Month: October 2022

Waterford, Matthew; Saubern, Simon; Hornung, Christian H. published their research in Australian Journal of Chemistry in 2021. The article was titled 《Evaluation of a Continuous-Flow Photo-Bromination Using N-Bromosuccinimide for Use in Chemical Manufacture》.SDS of cas: 2635-13-4 The article contains the following contents:

A continuous-flow photo-bromination reaction on benzyl and Ph groups was conducted using N-bromosuccinimide as the bromine source inside a preparatory-scale glass plate reactor. This flow reactor system was capable of independently controlling light intensity, wavelength, and reaction temperature, hence exerting an exceptional level of control over the reaction. A short optimization study for the synthesis of 2-bromomethyl-4-trifluoromethoxyphenylboronic acid pinacol ester resulted in best conditions of 20° and 10 min residence time using an LED (light-emitting diode) array at 405 nm and acetonitrile as the solvent. The present study evaluates the potential for this easy-to-handle bromination system to be scaled up for chem. manufacture inside a continuous-flow glass plate reactor. The combination with an in-line continuous flow liquid-liquid extraction and separation system, using a membrane separator, demonstrates the potential for continuous flow reaction with purification in an integrated multi-stage operation with minimal manual handling in between. After reading the article, we found that the author used 5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4SDS of cas: 2635-13-4)

Furthermore, the coupling of 5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4) with β-methallyl alcohol was catalyzed by Pd(OAc)2 in combination with P(t-Bu)3.SDS of cas: 2635-13-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Tropmann, Katharina; Bresinsky, Merlin; Forster, Lisa; Moennich, Denise; Buschauer, Armin; Wittmann, Hans-Joachim; Huebner, Harald; Gmeiner, Peter; Pockes, Steffen; Strasser, Andrea published their research in Journal of Medicinal Chemistry in 2021. The article was titled 《Abolishing Dopamine D2long/D3 Receptor Affinity of Subtype-Selective Carbamoylguanidine-Type Histamine H2 Receptor Agonists》.Formula: C4H7BrO2 The article contains the following contents:

3-(2-Amino-4-methylthiazol-5-yl)propyl-substituted carbamoylguanidines are potent, subtype-selective histamine H2 receptor (H2R) agonists, but their applicability as pharmacol. tools to elucidate the largely unknown H2R functions in the central nervous system (CNS) is compromised by their concomitant high affinity toward dopamine D2-like receptors (especially to the D3R). To improve the selectivity, a series of novel carbamoylguanidine-type ligands containing various heterocycles, spacers, and side residues were rationally designed, synthesized, and tested in binding and/or functional assays at H1-4 and D2long/3 receptors. This study revealed a couple of selective candidates (among others 31 and 47), and the most promising ones were screened at several off-target receptors, showing good selectivities. Docking studies suggest that the amino acid residues (3.28, 3.32, E2.49, E2.51, 5.42, and 7.35) are responsible for the different affinities at the H2- and D2long/3-receptors. These results provide a solid base for the exploration of the H2R functions in the brain in further studies. In the experiment, the researchers used 4-Bromobutanoic acid(cas: 2623-87-2Formula: C4H7BrO2)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Formula: C4H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wang, Ya-Hao; Yan, Feng; Li, Dong-Fang; Xi, Yan-Feng; Cao, Rui; Zheng, Ju-Fang; Shao, Yong; Jin, Shan; Chen, Jing-Zhe; Zhou, Xiao-Shun published their research in Journal of Physical Chemistry Letters in 2021. The article was titled 《Enhanced gating performance of single-molecule conductance by heterocyclic molecules》.Safety of 2,5-Dibromothiophene The article contains the following contents:

Enhancing the gating performance of single-mol. conductance is significant for realizing mol. transistors. Herein, we report a new strategy to improve the electrochem. gating efficiency of single-mol. conductance with fused mol. structures consisting of heterocyclic rings of furan, thiophene, or selenophene. One order magnitude of gating ratio is achieved within a potential window of 1.2 V for the selenophene-based mol., which is significantly greater than that of other heterocyclic and benzene ring mols. This is caused by the different electronic structures of heterocyclic mols. and transmission coefficients T(E), and preliminary resonance tunneling is achieved through the HOMO at high potential. The current work exptl. shows that electrochem. gating performance can be significantly modulated by the alignment of the conducting orbital of the heterocyclic mol. relative to the metal Fermi energy. In the experimental materials used by the author, we found 2,5-Dibromothiophene(cas: 3141-27-3Safety of 2,5-Dibromothiophene)

2,5-Dibromothiophene(cas: 3141-27-3) , is mainly used as pharmaceutical intermediate and synthesis intermediate. 2,5-Dibromothiophene may be used as starting reagent for the synthesis of α,α′-didecylquater-, -quinque- and -sexi-thiophenes.Safety of 2,5-Dibromothiophene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Xu, Linli; Sun, Jibin; Tang, Tianhong; Zhang, Hongyang; Sun, Mingzi; Zhang, Jianqi; Li, Jiahua; Huang, Bolong; Wang, Zhengping; Xie, Zheng; Wong, Wai-Yeung published an article in 2021. The article was titled 《Metallated Graphynes as a New Class of Photofunctional 2D Organometallic Nanosheets》, and you may find the article in Angewandte Chemie, International Edition.Related Products of 4316-58-9 The information in the text is summarized as follows:

Two-dimensional (2D) nanomaterials are attracting much attention due to their excellent electronic and optical properties. Here, we report the first exptl. preparation of two free-standing mercurated graphyne nanosheets via the interface-assisted bottom-up method, which integrates both the advantages of metal center and graphyne. The continuous large-area nanosheets derived from the chem. growth show the layered mol. structural arrangement, controllable thickness and enhanced π-conjugation, which result in their stable and outstanding broadband nonlinear saturable absorption (SA) properties (at both 532 and 1064 nm). The passively Q-switched (PQS) performances of these two nanosheets as the saturable absorbers are comparable to or higher than those of the state-of-the-art 2D nanomaterials (such as graphene, black phosphorus, MoS2, γ-graphyne, etc.). Our results illustrate that the two metalated graphynes could act not only as a new class of 2D carbon-rich materials, but also as inexpensive and easily available optoelectronic materials for device fabrication. In the experiment, the researchers used Tris(4-bromophenyl)amine(cas: 4316-58-9Related Products of 4316-58-9)

In other references, Tris(4-bromophenyl)amine(cas: 4316-58-9) is often used in the synthesis of porous luminescent covalent–organic polymers (COPs)Related Products of 4316-58-9

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhang, Qingyang; Barrett, Brandon; Lee, Taein; Mukhopadhyaya, Tushita; Lu, Chengchangfeng; Plunkett, Evan C.; Kale, Tejaswini; Chi, Chen; Livi, Kenneth J. T.; McGuiggan, Patricia; Reich, Daniel H.; Thon, Susanna; Bragg, Arthur E.; Katz, Howard E. published an article in 2021. The article was titled 《Maximized Hole Trapping in a Polystyrene Transistor Dielectric from a Highly Branched Iminobis(aminoarene) Side Chain》, and you may find the article in ACS Applied Materials & Interfaces.Computed Properties of C9H11BrO3 The information in the text is summarized as follows:

We synthesized highly branched and electron-donating side chain subunits and attached them to polystyrene (PS) used as a dielec. layer in a pentacene field-effect transistor. The influence of these groups on dielec. function, charge retention, and threshold voltage shifts (ΔVth) depending on their positions in dielec. multilayers was determined We compared the observations made on an N-perphenylated iminobisaniline side chain with those from the same side chains modified with ZnO nanoparticles and with an adduct formed from tetracyanoethylene (TCNE). We also synthesized an analog in which six methoxy groups are present instead of two amine nitrogens. At 6 mol % side chain, hopping transport was sufficient to cause shorting of the gate, while at 2 mol %, charge trapping was observable as transistor threshold voltage shifts (ΔVth). We created three types of devices: with the substituted PS layer as single-layer dielec., on top of a cross-linked PS layer but in contact with the pentacene (bilayers), and sandwiched between two PS layers in trilayers. Especially large bias stress effects and ΔVth, larger than those in the case of the hexamethoxy and previously studied dimethoxy analogs, were observed in the second case, and the effects increased with the increasing electron-donating properties of the modified side chains. The highest ΔVth was consistent with a majority of the side chains stabilizing the trapped charge. Trilayer devices showed decreased charge storage capability compared to previous work in which we used less donating side chains but in higher concentrations The ZnO and TCNE modifications resulted in slightly more and less neg. ΔVth, resp., when the side chain polystyrene was not in contact with the pentacene and isolated from the gate electrode. The results indicate a likely maximum combination of mol. charge stabilizing activity and side chain concentration that still allows gate dielec. function. The experimental part of the paper was very detailed, including the reaction process of 1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8Computed Properties of C9H11BrO3)

1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.Computed Properties of C9H11BrO31-Bromo-3,4,5-trimethoxybenzene can be used to synthesize analogs of HA14-1, which shows promising anticancer properties.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Shyam, Radhe; Forestier, Christiane; Charbonnel, Nicolas; Roy, Olivier; Taillefumier, Claude; Faure, Sophie published an article in 2021. The article was titled 《Solution-phase synthesis of backbone-constrained cationic peptoid hexamers with antibacterial and anti-biofilm activities》, and you may find the article in European Journal of Organic Chemistry.SDS of cas: 5437-45-6 The information in the text is summarized as follows:

Submonomer synthesis in solution and block-coupling protocols were combined to prepare amphiphilic peptoid hexamers. The amphipathic character arises from the use of hydrophobic aliphatic tert-Bu side-chains imposing the cis-amide backbone conformation and various cationic side-chains periodically introduced each three residues. Evaluation of the effect on Gram-pos. and Gram-neg. bacterial strains as well as the capacity to impair biofilm formation and the toxicity of one selected compound allowed to highlight the potential of a short constrained peptoid carrying triazolium-type cationic pendant groups. In addition to this study using Benzyl 2-bromoacetate, there are many other studies that have used Benzyl 2-bromoacetate(cas: 5437-45-6SDS of cas: 5437-45-6) was used in this study.

Benzyl 2-bromoacetate(cas: 5437-45-6) has been used in the alkylation of (-)-2,3-O-isopropylidene-D-threitol that afforded lipopeptide, 2-[(4R,5R)-5-({[(9H-fluoren-9-yl)methoxy]carbonylaminomethyl}-2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]acetic acid.SDS of cas: 5437-45-6

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Tsukamoto, Takamasa; Imaoka, Takane; Yamamoto, Kimihisa published an article in 2021. The article was titled 《Unique Functions and Applications of Rigid Dendrimers Featuring Radial Aromatic Chains》, and you may find the article in Accounts of Chemical Research.Electric Literature of Br3In The information in the text is summarized as follows:

Conspectus: Dendrimers, which are highly branched polymers and regarded as huge single mols., are interesting substances from the aspect of not only polymer chem. but also mol. chem. Various applications in material science and life science have been investigated by taking advantage of the radially layered structures and intramol. nanospaces of dendrimers. Most dendrimers have flexible structures that originate from their organic chains which contain many sp3-type atoms, while relatively rigid dendrimers composed only of sp2-type atoms have rarely been reported. It has been recently clarified that such rigid dendrimers exhibit a specific aromatic property not found in other materials. Dendritic phenylazomethines (DPAs), as one of the rigid dendrimers, have only sp2-type C and N atoms and possess a radially branched π-conjugation system in their own macromol. chains. Such geometric and electronic structures heighten the electron d. at the core of the dendrimer and induce an intramol. potential gradient, which affords unique reactivities that lead to extraordinary functions. This unique property of the rigid dendrimers can be regarded as a new atypical electronic state based on radial aromatic chains not found in conventional aromatic compounds containing spherical aromaticity, Mobius aromaticity, metal aromaticity, and conductive polymers. Therefore, this as-yet-unknown characteristic is expected to contribute to the further development of fundamental and materials chem. In this Account, we highlight the rigid DPA dendrimers and their peculiar atomically precise and selective assembly behaviors that originate from the radial aromatic chains. One of the most noteworthy attainments based on the radial aromatic chains is the precise synthesis of a multimetallic multinuclear complex of a dendrimer containing a total of 13 elements. Next, we describe the electrochem. and catalytic functionalization of such multinuclear dendrimer complexes and the construction of supramol. nanoarchitectures by the polymerization of DPAs. These complexes exhibit encapsulation-release switching of guests and additive-free catalytic ability similar to proteins and enzymes. Such selective and accurate control of the intramol. assembly of guests and the intermol. arrangement of hosts realized by the radial aromatic chains of dendrimers will enable supramol. chem. and biochem. to be linked from a new aspect. In addition, the multimetallic multinuclear complexes of dendrimers afford a novel approach to precisely synthesize subnanoparticles with ultrasmall particle sizes (1 nm) that have been tech. difficult to obtain by conventional nanotechnol. We discuss the method for the synthesis of these subnanoparticles with well-controlled atomicity and composition using DPA complexes as a template, and recent advances to reveal their specific phys. and chem. properties. These results suggest that the unique electronic states induced in such radial aromatics could play an important role in the development of next-generation chem. In addition to this study using Indium(III) bromide, there are many other studies that have used Indium(III) bromide(cas: 13465-09-3Electric Literature of Br3In) was used in this study.

Indium(III) bromide(cas: 13465-09-3) is used in organic synthesis as a water tolerant Lewis acid. It efficiently catalyzes the three-component coupling of β-keto esters, aldehydes and urea (or thiourea) to afford the corresponding dihydropyrimidinones.Electric Literature of Br3In

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Mandal, Tanumoy; Azim, Aznur; Das, Sanju; De Sarkar, Suman published an article in 2022. The article was titled 《Organophotoredox Catalyzed Stereoselective Nitration of Olefins with tert-Butyl Nitrite under Air》, and you may find the article in Asian Journal of Organic Chemistry.Application In Synthesis of Ethyltriphenylphosphonium bromide The information in the text is summarized as follows:

An efficient method for the E-selective synthesis of nitroolefins was developed by employing DDQ as the organophotoredox catalyst in combination with tert-BuONO (TBN) as a nitrating agent under visible-light irradiation This green transition metal-free approach utilizes aerial oxygen as the terminal oxidant and occurs at room temperature Following the established protocol, 41 different olefines containing broad diversity of substituents were nitrated in good to excellent yields. Mechanistic experiments and photophys. studies revealed the probable mechanism. In the experiment, the researchers used Ethyltriphenylphosphonium bromide(cas: 1530-32-1Application In Synthesis of Ethyltriphenylphosphonium bromide)

Ethyltriphenylphosphonium bromide(cas: 1530-32-1) is a phase transfer catalyst, used to accelerate the cure of phenolic-based epoxy resins, certain fluoroelastomer resins and thermosetting powder coatings. It is also used as catalysts in the synthesis of certain organic compounds and as a pharmaceutical intermediate.Application In Synthesis of Ethyltriphenylphosphonium bromide

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhao, Lei; Zhu, Yuqin; Liu, Mengyuan; Xie, Leipeng; Liang, Jimin; Shi, Haoran; Meng, Xiao; Chen, Zhengyang; Han, Jian; Wang, Chao published an article in 2022. The article was titled 《Ligand-Controlled NiH-Catalyzed Regiodivergent Chain-Walking Hydroalkylation of Alkenes》, and you may find the article in Angewandte Chemie, International Edition.Computed Properties of C4H7Br The information in the text is summarized as follows:

A NiH-catalyzed migratory hydroalkylation of alkenyl amines with predictable and switchable regioselectivity is reported. By utilizing a ligand-controlled, directing group-assisted strategy, various alkyl units are site-selectively installed at inert sp3 C-H sites far away from the original C=C bonds. A range of structurally diverse α- and β-branched protected amines are conveniently synthesized via stabilization of 5- and 6-membered nickelacycles resp. This method exhibits broad scope and high functional group tolerance, and can be applied to late-stage modification of medicinally relevant mols. In the experiment, the researchers used (Bromomethyl)cyclopropane(cas: 7051-34-5Computed Properties of C4H7Br)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Computed Properties of C4H7Br

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Schafer, Thomas C.; Becker, Jonathan; Seuffert, Marcel T.; Heuler, Dominik; Sedykh, Alexander E.; Mueller-Buschbaum, Klaus published an article in 2022. The article was titled 《Iodine-Chemisorption, Interpenetration and Polycatenation: Cationic MOFs and CPs from Group 13 Metal Halides and Di-Pyridyl-Linkers》, and you may find the article in Chemistry – A European Journal.Category: bromides-buliding-blocks The information in the text is summarized as follows:

Eight cationic, two-dimensional metal-organic frameworks (MOFs) were synthesized in reactions of the group 13 metal halides AlBr3, AlI3, GaBr3, InBr3 and InI3 with the dipyridyl ligands 1,2-di(4-pyridyl)ethylene (bpe), 1,2-di(4-pyridyl)ethane (bpa) and 4,4′-bipyridine (bipy). Seven of them follow the general formula 2∞[MX2(L)2]A, M = Al, In, X = Br, I, A-=[MX4]-, I-, I3-, L = bipy, bpa, bpe. Thereby, the porosity of the cationic frameworks can be used to take up the heavy mol. iodine in gas-phase chemisorption vital for the capture of iodine radioisotopes. This is achieved by switching between I- and the polyiodide I3- in the cavities at room temperature, including single-crystal-to-single-crystal transformation. The MOFs are 2-dimensional networks that exhibit (4,4)-topol. in general or (6,3)-topol. for 2∞[(GaBr2)2(bpa)5][GaBr4]2·bpa. The two-dimensional networks can either be arranged to an inclined interpenetration of the cationic two-dimensional networks, or to stacked networks without interpenetration. Interpenetration is accompanied by polycatenation. Due to the cationic character, the MOFs require the counterions [MX4]-, I- or I3- counterions in their pores. Whereas the [MX4]-, ions are immobile, iodide allows for chemisorption. Also, eight addnl. coordination polymers and complexes were identified and isolated that elaborate the reaction space of the herein reported syntheses. In the part of experimental materials, we found many familiar compounds, such as Indium(III) bromide(cas: 13465-09-3Category: bromides-buliding-blocks)

Indium(III) bromide(cas: 13465-09-3) is used in organic synthesis as a water tolerant Lewis acid. It efficiently catalyzes the three-component coupling of β-keto esters, aldehydes and urea (or thiourea) to afford the corresponding dihydropyrimidinones.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary