Month: October 2022

Zhang, Kaiyue; Lu, Guilong; Chu, Feng; Huang, Xiubing published the artcile< Au/TiO2 nanobelts: thermal enhancement vs. plasmon enhancement for visible-light-driven photocatalytic selective oxidation of amines into imines>, Recommanded Product: 4-Bromobenzylamine, the main research area is mixed phase titanium dioxide nanobelt preparation; Au loaded titanium dioxide preparation; imine selective preparation; amine oxidation titanium dioxide nanocatalyst.

Herein, photocatalytic selective aerobic oxidation of amines to imines RCH2N=CHR1 [R = R1 = Ph, 2-BrC6H4, 3-pyridyl, etc.] was investigated under visible light irradiation over heterostructured TiO2(B)/anatase and Au/TiO2 nanobelts at specific temperatures (20-60°C). The surface amine substrate complexed on TiO2 could broaden the visible-light absorption region via the ligand-to-metal charge transfer (LMCT) effect. Interestingly, the pristine TiO2 achieved the best photocatalytic performance (>99% benzylamine conversion and >99% N-benzylidenebenzylamine selectivity) at 60°C after 12 h irradiation while the Au nanoparticles (NPs) were observed to improve the activity of TiO2 only in a low temperature range (<40°C). Moreover, excessive Au NPs loaded on TiO2 could inhibited the amine conversion and reduced the imine selectivity in the whole temperature range of 20-60°C, which was attributed to the decreased oxygen vacancies and poor amine adsorption ability on the surface of Au/TiO2. Catalysis Science & Technology published new progress about Aromatic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Recommanded Product: 4-Bromobenzylamine.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Yamaguchi, Isao; Fukumoto, Daiki; Wang, Aohan published the artcile< Synthesis and optical properties of pi-conjugated polymers and oligomers bearing hexaphenylbenzene and tetraphenyl ethene units>, Reference of 184239-35-8, the main research area is hexaphenylbenzene tetraphenylethene polymer preparation optical property.

π-Conjugated polymers (CPs) and oligomers (COs) bearing hexaphenylbenzene (HPB) and tetra-Ph ethene (TPE) units were synthesized by Sonogashira and Suzuki-Miyaura coupling reactions. The optical properties of the CPs and COs were investigated by UV-vis, photoluminescence (PL), and fluorescence lifetime (τ) measurements. The PL intensities of the solutions of the CPs and COs synthesized by Sonogashira coupling were reduced upon addition of poor solvent like water, which is attributed to aggregation-caused quenching. In contrast, the CP and COs bearing the TPE unit synthesized by Suzuki-Miyaura coupling exhibited aggregation-induced emission enhancement in solution This difference in fluorescence behavior is discussed herein in terms of the mol. sizes, conformations in solution, and τ values of the CPs and COs.

Journal of Polymer Science (Hoboken, NJ, United States) published new progress about Aggregation-induced emission. 184239-35-8 belongs to class bromides-buliding-blocks, and the molecular formula is C26H18Br2, Reference of 184239-35-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhang, Zeyuan; Dai, Zhen; Ma, Xinkun; Liu, Yihan; Ma, Xiaojun; Li, Wanli; Ma, Chen published the artcile< Cu-catalyzed one-pot synthesis of fused oxazepinone derivatives via sp2 C-H and O-H cross-dehydrogenative coupling>, Recommanded Product: 2-Bromo-4-(trifluoromethyl)phenol, the main research area is oxazepinone preparation; benzamide quinolinyl phenol halo cross dehydrogenative coupling copper catalyst.

An efficient Cu-catalyzed cascade reaction protocol was developed for the synthesis of fused oxazepinone derivatives I (R1 = H, 7-Cl, 8-Me, 9-CF3, etc.; R2 = H, 3-Br, 4-Cl, 3-MeO, etc.; Q = quinolin-8-yl, 5-methoxyquinolin-8-yl; A = N, C) via sp2 C-H and O-H cross-dehydrogenative coupling. A readily available catalyst, Cu2O, was used in this modular and convergent approach. An unusual Smiles rearrangement reaction was involved in this synthesis. Various reaction parameters were evaluated and optimized and the target compounds were obtained in good-to-excellent yields.

Organic Chemistry Frontiers published new progress about Benzamides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (heteroaryl). 81107-97-3 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3O, Recommanded Product: 2-Bromo-4-(trifluoromethyl)phenol.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Ghochikyan, Tariel V.; Vardanyan, Arpine S.; Samvelyan, Melanya A.; Galstyan, Armen S.; Langer, Peter published the artcile< Synthesis of cinnamyl substituted dihydrofuranones by the Heck cross-coupling reaction>, Application of C7H4BrF3, the main research area is cinnamyl substituted dihydrofuranone preparation; allyldihydrofuranone aryl bromide Heck palladium catalyst.

The Heck cross-coupling of 3-allyldihydrofuran-2(3H)-ones with aryl bromides afforded the corresponding 3-cinnamyl derivatives I [R = H, Me; R1 = H, CO2Et; Ar = Ph, 4-CO2MeC6H4, 3-F3CC6H4, etc.]. The structure of the products was confirmed by NMR spectroscopy, mass spectrometry and X-ray diffraction.

Mendeleev Communications published new progress about Aryl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Application of C7H4BrF3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Cardinal-David, Benoit; Raup, Dustin E. A.; Scheidt, Karl A. published the artcile< Cooperative N-Heterocyclic Carbene/Lewis Acid Catalysis for Highly Stereoselective Annulation Reactions with Homoenolates>, SDS of cas: 3893-18-3, the main research area is enal chalcone heterocyclic carbene Lewis acid catalyst stereoselective cyclization; cis trisubstituted cyclopentene stereoselective preparation.

A new approach that takes advantage of N-heterocyclic carbene/Lewis acid cooperative catalysis provides access to cis-1,3,4-trisubstituted cyclopentenes, e.g. I, from enals and chalcone derivatives with high levels of diastereoselectivity and enantioselectivity. The presence of Ti(OiPr)4 as the Lewis acid allows for efficient substrate preorganization, which translates into high levels of diastereoselectivity. Addnl., we demonstrate the possibility of controlling the absolute stereochem. of NHC-catalyzed reactions by employing a catalytic amount of a chiral Lewis acid as the unique source of optically active promoter.

Journal of the American Chemical Society published new progress about Alkenals Role: RCT (Reactant), RACT (Reactant or Reagent). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, SDS of cas: 3893-18-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Mo, Cheng; Zhang, Zhang; Li, Yupeng; Huang, Minhao; Zou, Jian; Luo, Jinfeng; Tu, Zheng-Chao; Xu, Yong; Ren, Xiaomei; Ding, Ke; Lu, Xiaoyun published the artcile< Design and Optimization of 3'-(Imidazo[1,2-a]pyrazin-3-yl)-[1,1'-biphenyl]-3-carboxamides as Selective DDR1 Inhibitors>, Application In Synthesis of 51605-97-1, the main research area is imidazo pyrazinyl carboxamide derivative preparation DDR1 inhibitor cancer.

DDR1 is considered as a promising target for cancer therapy, and selective inhibitors against DDR1 over other kinases may be considered as promising therapeutic agents. Herein, we have identified a series of 3′-(imidazo[1,2-a]pyrazin-3-yl)-[1,1′-biphenyl]-3-carboxamides as novel selective DDR1 inhibitors. Among these, compound 8v potently inhibited DDR1 with an IC50 of 23.8 nM, while it showed less inhibitory activity against DDR2 (IC50 = 1740 nM) and negligible activities against Bcr-Abl (IC50 > 10μM) and c-Kit (IC50 > 10μM). 8v also exhibited excellent selectivity in a KINOMEscan screening platform with 468 kinases. This compound dose-dependently suppressed NSCLC cell tumorigenicity, migration, and invasion. Collectively, these studies support its potential application for treatment of NSCLC.

ACS Medicinal Chemistry Letters published new progress about Antitumor agents. 51605-97-1 belongs to class bromides-buliding-blocks, and the molecular formula is C9H12BrN, Application In Synthesis of 51605-97-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Nishitani, Shohei; Sekiya, Ryo; Matsumoto, Ikuya; Haino, Takeharu published the artcile< Blueish-white-light-emitting Nanographenes Developed by Pd-catalyzed Suzuki-Miyaura Cross Coupling Reactions>, Product Details of C7H8BrN, the main research area is lead catalyst cross coupling reaction light emitting nanographene.

Top-down methods produce nanographenes with many carboxy groups on their edges. These functional groups can be utilized for developing multichromophoric systems. As proof of concept, pyrene is installed on the edges by Pd-catalyzed cross-coupling reactions. The lack of monomer emissions from the functionalized nanographenes indicates that the neighboring chromophores are sufficiently distant to form the excimer. The pyrene-installed nanographene emits bluish-white-light. Its lipophilic nature allows fabricating a nanographene-dispersed polymethyl methacrylate film emitting visible light.

Chemistry Letters published new progress about Carboxyl group. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Product Details of C7H8BrN.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Xu, Pin; Fan, Wenzheng; Chen, Pinhong; Liu, Guosheng published the artcile< Enantioselective Radical Trifluoromethylation of Benzylic C-H Bonds via Cooperative Photoredox and Copper Catalysis>, Quality Control of 2725-82-8, the main research area is benzylic trifluoromethyl preparation enantioselective; alkyl arene trifluoromethylation photoredox copper catalyst.

The first enantioselective radical trifluoromethylation of benzylic C-H bonds has been established by a cooperative photoredox and copper catalysis system, providing straightforward access to structurally diverse benzylic trifluoromethylation products RCH(CF3)CH2R1 [R = Ph, 2-phenyl-1,3-benzothiazol-6-yl, 4-cyclopropylphenyl, etc.; R1 = H, n-Pr, 2-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)ethyl, 2-chloroethyl, etc.] in good yields with excellent enantioselectivities under mild conditions. A broad substrate scope and excellent functional group compatibility were reported. Merging the cooperative photoredox catalysis with copper catalysis is essential for the reaction, where the photoredox catalysis is used for the generation of benzylic radicals from alkyl arenes alkyl arenes RCH2CH2R1 through a hydrogen atom transfer process and the copper catalysis is used for the enantioselective trifluoromethylation of the benzylic radicals.

Journal of the American Chemical Society published new progress about Alkylarenes Role: RCT (Reactant), RACT (Reactant or Reagent). 2725-82-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H9Br, Quality Control of 2725-82-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Tan, Mei-Ling; Tong, Shuo; Hou, Sheng-Kai; You, Jingsong; Wang, Mei-Xiang published the artcile< Copper-Catalyzed N,N-Diarylation of Amides for the Construction of 9,10-Dihydroacridine Structure and Applications in the Synthesis of Diverse Nitrogen-Embedded Polyacenes>, Synthetic Route of 89003-95-2, the main research area is amide haloarylmethane diarylation copper; acyldihydroacridine preparation deacylation oxidative aromatization; tetracene pentacene preparation; polyacene preparation; copper arylation catalyst.

A CuI/DMEDA catalyzed N,N-diarylation reaction of amides with various di(o-bromoaryl)methanes to produce diverse 9,10-dihydroacridine derivatives, is reported. The resulting 9,10-dihydroacridine derivatives were oxidized selectively under mild conditions to afford acridine, acridinone, and acridinium derivatives The copper-catalyzed N,N-diarylation reaction coupled with oxidative aromatization reaction enabled the facile construction of nitrogen atom-embedded tetracenes and pentacenes of different ortho-fused patterns. The luminescence properties, especially the effect of fusion pattern on fluorescence emission of acquired N-polyacenes, were also demonstrated.

Organic Letters published new progress about Absorption. 89003-95-2 belongs to class bromides-buliding-blocks, and the molecular formula is C8H4BrNO, Synthetic Route of 89003-95-2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhao, Gui-Ling; Ullah, Farman; Deiana, Luca; Lin, Shuangzheng; Zhang, Qiong; Sun, Junliang; Ibrahem, Ismail; Dziedzic, Pawel; Cordova, Armando published the artcile< Dynamic kinetic asymmetric transformation (DYKAT) by combined amine- and transition-metal-catalyzed enantioselective cycloisomerization>, Electric Literature of 3893-18-3, the main research area is cyclopentene derivative asym synthesis; unsaturated aldehyde propargylated acid dynamic kinetic asym transformation cycloisomerization.

The first examples of one-pot highly chemo- and enantioselective dynamic kinetic asym. transformations (DYKATs) involving α,β-unsaturated aldehydes and propargylated carbon acids are presented. These DYKATs, which proceed by a combination of catalytic iminium activation, enamine activation, and Pd0-catalyzed enyne cycloisomerization, give access to functionalized cyclopentenes e. g., I with up to 99 % ee and can be used for the generation of all-carbon quaternary stereocenters.

Chemistry – A European Journal published new progress about Amines, chiral Role: CAT (Catalyst Use), USES (Uses). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Electric Literature of 3893-18-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary