Month: October 2022

《Cytotoxicity of Mn-based photoCORMs of ethynyl-α-diimine ligands against different cancer cell lines: The key role of CO-depleted metal fragments》 was written by Rossier, Jeremie; Delasoie, Joachim; Haeni, Laetitia; Hauser, Daniel; Rothen-Rutishauser, Barbara; Zobi, Fabio. Recommanded Product: Bromopentacarbonylmanganese(I) And the article was included in Journal of Inorganic Biochemistry in 2020. The article conveys some information:

A series of tricarbonyl manganese complexes bearing 4-ethynyl-2,2′-bipyridine and 5-ethynyl-1,10-phenanthroline α-diimine ligands were synthesized, characterized and conjugated to vitamin B12, previously used as a vector for drug delivery, to take advantage of its water solubility and specificity toward cancer cells. The compounds act as photoactivatable carbon monoxide-releasing mols. rapidly liberating on average ca. 2.3 equiv of CO upon photo-irradiation Complexes and conjugates were tested for their anticancer effects, both in the dark and following photo-activation, against breast cancer MCF-7, lung carcinoma A549 and colon adenocarcinoma HT29 cell lines as well as immortalized human bronchial epithelial cells 16HBE14o- as the non-carcinogenic control. Our results indicate that the light-induced cytotoxicity these mols. can be attributed to both their released CO and to their CO-depleted metal fragments including liberated ligands. In the experiment, the researchers used many compounds, for example, Bromopentacarbonylmanganese(I)(cas: 14516-54-2Recommanded Product: Bromopentacarbonylmanganese(I))

Bromopentacarbonylmanganese(I)(cas: 14516-54-2) has many other uses. It is used in the formation of (eta6-arene)tricarbonylmanganese(I) by reacting with arene (arene= hexamethyl benzene, 1,2,4,5-tetramethyl benzene, mesitylene, p-xylene and toluene) in the presence silver salt.Recommanded Product: Bromopentacarbonylmanganese(I)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Fabrication of a Hydrogen-Bonded Organic Framework Membrane through Solution Processing for Pressure-Regulated Gas Separation》 was written by Feng, Shou; Shang, Yanxue; Wang, Zhikun; Kang, Zixi; Wang, Rongming; Jiang, Jianzhuang; Fan, Lili; Fan, Weidong; Liu, Zhanning; Kong, Guodong; Feng, Yang; Hu, Songqing; Guo, Hailing; Sun, Daofeng. Application In Synthesis of Tris(4-bromophenyl)amine And the article was included in Angewandte Chemie, International Edition in 2020. The article conveys some information:

Ordered and flexible porous frameworks with solution processability are highly desirable to fabricate continuous and large-scale membranes for the efficient gas separation Herein, the first microporous hydrogen-bonded organic framework (HOF) membrane has been fabricated by an optimized solution-processing technique. The framework exhibits the superior stability because of the abundant hydrogen bonds and strong π-π interactions. Thanks to the flexible HOF structure, the membrane possesses the unprecedented pressure-responsive H2/N2 separation performance. Furthermore, the scratched membrane can be healed by the treatment of solvent vapor, achieving the recovery of separation performance. In addition to this study using Tris(4-bromophenyl)amine, there are many other studies that have used Tris(4-bromophenyl)amine(cas: 4316-58-9Application In Synthesis of Tris(4-bromophenyl)amine) was used in this study.

In other references, Tris(4-bromophenyl)amine(cas: 4316-58-9) is often used in the synthesis of porous luminescent covalent–organic polymers (COPs)Application In Synthesis of Tris(4-bromophenyl)amine

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《A Green-Emission Metal-Organic Framework-Based Nanoprobe for Imaging Dual Tumor Biomarkers in Living Cells》 was written by Kong, Xiang-Jing; Ji, Xiaoting; He, Tao; Xie, Lin-Hua; Zhang, Yong-Zheng; Lv, Haoyuan; Ding, Caifeng; Li, Jian-Rong. Safety of 3,6-Dibromo-9H-carbazole And the article was included in ACS Applied Materials & Interfaces in 2020. The article conveys some information:

The modular nature of metal-organic frameworks (MOFs) permits their tunable structure and function for target application, such as in biomedicine. Herein, a green-emission Zr(IV)-MOF (BUT-88) was constructed from a customized luminescent carbazolyl ligand. BUT-88 represents the first bcu-type MOF with both organic linker and metal node in eight connections and shows medium-sized pores, rich accessible linking sites, and good water stability and biocompatibility. In virtue of these merits, BUT-88 was then fabricated into a MOF-based fluorescent nanoprobe, drDNA-BUT-88. Using it, the live-cell imaging of dual tumor biomarkers was achieved for the first time upon a MOF-based probe, offering enhanced detection precision in early cancer diagnosis. Particularly, the probe showed efficient ratiometric fluorescent sensing toward the cytoplasmic biomarker microRNA-21, further improving the detection accuracy at the cellular level. The elaborate combination of MOF engineering and the fluorescent detection technique has contributed a facile biosensing platform, unlocking more possibilities of MOF chem. The results came from multiple reactions, including the reaction of 3,6-Dibromo-9H-carbazole(cas: 6825-20-3Safety of 3,6-Dibromo-9H-carbazole)

3,6-Dibromo-9H-carbazole(cas: 6825-20-3) is used as a pharmaceutical intermediate, and also an important intermediate of synthesizing optoelectronic materials. It has been used as a reagent in the synthesis of P7C3-A20 which is a potent neuroprotective agent.Safety of 3,6-Dibromo-9H-carbazole

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Metal-Templated, Tight Loop Conformation of a Cys-X-Cys Biomimetic Assembles a Dimanganese Complex》 was written by Le, Trung; Nguyen, Hao; Perez, Lisa M.; Darensbourg, Donald J.; Darensbourg, Marcetta Y.. Computed Properties of C5BrMnO5 And the article was included in Angewandte Chemie, International Edition in 2020. The article conveys some information:

With the goal of generating anionic analogs to MN2S2·Mn(CO)3Br the authors introduced metallodithiolate ligands, MN2S22- prepared from the Cys-X-Cys biomimetic, ema4- ligand (ema = N,N’-ethylenebis(mercaptoacetamide); M = NiII, [VIV O]2+ and FeIII) to Mn(CO)5Br. An unexpected, remarkably stable dimanganese product, (H2N2(CH2C:O(μ-S))2)[Mn(CO)3]2 resulted from loss of M originally residing in the N2S24- pocket, replaced by protonation at the amido nitrogens, generating H2ema2-. Accordingly, the ema ligand has switched its coordination mode from an N2S24- cavity holding a single metal, to a binucleating H2ema2- with bridging sulfurs and carboxamide oxygens within Mn-μ-S-CH2-C-O, 5-membered rings. In situ metal-templating by zinc ions gives quant. yields of the Mn2 product. By computational studies the authors compared the conformations of “”linear”” ema4- to ema4- frozen in the “”tight-loop”” around single metals, and to the “”looser”” fold possible for H2ema2- that is the optimal arrangement for binucleation. XRD mol. structures show extensive H-bonding at the amido-nitrogen protons in the solid state. In addition to this study using Bromopentacarbonylmanganese(I), there are many other studies that have used Bromopentacarbonylmanganese(I)(cas: 14516-54-2Computed Properties of C5BrMnO5) was used in this study.

Bromopentacarbonylmanganese(I)(cas: 14516-54-2) has many other uses. It is used in the formation of (eta6-arene)tricarbonylmanganese(I) by reacting with arene (arene= hexamethyl benzene, 1,2,4,5-tetramethyl benzene, mesitylene, p-xylene and toluene) in the presence silver salt.Computed Properties of C5BrMnO5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Membrane-Anchoring Photosensitizer with Aggregation-Induced Emission Characteristics for Combating Multidrug-Resistant Bacteria》 was written by Chen, Huan; Li, Shengliang; Wu, Min; Kenry; Huang, Zhongming; Lee, Chun-Sing; Liu, Bin. Recommanded Product: 1-Bromo-3,4,5-trimethoxybenzene And the article was included in Angewandte Chemie, International Edition in 2020. The article conveys some information:

Traditional photosensitizers (PSs) show reduced singlet oxygen (1O2) production and quenched fluorescence upon aggregation in aqueous media, which greatly affect their efficiency in photodynamic therapy (PDT). Meanwhile, non-targeting PSs generally yield low efficiency in antibacterial performance due to their short lifetimes and small effective working radii. Herein, a water-dispersible membrane anchor (TBD-anchor) PS with aggregation-induced emission is designed and synthesized to generate 1O2 on the bacterial membrane. TBD-anchor showed efficient antibacterial performance towards both Gram-neg. (Escherichia coli) and Gram-pos. bacteria (Staphylococcus aureus). Over 99.8% killing efficiency was obtained for methicillin-resistant S. aureus (MRSA) when they were exposed to 0.8μm of TBD-anchor at a low white light dose (25 mW cm-2) for 10 min. TBD-anchor thus shows great promise as an effective antimicrobial agent to combat the menace of multidrug-resistant bacteria. In the experiment, the researchers used 1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8Recommanded Product: 1-Bromo-3,4,5-trimethoxybenzene)

1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.Recommanded Product: 1-Bromo-3,4,5-trimethoxybenzene1-Bromo-3,4,5-trimethoxybenzene can be used to synthesize analogs of HA14-1, which shows promising anticancer properties.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Sheng, Jie; Ni, Hui-Qi; Ni, Shan-Xiu; He, Yan; Cui, Ru; Liao, Guang-Xu; Bian, Kang-Jie; Wu, Bing-Bing; Wang, Xi-Sheng published their research in Angewandte Chemie, International Edition in 2021. The article was titled 《Diversity-Oriented Synthesis of Aliphatic Fluorides via Reductive C(sp3)-C(sp3) Cross-Coupling Fluoroalkylation》.Application In Synthesis of 4-Bromobutanoic acid The article contains the following contents:

A direct nickel-catalyzed monofluoromethylation of unactivated alkyl halides e.g., (3-bromopropyl)benzene using a low-cost industrial raw material, bromofluoromethane, by demonstrating a general and efficient reductive cross-coupling of two alkyl halides e.g., (3-bromopropyl)benzene and e.g., (2-bromo-2-fluoroethyl)benzene was described. Results with 1-bromo-1-fluoroalkane also demonstrate the viability of monofluoroalkylation, which further established the first example of reductive C(sp3)-C(sp3) cross-coupling fluoroalkylation. These transformations demonstrate high efficiency, mild conditions, and excellent functional-group compatibility, especially for a range of pharmaceuticals and biol. active compounds Mechanistic studies support a radical pathway. Kinetic studies reveal that the reaction is first-order dependent on catalyst and alkyl bromide whereas the generation of monofluoroalkyl radical is not involved in the rate-determining step. This strategy provides a general and efficient method for the synthesis of aliphatic fluorides e.g, (4-fluorobutyl)benzene. In addition to this study using 4-Bromobutanoic acid, there are many other studies that have used 4-Bromobutanoic acid(cas: 2623-87-2Application In Synthesis of 4-Bromobutanoic acid) was used in this study.

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Application In Synthesis of 4-Bromobutanoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Luo, Guoshun; Lin, Xin; Ren, Shengnan; Wu, Shuangjie; Wang, Xin; Ma, Luyu; Xiang, Hua published their research in European Journal of Medicinal Chemistry in 2021. The article was titled 《Development of novel tetrahydroisoquinoline-hydroxamate conjugates as potent dual SERDs/HDAC inhibitors for the treatment of breast cancer》.Category: bromides-buliding-blocks The article contains the following contents:

Concomitant inhibition of estrogen receptor alpha (ERα) and histone deacetylase (HDAC) signaling has been proven effective in endocrine-resistant ER+ breast cancers. Herein, a series of tetrahydroisoquinoline (THIQ)-hydroxamate conjugates were rationally designed and synthesized as dual SERDs/HDAC inhibitors by incorporating the hydroxamate, a known HDAC pharmacophore, into a privileged THIQ scaffold of selective ERα degraders (SERDs). Some of these THIQ-hydroxamate conjugates displayed remarkable HDAC6 inhibition and improved antiproliferative activity against MCF-7 cells. Particularly, the most potent HDAC inhibitor 19k also exhibits potent ERα binding affinity, good ERα degradation efficacy and the best antiproliferative activity. Besides, 19k displayed superior antitumor efficacy than the drug combination (Fulvestrant + SAHA) through promoting ERα degradation and histone acetylation in an MCF-7 xenograft model, without causing observable toxicity. Collectively, this study validates the therapeutic potential of a dual-acting compound with potent ERα degradation efficacy and HDAC6 inhibition in breast cancer. In the part of experimental materials, we found many familiar compounds, such as Ethyl 3-bromopropanoate(cas: 539-74-2Category: bromides-buliding-blocks)

Ethyl 3-bromopropanoate(cas: 539-74-2) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides. Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Baalbaki, Hassan A.; Roshandel, Hootan; Hein, Jason E.; Mehrkhodavandi, Parisa published their research in Catalysis Science & Technology in 2021. The article was titled 《Conversion of dilute CO2 to cyclic carbonates at sub-atmospheric pressures by a simple indium catalyst》.Related Products of 13465-09-3 The article contains the following contents:

The transformation of CO2 to value added commodity chems. presents an impactful strategy to obtain products that are less dependent on fossil fuels. In this study, indium tribromide (InBr3) mixed with tetrabutylammonium bromide (NBu4Br) co-catalyst has been identified as a simple, highly efficient catalyst for the synthesis of cyclic carbonates from epoxides and CO2 at sub-atm. pressures, room temperature, and under solvent-free conditions. The InBr3/NBu4Br catalytic system is tolerant toward different functional groups with high conversions and >99% selectivity for cyclic carbonate without resorting to high pressures and temperatures Moreover, a combination of in situ IR, NMR spectroscopy, and substrate labeling experiments enabled the proof of key catalytic steps and detection of reaction intermediates to elucidate the reaction mechanism. This technol. represents a potential scalable system for the utilization of waste CO2. After reading the article, we found that the author used Indium(III) bromide(cas: 13465-09-3Related Products of 13465-09-3)

Indium(III) bromide(cas: 13465-09-3) is used in organic synthesis as a water tolerant Lewis acid. It efficiently catalyzes the three-component coupling of β-keto esters, aldehydes and urea (or thiourea) to afford the corresponding dihydropyrimidinones.Related Products of 13465-09-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Gu, Ruirui; Lehn, Jean-Marie published their research in Journal of the American Chemical Society in 2021. The article was titled 《Constitutional Dynamic Selection at Low Reynolds Number in a Triple Dynamic System: Covalent Dynamic Adaptation Driven by Double Supramolecular Self-Assembly》.Related Products of 2969-81-5 The article contains the following contents:

A triple dynamic complex system has been designed, implementing a dynamic covalent process coupled to two supramol. self-assembly steps. To this end, two dynamic covalent libraries (DCLs), DCL-1 and DCL-2, have been established on the basis of dynamic covalent C=C/C=N organo-metathesis between two Knoevenagel derivatives and two imines. Each DCL contains a barbituric acid-based Knoevenagel constituent that may undergo a sequential double self-organization process involving first the formation of hydrogen-bonded hexameric supramol. macrocycles that subsequently undergo stacking to generate a supramol. polymer SP yielding a viscous gel state. Both DCLs display selective self-organization-driven amplification of the constituent that leads to the SP. Dissociation of the SP on heating causes reversible randomization of the constituent distributions of the DCLs as a function of temperature Furthermore, diverse distribution patterns of DCL-2 were induced by modulation of temperature and solvent composition The present dynamic systems display remarkable self-organization-driven constitutional adaptation and tunable composition by coupling between dynamic covalent component selection and two-stage supramol. organization. In more general terms, they reveal dynamic adaptation by component selection in low Reynolds number conditions of living systems where frictional effects dominate inertial behavior. In the experimental materials used by the author, we found Ethyl 4-bromobutyrate(cas: 2969-81-5Related Products of 2969-81-5)

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Related Products of 2969-81-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Yu, You-Jie; Zhang, Feng-Lian; Peng, Tian-Yu; Wang, Chang-Ling; Cheng, Jie; Chen, Chen; Houk, Kendall N.; Wang, Yi-Feng published their research in Science (Washington, DC, United States) in 2021. The article was titled 《Sequential C-F bond functionalizations of trifluoroacetamides and acetates via spin-center shifts》.Electric Literature of C19H18BrP The article contains the following contents:

Defluorinative functionalization of readily accessible trifluoromethyl groups constitutes an economical route to partially fluorinated mols. However, the controllable replacement of one or two fluorine atoms while maintaining high chemoselectivity remains a formidable challenge. Here we describe a general strategy for sequential carbon-fluorine (C-F) bond functionalizations of trifluoroacetamides and trifluoroacetates. The reaction begins with the activation of a carbonyl oxygen atom by a 4-dimethylaminopyridine-boryl radical, followed by a spin-center shift to trigger the C-F bond scission. A chemoselectivity-controllable two-stage process enables sequential generation of difluoro- and monofluoroalkyl radicals, which are selectively functionalized with different radical traps to afford diverse fluorinated products. The reaction mechanism and the origin of chemoselectivity were established by exptl. and computational approaches. After reading the article, we found that the author used Methyltriphenylphosphonium bromide(cas: 1779-49-3Electric Literature of C19H18BrP)

Methyltriphenylphosphonium bromide(cas: 1779-49-3) is an organophosphorus compound, with potential use as a precursor and a solvent in organic synthesis. And it is used widely for methylenation via the Wittig reaction.Electric Literature of C19H18BrP

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary