Month: October 2022

The author of 《Mechanistic Dichotomy of Magnesium- and Zinc-Based Germanium Nucleophiles in the C(sp3)-Ge Cross-Coupling with Alkyl Electrophiles》 were Xue, Weichao; Mao, Wenbin; Zhang, Liangliang; Oestreich, Martin. And the article was published in Angewandte Chemie, International Edition in 2019. Application of 7051-34-5 The author mentioned the following in the article:

Robust procedures for two mechanistically distinct C(sp3)-Ge bond formations from alkyl electrophiles and germanium nucleophiles are reported. The germanium reagents were made available as bench-stable solutions by lithium-to-magnesium and lithium-to-zinc transmetalation, resp. The germanium Grignard reagent reacts with various primary and secondary alkyl electrophiles by an ionic nucleophilic displacement. Conversely, the coupling of the corresponding zinc reagent requires a nickel catalyst, which then engages in radical bond formations with primary, secondary, and even tertiary alkyl bromides. Both methods avoid the regioselectivity issue of alkene hydrogermylation and enable the synthesis of a wide range of functionalized alkyl-substituted germanes. In the part of experimental materials, we found many familiar compounds, such as (Bromomethyl)cyclopropane(cas: 7051-34-5Application of 7051-34-5)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Application of 7051-34-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Hybrid molecules of scutellarein and tertramethylpyrazine’s active metabolites for ischemic stroke》 were Dong, Yongxi; Zhang, Xiaohe; Liu, Mingji; Yang, Yang; Guo, Ting; Mao, Yuanhu; Zhang, Jiquan; Fu, Xiaozhong; Zhao, Yonglong; Chen, Jinglei; Dong, Li; Qiao, Chunhua. And the article was published in Bioorganic & Medicinal Chemistry Letters in 2019. Quality Control of 4-Bromobutanoic acid The author mentioned the following in the article:

A series of hybrid mols. of scutellarein and tertramethylpyrazine’s active metabolites have been synthesized. Compared to the original compound, these prepared compounds exhibited higher water solubility, more appropriate logP and better stability. Importantly, compounds I [R = Me, iBu, sec-Bu] showed improved neuroprotective activity against the H2O2-induced cell death in PC12 cells, and better antithrombosis activity. The optimized compound I [R = Me] was further evaluated by cerebral ischemia/ reperfusion in the middle cerebral artery occlusion (MCAO) model, the results showed that the compound could significantly reduce the infarct area and decrease the neuronal cell damage in CA1 pyramidal neurons. Overall, we demonstrated that the twin drug strategy could be applied in the development of agents for the treatment of ischemic stroke. In the experimental materials used by the author, we found 4-Bromobutanoic acid(cas: 2623-87-2Quality Control of 4-Bromobutanoic acid)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Quality Control of 4-Bromobutanoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Synthesis of binuclear isoquinoline- and pyridine-fused benzimidazole-4,7-diones by magnetic MOF-199-catalyzed C-C coupling/cyclization followed by oxidation》 were Diep, Thi Duyen; Dao, Pham Duy Quang; Cho, Chan Sik. And the article was published in European Journal of Organic Chemistry in 2019. HPLC of Formula: 6630-33-7 The author mentioned the following in the article:

Binuclear isoquinoline- and pyridine-fused benzimidazoles such as I [R = Ph, 4-FC6H4, 2-furyl, etc.; R1 = H, 3-Me, 2-F, 2-MeO] were prepared from 2-(2-bromoaryl)-4,7-dimethoxy-1H-benzo[d]imidazoles and (Z)-2-(2-bromovinyl)-4,7-dimethoxy-1H-benzo[d]imidazoles with 1,3-diketones by microwave irradiation in DMF in the presence of a catalytic amount of recyclable Fe3O4@SiO2@MOF-199 along with a base. Treatment of such binuclear N-fused hybrid scaffolds with ceric ammonium nitrate in acetonitrile/H2O or HBr/FeCl3 in H2O afforded binuclear isoquinoline- and pyridine-fused benzimidazole-4,7-diones II [R2 = Me, 2-MeC6H4, 4-MeOC6H4, etc.; R3 = H, 3-Me, 2-F, 2-MeO] in good to high yields. The experimental process involved the reaction of o-Bromobenzaldehyde(cas: 6630-33-7HPLC of Formula: 6630-33-7)

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.HPLC of Formula: 6630-33-7Synthetic applications of o-Bromobenzaldehyde include: synthesis of aza-fused polycyclic quinolines through copper-catalyzed cascade reaction, preparation of 1-substituted indazoles by CuI-catalyzed coupling with N-aryl hydrazides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Ni-Catalyzed Reductive Liebeskind-Srogl Alkylation of Heterocycles》 were Ma, Yuanhong; Cammarata, Jose; Cornella, Josep. And the article was published in Journal of the American Chemical Society in 2019. Recommanded Product: 7051-34-5 The author mentioned the following in the article:

Herein we present a Ni-catalyzed alkylation of C-SMe with alkyl bromides for the decoration of heterocyclic frameworks I (R = H, 6-CN, 5-CF3, 2-thienyl, etc.; R1 = cyclohexyl, cyclobutyl, 4-pyranyl, etc.). The protocol, reminiscent to the Liebeskind-Srogl coupling, makes use of simple C(sp2)-SMe to be engaged in a reductive coupling. The reaction is suitable for a preponderance of highly valuable heterocyclic motifs. In addition to cyclic bromides, noncyclic alkyl bromides are well accommodated with exquisite levels of retention over isomerization. The protocol is scalable and permits orthogonal couplings in the presence of other functionalization handles. After reading the article, we found that the author used (Bromomethyl)cyclopropane(cas: 7051-34-5Recommanded Product: 7051-34-5)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Recommanded Product: 7051-34-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Iron-Catalyzed Tunable and Site-Selective Olefin Transposition》 was published in Journal of the American Chemical Society in 2020. These research results belong to Yu, Xiaolong; Zhao, Haonan; Li, Ping; Koh, Ming Joo. Related Products of 1779-49-3 The article mentions the following:

The catalytic isomerization of C-C double bonds is an indispensable chem. transformation used to deliver higher-value analogs and has important utility in the chem. industry. Notwithstanding the advances reported in this field, there is compelling demand for a general catalytic solution that enables precise control of the C=C bond migration position, in both cyclic and acyclic systems, to furnish disubstituted and trisubstituted alkenes. Here, we show that catalytic amounts of an appropriate earth-abundant iron-based complex, a base and a boryl compound, promote efficient and controllable alkene transposition. Mechanistic investigations reveal that these processes likely involve in situ formation of an iron-hydride species which promotes olefin isomerization through sequential olefin insertion/β-hydride elimination. Through this strategy, regiodivergent access to different products from one substrate can be facilitated, isomeric olefin mixtures commonly found in petroleum-derived feedstock can be transformed to a single alkene product, and unsaturated moieties embedded within linear and heterocyclic biol. active entities can be obtained. In the experiment, the researchers used many compounds, for example, Methyltriphenylphosphonium bromide(cas: 1779-49-3Related Products of 1779-49-3)

Methyltriphenylphosphonium bromide(cas: 1779-49-3) is used for methylenation through the Wittig reaction. It is utilized in the synthesis of an enyne and 9-isopropenyl -phenanthrene by using sodium amide as reagent. Related Products of 1779-49-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《SO4-2/SnO2-catalyzed cyclocondensation for the synthesis of fully functionalized pyridines》 was published in Journal of Heterocyclic Chemistry in 2020. These research results belong to Koduri, Ramesh Goud; Pagadala, Ramakanth; Boodida, Sathyanarayana; Varala, Ravi. SDS of cas: 6630-33-7 The article mentions the following:

An efficient and promising synthetic approach to assemble skeletons of multifunctionalized pyridine derivatives I [R = H, 4-Br, 2-Cl, 2-OMe, etc.; R1 = R2 = Me; R1R2 = -(CH2)5-] in presence of recyclable heterogeneous sulfated tin oxide (STO) catalyst has been evolved. The STO catalyst was used as a promoter for the cyclocondensation process in ethanol at 70°C. Overall performance of this catalyst was attributed to the cooperative contribution of its Lewis and Bronsted-Lowry acidic sites. Nanosized STO catalyst was synthesized by using sol-gel process and characterized by Fourier transform IR (FTIR) spectroscopy, X-ray diffraction (XRD), 1H-NMR, and SEM (SEM). This catalyst tolerates most of the substrates, and the protocol shows precious capabilities consisting of high yields, operational simplicity, less reaction time, and eco-friendly conditions. The newly synthesized heterogeneous catalyst was easily separated and reused. All the reactions are carried out for subsequent cycles without significant loss of catalytic activity and with good proficiency. In addition to this study using o-Bromobenzaldehyde, there are many other studies that have used o-Bromobenzaldehyde(cas: 6630-33-7SDS of cas: 6630-33-7) was used in this study.

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.SDS of cas: 6630-33-7It is a key starting material in the total synthesis of an anticancer agent, (-)-taxol.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Design, synthesis and biological activity of novel substituted 3-benzoic acid derivatives as MtDHFR inhibitors》 was published in Bioorganic & Medicinal Chemistry in 2020. These research results belong to Kronenberger, Thales; Ferreira, Glaucio Monteiro; Ferreira de Souza, Alfredo Danilo; da Silva Santos, Soraya; Poso, Antti; Ribeiro, Joao Augusto; Tavares, Mauricio Temotheo; Pavan, Fernando Rogerio; Trossini, Gustavo Henrique Goulart; Dias, Marcio Vinicius Bertacine; Parise-Filho, Roberto. Synthetic Route of C9H9BrO2 The article mentions the following:

The fragment MB872 I [R1 = H; R2 = 3-C(O)OH; W = O; Y = CH2] was used as a prototype for analog development by bioisosterism/retro-bioisosterism, which resulted in substituted 3-benzoic acid derivatives I [R1 = H, OH, OMe, NO2; R2 = 3-C(O)OH, 4-C(O)OH, 3-C(O)OMe, 4-C(O)OMe, 3-NO2; W = O, S, NH, CH2; Y = O, CH2]. Compounds I were active against MtDHFR, with IC50 values ranging from 7 to 40μM, where compound I [R1 = H; R2 = 3-C(O)OH; W = NH; Y = CH2] not only had the best inhibitory activity (IC50 = 7μM), but also was 71-fold more active than the original fragment MB872. The compound I [R1 = H; R2 = 3-C(O)OH; W = NH; Y = CH2] inhibition kinetics indicated an uncompetitive mechanism, which was supported by mol. modeling which suggested that the compounds I could access an independent backpocket from the substrate and competitive inhibitors. Thus, based on these results, substituted 3-benzoic acid derivatives I had strong potential to be developed as novel MtDHFR inhibitors and also anti-TB agents. In the experiment, the researchers used Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Synthetic Route of C9H9BrO2)

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. Synthetic Route of C9H9BrO2 Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Toward the Synthesis of a Highly Strained Hydrocarbon Belt》 was published in Journal of the American Chemical Society in 2020. These research results belong to Shi, Tan-Hao; Guo, Qing-Hui; Tong, Shuo; Wang, Mei-Xiang. Recommanded Product: 1-Bromo-2-isopropylbenzene The article mentions the following:

In this communication a general approach to hydrocarbon belts and their derivatives was reported. Closing up all four fjords of resorcin[4]arene derivatives through multiple intramol. Friedel-Crafts alkylation reactions in an operationally simple one-pot reaction manner enabled efficient construction of octohydrobelt[8]arenes. Synthesis of belt[8]arene from DDQ-oxidized aromatization of octohydrobelt[8]arene under different conditions resulted in aromatization and simultaneous [4 + 2] cycloaddition reactions with DDQ or TCNE to produce selectively tetrahydrobelt[8]arene-DDQ2, tetrahydrobelt[8]arene-TCNE2, and belt[8]arene-DDQ4 adducts. Formation of belt[8]arene, a fully conjugated hydrocarbon belt, was observed from retro-Diels-Alder reaction of a belt[8]arene-DDQ4 adduct with laser irradiation under MALDI conditions. The new and practical synthetic method established would open an avenue to create belt-shaped mols. from easily available starting materials.1-Bromo-2-isopropylbenzene(cas: 7073-94-1Recommanded Product: 1-Bromo-2-isopropylbenzene) was used in this study.

1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals.Recommanded Product: 1-Bromo-2-isopropylbenzene Organobromine compounds have fallen under increased scrutiny for their environmental impact.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Application of Hammett equation to hydrogen bond interactions of benzoic acid in chloroform/water system and explanation for non-linear Hammett relation to partition coefficients for the same system》 was published in Computational & Theoretical Chemistry in 2020. These research results belong to Rachuru, Sanjeev; Skelton, Adam A.; Vandanapu, Jagannadham. Reference of 4-Bromobenzoic acid The article mentions the following:

It is well known that benzoic acid distributes itself between chloroform and water. The partition coefficients (Kp) of seven different benzoic acids in chloroform/water are documented in the literature. Plausible hydrogen bonded structures of these seven benzoic acids with the two immiscible solvents were envisaged and the DFT calculation for these hydrogen bonds were carried out. Further, the conformity of Hammett relation to the hydrogen bond interactions was assessed. Application of Hammett equation to the hydrogen bonding of distribution of different para-substituted benzoic acids to these immiscible solvents is done for the first time. Further, an explanation for non-linear plot of partition coefficients logKp of para-substituted benzoic acids in chloroform-water system vs. Hammett σ value has been explained for the first time. In the experiment, the researchers used 4-Bromobenzoic acid(cas: 586-76-5Reference of 4-Bromobenzoic acid)

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography.Reference of 4-Bromobenzoic acid It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Tumor-Triggered Disassembly of a Multiple-Agent-Therapy Probe for Efficient Cellular Internalization》 was published in Angewandte Chemie, International Edition in 2020. These research results belong to Yang, Juliang; Dai, Jun; Wang, Quan; Cheng, Yong; Guo, Jingjing; Zhao, Zujin; Hong, Yuning; Lou, Xiaoding; Xia, Fan. COA of Formula: C6H12Br2 The article mentions the following:

Integration of multiple agent therapy (MAT) into one probe is promising for improving therapeutic efficiency for cancer treatment. However, MAT probe, if entering the cell as a whole, may not be optimal for each therapeutic agent (with different physicochem. properties), to achieve their best performance, hindering strategy optimization. A peptide-conjugated-AIEgen (FC-PyTPA) is presented: upon loading with siRNA, it self-assembles into FCsiRNA-PyTPA. When approaching the region near tumor cells, FCsiRNA-PyTPA responds to extracellular MMP-2 and is cleaved into FCsiRNA and PyTPA. The former enters cells mainly by macropinocytosis and the latter is internalized into cells mainly through caveolae-mediated endocytosis. This two-part strategy greatly improves the internalization efficiency of each individual therapeutic agent. Inside the cell, self-assembly of nanofiber precursor F, gene interference of CsiRNA, and ROS production of PyTPA are activated to inhibit tumor growth. After reading the article, we found that the author used 1,6-Dibromohexane(cas: 629-03-8COA of Formula: C6H12Br2)

1,6-Dibromohexane(cas: 629-03-8) is generally used to introduce C6 spacer in the molecular architecture. Some of the examples are: synthesis of pyrrolo-tetrathiafulvalene molecular bridge (6PTTF6) to study redox switching behavior of single molecules; synthesis of water-soluble thermoresponsive polylactides.COA of Formula: C6H12Br2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary