Month: October 2022

Application of 6630-33-7In 2021 ,《Mildness in preparative conditions directly affects the otherwise straightforward syntheses outcome of Schiff-base isoniazid derivatives: Aroylhydrazones and their solvolysis-related dihydrazones》 was published in Journal of Molecular Structure. The article was written by Cukierman, Daphne S.; Evangelista, Beatriz N.; Neto, Carlos Castanho; Franco, Chris H. J.; Costa, Luiz Antonio S.; Diniz, Renata; Limberger, Jones; Rey, Nicolas A.. The article contains the following contents:

The two series of novel isoniazid-derived compounds prepared from a pair of different aldehyde precursors, as well as the solvolysis, under harsh synthetic conditions, of the initially formed aroylhydrazones, leaded to unexpected dihydrazones was described. All compounds were unequivocally characterized in solution using 1D and 2D NMR experiments in DMSO-d6 and, in the solid-state, by other classic techniques. System I was composed by 2-(1H-pyrazol-1-yl)benzaldehyde and its hydrazone derivatives, while system II comprised 2-(4-metoxyphenoxy)benzaldehyde and its related Schiff-base products. The first aldehyde was obtained for the first time via the copper-catalyzed Ullmann C-N coupling between 2-bromobenzaldehyde and pyrazole. Single crystals of its aroylhydrazone and dihydrazone derivatives were isolated and thoroughly characterized, included Hirshfeld surfaces and energy frameworks studies. Finally, it was described as NMR and theor.-based proposed reaction pathway for the unexpected formation of the dihydrazones involving the solvolysis of the initially formed isonicotinoyl hydrazone followed by attack to a second free aldehyde mol. In the experimental materials used by the author, we found o-Bromobenzaldehyde(cas: 6630-33-7Application of 6630-33-7)

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Application of 6630-33-7It is also used in L-threonine aldolase-catalyzed enantio and diastereoselective aldol reactions. Further, it reacts with trichloromethane to prepare 1-(2-bromo-phenyl)-2,2,2-trichloro-ethanol.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Application In Synthesis of 3,6-Dibromo-9H-carbazoleIn 2019 ,《Analysis of polyhalogenated carbazoles in sediment using liquid chromatography-tandem mass spectrometry》 was published in Ecotoxicology and Environmental Safety. The article was written by Zhou, Wenxiu; Huang, Xinwen; Lin, Kunde. The article contains the following contents:

The purpose of this study was to develop a novel and sensitive method for the anal. of carbazole and polyhalogenated carbazoles (PHCs) in sediment using ultra performance liquid chromatog.-tandem mass spectrometry (UPLC-MS/MS). Briefly, 5.0 g of freeze-dried sediment samples were extracted with dichloromethane using pressurized liquid extraction (PLE). The extract was purified with Florisil solid phase extraction cartridge, filtered through 0.22μm polytetrafluoroethylene filter using a glass syringe, followed by LC-MS/MS anal. Besides parameters for LC-MS/MS anal., sample preparation procedures (including solvents for PLE, sorbents for cleanup, and filters for sample filtration) were optimized. The limits of detection and limits of quantification of target compounds were in the ranges of 3.0 × 10-3 to 0.22 ng g-1 dry weight (d.w.) and 1.0 × 10-2 to 0.75 ng g-1 d.w., resp. The recoveries of target compounds in the spiked sediments at 2.0 ng g-1 d.w. and 10 ng g-1 d.w. were 64.8-91.8% and 70.9-124.7%, resp., with relative standard deviations being less than 13.2%. Except that 36-BCZ had pos. matrix effects of 63.3%, the sediment matrixes generally displayed low or medium neg. matrix effects on the other target compounds during LC-MS/MS anal. The developed method was applied in the anal. of carbazoles and PHCs in sediment samples from Jiulong River, Fujian, China and all the target compounds were detected in the samples. In the experiment, the researchers used 3,6-Dibromo-9H-carbazole(cas: 6825-20-3Application In Synthesis of 3,6-Dibromo-9H-carbazole)

3,6-Dibromo-9H-carbazole(cas: 6825-20-3) is used as a pharmaceutical intermediate, and also an important intermediate of synthesizing optoelectronic materials. It has been used in the preparation of N-(2-hydroxyethyl)-3,6-dibromocarbazole.Application In Synthesis of 3,6-Dibromo-9H-carbazole

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Application In Synthesis of Ethyltriphenylphosphonium bromideIn 2020 ,《Influence of Small Molecular Property on Antibody Response》 was published in Journal of Agricultural and Food Chemistry. The article was written by Wen, Kai; Bai, Yuchen; Wei, Yujie; Li, Chenglong; Shen, Jianzhong; Wang, Zhanhui. The article contains the following contents:

Antibodies with high titer and affinity to small mols. are critical in the field of vaccines against drugs of abuse, antidotes to toxins, and immunoassays for compounds However, little is known regarding how properties of small mols. have influence and which mol. descriptors could indicate the degree of the antibody response. On the basis of our previous study, we designed and synthesized two groups of hapten mols. with varied hydrophobicity to investigate the relationship between the properties of the small mols. and the antibody response in terms of titer and affinity. We found that the magnitude of the antibody response was pos. correlated with the degree of mol. hydrophobicity and related descriptors. This study provides insight into the immunol. characteristics of small mols. themselves and useful clues to produce high-quality antibodies against small mols. After reading the article, we found that the author used Ethyltriphenylphosphonium bromide(cas: 1530-32-1Application In Synthesis of Ethyltriphenylphosphonium bromide)

Ethyltriphenylphosphonium bromide(cas: 1530-32-1) is a phase transfer catalyst, used to accelerate the cure of phenolic-based epoxy resins, certain fluoroelastomer resins and thermosetting powder coatings. CatOnium ETPB is also used as catalysts in the synthesis of certain organic compounds.Application In Synthesis of Ethyltriphenylphosphonium bromide

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

HPLC of Formula: 76006-33-2In 2020 ,《Determination and Analysis of Solubility of 3-Bromo-2-Methylbenzoic Acid in Different Solvent Systems at Different Temperatures (T = 278.15-328.15 K)》 was published in Journal of Chemical & Engineering Data. The article was written by Gu, Yuanyun; Yang, Wenge; Hao, Aixiang; Xu, Qiang; Hu, Yonghong. The article contains the following contents:

In the present study, the solubility properties of 3-bromo-2-Me benzoic acid were studied by the gravimetric method under atm. pressure. In this experiment, we chose the following eight pure solvents and three binary solvent mixtures: THF, N,N-dimethylformamide, methanol, Et acetate, ethanol, acetonitrile, water, cyclohexane, (water + N,N-dimethylformamide), (Et acetate + Tetrahydrofuran), and (acetonitrile + N,N-dimethylformamide), resp. The exptl. temperature ranged from 278.15 to 328.15 K. The solubility data of 3-bromo-2-Me benzoic acid in different pure solvents were fitted by the modified Apelblat model and the Buchowski-Ksiazaczak λh model. For the solubility data of 3-bromo-2-Me benzoic acid in the three groups of binary solvent mixtures, two binary solvents – solvent-fitting models (combined nearly ideal binary solvent/Redlich-Kister (CNIBS/R-K) model and Jouyban-Acree model) and the modified Apelblat model- were used. By comparing the fitting results of each model, it could be seen that as long as the initial component was determined, the modified Apelblat model had a better correlation in both pure solvents and binary solvent mixtures The exptl. data showed that water, acetonitrile, or cyclohexane could be used as effective antisolvents of 3-bromo-2-Me benzoic acid. In the experiment, the researchers used many compounds, for example, 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2HPLC of Formula: 76006-33-2)

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals.HPLC of Formula: 76006-33-2 The most pervasive is the naturally produced bromomethane.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Computed Properties of C6H5Br2NIn 2020 ,《Stafia-1: a STAT5a-Selective Inhibitor Developed via Docking-Based Screening of in Silico O-Phosphorylated Fragments》 was published in Chemistry – A European Journal. The article was written by Natarajan, Kalaiselvi; Mueller-Klieser, Daniel; Rubner, Stefan; Berg, Thorsten. The article contains the following contents:

We present a new approach for the identification of inhibitors of phosphorylation-dependent protein-protein interaction domains, in which phenolic fragments are adapted by in silico O-phosphorylation before docking-based screening. From a database of 10 369 180 compounds, we identified 85 021 natural product-derived phenolic fragments, which were virtually O-phosphorylated and screened for in silico binding to the STAT3 SH2 domain. Nine screening hits were then synthesized, eight of which showed a degree of in vitro inhibition of STAT3. After anal. of its selectivity profile, the most potent inhibitor was then developed to Stafia-1, the first small mol. shown to preferentially inhibit the STAT family member STAT5a over the close homolog STAT5b. A phosphonate prodrug based on Stafia-1 inhibited STAT5a with selectivity over STAT5b in human leukemia cells, providing the first demonstration of selective in vitro and intracellular inhibition of STAT5a by a small-mol. inhibitor. The experimental process involved the reaction of 3,5-Dibromoaniline(cas: 626-40-4Computed Properties of C6H5Br2N)

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).Computed Properties of C6H5Br2N

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Application In Synthesis of o-BromobenzaldehydeIn 2020 ,《Construction of Various Bridged Polycyclic Skeletons by Palladium-Catalyzed Dearomatization》 was published in Angewandte Chemie, International Edition. The article was written by Mu, Xingye; Yu, Hanxiao; Peng, Henian; Xiong, Wenrui; Wu, Ting; Tang, Wenjun. The article contains the following contents:

In the presence of [Pd(cinnamyl)Cl]2, an arylbenzoxaphospholane ligand, and K2CO3 in toluene, bromoaryl-substituted bicyclic phenols such as I underwent dearomative cyclization reactions to yield tetracyclic arenes such as II; a variety of ring systems with differing bridging patterns and carbocyclic and heterocyclic linkers were prepared using the method. The method was used to prepare partial ring systems for the alkaloids aspernomine and strychnochromine and to prepare dracaenone analogs. Bis(bromophenyl)- and bis(bromobenzyl)-substituted bicycles underwent enantioselective desymmetrization by dearomative cyclization using [Pd(cinnamyl)Cl]2 and nonracemic arylbenzoxaphospholane ligands to give bromoaryl- and bromobenzyl-substituted tetracycles in 33-99% ee (absolute configuration undetermined). After reading the article, we found that the author used o-Bromobenzaldehyde(cas: 6630-33-7Application In Synthesis of o-Bromobenzaldehyde)

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Application In Synthesis of o-BromobenzaldehydeIt is also used in L-threonine aldolase-catalyzed enantio and diastereoselective aldol reactions. Further, it reacts with trichloromethane to prepare 1-(2-bromo-phenyl)-2,2,2-trichloro-ethanol.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Category: bromides-buliding-blocksIn 2021 ,《Design, synthesis, biological evaluation and pharmacophore model analysis of novel tetrahydropyrrolo[3,4-c]pyrazol derivatives as potential TRKs inhibitors》 was published in European Journal of Medicinal Chemistry. The article was written by Wu, Tianxiao; Zhang, Chu; Lv, Ruicheng; Qin, Qiaohua; Liu, Nian; Yin, Wenbo; Wang, Ruifeng; Sun, Yin; Wang, Xiaoyan; Sun, Yixiang; Zhao, Dongmei; Cheng, Maosheng. The article contains the following contents:

Synthesis, biol. evaluation and pharmacophore model anal. of novel tetrahydropyrrolo[3,4-c]pyrazol derivatives I [Ar1 = Ph, 2-FC6H4, 3-ClC6H4, etc.] and II [R1 = H, F; R2 = H, F; Ar2 = 4-FC6H4, 2-naphthyl, 4-morpholinophenyl, etc.] as potential TRKs inhibitors were obtained using scaffold hopping strategy. Compound II [R1 = H; R2 = F; Ar2 = 4-(4-methylpiperazin-1-yl)-phenyl] significantly inhibited the proliferation of TRK-dependent cell lines (Km-12), while it had no inhibitory effect on TRK-independent cell lines (A549 and THLE-2). Furthermore, kinases selectivity profiling showed that in addition to TRKs, compound II [R1 = H; R2 = F; Ar2 = 4-(4-methylpiperazin-1-yl)-phenyl] only displayed relatively strong inhibitory activity on ALK. These data might indicated that compound II [R1 = H; R2 = F; Ar2 = 4-(4-methylpiperazin-1-yl)-phenyl] had a good drug safety. Partial ADME properties were evaluated in vitro and in vivo and compound II [R1 = H; R2 = F; Ar2 = 4-(4-methylpiperazin-1-yl)-phenyl] exhibited a good AUC values and volume of distribution and low clearance in the pharmacokinetics experiment of rats. In the experiment, the researchers used many compounds, for example, 4-Bromobenzoic acid(cas: 586-76-5Category: bromides-buliding-blocks)

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography. It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

SDS of cas: 2623-87-2In 2022 ,《Molecular Docking, Synthesis, characterization and preliminary cytotoxic evaluation of new 1, 3,4-Thiadiazole derivatives as EGFR inhibitors》 was published in Materials Today: Proceedings. The article was written by Abdulkhaleq, Zainab M.; Hassan Mohammed, Mohammed. The article contains the following contents:

A new 1,3,4-Thiadiazole derivatives derived from the Methyl-3-hydroxy benzoate were synthesized by a conventional method. The mol.-docking study of the synthesized compounds(s) against EGFR kinase revealed that such compounds occupied the critical site of EGFR kinase pocket with good positioning.compounds (M1,M2,M3 and M4) showed an inhibitory effect against EGFR kinase. Novel compounds were synthesized and confirmed by spectroscopic anal., including AT-IR, 1HNMRS and13C-NMRS. The crystal structure of EGFR with a Gefitinib as a co-crystalized ligand was gained from the protein data-bank (PDB code 4WKQ). The docking was carried by Autodock vina and the visualization by chimera, the charge of the protein mols. was modelled by AMBERff14SB force field, while the small mols. by AM1-BCC. Compounds M2,M4 IC50 (11 mM) and (7.9 mM) resp., exhibited cytotoxic activity against A549 lung cancer cells better than standard (gefitinib IC50 = 20.8 Mm). which were matched by the mol. docking studies that showed that the target compounds may be considered as potential inhibitors of EGFR kinase. From the docking study, it was concluded that piperidine, morpholine and methyl-piperazine moiety were very successful to bind tightly to EGFR kinase pocket receptors by making numerous interaction modes. In addition to this study using 4-Bromobutanoic acid, there are many other studies that have used 4-Bromobutanoic acid(cas: 2623-87-2SDS of cas: 2623-87-2) was used in this study.

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).SDS of cas: 2623-87-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Biocidal polymers: synthesis, characterization and antimicrobial activity of bis-quaternary onium salts of poly(aspartate-co-succinimide)》 was written by El-Newehy, Mohamed H.; Meera, Moydeen A.; Aldalbahi, Ali K.; Thamer, Badr M.; Mahmoud, Yehia A.-G.; El-Hamshary, Hany. Quality Control of Methyltriphenylphosphonium bromideThis research focused onwater soluble biocidal polymer antimicrobial activity thermal stability; antimicrobial activity; poly(aspartate-co-succinimide); quaternary salts; water-soluble polymers. The article conveys some information:

Microbial multidrug resistance presents a real problem to human health. Therefore, water-soluble polymers based on poly(aspartate-co-succinimide) were synthesized via reaction of poly(aspartate-co-succinimide) with bis-quaternary ammonium or quaternary salts. The resultant copolymers were characterized by various techniques such as FTIR, TGA, 1HNMR, 13CNMR and elemental microanal. Antimicrobial activities of the new onium salts were investigated against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Salmonella typhi, and the fungi; Candida albicans, Aspergillus niger, Cryptococcus neoformans and Aspergillus flavus by agar diffusion method. Antimicrobial activity was studied in terms of inhibition zone diameters, in addition to the estimation of minimal inhibitory concentration (MIC) of the prepared compounds A. niger and E. coli were the most affected microorganisms among the tested microorganisms with an inhibition zone of 19-21 (mm) in case of biocides, (V) and (VII). The obtained results showed that the quaternary onium salts have higher activity compared to the aspartate copolymer with MIC concentrations of 25 mg/mL for (VII) and (V) and 50 mg/mL for (VI) and (IV). The results came from multiple reactions, including the reaction of Methyltriphenylphosphonium bromide(cas: 1779-49-3Quality Control of Methyltriphenylphosphonium bromide)

Methyltriphenylphosphonium bromide(cas: 1779-49-3) is a lipophilic molecule with a cation allowing for it to be used to deliver molecules to specific cell components. Also considered an antineoplastic agent.Quality Control of Methyltriphenylphosphonium bromide

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Novel Deazaflavin Analogues Potently Inhibited Tyrosyl DNA Phosphodiesterase 2 (TDP2) and Strongly Sensitized Cancer Cells toward Treatment with Topoisomerase II (TOP2) Poison Etoposide》 was written by Kankanala, Jayakanth; Ribeiro, Carlos J. A.; Kiselev, Evgeny; Ravji, Azhar; Williams, Jessica; Xie, Jiashu; Aihara, Hideki; Pommier, Yves; Wang, Zhengqiang. Safety of Methyl 3-(bromomethyl)benzoateThis research focused onTyrosyl DNA phosphodiesterase 2 sensitize cancer cells etoposide deazaflavin. The article conveys some information:

Topoisomerase II (TOP2) poisons as anticancer drugs work by trapping TOP2 cleavage complexes (TOP2cc) to generate DNA damage. Repair of such damage by tyrosyl DNA phosphodiesterase 2 (TDP2) could render cancer cells resistant to TOP2 poisons. Inhibiting TDP2, thus, represents an attractive mechanism-based chemosensitization approach. Currently known TDP2 inhibitors lack cellular potency and/or permeability. We report herein two novel subtypes of the deazaflavin TDP2 inhibitor core. By introducing an addnl. Ph ring to the N-10 Ph ring (subtype 11) or to the N-3 site of the deazaflavin scaffold (subtype 12), we have generated novel analogs with considerably improved biochem. potency and/or permeability. Importantly, many analogs of both subtypes, particularly compounds 11a, 11e, 12a, 12b, and 12h, exhibited much stronger cancer cell sensitizing effect than the best previous analog 4a toward the treatment with etoposide, suggesting that these analogs could serve as effective cellular probes. After reading the article, we found that the author used Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Safety of Methyl 3-(bromomethyl)benzoate)

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Safety of Methyl 3-(bromomethyl)benzoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary