Month: October 2022

In 2022,Teng, Jin-Ming; Zhang, Da-Wei; Wang, Yin-Feng; Chen, Chuan-Feng published an article in ACS Applied Materials & Interfaces. The title of the article was 《Chiral Conjugated Thermally Activated Delayed Fluorescent Polymers for Highly Efficient Circularly Polarized Polymer Light-Emitting Diodes》.Safety of 3,6-Dibromo-9H-carbazole The author mentioned the following in the article:

Two novel chiral conjugated polymers R-P and S-P designed and synthesized from a pair of circularly polarized thermally activated delayed fluorescence (CP-TADF) enantiomers are presented in this work. The two polymers exhibited excellent TADF properties with small singlet-triplet energy gaps (ΔEST) of 0.045 and 0.061 eV and relatively high photoluminescence quantum yields (PLQYs) of 72 and 76%, resp. Besides, intense mirror-image circularly polarized luminescence signals were detected from R-P and S-P in both solution and film states with dissymmetry factors (|glum|) of up to 1.9 x 10-3. Furthermore, solution-processed circularly polarized polymer light-emitting diodes (CP-PLEDs) fabricated with R-P and S-P achieved high maximum external quantum efficiencies of 14.9 and 15.8% and high maximum brightness (Lmax) of 8940 and 12,180 cd/m2 with yellowish-green emission peaks at 546 and 544 nm, resp. Moreover, intense circularly polarized electroluminescence signals with electroluminescence dissymmetry factors (gEL) of -1.5 x 10-3 and +1.6 x 10-3 were detected from the CP-PLED devices fabricated with R-P and S-P, resp. The results came from multiple reactions, including the reaction of 3,6-Dibromo-9H-carbazole(cas: 6825-20-3Safety of 3,6-Dibromo-9H-carbazole)

3,6-Dibromo-9H-carbazole(cas: 6825-20-3) is used as a pharmaceutical intermediate, and also an important intermediate of synthesizing optoelectronic materials. It has been used as a reagent in the synthesis of P7C3-A20 which is a potent neuroprotective agent.Safety of 3,6-Dibromo-9H-carbazole

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Wang, Hang; Lu, Hao; Chen, Ya-Nan; Ran, Guangliu; Zhang, Andong; Li, Dawei; Yu, Na; Zhang, Zhe; Liu, Yahui; Xu, Xinjun; Zhang, Wenkai; Bao, Qinye; Tang, Zheng; Bo, Zhishan published an article in Advanced Materials (Weinheim, Germany). The title of the article was 《Chlorination Enabling a Low-Cost Benzodithiophene-Based Wide-Bandgap Donor Polymer with an Efficiency of over 17%》.Electric Literature of C4H2Br2S The author mentioned the following in the article:

Three regioregular benzodithiophene-based donor-donor (D-D)-type polymers (PBDTT, PBDTT1Cl, and PBDTT2Cl) are designed, synthesized, and used as donor materials in organic solar cells (OSCs). Because of the weak intramol. charge-transfer effect, these polymers exhibit large optical bandgaps (>2.0 eV). Among these three polymers, PBDTT1Cl exhibits more ordered and closer mol. stacking, and its devices demonstrate higher and more balanced charge mobilities and a longer charge-separated state lifetime. As a result of these comprehensive benefits, PBDTT1Cl-based OSCs give a very impressive power conversion efficiency (PCE) of 17.10% with a low nonradiative energy loss (0.19 eV). Moreover, PBDTT1Cl also possesses a low figure-of-merit value and good universality to match with different acceptors. This work provides a simply and efficient strategy to design low-cost high-performance polymer donor materials. In the part of experimental materials, we found many familiar compounds, such as 2,5-Dibromothiophene(cas: 3141-27-3Electric Literature of C4H2Br2S)

2,5-Dibromothiophene(cas: 3141-27-3) , is mainly used as pharmaceutical intermediate and synthesis intermediate. 2,5-Dibromothiophene may be used in the preparation of soluble α,ω-diformyl-a-oligothiophenes.Electric Literature of C4H2Br2S

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Liu, Yulin; Uras, Giuseppe; Onuwaje, Itse; Li, Wenlong; Yao, Hong; Xu, Shengtao; Li, Xinuo; Li, Xinnan; Phillips, James; Allen, Stephanie; Gong, Qi; Zhang, Haiyan; Zhu, Zheying; Liu, Jie; Xu, Jinyi published an article in European Journal of Medicinal Chemistry. The title of the article was 《Novel inhibitors of AChE and Aβ aggregation with neuroprotective properties as lead compounds for the treatment of Alzheimer’s disease》.Recommanded Product: Ethyl 3-bromopropanoate The author mentioned the following in the article:

A series of sulfone analogs of donepezil I (R1 = H, F; R2 = H, 4-F, 3-Cl, etc.) were designed and synthesized as novel acetylcholinesterase (AChE) inhibitors with the potent inhibiting Aβ aggregation and providing neuroprotective effects as potential modalities for Alzheimer’s disease (AD). Most of the target compounds displayed effective inhibition of AChE, especially compound II which displayed powerful inhibitory activity (IC50 = 2.4 nM). Kinetic and docking studies indicated that compound II was a mixed-type inhibitor. Furthermore, in glyceraldehyde (GA)-exposed SH-SY5Y differentiated neuronal cells, compound II could potently inhibit AChE, reduce tau phosphorylation at S396 residue, provide neuroprotection by rescuing neuronal morphol. and increasing cell viability. It was also found to reduce amyloid aggregation in the presence of AChE. In addition, compound II showed evident protections from mitochondrial membrane dysfunction and oxidative stress in okadaic acid-induced pharmacol. models. Moreover, compound II exhibited more effective treatment prospects in vivo than donepezil, including a moderate blood-brain barrier permeability, a more potent AChE inhibitory activity and behavioral improvement in scopolamine-induced cognition-impaired mice model at a much lower dose. Collectively, compound II is a promising lead compound for further investigation to discovery and development of new anti-AD agents. The experimental process involved the reaction of Ethyl 3-bromopropanoate(cas: 539-74-2Recommanded Product: Ethyl 3-bromopropanoate)

Ethyl 3-bromopropanoate(cas: 539-74-2) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Recommanded Product: Ethyl 3-bromopropanoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Xu, Kaidi; Li, Bin; Yao, Shibo; Li, Zhaoxian; Lu, Yunfeng; Dong, Ming; Qiu, Jianfeng; Luo, Liqiang; Li, Chunju published an article in Angewandte Chemie, International Edition. The title of the article was 《Modular Introduction of endo-Binding Sites in a Macrocyclic Cavity towards Selective Recognition of Neutral Azacycles》.Electric Literature of C14H8Br2 The author mentioned the following in the article:

Macrocycles with a functionalized interior, which is a general cavity feature of bioreceptors, are relatively hard to synthesize. Here authors report a modular strategy to customize diverse endo-binding sites in the macrocycle cavity. Only two steps are needed. First, one V-shaped functional module bearing an embedded binding site and two 2,5-dimethoxyphenyls as reaction modules are connected. Then the condensation of the resulting monomer and paraformaldehyde directly produces the designed macrocycle. V-shaped monomers are deliberately used to guarantee the binding sites equatorially directing inward into the cavity and 2,5-dimethoxyphenyls standing axially as macrocycle sidewalls. More than a dozen endo-functionalized macrocyclic receptors have been constructed. Host-guest complexation studies show that interior OH moieties in macrocycle I can strongly encapsulate neutral azacycles by forming inner hydrogen bonds, giving a high association constant of 4.59×104 M-1 in non-polar media. The results came from multiple reactions, including the reaction of 9,10-Dibromoanthracene(cas: 523-27-3Electric Literature of C14H8Br2)

9,10-Dibromoanthracene(cas: 523-27-3) is synthesized by the bromination of anthracene. The bromination reaction is carried out at room temperature using carbon tetrachloride as a solvent. Using 80-85% anthracene as raw material, adding bromine to react for half an hour, the yield is 83-88%.Electric Literature of C14H8Br2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Zhu, Jin; Wang, Yidong; Charlack, Aaron D.; Wang, Yi-Ming published an article in Journal of the American Chemical Society. The title of the article was 《Enantioselective and Diastereodivergent Allylation of Propargylic C-H Bonds》.Product Details of 2635-13-4 The author mentioned the following in the article:

An iridium-catalyzed stereoselective coupling of allylic ethers and alkynes to generate 3,4-substituted 1,5-enynes was reported. Under optimized conditions, the coupling products were formed with excellent regio-, diastereo-, and enantioselectivities, and the protocol was functional group tolerant. Moreover, conditions that allowed the reaction to proceed with complete reversal of diastereoselectivity was reported. Mechanistic studies were consistent with an unprecedented dual role for the iridium catalyst, enabling the propargylic deprotonation of the alkyne through π-coordination, as well as the generation of a π-allyl species from the allylic ether starting material. The experimental part of the paper was very detailed, including the reaction process of 5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4Product Details of 2635-13-4)

Furthermore, the coupling of 5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4) with β-methallyl alcohol was catalyzed by Pd(OAc)2 in combination with P(t-Bu)3.Product Details of 2635-13-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Oe, Yuno; Yoshida, Ryuhei; Tanaka, Airi; Adachi, Akiya; Ishibashi, Yuichiro; Okazoe, Takashi; Aikawa, Kohsuke; Hashimoto, Takuya published an article in Journal of the American Chemical Society. The title of the article was 《An N-Fluorinated Imide for Practical Catalytic Imidations》.HPLC of Formula: 3141-27-3 The author mentioned the following in the article:

Hherein the development of a novel N-fluorinated imide, N-fluoro-N-(fluorosulfonyl)carbamate (NFC), by which the attached imide moiety acted as a modular synthetic handle for one-step derivatization to amines, sulfonamides, and sulfamides was reported. Furthermore, this study revealed the superior reactivity of NFC as showcased in a copper-catalyzed imidation of benzene derivatives and imidocyanation of aliphatic alkenes, overcoming the limitation of NFSI-mediated reactions.2,5-Dibromothiophene(cas: 3141-27-3HPLC of Formula: 3141-27-3) was used in this study.

2,5-Dibromothiophene(cas: 3141-27-3) , is mainly used as pharmaceutical intermediate and synthesis intermediate. 2,5-Dibromothiophene may be used as starting reagent for the synthesis of α,α′-didecylquater-, -quinque- and -sexi-thiophenes.HPLC of Formula: 3141-27-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Kawashima, Kanako; Hirota-Tsukimachi, Mayuko; Toma, Tsugumasa; Koga, Ryoko; Iwamaru, Kana; Kanemaru, Yosuke; Yanae, Misato; Ahagon, Ami; Nakamura, Yurine; Anraku, Kensaku; Tateishi, Hiroshi; Gohda, Jin; Inoue, Jun-ichiro; Otsuka, Masami; Fujita, Mikako published an article in Chemical Biology & Drug Design. The title of the article was 《Development of chimeric receptor activator of nuclear factor-kappa B with glutathione S-transferase in the extracellular domain: Artificial switch in a membrane receptor》.Application In Synthesis of 8-Bromooctanoic acid The author mentioned the following in the article:

Various chimeric receptors have been developed and used for biol. experiments In the present study, we constructed three types of chimeric receptor activator of nuclear factor-kappa B (RANK) with the glutathione S-transferase (GST) protein in the extracellular domain, and stimulated them using newly synthesized chem. trimerizers with three glutathiones. Although this stimulation did not activate these proteins, we unexpectedly found that the chimera named RANK-GST-SC, in which GST replaced a major part of the RANK extracellular domain, activated nuclear factor-kappa B (NF-κB) signaling approx. sixfold more strongly than wild-type RANK without the ligand. The dimerization of extracellular GST is considered to function as a switch outside the cell, and signal transduction then occurs. GST has been widely employed as a tag for protein purification; GST-fusion protein can be conveniently captured by glutathione-conjugated beads and easily purified from impurity. The present study is a pioneering example of the novel utility of GST and provides information for the development of new chem. biol. systems.8-Bromooctanoic acid(cas: 17696-11-6Application In Synthesis of 8-Bromooctanoic acid) was used in this study.

8-Bromooctanoic acid(cas: 17696-11-6) acid is used in the synthesis of 8-(N-Methyl-4,4′-bipyridinyl)- octanoic acid. 8-Mercaptooctanoic acid was prepared from 8-bromooctanoic acid.Application In Synthesis of 8-Bromooctanoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Ruhland, Klaus; Horny, Robert; Wanzel, Andrea; Reisach, Sebastian; Nizamutdinova, Alina; Kirchhain, Holger; Rehfuss, Ulrich; van Wuellen, Leo; Fischer, Andreas; Scheliga, Felix; Huebner, Tobias published an article in Journal of Applied Polymer Science. The title of the article was 《Investigation of the chemical changes during the thermal treatment of acrylonitrile -co- methyl acrylate-polymer (polyacrylonitrile-precursor) focusing on the fate of the methyl acrylate moiety》.Category: bromides-buliding-blocks The author mentioned the following in the article:

Seventeen samples of acrylonitrile (AN)-co-Me acrylate (MA)-polymer (MA content 0-11 mol%) are examined Several selective isotopic labelings are employed (d1-MA, d2-MA, 13CO-MA, CD3-MA, d1-AN, d2-AN, and 15N-AN). The thermal treatment under inert atm. is investigated to gain insight into the chem. transformation mechanisms concerning the MA sub-unit. The volatiles are determined by means of evolved gas anal. (EGA) (Fourier transform IR [FTIR] and GC/MS). Methanol is found for the first time as one decisive volatile stemming from the MA sub-unit, next to water and carbon dioxide. In addition, methylamines are proven to be formed by reaction of ammonia with the MA sub-unit, while a similar reaction of hydrogen cyanide (HCN) yielding in acetonitrile could be ruled out. Several volatile compounds could even be quantified. The non-volatile polymeric material is characterized by means of simultaneous thermal anal. (differential scanning calorimetry, thermogravimetric anal.), in-situ-FTIR spectroscopy and sophisticated solid-state NMR methods. Selected defined model compounds are synthesized and analyzed for comparison. Detailed reaction mechanisms for the thermal transformation are concluded from the results, pointing in particular to the importance of ammonia for all processes as stoichiometric and/or catalytic reagent. In the experiment, the researchers used many compounds, for example, Methyl 3-bromopropanoate(cas: 3395-91-3Category: bromides-buliding-blocks)

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

HPLC of Formula: 623-24-5In 2020 ,《Synthesis of poly(phenylene methylenes) via a AlCl3-mediated Friedel-Craft alkylation of multi-substituted benzyl bromide with benzene》 appeared in Journal of Applied Polymer Science. The author of the article were Teng, Dao-Guang; Wei, Xian-Yong; Yang, Zheng; Zhu, Qing-Jiang; Gao, Hua-Shuai; Li, Jia-Hao; Zhang, Min; Zong, Zhi-Min; Kang, Yv-Hong. The article conveys some information:

A facile AlCl3-mediated Friedel-Craft alkylation between a multi-substituted benzyl bromide and benzene is established, in which a wide set of poly(phenylene methylenes) (MMSs) are synthesized through a two-step strategy under metal-free conditions with high yields (slightly lower than theor. yields). The resulting MMSs, characterized by Fourier transform IR spectrometry, NMR spectrometry, thermogravimetric anal., elemental anal., gel permeation chromatog., UV-vis and fluorescence spectrometry, feature large mol. mass, outstanding fluorescence, and excellent thermal/chem. stabilities. Moreover, a gram-scale reaction was carried out under the standard conditions to produce MMSs, exhibiting a promising potential application in industrial practice. In the experiment, the researchers used many compounds, for example, 1,4-Bis(bromomethyl)benzene(cas: 623-24-5HPLC of Formula: 623-24-5)

1,4-Bis(bromomethyl)benzene(cas: 623-24-5) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. HPLC of Formula: 623-24-5 Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Reference of o-BromobenzaldehydeIn 2019 ,《A Microwave Accelerated Sustainable Approach for the Synthesis of 2-amino-4H-chromenes Catalyzed by WEPPA: A Green Strategy》 appeared in Current Microwave Chemistry. The author of the article were Hiremath, Prashant B.; Kamanna, Kantharaju. The article conveys some information:

We established an efficient, simple, agro-waste based catalytic approach for the synthesis of 2-amino-4H-chromene derivatives I [R1 = H, 2-Cl, 4-MeO, etc.], II [ R2 = H, 4-Me, 2-Cl, 4-Cl, 4-MeO] and III [R3 = H, 4-OH, 3-NO2, etc.] from the condensation of arylaldehyde, malononitrile and resorcinol/α-naphthol/β-naphthol employing WEPPA as an efficient catalyst under microwave synthesis. The method was found to be a greener, economic and eco-friendly approach for the synthesis of chromene scaffolds. The advantages of the present approach were solvent-free, no external metal, chem. base free, short reaction time and isolated product in good to excellent yields. The catalyst was agro-waste derived, which has abundant natural sources available, thus making the present approach a greener one. After reading the article, we found that the author used o-Bromobenzaldehyde(cas: 6630-33-7Reference of o-Bromobenzaldehyde)

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Reference of o-BromobenzaldehydeIt is also used in L-threonine aldolase-catalyzed enantio and diastereoselective aldol reactions. Further, it reacts with trichloromethane to prepare 1-(2-bromo-phenyl)-2,2,2-trichloro-ethanol.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary