Month: October 2022

In 2022,Thomas, Jisha Mary; Vidhyapriya, Pitchavel; Sivan, Akhil K.; Sakthivel, Natarajan; Sivasankar, Chinnappan published an article in Applied Organometallic Chemistry. The title of the article was 《Synthesis, spectroscopic, CO-releasing ability, and anticancer activity studies of [Mn(CO)3(L-L)Br] complexes: Experimental and density functional theory studies》.SDS of cas: 14516-54-2 The author mentioned the following in the article:

Two different series of manganese(I) tricarbonyl complexes containing phosphine-based (1-5) and 4′-substituted 2,2′:6′,2′′-terpyridine-based ligands (6-10) have been synthesized in order to study their CO-releasing ability and to investigate their anticancer activity. All the synthesized complexes (1-10) have been fully characterized using standard spectroscopic and anal. techniques. Further 5, 7, and 9 have also been characterized by single-crystal x-ray diffraction studies. Although both the sets of ligands are π-acceptors, they tend to change the Mn-CO bond strength upon complexation, thus affecting the CO release. Photoactivation of 1-5 and 6-10 has been achieved using 365 nm UV irradiation and low intensity visible light, resp. The MnCO bond strength has been examined using the d. functional theory (DFT) and time-dependent DFT (TD-DFT) calculations In order to find the therapeutic viability of the visible light activated complexes, their cytotoxicity has been investigated both in the dark and under irradiation The MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) assay reveals the potential application of some of the synthesized complexes especially towards the lung cancer cells in the dark condition. In the experimental materials used by the author, we found Bromopentacarbonylmanganese(I)(cas: 14516-54-2SDS of cas: 14516-54-2)

Bromopentacarbonylmanganese(I)(cas: 14516-54-2) has many other uses. It is used in the formation of (eta6-arene)tricarbonylmanganese(I) by reacting with arene (arene= hexamethyl benzene, 1,2,4,5-tetramethyl benzene, mesitylene, p-xylene and toluene) in the presence silver salt.SDS of cas: 14516-54-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Safety of 3,6-Dibromo-9H-carbazoleIn 2019 ,《Method development for analyzing ultratrace polyhalogenated carbazoles in soil and sediment》 appeared in Ecotoxicology and Environmental Safety. The author of the article were Zhou, Yanxiao; Zhu, Guohua; Li, Mufei; Liu, Jinsong; Li, Zuguang; Sun, Junjun; Gong, Hongping; Wang, Ling; Wu, Chenwang; Zhou, Xin; Yin, Ge. The article conveys some information:

In the past few years, polyhalogenated carbazoles (PHCZs) have been of increasing concern because their structure is similar to that of legacy POPs. In the present study, an anal. method, including intensive cleanup and fractionation procedures in combination with instrumental parameters, was developed to determine ultratrace polyhalogenated carbazoles (PHCZs) in soil and sediment. The eluting sorbents, volume and packing of the column were optimized. Our results showed that 5 g of florisil and 4 g of silica gel under 150 mL of hexane/DCM = 3:1 presented good performance in terms of recovery and repeatability. GC-HRMS, GC-MS/MS (EI-MRM) and GC-MS (EI-SIM) were applied to compare the performance of PHCZ anal. For sensitivity, EI-MRM presents method detection limits comparable to those of GC-HRMS and much lower than those of EI-SIM. Regarding selectivity, GC-HRMS performed better than the other two techniques since GC-HRMS can reduce interference from perfluorokerosene (PFK) and DDX (DDT, DDE, and DDD) due to its high resolution GC-HRMS was then further optimized by shortening the run time and modifying the SIM ion. The final method was successfully applied to determine PHCZs in soil and sediment, and the target compounds had almost 100% detection frequency in the samples. The ubiquitous presence of PHCZ in soil and sediment calls for a further investigation of its source, distribution and degradation in the environment. In the part of experimental materials, we found many familiar compounds, such as 3,6-Dibromo-9H-carbazole(cas: 6825-20-3Safety of 3,6-Dibromo-9H-carbazole)

3,6-Dibromo-9H-carbazole(cas: 6825-20-3) is used as a pharmaceutical intermediate, and also an important intermediate of synthesizing optoelectronic materials. It has been used in the preparation of N-(2-hydroxyethyl)-3,6-dibromocarbazole.Safety of 3,6-Dibromo-9H-carbazole

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Recommanded Product: 629-03-8In 2021 ,《Removal of Co2+, Cu2+ and Au3+ ions from contaminated wastewater by using new fluorescent and antibacterial polymer as sorbent》 appeared in Polymer Bulletin (Heidelberg, Germany). The author of the article were Qureshi, Farah; Memon, Saima Q.; Khuhawar, Muhammad Yar; Jahangir, Taj Muhammad. The article conveys some information:

New Schiff base polymer was synthesized through polycondensation reaction of dialdehyde (2,2′-hexamethylenebis(oxybenzaldehyde)) and diamine (dapsone). The resulting polymer was characterized through CHN anal., 1HNMR, FT-IR, UV-Vis spectroscopy, fluorescence spectroscopy, TG/DTA and SEM. The synthesized polymer was fluorescent and showed violet color emission. The antimicrobial activity of the polymer was tested, and the polymer showed moderate antibacterial activity against Shigella flexneri. New effective method was developed for the removal of Co2+, Cu2+ and Au3+ ions from contaminated wastewater, and the synthesized polymer was employed as sorbent. Multivariate optimization of parameters (pH, concentration, amount and time) was attained through factorial design (face-centered Draper-Lin composite design) with 18 batch experiments The method was applied successfully at predicted optimum conditions for the removal of heavy metal ions (Co2+, Cu2+ and Au3+) from contaminated wastewater samples. The synthesized sorbent polymer removed up to 78% Co2+, 99% Cu2+ and 98% Au3+ from wastewater samples. The concentration of metal ions before and after adsorption was measured through AAS. The presence of metal ions on the polymer surface was confirmed through SEM and EDX anal. of the polymer after adsorption. Equilibrium of the adsorption process was studied through Langmuir, Freundlich and D-R isotherms, and kinetics was studied through Lagergren pseudo-first-order, Lagergren pseudo-second-order and intra-particle diffusion models. The experimental part of the paper was very detailed, including the reaction process of 1,6-Dibromohexane(cas: 629-03-8Recommanded Product: 629-03-8)

1,6-Dibromohexane(cas: 629-03-8) is generally used to introduce C6 spacer in the molecular architecture. Some of the examples are: synthesis of pyrrolo-tetrathiafulvalene molecular bridge (6PTTF6) to study redox switching behavior of single molecules; synthesis of water-soluble thermoresponsive polylactides.Recommanded Product: 629-03-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of C6H5Br2NIn 2021 ,《Aggregation-induced fluorescent response of urea-bearing polyphenyleneethynylenes toward anion sensing》 appeared in Science and Technology of Advanced Materials. The author of the article were Li, Jian; Saleem, Muhammad; Duan, Qian; Kakuchi, Toyoji; Chen, Yougen. The article conveys some information:

A π-conjugated urea-bearing phenyleneethynylene polymer () was rationally designed by the Sonogashira coupling condensation reaction and had been demonstrated to have a unique fluorescent quenching effect for the optical detection of all determined anions, especially for CN-. The fluorescent emission of was significantly quenched upon adding CN-, together accompanied with a continuous red shift of the emission peak from 442 to 464 nm with the cyanide concentration increased from 0 to 1.0 mM. On the contrary, its precursor polymer, , itself also displayed fluorescent responsibility with all selected anions but had no obvious selectivity and tendency. For instance, the addition of highly basic CN-, N3-, AcO-, or F- to solution in DMF/H2O (volume/volume = 1:1) led to the photoluminescence amplification, while the addition of weakly basic anions like Cl-, I-, and Br- showed a fluorescence quenching effect. Both polymers were in a seriously self-aggregated state in solution no matter in the absence or presence of an anion. Interestingly, it was found that exhibited an aggregation-induced emission behavior, while had an aggregation-caused quenching effect, based on the relationship between photoluminescence and polymer aggregation state. The structural characterizations were carried out by NMR spectroscopy and size exclusion chromatog. measurements; the photoluminescence properties of and together with anion sensing properties were followed by fluorescence spectroscopy, and the relationship between photoluminescence and aggregation behavior of both polymers in solution was investigated by dynamic light scattering measurements. In the part of experimental materials, we found many familiar compounds, such as 3,5-Dibromoaniline(cas: 626-40-4Synthetic Route of C6H5Br2N)

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Synthetic Route of C6H5Br2N

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Reference of Tris(4-bromophenyl)amineIn 2021 ,《A COF-Like N-Rich Conjugated Microporous Polytriphenylamine Cathode with Pseudocapacitive Anion Storage Behavior for High-Energy Aqueous Zinc Dual-Ion Batteries》 appeared in Advanced Materials (Weinheim, Germany). The author of the article were Zhang, Haozhe; Zhong, Linfeng; Xie, Jinhao; Yang, Fan; Liu, Xiaoqing; Lu, Xihong. The article conveys some information:

Conducting polymers with good electron conductivity and rich redox functional groups are promising cathode candidates for constructing high-energy aqueous zinc batteries. However, the glaring flaw of active-site underutilization impairs their electrochem. performance. Herein, we report a poriferous polytriphenylamine conjugated microporous polymer (CMP) cathode capable of accommodating Cl- anions in a pseudocapative-dominated manner for energy storage. Its specific 3D, covalent-organic-framework-like conjugated network ensures high accessibility efficacy of N active sites (up to 83.2% at 0.5 A g-1) and distinct physicochem. stability (87.6% capacity retention after 1000 cycles) during repeated charging/discharging courses. Such a robust CMP electrode also leads to a zinc dual-ion battery device with a high energy d. of 236 W h kg-1 and a maximum power d. of 6.8 kW kg-1, substantially surpassing most recently reported organic-based zinc batteries. This study paves the way for the rational design of advanced CMP-based organic cathodes for high-energy devices. The experimental part of the paper was very detailed, including the reaction process of Tris(4-bromophenyl)amine(cas: 4316-58-9Reference of Tris(4-bromophenyl)amine)

In general, Tris(4-bromophenyl)amine(cas: 4316-58-9) is often used in the synthesis of porous luminescent covalent–organic polymers (COPs)Reference of Tris(4-bromophenyl)amine

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

COA of Formula: C18H12Br3NIn 2021 ,《Porous Covalent Organic Polymers for Efficient Fluorocarbon-Based Adsorption Cooling》 appeared in Angewandte Chemie, International Edition. The author of the article were Zheng, Jian; Wahiduzzaman, Mohammad; Barpaga, Dushyant; Trump, Benjamin A.; Gutierrez, Oliver Y.; Thallapally, Praveen; Ma, Shengqian; McGrail, B. Peter; Maurin, Guillaume; Motkuri, Radha Kishan. The article conveys some information:

Adsorption-based cooling is an energy-efficient renewable-energy technol. that can be driven using low-grade industrial waste heat and/or solar heat. Here, we report the first exploration of fluorocarbon adsorption using porous covalent organic polymers (COPs) for this cooling application. High fluorocarbon R134a equilibrium capacities and unique overall linear-shaped isotherms are revealed for the materials, namely COP-2 and COP-3. The key role of mesoporous defects on this unusual adsorption behavior was demonstrated by mol. simulations based on atomistic defect-containing models built for both porous COPs. Anal. of simulated R134a adsorption isotherms for various defect-containing atomistic models of the COPs shows a direct correlation between higher fluorocarbon adsorption capacities and increasing pore volumes induced by defects. Combined with their high porosities, excellent reversibility, fast kinetics, and large operating window, these defect-containing porous COPs are promising for adsorption-based cooling applications. In the part of experimental materials, we found many familiar compounds, such as Tris(4-bromophenyl)amine(cas: 4316-58-9COA of Formula: C18H12Br3N)

In general, Tris(4-bromophenyl)amine(cas: 4316-58-9) is often used in the synthesis of porous luminescent covalent–organic polymers (COPs)COA of Formula: C18H12Br3N

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Category: bromides-buliding-blocksIn 2020 ,《Discovery of PROTAC BCL-XL degraders as potent anticancer agents with low on-target platelet toxicity》 appeared in European Journal of Medicinal Chemistry. The author of the article were Zhang, Xuan; Thummuri, Dinesh; Liu, Xingui; Hu, Wanyi; Zhang, Peiyi; Khan, Sajid; Yuan, Yaxia; Zhou, Daohong; Zheng, Guangrong. The article conveys some information:

Anti-apoptotic protein BCL-XL plays a key role in tumorigenesis and cancer chemotherapy resistance, rendering it an attractive target for cancer treatment. However, BCL-XL inhibitors such as ABT-263 cannot be safely used in the clinic because platelets solely depend on BCL-XL to maintain their viability. To reduce the on-target platelet toxicity associated with the inhibition of BCL-XL, we designed and synthesized PROTAC BCL-XL degraders that recruit CRBN or VHL E3 ligase because both of these enzymes are poorly expressed in human platelets compared to various cancer cell lines. We confirmed that platelet-toxic BCL-XL/2 dual inhibitor ABT-263 can be converted into platelet-sparing CRBN/VHL-based BCL-XL specific degraders. A number of BCL-XL degraders are more potent in killing cancer cells than their parent compound ABT-263. Specifically, XZ739, a CRBN-dependent BCL-XL degrader, is 20-fold more potent than ABT-263 against MOLT-4 T-ALL cells and has >100-fold selectivity for MOLT-4 cells over human platelets. Our findings further demonstrated the utility of PROTAC technol. to achieve tissue selectivity through recruiting differentially expressed E3 ligases. The results came from multiple reactions, including the reaction of Ethyl 5-bromovalerate(cas: 14660-52-7Category: bromides-buliding-blocks)

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Computed Properties of C4H2Br2SIn 2020 ,《Push-pull thiophene chromophores for electro-optic applications: from 1D linear to β-branched structures》 appeared in Physical Chemistry Chemical Physics. The author of the article were Rothe, Christian; Neusser, David; Hoppe, Niklas; Dirnberger, Klaus; Vogel, Wolfgang; Gamez-Valenzuela, Sergio; Lopez Navarrete, Juan T.; Villacampa, Belen; Berroth, Manfred; Ruiz Delgado, M. Carmen; Ludwigs, Sabine. The article conveys some information:

The authors report the synthesis and characterization of push-pull chromophores bearing one-dimensional (1D) linear and β-branched thiophenes as π-conjugated spacers between a 2,2,4,7-tetramethyl-1,2,3,4-tetrahydroquinoline electron donor unit and dicyano- and tricyanovinylene electron acceptor groups. The effect of the introduction of β-thiophenes on the linear and nonlinear optical (NLO) properties as well as electrochem. and thermal data is studied in detail by performing a comparative study between the branched and 1D linear systems. A parallel DFT computational study is used to evaluate structure-property relations. The NLO behavior of the mols. both in solution and in solid state as electrooptic (EO) films using a guest-host approach shows very promising performance for electrooptic applications with high mol. 1st hyperpolarizabilities (μβ) of 4840 × 10-48 esu and electrooptic coefficients r33 reaching 650 pm V-1. One highlight is that the EO films of the β-branched chromophores are superior in terms of thermal stability in device operation as measured by a transmissive modified reflective Teng-Man method. This work provides guidelines for the design of improved electrooptic materials including β-branched chromophores which could be useful for practical EO applications, where both enhanced β and r33 values together with chem. and thermal stability are necessary. After reading the article, we found that the author used 2,5-Dibromothiophene(cas: 3141-27-3Computed Properties of C4H2Br2S)

2,5-Dibromothiophene(cas: 3141-27-3) , is mainly used as pharmaceutical intermediate and synthesis intermediate. 2,5-Dibromothiophene polymerizes by debromination with magnesium catalyzed by nickel compounds to form poly(2,5- thienylene) .Computed Properties of C4H2Br2S

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Reference of o-BromobenzaldehydeIn 2019 ,《Nano-Zn[2-boromophenylsalicylaldiminemethylpyranopyrazole]Cl2 as a novel nanostructured Schiff base complex and catalyst for the synthesis of pyrano[2,3-d]pyrimidinedione derivatives》 appeared in Applied Organometallic Chemistry. The author of the article were Moosavi-Zare, A. R.; Goudarziafshar, H.; Jalilian, Z.. The article conveys some information:

Nano-Zn[2-bromophenylsalicylaldiminemethylpyranopyrazole]Cl2 (nano-[Zn-2BSMP]Cl2) as a novel nanostructured Schiff base complex was prepared and characterized using several techniques. Nano-[Zn-2BSMP]Cl2 was used as an effective catalyst for the preparation of some pyrano[2,3-d]pyrimidinedione derivatives by the multicomponent reaction of malononitrile, aryl aldehydes and barbituric acid derivatives The novelty and efficiency of nano-[Zn-2BSMP]Cl2 as a catalyst, in comparison with some other reported catalysts, for this synthetic transformation are the main features of this work. The results came from multiple reactions, including the reaction of o-Bromobenzaldehyde(cas: 6630-33-7Reference of o-Bromobenzaldehyde)

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Reference of o-BromobenzaldehydeIt is also used in L-threonine aldolase-catalyzed enantio and diastereoselective aldol reactions. Further, it reacts with trichloromethane to prepare 1-(2-bromo-phenyl)-2,2,2-trichloro-ethanol.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of C20H20BrPIn 2022 ,《Enantio- and Regioselective Ni-Catalyzed para-C-H Alkylation of Pyridines with Styrenes via Intermolecular Hydroarylation》 appeared in Journal of the American Chemical Society. The author of the article were Ma, Jun-Bao; Zhao, Xia; Zhang, Dongju; Shi, Shi-Liang. The article conveys some information:

Herein the first enantioselective para-C-H activation of pyridines through the use of a Ni-Al bimetallic catalyst system and N-heterocyclic carbene (NHC) ligand for intermol. hydroarylation of styrenes was described. The reaction proceeded in high to excellent enantioselectivities (up to 98.5:1.5 er) and high site-selectivities for both styrene and pyridine components (up to >98:2). Consequently, a broad range of enantioenriched 1,1-diarylalkanes containing pyridine moieties could be prepared in a single step with 100% atom economy. Computational studies supported a mechanism involving a ligand-to-ligand H-transfer (LLHT) and reductive elimination sequence, with LLHT being the rate- and enantioselectivity-determining step. DFT studies indicated that the π-π stacking interaction between the NHC aryl fragment and trans-styrenes was critical for high reactivity and enantiocontrol.Ethyltriphenylphosphonium bromide(cas: 1530-32-1Electric Literature of C20H20BrP) was used in this study.

Ethyltriphenylphosphonium bromide(cas: 1530-32-1) is a phase transfer catalyst, used to accelerate the cure of phenolic-based epoxy resins, certain fluoroelastomer resins and thermosetting powder coatings. CatOnium ETPB is also used as catalysts in the synthesis of certain organic compounds.Electric Literature of C20H20BrP

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary