Month: October 2022

Fouque, Amelie; Delalande, Olivier; Jean, Mickael; Castellano, Remy; Josselin, Emmanuelle; Malleter, Marine; Shoji, Kenji F.; Hung, Mac Dinh; Rampanarivo, Hariniaina; Collette, Yves; van de Weghe, Pierre; Legembre, Patrick published the artcile< Correction to A Novel Covalent mTOR Inhibitor, DHM25, Shows in Vivo Antitumor Activity against Triple-Negative Breast Cancer Cells [Erratum to document cited in CA163:325630]>, Category: bromides-buliding-blocks, the main research area is covalent mTOR inhibitor DHM25 antitumor breast cancer erratum.

The plots for T47-D cells in Figure 2A are incorrect; the corrected figure is provided here.

Journal of Medicinal Chemistry published new progress about Antitumor agents. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Category: bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Xie, Gaozhan; Brosius, Victor; Han, Jie; Rominger, Frank; Dreuw, Andreas; Freudenberg, Jan; Bunz, Uwe H. F. published the artcile< Stable Radical Cations of N,N'-Diarylated Dihydrodiazapentacenes>, Reference of 576-83-0, the main research area is diaryla dihydrodiazapentacene radical cation crystal structure UV EPR spectra; N,N′-diaryldiazapentacenes; oxidation; radical cation; single crystal structure.

A series of quinoidal N,N’-diaryldiaza-N,N’-dihydropentacenes (Quino) was prepared in a two-step reaction, starting from quinacridone. Oxidation of Quino furnishes stable radical cations, isoelectronic to the radical anions of the azaacenes, whereas the dicationic species are isoelectronic to neutral azapentacenes. The spectroscopic properties of the diaryldiazapentacenes and their oxidized mono- and dications are equivalent to that of the dianion of tetraazapentacene (TAP), its radical anion and the neutral TAP.

Chemistry – A European Journal published new progress about Aromaticity. 576-83-0 belongs to class bromides-buliding-blocks, and the molecular formula is C9H11Br, Reference of 576-83-0.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Xu, Miaomiao; Chen, Liang; Yan, Qiang published the artcile< Gas-Constructed Vesicles with Gas-Moldable Membrane Architectures>, SDS of cas: 576-83-0, the main research area is vesicle membrane carbon dioxide frustrated Lewis pair nanomaterial; carbon dioxide; frustrated Lewis pair; gas-bridged bond; nanomaterial; vesicle.

Integrating gas as a main building block into nanomaterial construction is a challenging mission that remains elusive. Herein, we report a gas-constructed vesicular system formed by CO2 gas and frustrated Lewis pairs (FLPs). Two mol. triads bearing three bulky borane and phosphine groups are designed as trivalent disk-like FLP monomers. CO2, as a gas cross-linker, can drive the two-dimensional polymerization of these two FLP monomers, leading to the generation of planar FLP networks that further transform into a thermodynamically favored membranous vesicle structure. Gas-guided vesicle formation is also applicable to other inert but FLP-activatable gases. Different gas linkages can form vesicles with distinct architectures, sizes, and morphologies. We envisage that this study would suggest a new concept that exploits gases to fabricate tunable nanomaterials.

Angewandte Chemie, International Edition published new progress about Electrospray ionization mass spectra. 576-83-0 belongs to class bromides-buliding-blocks, and the molecular formula is C9H11Br, SDS of cas: 576-83-0.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Miao, Shi-Xing; Wan, Lin-Xi; He, Zhen-Xiang; Zhou, Xian-Li; Li, Xiaohuan; Gao, Feng published the artcile< Pd-Catalyzed Direct Diversification of Natural Anti-Alzheimer's Disease Drug: Synthesis and Biological Evaluation of N-Aryl Huperzine A Analogues>, Computed Properties of 401-78-5, the main research area is aryl huperzine preparation anti Alzheimer activity acetylcholinesterase SAR chemoselective; huperzine aryl bromide Buchwald Hartwig coupling palladium catalyst.

The first systematic direct diversification of a complex natural product by metal-catalyzed N-H functionalization was carried out. A new series of N-(hetero)aryl analogs I (Ar = Ph, 2-naphthyl, 4-methylpyridin-2-yl, etc.) of the natural anti-Alzheimer’s disease drug huperzine A (HPA) was prepared via palladium-catalyzed Buchwald-Hartwig cross-coupling reactions of HPA with various aryl bromides ArBr in good yields. Most of the N-aryl-huperzine A (N-aryl-HPA) analogs showed good acetylcholinesterase (AChE) inhibitory activity in in vitro experiments Three arylated huperzine A analogs I (Ar = 4-FC6H4, 4-methoxy-2,6-dimethylphenyl, 5-methoxypyridin-2-yl) exhibited stronger anti-AChE activity than HPA. The 5-methoxy-2-pyridyl analog I (Ar = 5-methoxypyridin-2-yl) displayed the most potent AChE inhibition activity, with an IC50 value of 1.5μM, which was 7.6-fold more active than HPA. Compound I (Ar = 5-methoxypyridin-2-yl) also exhibited better neuroprotective activity for H2O2-induced damage in SH-SY5Y cells than HPA. Structure-activity relationship anal. suggested that the electron d. of the installed aromatic ring or heteroaromatic ring played a significant role in inducing the AChE inhibition activity. Overall, compound I (Ar = 5-methoxypyridin-2-yl) showed the advantages of easy synthesis, high potency and selectivity, and improved neuroprotection, making it a potential huperzine-type lead compound for Alzheimer’s disease drug development.

Journal of Natural Products published new progress about Alzheimer disease. 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Computed Properties of 401-78-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Ung, Sosthene P.-M.; Perepichka, Inna; Li, Chao-Jun published the artcile< Visible-Light Mediated Photooxidative Phosphorylation of Benzylamines: A Novel and Mild Pathway Towards α-Aminophosphorus Compounds>, COA of Formula: C7H8BrN, the main research area is benzylamine oxidative photochem phosphinylation preparation aminophosphine oxide; benzylidene benzylamine photochem generation addition preparation secondary aminophosphine oxide; iridium phenylpyridine bipyridine photocatalyst benzylamine oxidative preparation aminophosphine oxide.

Traditional syntheses of α-aminophosphorus therapeutic targets proceed through the hydrophosphorylation of C:N or C:O bonds, thus necessitating preliminary oxidized substrates. Cross-dehydrogenative coupling strategies can bypass this extra oxidation step by oxidizing simpler substrates in situ before phosphorylating them, but those protocols can suffer from the use of toxic stoichiometric oxidants. Photochem. strategies can access those oxidized intermediates without any harsh conditions and can use mol. oxygen as a benign and sustainable oxidant. We report herein a simple protocol using visible light, phosphinylidenes and benzylamine derivatives for the synthesis of α-aminophosphorus products under aerobic conditions and using an iridium photosensitizer.

Helvetica Chimica Acta published new progress about Aralkyl amines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (benzylamines). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, COA of Formula: C7H8BrN.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhou, Jie; Bie, Jianbo; Wang, Xiaoyu; Liu, Quan; Li, Rongcui; Chen, Hualong; Hu, Jinping; Cao, Hui; Ji, Wenming; Li, Yan; Liu, Shuainan; Shen, Zhufang; Xu, Bailing published the artcile< Discovery of N-Arylsulfonyl-Indole-2-Carboxamide Derivatives as Potent, Selective, and Orally Bioavailable Fructose-1,6-Bisphosphatase Inhibitors-Design, Synthesis, In Vivo Glucose Lowering Effects, and X-ray Crystal Complex Analysis>, Related Products of 89003-95-2, the main research area is T2MD liver FBPase inhibitors glucose lowering crystal structure binding.

Liver fructose-1,6-bisphosphatase (FBPase) is a key enzyme in the gluconeogenesis pathway. Inhibiting FBPase activity represents a potential treatment for type 2 diabetes mellitus. A series of novel N-arylsulfonyl-4-arylamino-indole-2-carboxamide derivatives have been disclosed as FBPase inhibitors. Through extensive structure-activity relationship investigations, a promising candidate mol. Cpd118 [sodium (7-chloro-4-((3-methoxyphenyl)amino)-1-methyl-1H-indole-2-carbonyl] [(4-methoxyphenyl)sulfonyl)amide](I) has been identified with high inhibitory activity against human liver FBPase (IC50, 0.029 ± 0.006 μM) and high selectivity relative to the other six AMP-binding enzymes. Importantly, Cpd118 produced significant glucose-lowering effects on both type 2 diabetic KKAy mice and ZDF rats as demonstrated by substantial reductions in the fasting and postprandial blood glucose levels, as well as the HbA1c level. Furthermore, Cpd118 elicited a favorable pharmacokinetic profile with an oral bioavailability of 99.1%. Moreover, the X-ray crystal structure of the Cpd118-FBPase complex was resolved, which revealed a unique binding mode and provided a structural basis for its high potency and selectivity.

Journal of Medicinal Chemistry published new progress about Bioavailability. 89003-95-2 belongs to class bromides-buliding-blocks, and the molecular formula is C8H4BrNO, Related Products of 89003-95-2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Li, Xuejing; Deng, Xingwang; Coyne, Anthony G.; Srinivasan, Rajavel published the artcile< meta-Nitration of Arenes Bearing ortho/para Directing Group(s) Using C-H Borylation>, Related Products of 401-78-5, the main research area is meta nitroarene regioselective preparation; arene borylation nitration tandem iridium catalyst copper; C−H borylation; copper catalysis; nitration; nitro(hetero)arenes; one-pot reactions.

The meta-nitration of arenes bearing ortho/para directing group(s) using the iridium-catalyzed C-H borylation reaction followed by a newly developed copper(II)-catalyzed transformation of the crude aryl pinacol boronate esters into the corresponding nitroarenes RNO2 [R = 4,5-di-ClC6H3, 3,4-di-BrC6H3, 5-Cl-3-pyridyl, etc.] in a one-pot fashion was reported. The reaction tolerated a wide array of ortho/para-directing groups, such as -F, -Cl, -Br, -CH3, -Et, -iPr -OCH3 and -OCF3. It also provided regioselective access to the nitro derivatives of π-electron-deficient heterocycles, such as pyridine and quinoline derivatives The application of this method was demonstrated in the late-stage modification of complex mols. and also in the gram-scale preparation of an intermediate en route to the FDA-approved drug Nilotinib. Finally, showed that the nitro product obtained by this strategy could also be directly converted to the aniline or hindered amine through Baran’s amination protocol.

Chemistry – A European Journal published new progress about Aromatic compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Related Products of 401-78-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Tang, Shibing; He, Jinmei; Sun, Yongquan; He, Liuer; She, Xuegong published the artcile< Efficient and Regioselective One-Pot Synthesis of 3-Substituted and 3,5-Disubstituted Isoxazoles>, Electric Literature of 3893-18-3, the main research area is isoxazole regioselective preparation; hydroxyl toluenesulfonamide unsaturated aldehyde ketone conjugate addition cyclization.

A series of 3-substituted and 3,5-disubstituted isoxazoles have been efficiently synthesized in moderate to excellent yields by the reaction of N-hydroxyl-4-toluenesulfonamide with α,β-unsaturated aldehydes/ketones. This novel strategy is associated with readily available starting materials, mild conditions, high regioselectivity, and wide scope.

Organic Letters published new progress about Conjugate addition reaction. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Electric Literature of 3893-18-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Fu, Zhenqian; Sun, Hui; Chen, Shaojin; Tiwari, Bhoopendra; Li, Guohui; Robin Chi, Yonggui published the artcile< Controlled β-protonation and [4+2] cycloaddition of enals and chalcones via N-heterocyclic carbene/acid catalysis: toward substrate independent reaction control>, Recommanded Product: 3-(4-Bromophenyl)acrylaldehyde, the main research area is enol lactone preparation enal chalcone cycloaddition NHC catalyst.

A substrate-independent selective generation of enolates over homoenolate equivalent in NHC-catalyzed reactions of enals and chalcones is disclosed. Acid co-catalysts play vital roles in control of the reaction pathways, allowing for individual access to diverse products from identical substrates.

Chemical Communications (Cambridge, United Kingdom) published new progress about [4+2] Cycloaddition reaction. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Recommanded Product: 3-(4-Bromophenyl)acrylaldehyde.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Shen, Cong; Zhu, Yuhang; Jin, Shuqi; Xu, Kejie; Luo, Shuxin; Xu, Lixia; Zhong, Guofu; Zhong, Liangjun; Zhang, Jian published the artcile< Regio- and stereo-selective olefinic C-H functionalization of aryl alkenes in ethanol>, Recommanded Product: Methyl 2-bromo-4-methoxybenzoate, the main research area is aryl alkene palladium catalyst regioselective diastereoselective alkenylation; preparation aryl alkadiene; phenyl alkatriene preparation.

N,N-bidentate-chelation-assisted α- and β-olefinic C-H alkenylation of aryl alkenes in ethanol to afford aryl dienes/trienes with excellent regio- and stereo-selectivities was reported. The reaction of 2-alkenyl benzylamine and benzoic acid derived substrates proceeded through six-membered exo-cyclometallation and seven-membered endo-cyclometallation. The aerobic protocols feature wide functionality tolerance, high selectivities and yields, mild conditions and scalable preparation, and the directing group can be easily removed to afford Boc-protected amine by simple reduction

Organic Chemistry Frontiers published new progress about Alkadienes Role: SPN (Synthetic Preparation), PREP (Preparation). 17100-65-1 belongs to class bromides-buliding-blocks, and the molecular formula is C9H9BrO3, Recommanded Product: Methyl 2-bromo-4-methoxybenzoate.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary