Month: October 2022

Singh, Abhishek Kumar; Schade, Boris; Wycisk, Virginia; Boettcher, Christoph; Haag, Rainer; von Berlepsch, Hans published their research in Journal of Physical Chemistry B in 2021. The article was titled 《Aggregation of Amphiphilic Carbocyanines: Fluorination Favors Cylindrical Micelles over Bilayered Tubes》.Safety of Ethyl 4-bromobutyrate The article contains the following contents:

The synthesis of a new amphiphilic 5,5,6,6-tetrachlorobenzimidacarbocyanine dye derivative with -(CH2)2-(CF2)5-CF3 chains attached to the nitrogen atoms in the 1,1-position, CF8O3, is reported. Depending on the dye concentration and the addition of MeOH, CF8O3 forms J- and H-aggregates in aqueous solutions The aggregation behavior was investigated using steady-state absorption, linear dichroism, and fluorescence spectroscopy, as well as by cryogenic transmission electron microscopy (cryo-TEM). The J-band of the MeOH-free solution is monomer-like, rather broad, and less red-shifted with respect to the monomer absorption, indicating weak excitonic coupling and disorder effects. Cryo-TEM reveals a diversity of supramol. structures, wherein linear and branched cylindrical micelles dominate. It is concluded that the high stiffness of fluoroalkyl chains does not allow the chains to splay and completely fill up the hydrophobic gap between opposing chromophores. This destabilizes the bilayers and favors the micellar structure motifs instead. The aggregates appearing at 30% MeOH show a split absorption spectrum consisting of a broad blue-shifted H-band and an accompanying sharp red-shifted J-band with perpendicular polarizations. These HJ-type aggregates are also composed of micellar fibers, but these bundle into rope-like strands. For 10% MeOH, a narrow bilayered tube is the dominating morphol. The observed MeOH dependence of aggregation reveals a clear cosolvent effect. The results came from multiple reactions, including the reaction of Ethyl 4-bromobutyrate(cas: 2969-81-5Safety of Ethyl 4-bromobutyrate)

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Safety of Ethyl 4-bromobutyrate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Iwami, Hikaru; Okamura, Masaya; Kondo, Mio; Masaoka, Shigeyuki published their research in Angewandte Chemie, International Edition in 2021. The article was titled 《Electrochemical Polymerization Provides a Function-Integrated System for Water Oxidation》.Electric Literature of C5H9BrO2 The article contains the following contents:

Water oxidation is a key reaction in natural and artificial photosynthesis. In nature, the reaction is efficiently catalyzed by a metal-complex-based catalyst surrounded by hole-transporting amino acid residues. However, in artificial systems, there is no example of a water oxidation system that has a catalytic center surrounded by hole transporters. Herein, we present a facile strategy to integrate catalytic centers and hole transporters in one system. Electrochem. polymerization of a metal-complex-based precursor afforded a polymer-based material (Poly-1). Poly-1 exhibited excellent hole-transporting ability and catalyzed water oxidation with high performance. It was also revealed that the catalytic activity was almost completely suppressed in the absence of the hole-transporting moieties. The present study provides a novel strategy for constructing efficient mol.-based systems for water oxidation In the part of experimental materials, we found many familiar compounds, such as Ethyl 3-bromopropanoate(cas: 539-74-2Electric Literature of C5H9BrO2)

Ethyl 3-bromopropanoate(cas: 539-74-2) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals.Electric Literature of C5H9BrO2 The most pervasive is the naturally produced bromomethane.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Meng, Lingpu; Yang, Jingjie; Duan, Mei; Wang, You; Zhu, Shaolin published an article in 2021. The article was titled 《Facile Synthesis of Chiral Arylamines, Alkylamines and Amides by Enantioselective NiH-Catalyzed Hydroamination》, and you may find the article in Angewandte Chemie, International Edition.Formula: C20H20BrP The information in the text is summarized as follows:

Regio- and enantioselective hydroarylamination, hydroalkylamination and hydroamidation of styrenes was developed by NiH catalysis with a simple bioxazoline ligand under mild conditions. A wide range of enantioenriched benzylic arylamines, alkylamines and amides was easily accessed by nitroarenes, hydroxylamines and dioxazolones, resp. as amination reagents. The chiral induction in these reactions was proposed to proceed through an enantiodifferentiating syn-hydronickellation step. In the experimental materials used by the author, we found Ethyltriphenylphosphonium bromide(cas: 1530-32-1Formula: C20H20BrP)

Ethyltriphenylphosphonium bromide(cas: 1530-32-1) is a phase transfer catalyst, used to accelerate the cure of phenolic-based epoxy resins, certain fluoroelastomer resins and thermosetting powder coatings. It is also used as catalysts in the synthesis of certain organic compounds and as a pharmaceutical intermediate.Formula: C20H20BrP

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Nakao, Shuichi; Saikai, Miki; Nishimoto, Yoshihiro; Yasuda, Makoto published an article in 2021. The article was titled 《InBr3-Catalyzed Coupling Reaction between Electron-Deficient Alkenyl Ethers with Silyl Enolates for Stereoselective Synthesis of 1,5-Dioxo-alk-2-enes》, and you may find the article in European Journal of Organic Chemistry.Application In Synthesis of Indium(III) bromide The information in the text is summarized as follows:

A coupling reaction of electron-deficient alkenyl ethers with silyl enolates catalyzed by InBr3 was achieved. Various silyl enolates and 2-carbonylalkenyl ethers were applicable, giving the corresponding 1,5-dioxo-alk-2-enes with perfect stereoselectivity of the alkene moieties. The present coupling reaction proceeds via the 1,4-addition of silyl enolates to alkenyl ethers followed by elimination of silyl alkoxides, in which moderate-Lewis acidic InBr3 performs both the activation of alkenyl ethers and the elimination of alkoxy groups regardless of the presence of various coordinative functional groups. In addition to this study using Indium(III) bromide, there are many other studies that have used Indium(III) bromide(cas: 13465-09-3Application In Synthesis of Indium(III) bromide) was used in this study.

Indium(III) bromide(cas: 13465-09-3) is used as a catalyst to produce dithioacetals when unactivated alkynes react with thiols and fields such as optics and microelectronics that utilize semiconductor technology have wide uses for indium in high-performing solar cells.Application In Synthesis of Indium(III) bromide

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Hassan, Mohamed; Krieg, Sara-Cathrin; Ndefo Nde, Cedric; Roos, Jessica; Maier, Thorsten J.; El Rady, Eman A.; Raslan, Mohamed A.; Sadek, Kamal U.; Manolikakes, Georg published an article in 2021. The article was titled 《Streamlined One-Pot Synthesis of Nitro Fatty Acids》, and you may find the article in European Journal of Organic Chemistry.Computed Properties of C4H7BrO2 The information in the text is summarized as follows:

A novel method for the synthesis of nitro fatty acids (NFAs), an intriguing class of endogenously occurring lipid mediators, is reported. This one-pot procedure enables the controlled and stereoselective construction of nitro fatty acids from a simple set of common building blocks in a highly facile manner. Thereby, this methodol. offers a streamlined, highly modular access to naturally occurring nitro fatty acids as well as non-natural NFA derivatives In addition to this study using 4-Bromobutanoic acid, there are many other studies that have used 4-Bromobutanoic acid(cas: 2623-87-2Computed Properties of C4H7BrO2) was used in this study.

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Computed Properties of C4H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhang, Cheng; Yue, Hu; Sun, Ping; Hua, Lei; Liang, Shuli; Ou, Yitao; Wu, Dan; Wu, Xinyi; Chen, Hao; Hao, Ying; Hu, Wenhui; Yang, Zhongjin published an article in 2021. The article was titled 《Discovery of chalcone analogues as novel NLRP3 inflammasome inhibitors with potent anti-inflammation activities》, and you may find the article in European Journal of Medicinal Chemistry.Quality Control of Ethyl 5-bromovalerate The information in the text is summarized as follows:

NLRP3 inflammasome activation plays a critical role in inflammation and its related disorders. Herein we report a hit-to-lead effort resulting in the discovery of a novel and potent class of NLRP3 inflammasome inhibitors. Among these, the most potent lead 40 exhibited improved inhibitory potency and almost no toxicity. Further mechanistic study indicated that compound 40 inhibited the NLRP3 inflammasome activation via suppressing ROS production More importantly, treatment with 40 showed remarkable therapeutic effects on LPS-induced sepsis and DSS-induced colitis. This study encourages further development of more potent inhibitors based on this chem. scaffold and provides a chem. tool to identify its cellular binding target. In the experiment, the researchers used many compounds, for example, Ethyl 5-bromovalerate(cas: 14660-52-7Quality Control of Ethyl 5-bromovalerate)

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Quality Control of Ethyl 5-bromovalerate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Oliva, Paola; Scortichini, Mirko; Dobelmann, Clemens; Jain, Shanu; Gopinatth, Varun; Toti, Kiran S.; Phung, Ngan B.; Junker, Anna; Jacobson, Kenneth A. published an article in 2021. The article was titled 《Structure-activity relationships of pyrimidine nucleotides containing a 5′-α,β-methylene diphosphonate at the P2Y6 receptor》, and you may find the article in Bioorganic & Medicinal Chemistry Letters.Related Products of 1129-28-8 The information in the text is summarized as follows:

The Gq-coupled P2Y6 receptor (P2Y6R) is a component of the purinergic signaling system and functions in inflammatory, cardiovascular and metabolic processes. UDP, the native P2Y6R agonist and P2Y14R partial agonist, is subject to hydrolysis by ectonucleotidases. Therefore, we have synthesized UDP/CDP analogs, e.g. I, containing a stabilizing α,β-methylene bridge as P2Y6R agonists and identified compatible affinity-enhancing pyrimidine modifications. A distal binding region on the receptor was explored with 4-benzyloxyimino CDP analogs and their potency determined in a calcium mobilization assay. A 4-trifluoromethyl-benzyloxyimino substituent provided the highest human P2Y6R potency (MRS4554, 0.57μM), and a 5-fluoro substitution of the cytosine ring similarly enhanced potency, with >175- and 39-fold selectivity over human P2Y14R, resp. However, 3-alkyl, β-D-arabinofuranose, and 6-aza substitution prevented P2Y6R activation. Thus, we have identified new α,β-methylene bridged N4-extended CDP analogs as P2Y6R agonists that are highly selective over the P2Y14R. In the experiment, the researchers used Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Related Products of 1129-28-8)

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.Organobromine chemicals are produced naturally by an array of biological and other chemical processes in our environment. Some of these compounds are identical to man-made organobromine compounds, such as methyl bromide, bromoform, and bromophenols, but many others are entirely new moleclar entities, often possessing extraordinary and important biological properties. Related Products of 1129-28-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Delledonne, Andrea; Orlandini, Martina; Mazzeo, Paolo P.; Sissa, Cristina; Bacchi, Alessia; Terenziani, Francesca; Pelagatti, Paolo published an article in Physical Chemistry Chemical Physics. The title of the article was 《Bis-isonicotinoyl linkers containing polyaromatic scaffolds: synthesis, structure and spectroscopic properties》.HPLC of Formula: 523-27-3 The author mentioned the following in the article:

New synthesis of extended linkers containing different polyaromatic chromophores functionalized with isonicotinoyl moieties I (R = 3,7-naphthalene-diyl, biphenyl-4,4′-diyl, fluorene-2,7-diyl, etc.) have been synthesized by Pd-catalyzed cross-coupling reactions involving isonicotinamide and the appropriate aromatic dibromides such as 2,6-dibromonaphthalene, 2,7-dibromofluorene, 9,10-dibromoanthracene, etc. The optimized protocol led to the isolation of the target mols. in good yield and with high purity. Electronic absorption and emission spectra were collected both in solution (DMF) and in the solid state. TDDFT calculations were carried out to investigate the effect of the isonicotinoyl moieties on the spectral features of the central chromophores. After reading the article, we found that the author used 9,10-Dibromoanthracene(cas: 523-27-3HPLC of Formula: 523-27-3)

9,10-Dibromoanthracene(cas: 523-27-3) can be sublimated and oxidized to generate anthraquinone. Soluble in hot benzene and hot toluene, slightly soluble in alcohol, ether and cold benzene, insoluble in water.HPLC of Formula: 523-27-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary