Month: October 2022

Cheredilin, D. N.; Sheloumov, A. M.; Senin, A. A.; Kozlova, G. A.; Afanas’ev, V. V.; Bespalova, N. B. published the artcile< Catalytic Properties of Chromium Complexes Based on 1,2-Bis(diphenylphosphino)benzene in the Ethylene Oligomerization Reaction>, Formula: C9H12BrN, the main research area is ethylene oligomerization bisdiphenylphosphinobenzene chromium complex catalytic property.

The activity of the catalyst systems of a number of diphosphine ligands and chromium complexes based on 1,2-bis(diphenylphosphino)benzene in the ethylene oligomerization reaction has been studied. Structural modifications of diphosphine ligands have been performed to create selective catalyst systems for ethylene oligomerization. It has been shown that the introduction of ortho-functional groups into one of the Ph substituents at the phosphorus atom in diphosphine ligands makes it possible to carry out the process of ethylene oligomerization to 1-hexene with the selectivity of 90 weight% and above. One of the complexes (chromium complex 15) with a functionalized diphosphine ligand has been characterized by X-ray structure anal. The influence of the change in the amount of the activator and its type on the activity of the catalyst systems has been studied. It has been shown that the replacement of some organoaluminum activator, methylaluminoxane, by trimethylaluminum does not decrease the productivity and selectivity of the catalyst systems based on diphosphine chromium complexes.

Petroleum Chemistry published new progress about Crystal structure. 51605-97-1 belongs to class bromides-buliding-blocks, and the molecular formula is C9H12BrN, Formula: C9H12BrN.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Yadav, Rahul; Darakshan; Bhaumick, Prabhas; Choudhury, Lokman H.; Parvin, Tasneem published the artcile< Synthesis of Pentacyclic Pyran Fused Pyrazolo Benzo[h]quinolines by Multicomponent Reaction and Their Photophysical Studies>, SDS of cas: 3893-18-3, the main research area is pentacyclic pyranpyrazolobenzoquinoline preparation photophys study; aldehyde hydroxy naphthoquinone aminopyrazole one pot three component reaction.

A one-pot method for the synthesis of pentacyclic pyran fused pyrazolo benzo[h]quinolines I (R1 = Ph, 4-chlorophenyl, anthracen-9-yl, etc.; R2 = Me, Ph, 4-methylphenyl, 4-chlorophenyl; R3 = Me, Ph, 4-methylphenyl) in acetic acid medium from the three-component reaction of 2-hydroxy-1,4-naphthoquinone, α, β-unsaturated aldehydes and 5-aminopyrazoles under the reflux conditions has been described. In this reaction, four new bonds (2 C-C, 1 C-N and 1 C-O) and two new rings (pyridine and pyran) were formed in one-pot. The novel products contain four bioactive moieties such as pyran, pyridine, pyrazole and α-naphthol. The salient features of this method are: one-pot process, short reaction time, easier purification, no need of column chromatog. and good yields of the products I. All the products I were characterized by IR, NMR and HRMS. Most of the synthesized compounds I were found highly fluorescent. Therefore, their photophys. properties were studied by UV-Visible and Fluorescence spectroscopy. Their quantum yields which were calculated and found in the range 0.243-0.424 in CHCl3 solution (c = 10-5 M) have been reported. Compound I (R1 = phenyl; R2 = phenyl; R3 = methyl) showed the highest quantum yield of 0.424.

ChemistrySelect published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, SDS of cas: 3893-18-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zeng, Liang; Fu, Hua; Qiao, Renzhong; Jiang, Yuyang; Zhao, Yufen published the artcile< Efficient copper-catalyzed synthesis of N-(alkyl)anthranilic acids via an ortho-substituent effect of the carboxyl group of 2-halobenzoic acids at room temperature>, Related Products of 16426-64-5, the main research area is anthranilic acid alkyl preparation copper iodide BINOL; Ullmann reaction amine halobenzoic acid amination copper BINOL.

A method for the synthesis of the title compounds [i.e., 2-(aminoalkyl)benzoic acid derivatives, N-(alkyl)anthranilic acids] is reported here. The protocol uses inexpensive copper iodide/racemic 1,1′-binaphthyl-2,2′-diol (racemic-BINOL) as catalyst/ligand system, readily available 2-halobenzoic acids and aliphatic amines as starting materials. The coupling reactions were performed at room temperature, and various functionalities in the substrates were tolerated.

Advanced Synthesis & Catalysis published new progress about Alicyclic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 16426-64-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrNO4, Related Products of 16426-64-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Anbardan, Soheil Zamani; Mokhtari, Javad; Yari, Ahmad; Bozcheloei, Abolfazl Hassani published the artcile< Direct synthesis of amides and imines by dehydrogenative homo or cross-coupling of amines and alcohols catalyzed by Cu-MOF>, Synthetic Route of 3959-07-7, the main research area is amine benzyl alc copper MOF catalyst dehydrogenative cross coupling; benzamide preparation green chem; benzyl amine copper MOF catalyst dehydrogenative homo coupling; benzylphenyl methanimine preparation green chem.

Oxidative dehydrogenative homo-coupling of amines to imines and cross-coupling of amines with alcs. to amides were achieved with high to moderate yields at room temperature in THF using Cu-MOF as an efficient and recyclable heterogeneous catalyst under mild conditions. Different primary benzyl amines and alcs. were utilized for the synthesis of a wide variety of amides and imines. The Cu-MOF catalyst was recycled and reused four times without loss of catalytic activity.

RSC Advances published new progress about Aralkyl alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Synthetic Route of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Mousseau, James J.; Vallee, Frederic; Lorion, Melanie M.; Charette, Andre B. published the artcile< Umpolung Direct Arylation Reactions: Facile Process Requiring Only Catalytic Palladium and Substoichiometric Amount of Silver Salts>, Computed Properties of 6942-39-8, the main research area is palladium catalyzed umpolung direct arylation aryl halide arene; biaryl preparation umpolung direct arylation palladium catalyst; aryl iodide bromide arene reactant palladium catalyzed direct arylation.

An umpolung direct arylation process is described. The reaction requires only a catalytic amount of Pd(OAc)2 and a substoichiometric amount of silver salts, without any external base or ligand to proceed. The directed oxidative insertion of the transition metal followed by the coupling into the C-H bond of an unactivated arene has surprisingly not yet been reported, despite the clear advantages in the ease of starting material synthesis. The reaction is regioselective with regards to the arene partner, and the role of the acetate and carbonate groups has been elucidated. This methodol. adds to the very few examples of benzene coupling without the inclusion of electron-withdrawing groups to increase acidity.

Journal of the American Chemical Society published new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent). 6942-39-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H6BrFO2, Computed Properties of 6942-39-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Borrajo-Calleja, Gustavo M.; Bizet, Vincent; Mazet, Clement published the artcile< Palladium-Catalyzed Enantioselective Intermolecular Carboetherification of Dihydrofurans>, Application of C7H7BrO2, the main research area is tetrahydrofurobenzofuran preparation enantioselective intermol carboetherification palladium catalyst; carboetherification in situ generated chiral bisphosphine mono oxide ligand.

A novel enantioselective Pd-catalyzed intermol. carboetherification of dihydrofurans is reported. The in situ generation of chiral bis-phosphine mono-oxide ligands is crucial, and a general catalytic system has been identified based on this approach. It provides access to a variety of fused tetrahydrofurobenzofurans in consistently high yield and enantiomeric excess.

Journal of the American Chemical Society published new progress about Benzofurans Role: SPN (Synthetic Preparation), PREP (Preparation) (furobenzofurans). 135999-16-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H7BrO2, Application of C7H7BrO2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Li, Xiang; Huang, Wei; Liu, Yan-Qing; Kang, Jing-Wen; Xia, Dan; He, Gu; Peng, Cheng; Han, Bo published the artcile< Control of Activation Mode To Achieve Diastereodivergence in Asymmetric Syntheses of Chiral Spiropiperidinone Derivatives>, Category: bromides-buliding-blocks, the main research area is crystal mol structure furanyl tosyl azaspiro decanedione; azaspiro decanedione preparation; spiropiperidinone preparation stereoselective Michael hemiaminalization cascade aldehyde cyclic ketoamide; stereoselective Michael hemiaminalization cascade unsaturated aldehyde cyclic ketoamide; HOMO LUMO activation stereoselective Michael hemiaminalization cascade aldehyde ketoamide.

An efficient organocatalytic cascade reaction has been developed involving a Michael-hemiaminalization relay for the asym. synthesis of spiropiperidinone derivatives bearing adjacent quaternary and tertiary chiral centers via LUMO or HOMO activation. Importantly, this methodol. demonstrates that applying distinct activation modes to different substrates in the same reaction can diverge diastereoselectivity. To our knowledge, this is also one of the few published cases of primary amine catalytic [3+3] cycloaddition reactions involving α-branched β-ketoamides.

Journal of Organic Chemistry published new progress about Amides, oxo Role: RCT (Reactant), RACT (Reactant or Reagent). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Category: bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Lawson, Edward C.; Luci, Diane K.; Ghosh, Shyamali; Kinney, William A.; Reynolds, Charles H.; Qi, Jenson; Smith, Charles E.; Wang, Yuanping; Minor, Lisa K.; Haertlein, Barbara J.; Parry, Tom J.; Damiano, Bruce P.; Maryanoff, Bruce E. published the artcile< Nonpeptide Urotensin-II Receptor Antagonists: A New Ligand Class Based on Piperazino-Phthalimide and Piperazino-Isoindolinone Subunits>, Recommanded Product: Methyl 3-bromo-2-(bromomethyl)benzoate, the main research area is urotensin receptor antagonist preparation structure activity piperazino phthalimide isoindolinone.

We have discovered two related chem. series of nonpeptide urotensin-II (U-II) receptor antagonists based on piperazino-phthalimide (5 and 6) and piperazino-isoindolinone (7) scaffolds. These structure types are distinctive from those of U-II receptor antagonist series reported in the literature. One of the antagonists exhibited single-digit nanomolar potency in rat and human cell-based functional assays, as well as strong binding to the human U-II receptor. In advanced pharmacol. testing, one of the antagonists blocked the effects of U-II in vitro in a rat aortic ring assay and in vivo in a rat ear-flush model. A discussion of U-II receptor antagonist pharmacophores is presented, and a specifically defined model is suggested from tricycle compound, which has a high degree of conformational constraint.

Journal of Medicinal Chemistry published new progress about Biological ion transport, calcium. 337536-14-8 belongs to class bromides-buliding-blocks, and the molecular formula is C9H8Br2O2, Recommanded Product: Methyl 3-bromo-2-(bromomethyl)benzoate.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Benzai, Amal; Shi, Xinzhe; Derridj, Fazia; Roisnel, Thierry; Doucet, Henri; Soule, Jean-Francois published the artcile< Late-Stage Diversification of Imidazole-Based Pharmaceuticals through Pd-Catalyzed Regioselective C-H Bond Arylations>, Category: bromides-buliding-blocks, the main research area is imidazole regioselective arylation aryl bromide palladium catalyst; Bifonazole regioselective arylation aryl bromide palladium catalyst; Climbazole regioselective arylation aryl bromide palladium catalyst; Ketoconazole regioselective arylation aryl bromide palladium catalyst.

Palladium-catalyzed C-H bond arylation of imidazoles has been applied to pharmaceuticals such as Bifonazole, Climbazole, and Ketoconazole. In the presence of phosphine-free Pd(OAc)2 catalyst, aryl bromides are efficiently coupled at the C5-position of the imidazole units, which are widely decorated. Under these conditions, only the C-H bond arylation reaction occurred without affecting the integrity of chem. structure of the imidazole-based pharmaceuticals. Moreover, with Bifonazole, Pd-catalyzed C-H bond diarylation at the C2- and C5-positions of imidazole unit has also been performed.

Journal of Organic Chemistry published new progress about Aryl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Category: bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Xu, Guowei; Yang, Yaqing; Yang, Yanming; Song, Gao; Li, Shanshan; Zhang, Jiajun; Yang, Weimin; Wang, Liang-Liang; Weng, Zhiying; Zuo, Zhili published the artcile< The discovery, design and synthesis of potent agonists of adenylyl cyclase type 2 by virtual screening combining biological evaluation>, Safety of 4-Bromoisobenzofuran-1,3-dione, the main research area is adenylate cyclase agonist virtual screening cyclic adenosine monophosphate IL6; Adenylate cyclase; Agonist; Cyclic adenosine monophosphate; Interleukin-6; Virtual screening.

Adenylate cyclases (ACs), play a critical role in the conversion of ATP (ATP) into the second messenger cyclic adenosine monophosphate (cAMP). Studies have indicated that adenylyl cyclase type 2 (AC2) is potential drug target for many diseases, however, up to now, there is no AC2-selective agonist reported. In this research, docking-based virtual screening with the combination of cell-based biol. assays have been performed for discovering novel potent and selective AC2 agonists. Virtual screening disclosed a novel hit compound 8 as an AC2 agonist with EC50 value of 8.10μM on recombinant human hAC2 + HEK293 cells. The SAR (structure activity relationship) based on the derivatives of compound 8 was further explored on recombinant AC2 cells and compound 73 was found to be the most active agonist with the EC50 of 90 nM, which is 160-fold more potent than the reported agonist Forskolin and could selectively activate AC2 to inhibit the expression of Interleukin-6. The discovery of a new class of AC2-selective agonists would provide a novel chem. probe to study the physiol. function of AC2.

European Journal of Medicinal Chemistry published new progress about Drug screening (docking-based virtual screening). 82-73-5 belongs to class bromides-buliding-blocks, and the molecular formula is C8H3BrO3, Safety of 4-Bromoisobenzofuran-1,3-dione.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary