H15BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Synthesis of 3,4-dihydropyrimidin-2(1H)-one via retro-Biginelli reaction》 was published in Journal of Heterocyclic Chemistry in 2020. These research results belong to Mondal, Sudipta; Mondal, Mohabul A.. Quality Control of o-Bromobenzaldehyde The article mentions the following:

Hydrolytic behavior of 5-acetyl-6-methyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-ones under alk. condition had been explored. Mechanistic details were established by LCMS and HPLC. Evidence suggested that the deacetylative benzylidenation proceeded through the retro-Biginelli reaction. The scope of the retro-Biginelli reaction had been explored by the synthesis of substituted DHPs I [Ar = Ph, 4-MeC6H4, 2-BrC6H4; Ar1 = Ph, 4-MeC6H4, 2-BrC6H4, 3-MeOC6H4]. In the experimental materials used by the author, we found o-Bromobenzaldehyde(cas: 6630-33-7Quality Control of o-Bromobenzaldehyde)

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Quality Control of o-BromobenzaldehydeIt is a key starting material in the total synthesis of an anticancer agent, (-)-taxol.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Ligand-Free Iron-Catalyzed Homo-Coupling of Aryllithium Reagents》 was published in Asian Journal of Organic Chemistry in 2020. These research results belong to Wang, Zhi-Yong; Peng, Xiao-Shui; Wong, Henry N. C.. Safety of 1-Bromo-3,4,5-trimethoxybenzene The article mentions the following:

The synthesis of sym. biaryls via the iron-catalyzed homo-coupling of aryllithium reagents was developed under a mild condition, in the absence of ligand, with wide range of scope, and in good yields. Investigation on reaction concentration and practical utility of this environmentally friendly procedure also indicates a promising application outlook. The experimental process involved the reaction of 1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8Safety of 1-Bromo-3,4,5-trimethoxybenzene)

1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.Safety of 1-Bromo-3,4,5-trimethoxybenzene1-Bromo-3,4,5-trimethoxybenzene can be used to synthesize symmetric 3,3′,4,4′,5,5′-hexamethoxydiphenylacetylene via Stille-type coupling with bis-(tributylstannyl)acetylene.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《The first used butylene linked bis(N-heterocyclic carbene)-palladium-PEPPSI complexes in the direct arylation of furan and pyrrole》 was published in Journal of Organometallic Chemistry in 2020. These research results belong to Kaloglu, Murat; Dusunceli, Serpil Demir; Ozdemir, Ismail. SDS of cas: 402-43-7 The article mentions the following:

The synthesis and characterization of butylene linked bis-benzimidazole based N-heterocyclic carbene (NHC) precursors I [R = 2-[bis(propan-2-yl)amino]ethyl, propan-2-yl, (pentamethylphenyl)methyl] and their PEPPSI-type bimetallic Pd-complexes II were reported, and its activities in the direct C5-arylation of 2-acetylfuran and 1-methylpyrrole-2-carboxaldehyde with various aryl bromides 4-R1C6H4Br (R1= H, MeO, Me, CHO, C(O)Me, CF3) and 3-bromoquinoline were implemented. The catalytic activities of the synthesized palladium-complexes II were found to be very high. The experimental process involved the reaction of 1-Bromo-4-(trifluoromethyl)benzene(cas: 402-43-7SDS of cas: 402-43-7)

1-Bromo-4-(trifluoromethyl)benzene(cas: 402-43-7) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. SDS of cas: 402-43-7 Due to the reactivity of bromide, they are used as potential precursors or important intermediates in organic synthesis.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Discovery and Development of S6821 and S7958 as Potent TAS2R8 Antagonists》 was published in Journal of Medicinal Chemistry in 2020. These research results belong to Fotsing, Joseph R.; Darmohusodo, Vincent; Patron, Andrew P.; Ching, Brett W.; Brady, Thomas; Arellano, Melissa; Chen, Qing; Davis, Timothy J.; Liu, Hanghui; Servant, Guy; Zhang, Lan; Williams, Mark; Saganich, Michael; Ditschun, Tanya; Tachdjian, Catherine; Karanewsky, Donald S.. Name: Methyl 3-(bromomethyl)benzoate The article mentions the following:

In humans, bitter taste is mediated by 25 TAS2Rs. Many compounds, including certain active pharmaceutical ingredients, excipients, and nutraceuticals, impart their bitter taste (or in part) through TAS2R8 activation. However, effective TAS2R8 blockers that can either suppress or reduce the bitterness of these compounds have not been described. We are hereby reporting a series of novel 3-(pyrazol-4-yl) imidazolidine-2,4-diones as potent and selective TAS2R8 antagonists. In human sensory tests, S6821(I) and S7958(II), two of the most potent analogs from the series, demonstrated efficacy in blocking TAS2R8-mediated bitterness and were selected for development. Following data evaluation by expert panels of a number of national and multinational regulatory bodies, including the US, the EU, and Japan, S6821 and S7958 were approved as safe under conditions of intended use as bitter taste blockers. In the experimental materials used by the author, we found Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Name: Methyl 3-(bromomethyl)benzoate)

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. Name: Methyl 3-(bromomethyl)benzoate The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary