Month: October 2022

Moschona, Fotini; Misirlaki, Christina; Karadimas, Nikolaos; Koutiva, Maria; Savvopoulou, Ioanna; Rassias, Gerasimos published the artcile< Organocatalytic Asymmetric Halocyclization of Allylic Amides to Chiral Oxazolines Using DTBM-SEGPHOS-Mechanistic Implications from Hammett Plots>, Name: 3-Bromobenzotrifluoride, the main research area is oxazoline preparation enantioselective regioselective; allylic amide chlorocyclization chiral diphosphine organocatalyst.

The intramol. halocyclization of alkenes possessing an internal heteroatom nucleophile leads to multifunctional heterocycles which are useful versatile intermediates in organic synthesis. The asym. chlorocyclization of 2-substituted allylic amides ArC(O)NHCH2C(=CH2)R (R = Ph, 4-FC6H4, pyridin-3-yl, naphthalen-1-yl, etc.; Ar = Ph, 4-MeOC6H4, 4-MeC6H4, etc.) gives access to chiral oxazolines I (X = Cl) bearing a chloromethyl moiety for further synthetic manipulation. The literature reports on this transformation involve complex syntheses of the 2-substituted allylic amides and cryogenic temperatures for achieving high enantioselectivities in the organocatalyzed halocyclization step. Based on the Heck reaction of aryl bromides ArBr (Ar = Ph, 4-CNC6H4, pyridin-3-yl, naphthalen-1-yl, etc.;) and Boc-protected allylamine or allylamine benzamides, a practical synthesis of 2-substituted allylic amides that does not require chromatog. was developed and accomplished their asym. halocyclization reaction with 24-92%ee under practical conditions (5°C, CpME) catalyzed by (S)-(+)-DTBM-SEGPHOS. In addition, using appropriately substituted substrates, Hammett plots were generated and formulated a consistent mechanism for the halocyclization reaction which involves two competing modes of formation of the haliranium intermediate whose relative kinetics are governed by the electronic properties of the substrate.

Symmetry published new progress about Aromatic amines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Name: 3-Bromobenzotrifluoride.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Chen, Lian-Mei; Zhou, Chuang; Li, Jing; Li, Jun; Guo, Xiao-Qiang; Kang, Tai-Ran published the artcile< Copper-catalyzed reactions of α,β-unsaturated N-tosylhydrazones with diaryliodonium salts to construct N-arylpyrazoles and diaryl sulfones>, Name: 3-(4-Bromophenyl)acrylaldehyde, the main research area is propenyl tosylhydrazone diaryliiodonium triflate copper catalyst tandem heterocyclization Ullman; arylpyrazole diarylsulfone preparation regioselective.

An economical copper-catalyzed reaction of α,β-unsaturated N-tosylhydrazones with diaryliodonium salts to construct both N-arylpyrazoles and diaryl sulfones was developed. Both the p-toluenesulfonyl anion and the 3-arylpyrazole intermediates were formed in-situ from N-tosylhydrazones. Subsequently, the former reacted rapidly with diaryliodonium salts to give diaryl sulfones and aryl iodide intermediates and the latter reacted with aryl iodide to give N-arylpyrazoles under copper-catalyzed conditions. Using unsym. mesityl phenyliodonium salts as substrates, mesityl p-toluenesulfide was obtained as the major product. This reaction took full advantage of the “”waste”” part of substrates to form an extra diaryl sulfone.

Organic & Biomolecular Chemistry published new progress about Aromatic compounds, sulfones Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Name: 3-(4-Bromophenyl)acrylaldehyde.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Rothenbuhler, Simon; Iacovache, Ioan; Langenegger, Simon M.; Zuber, Benoit; Haner, Robert published the artcile< Supramolecular assembly of DNA-constructed vesicles>, Quality Control of 184239-35-8, the main research area is DNA membrane vesicle self assembly cryoelectron microscopy.

The self-assembly of DNA hybrids possessing tetraphenylethylene sticky ends at both sides into vesicular architectures in aqueous medium is demonstrated. Cryo-electron microscopy reveals the formation of different types of morphologies from the amphiphilic DNA-hybrids. Depending on the conditions, either an extended (sheet-like) or a compact (columnar) alignment of the DNA hybrids is observed The different modes of DNA arrangement lead to the formation of vesicles appearing either as prolate ellipsoids (type I) or as spheres (type II). The type of packing has a significant effect on the accessibility of the DNA, as evidenced by intercalation and light-harvesting experiments Only the vesicles exhibiting the sheet-like DNA alignment are accessible for intercalation by ethidium bromide or for the integration of chromophore-labeled DNA via a strand exchange process. The dynamic nature of type I vesicles enables their elaboration into artificial light-harvesting complexes by DNA-guided introduction of Cy3-acceptor chromophores. DNA-constructed vesicles of the kind shown here represent versatile intermediates that are amenable to further modification for tailored nanotechnol. applications.

Nanoscale published new progress about Aggregation-induced emission. 184239-35-8 belongs to class bromides-buliding-blocks, and the molecular formula is C26H18Br2, Quality Control of 184239-35-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Rabal, Obdulia; Sanchez-Arias, Juan A.; Cuadrado-Tejedor, Mar; de Miguel, Irene; Perez-Gonzalez, Marta; Garcia-Barroso, Carolina; Ugarte, Ana; Estella-Hermoso de Mendoza, Ander; Saez, Elena; Espelosin, Maria; Ursua, Susana; Tan, Haizhong; Wu, Wei; Xu, Musheng; Garcia-Osta, Ana; Oyarzabal, Julen published the artcile< Design, synthesis, biological evaluation and in vivo testing of dual phosphodiesterase 5 (PDE5) and histone deacetylase 6 (HDAC6)-selective inhibitors for the treatment of Alzheimer's disease>, Quality Control of 85070-57-1, the main research area is phosphodiesterase PDE5 histone deacetylase HDAC6 inhibitor Alzheimer disease; Alzheimer; Dual inhibitors; HDAC6 selective; In-vivo test; PDE5 inhibition; Pharmacological tool compound; Tg2576 mice.

The authors have identified chem. probes that act as dual phosphodiesterase 5 (PDE5) and histone deacetylase 6 (HDAC6)-selective inhibitors (>1 log unit difference vs. class I HDACs) to decipher the contribution of HDAC isoforms to the pos. impact of dual-acting PDE5 and HDAC inhibitors on mouse models of Alzheimer’s disease (AD) and fine-tune this systems therapeutics approach. Structure- and knowledge-based approaches led to the design of first-in-class mols. with the desired target compound profile: dual PDE5 and HDAC6-selective inhibitors. Compound 44b (5-[[4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]methyl]thiophene-2-carbohydroxamic acid), which fulfilled the biochem., functional and ADME-Tox profiling requirements and exhibited adequate pharmacokinetic properties, was selected as pharmacol. tool compound and tested in a mouse model of AD (Tg2576) in vivo.

European Journal of Medicinal Chemistry published new progress about Alzheimer disease. 85070-57-1 belongs to class bromides-buliding-blocks, and the molecular formula is C9H8BrFO2, Quality Control of 85070-57-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Goldberg, Frederick W.; Kettle, Jason G.; Xiong, Jian; Lin, Daoguang published the artcile< General synthetic strategies towards N-alkyl sulfoximine building blocks for medicinal chemistry and the use of dimethylsulfoximine as a versatile precursor>, COA of Formula: C7H4BrNO4, the main research area is alkyl sulfoximine preparation; sulfide amination oxidation alkylation.

The sulfoximine group has great potential as a substituent in drug discovery, as evidenced by two new clin. candidates, and can be viewed as an isosteric alternative to the commonly used sulfone. Our aim was to improve the accessibility of this group by synthesizing a diverse range of S-alkyl and N-alkyl sulfoximine building blocks with procedures that are applicable on a practical scale (>10 g). In particular, synthesis of the less well exploited N-alkyl sulfoximines and the use of dimethylsulfoximine as a versatile, com. available precursor is discussed.

Tetrahedron published new progress about Alkylation. 16426-64-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrNO4, COA of Formula: C7H4BrNO4.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Li, Ankun; Li, Yuxuan; Liu, Junjie; Chen, Jingqi; Lu, Kui; Qiu, Di; Fagnoni, Maurizio; Protti, Stefano; Zhao, Xia published the artcile< Metal-Free Trifluoromethylthiolation of Arylazo Sulfones>, Recommanded Product: (3-Bromophenyl)(trifluoromethyl)sulfane, the main research area is fluoromethylthiolation arylazo sulfone fluoromethyl arylsulfonothioate.

A visible-light-driven protocol for the synthesis of aryl trifluoromethyl thioethers under photocatalyst- and metal-free conditions has been pursued. The procedure exploits the peculiar properties of arylazo sulfones (having electron-rich or electron-poor substituents on the (hetero)aromatic ring) as photochem. precursors of aryl radicals and S-trifluoromethyl arylsulfonothioates as easy-to-handle trifluoromethylthiolating agents.

Journal of Organic Chemistry published new progress about Aromatic compounds, azo Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 2252-45-1 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3S, Recommanded Product: (3-Bromophenyl)(trifluoromethyl)sulfane.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Liu, Jian; Vasamsetty, Laxmaiah; Anwar, Muhammad; Yang, Shuang; Xu, Weici; Liu, Jinggong; Nagaraju, Sakkani; Fang, Xinqiang published the artcile< Organocatalyzed Kinetic Resolution of α-Functionalized Ketones: The Malonate Unit Leads the Way>, SDS of cas: 3893-18-3, the main research area is ketone kinetic resolution organocatalyst.

Developing a catalytic kinetic resolution (KR) protocol affording enantioenriched α-functionalized ketones (R/S)-RC(O)C(R1)(X)(CH2)nCH(C(O)OMe)2, (I) (R = Ph, ethoxy, benzyloxy, 2-furyl, etc.; R1 = Me, benzylthio, cyclohexylthio, etc.; n = 0, 1; X = H, D, F) with broad substrate scope and high efficiency has been a longstanding challenge. A successful protocol toward addressing this issue via an organocatalyzed cascade annulation was reported. The protocol could afford 11 classes of enantioenriched α-functionalized ketones (I) using a single catalytic system and avoid the frequent alterations of reaction conditions used in conventional methods. Up to 684 of the selectivity factor (s) is observed, and in most case, the s values are higher than 100. An aminolactam additive 1-(3-aminopropyl)azepan-2-one proves essential in promoting the resolution efficiency. Moreover, many previously unavailable enantiopure α-functionalized ketones are now accessible, and the annulation products are also useful building blocks and can be further transferred to densely substituted ketones without erosion of the optical purity. Mechanistically, in sharp contrast to the currently used direct one-step resolution patterns, a two-key-step resolution mode, in which the enantiomer discrimination happens at the second aldol step and the enantioenriched ketones are recovered by the reversible initial Michael reaction, is proposed, which provides opportunities addressing the challenging tasks that could not be solved by conventional resolution techniques.

ACS Catalysis published new progress about Aldol addition, stereoselective. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, SDS of cas: 3893-18-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Liu, Shufang; Su, Qing; Qi, Wei; Luo, Kexin; Sun, Xiaoman; Ren, Hao; Wu, Qiaolin published the artcile< Highly hydrophilic covalent organic frameworks as efficient and reusable photocatalysts for oxidative coupling of amines in aqueous solution>, Recommanded Product: 4-Bromobenzylamine, the main research area is covalent organic framework catalyst preparation thermal stability; benzyl amine covalent organic framework catalyst photochem oxidative coupling; phenyl benzyl methanimine diastereoselective preparation.

Three hydrophilic two-dimensional (2D) COFs achieved by a polycondensation reaction of 2,5-dimethoxyterephthalohydrazide (DMTH), 1,3,5-triformylbenzene (TFB) and 2-hydroxy-1,3,5-benzene tricarbaldehyde (SOH) under solvothermal conditions was reported. The resulted COF materials, TFB-XX-DMTH (XX = 33, 50 and 66, corresponding to a molar ratio of TFB/SOH = 1 : 2, 1 : 1 and 2 : 1), were successfully constructed by a three-component in-situ assembly strategy and thus exhibited high crystallinity, large surface areas (up to 1808 m2 g-1) and good thermal and chem. stability. Moreover, benefiting from the enhanced charge separation efficiency and high hydrophilicity, the TFB-XX-DMTH materials were employed as photocatalysts for visible-light-driven oxidative coupling reactions of benzylamines in aqueous solution The photocatalytic performance with high conversion, selectivity and recyclability could be attributed to a combined result of efficient generation, migration and separation of photogenerated carriers in such a platform. This results provide insights into the structure-function correlation of COF photocatalysts and also highlight their potential in developing photofunctional COFs for sustainable organic transformations.

Catalysis Science & Technology published new progress about Aralkyl amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Recommanded Product: 4-Bromobenzylamine.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Kim, Kyeongha; Kim, Hun Young; Oh, Kyungsoo published the artcile< Aerobic Oxidation Approaches to Indole-3-carboxylates: A Tandem Cross Coupling of Amines-Intramolecular Mannich-Oxidation Sequence>, Formula: C7H8BrN, the main research area is indole amine cross coupling Mannich cyclization oxidation; indolecarboxylate preparation.

A tandem aerobic oxidation protocol has been developed for the facile synthesis of indole-3-carboxylates. Two readily available starting materials, anilines and benzylamines, were efficiently cross-coupled under the o-naphthoquinone-catalyzed aerobic oxidation conditions to the corresponding 2-arylmethyleneaminophenylacetates that in turn smoothly underwent the Cu(II)-catalyzed intramol. Mannich reaction. The resulting indoline derivatives were aerobically oxidized to indole-3-carboxylates, providing a ready access to indole derivatives from two simple amine derivatives

Organic Letters published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Formula: C7H8BrN.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Xu, Yuan; Tao, Chen-Lei; Yu, Maoxing; Xiong, Yi; Ouyang, Ya-Ni; Liu, Xun-Gao; Zhao, Zujin published the artcile< Tetraphenylethene-Based Luminescent Metal-Organic Framework for Effective Differentiation of cis/trans Isomers>, Related Products of 184239-35-8, the main research area is tetraphenylethene luminescent metal organic framework cis trans isomer; cis/trans differentiation; luminescent metal−organic framework; sensors; tetraphenylethene.

Luminescent metal-organic frameworks (LMOFs) that can effectively differentiate cis/trans isomers are rarely reported. Herein, we report a novel non-interpenetrated pillared-layered LMOF [Zn(HIPA)(BPyTPE)] (1) (BPyTPE = (E)-1,2-diphenyl-1,2-bis(4-(pyridin-4-yl)phenyl)ethene; HIPA = (5-hydroxyisophthalic acid)) with a high fluorescence quantum yield of 90.1%. The activated 1 exhibits high thermal stability and strong fluorescence in a methanol suspension. The fluorescence of activated 1 can be much more efficiently quenched by trans-dimethyl-2-butenedioate and trans-2-butene-1,4-diol than cis-dimethyl-2-butenedioate and cis-2-butene-1,4-diol, which enables it to differentiate these cis/trans isomers. This interesting LMOF could be a new type of fluorescence sensor to effectively detect cis/trans isomers.

ACS Applied Materials & Interfaces published new progress about Aggregation-induced emission. 184239-35-8 belongs to class bromides-buliding-blocks, and the molecular formula is C26H18Br2, Related Products of 184239-35-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary