Month: October 2022

In 2022,Yan, Xiang-Yu; Leng, Jia-Fu; Chen, Ting-Ting; Zhao, Yong-Jun; Kong, Ling-Yi; Yin, Yong published an article in European Journal of Medicinal Chemistry. The title of the article was 《Design, synthesis, and biological evaluation of novel diphenylamine derivatives as tubulin polymerization inhibitors targeting the colchicine binding site》.HPLC of Formula: 2635-13-4 The author mentioned the following in the article:

A novel series of diphenylamine derivatives were designed and synthesized I and their biol. activities were evaluated. The anti-proliferative activities of the derivatives were tested against five human cancer cell lines (MCF-7, MDA-MB-231, A549, HeLa and HT29). Among them, I exhibited the promising anti-proliferative activity against HT29 cell lines with the IC50 value of 23 nM. Further biol. studies depicted that I inhibited cancer cell migration, colony formation and angiogenesis. Besides, dynamics studies and mol. docking studies revealed that I inhibited tubulin polymerization which may be a result of the compound binding to the colchicine site of tubulin. Furthermore,I arrested HT29 cell cycle at G2/M phase, and induced HT29 cell apoptosis by upregulating cyclin B1, Bcl-2, Bax, Cleaved-caspase9, Cleaved-caspase3, PARP, Cleaved-PARP proteins, and downregulating p-cdc25c (S216), p-cdc2 (T15) proteins. Mitochondrial membrane potential (MMP) and reactive oxygen species (ROS) were also determined to confirm the cell apoptosis process. Finally, I greatly inhibited the tumor growth in HT29 xenograft mice by 75.5% at 10 mg/kg. Meanwhile, I owned the good pharmacokinetic properties. All the results promised that I is of potential to act as an antitumor candidate and worthy of further investigation. In the part of experimental materials, we found many familiar compounds, such as 5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4HPLC of Formula: 2635-13-4)

Furthermore, the coupling of 5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4) with β-methallyl alcohol was catalyzed by Pd(OAc)2 in combination with P(t-Bu)3.HPLC of Formula: 2635-13-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Dong, Yuyang; Shin, Kwangmin; Mai, Binh Khanh; Liu, Peng; Buchwald, Stephen L. published an article in Journal of the American Chemical Society. The title of the article was 《Copper Hydride-Catalyzed Enantioselective Olefin Hydromethylation》.Recommanded Product: 1530-32-1 The author mentioned the following in the article:

The enantioselective installation of a Me group onto a small mol. can result in the significant modification of its biol. properties. While hydroalkylation of olefins represents an attractive approach to introduce alkyl substituents, asym. hydromethylation protocols are often hampered by the incompatibility of highly reactive methylating reagents and a lack of general applicability. Herein, authors report an asym. olefin hydromethylation protocol enabled by CuH catalysis. This approach leverages Me tosylate as a Me source compatible with the reducing base-containing reaction environment, while a catalytic amount of iodide ion transforms the Me tosylate in situ into the active reactant, Me iodide, to promote the hydromethylation. This method tolerates a wide range of functional groups, heterocycles, and pharmaceutically relevant frameworks. D. functional theory studies suggest that after the stereoselective hydrocupration, the methylation step is stereoretentive, taking place through an SN2-type oxidative addition mechanism with Me iodide followed by a reductive elimination. The experimental process involved the reaction of Ethyltriphenylphosphonium bromide(cas: 1530-32-1Recommanded Product: 1530-32-1)

Ethyltriphenylphosphonium bromide(cas: 1530-32-1) is a phase transfer catalyst, used to accelerate the cure of phenolic-based epoxy resins, certain fluoroelastomer resins and thermosetting powder coatings. CatOnium ETPB is also used as catalysts in the synthesis of certain organic compounds.Recommanded Product: 1530-32-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Application of 6630-33-7In 2020 ,《One-pot multicomponent synthesis of a new series of curcumin-derived 4H-pyrans under ambient conditions》 appeared in Journal of Heterocyclic Chemistry. The author of the article were Brahmachari, Goutam; Mandal, Mullicka. The article conveys some information:

The design and synthesis of a new series of pharmaceutically interesting curcumin-derived 4H-pyrans I (R = H, 2-Br, 4-Br, 4-Cl, 2,4-Cl2, 2-F, 4-F, 4-CF3) have been accomplished via a one-pot tandem reaction between curcumin, aromatic aldehydes, and malononitrile under the influence of sodium formate as a mild base in ethanol at ambient conditions. Operational simplicity, mild reaction conditions, use of a cheap and nontoxic organo-catalyst, and eco-friendly solvent, and easy isolation of target products are the key benefits associated with the process. In the part of experimental materials, we found many familiar compounds, such as o-Bromobenzaldehyde(cas: 6630-33-7Application of 6630-33-7)

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Application of 6630-33-7It is also used in L-threonine aldolase-catalyzed enantio and diastereoselective aldol reactions. Further, it reacts with trichloromethane to prepare 1-(2-bromo-phenyl)-2,2,2-trichloro-ethanol.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Application In Synthesis of Tris(4-bromophenyl)amineIn 2021 ,《Pyrene-containing conjugated organic microporous polymers for photocatalytic hydrogen evolution from water》 appeared in Catalysis Science & Technology. The author of the article were Mohamed, Mohamed Gamal; Elsayed, Mohamed Hammad; Elewa, Ahmed M.; EL-Mahdy, Ahmed F. M.; Yang, Cheng-Han; Mohammed, Ahmed A. K.; Chou, Ho-Hsiu; Kuo, Shiao-Wei. The article conveys some information:

Photoactive conjugated microporous polymers (CMPs) are emerging as porous materials capable of mediating the photocatalytic evolution of H2 from water. In this study, we synthesized three pyrene-based CMPs (Py-F-CMP, Py-TPA-CMP, Py-TPE-CMP) through Sonogashira-Hagihara cross-couplings of 1,3,6,8-tetraethynylpyrene (Py-T, as a common monomer building block) with 2,7-dibromo-9H-fluorene (F-Br2), tris(4-bromophenyl)amine (TPA-Br3), and 1,1,2,2-tetrakis(4-bromophenyl)ethene (TPE-Br4), resp., in the presence of Pd(PPh3)4 in DMF/Et3N. We then characterized the chem. structures, crystallinities, thermal stabilities, surface morphologies, and porosities of these three new CMPs. Brunauer-Emmett-Teller (BET) analyses and tests of photocatalytic H2 production revealed that Py-TPA-CMP displayed the highest BET surface area (454 m2 g-1), highest total pore volume (0.28 cm3 g-1), highest H2 evolution rate (19 200 μmol h-1 g-1), and highest apparent quantum yield (15.3%) when compared with those of Py-F-CMP, Py-TPE-CMP, and other organic porous materials. In the experimental materials used by the author, we found Tris(4-bromophenyl)amine(cas: 4316-58-9Application In Synthesis of Tris(4-bromophenyl)amine)

In general, Tris(4-bromophenyl)amine(cas: 4316-58-9) is often used in the synthesis of porous luminescent covalent–organic polymers (COPs)Application In Synthesis of Tris(4-bromophenyl)amine

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Quality Control of 4-Bromobenzoic acidIn 2021 ,《Influence of Isomerism on Radioluminescence of Purely Organic Phosphorescence Scintillators》 appeared in Angewandte Chemie, International Edition. The author of the article were Dong, Chaomin; Wang, Xiao; Gong, Wenqi; Ma, Wenbo; Zhang, Meng; Li, Jingjie; Zhang, Yuan; Zhou, Zixing; Yang, Zhijian; Qu, Shuli; Wang, Qian; Zhao, Zhu; Yang, Guohui; Lv, Anqi; Ma, Huili; Chen, Qiushui; Shi, Huifang; Yang, Yang; An, Zhongfu. The article conveys some information:

There are few reports about purely organic phosphorescence scintillators, and the relation between mol. structures and radioluminescence in organic scintillators is still unclear. An isomerism strategy to study the effect of mol. structures on radioluminescence is presented. Bromobenzoic acid (BA) isomers can achieve phosphorescence efficiency of ≤22.8% by UV irradiation Under x-ray irradiation, both m-BA and p-BA show excellent radioluminescence, while o-BA has almost no radioluminescence. Through exptl. and theor. study, radioluminescence was not only affected by nonradiation in emissive process, but also highly depended on the material conductivity caused by the different mol. packing. This study allows clear understanding of the relation between the mol. structures and radioluminescence and provides a guidance to rationally design new organic scintillators.4-Bromobenzoic acid(cas: 586-76-5Quality Control of 4-Bromobenzoic acid) was used in this study.

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography. It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.Quality Control of 4-Bromobenzoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Product Details of 13465-09-3In 2018 ,《Indium(III) as π-acid catalyst for the electrophilic activation of carbon-carbon unsaturated systems》 appeared in Organic & Biomolecular Chemistry. The author of the article were Perez Sestelo, Jose; Sarandeses, Luis A.; Martinez, M. Montserrat; Alonso-Maranon, Lorena. The article conveys some information:

A review. This review focuses on the utilization of indium(III) as a π-acid for the activation of C-C unsaturated bonds in organic synthesis. In addition to its well-known σ-coordination with carbonyl derivatives, indium(III) undergoes efficient π-coordination with unsaturated systems to trigger nucleophilic addition Accordingly, indium(III) halides and salts (InX3, X = Cl, Br, I, OTf, ONf, NTf2) have been reported as useful catalysts for a broad range of carbon-carbon and carbon-heteroatom bond formation reactions, including hydrofunctionalization (hydroarylation, hydroamination, hydroalkoxylation, and hydrothiolation), enyne cycloisomerization, and related reactions. In these reactions the counterion has a significant effect on the catalytic activity, and the development of novel In(III) complexes and the generation of highly electrophilic cationic indium(III) species has increased its synthetic applications as a π-acid catalyst. The experimental process involved the reaction of Indium(III) bromide(cas: 13465-09-3Product Details of 13465-09-3)

Indium(III) bromide(cas: 13465-09-3) is used as a catalyst to produce dithioacetals when unactivated alkynes react with thiols and fields such as optics and microelectronics that utilize semiconductor technology have wide uses for indium in high-performing solar cells.Product Details of 13465-09-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Safety of Ethyltriphenylphosphonium bromideIn 2021 ,《Ruthenium Removal Using Silica-Supported Aromatic Isocyanides》 was published in Journal of Organometallic Chemistry. The article was written by Gregg, Zackary R.; Glickert, Elise; Xu, Ruoshui; Diver, Steven T.. The article contains the following contents:

New silica gel scavengers containing aromatic isocyanides have been synthesized and evaluated for Ru removal. A thiol-ene click reaction was used to attach the isocyanide precursor to a thiol-containing siloxane. Conventional methods for grafting to silica gel at elevated temperature resulted in significant hydrolysis of the isocyanide. A novel cleavage reaction was developed to quantitate the amount of surface-loaded isocyanide. Binding by the new materials was comparatively evaluated for a variety or Ru carbene catalysts. The optimal conditions were extended to two ring-closing metatheses (RCM). The residual Ru was determined by inductively coupled plasma mass spectrometry (ICP-MS). For facile RCM reactions, the UV data agreed with the ICP-MS results. However, more difficult RCM did not correlate well with the UV data. This was interpreted in terms of varying extent of catalyst decomposition In all cases, isocyanide scavenger reagents were found to be superior to commonly used silica gel-based metal scavengers. The experimental process involved the reaction of Ethyltriphenylphosphonium bromide(cas: 1530-32-1Safety of Ethyltriphenylphosphonium bromide)

Ethyltriphenylphosphonium bromide(cas: 1530-32-1) is a phase transfer catalyst, used to accelerate the cure of phenolic-based epoxy resins, certain fluoroelastomer resins and thermosetting powder coatings. CatOnium ETPB is also used as catalysts in the synthesis of certain organic compounds.Safety of Ethyltriphenylphosphonium bromide

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Name: 2,5-DibromothiopheneIn 2020 ,《Novel Sulfur-Containing Cross-Linking Agent for Si-Based Preceramic Polymers》 was published in Macromolecular Chemistry and Physics. The article was written by Taheri, Poroshat; Bokka, Apparao; Asgari, Parham; Jeon, Junha; Lang, John C.; Campostrini, Renzo; Soraru, Gian Domenico; Kroll, Peter. The article contains the following contents:

Crosslinking polymethylhydrosiloxane (PMHS) with divinylthiophene (DVT) via hydrosilylation in highly dilute conditions and subsequent supercritical drying in CO2 yield a polymeric aerogel containing aromatic sulfur integrally and uniformly distributed throughout the monolith. Fourier-transform IR (FT-IR) spectroscopy indicates almost complete consumption of vinyl groups and Si-H bonds in the product. Both FT-IR and Raman spectroscopic analyses support loss of conjugation of vinyl groups with the retained double bonds of the thiophene ring. SEM indicates a condensed colloidal structure with characteristic particulate diameters of about 165 nm. SEM coupled with energy dispersive X-ray spectroscopy elemental mapping shows that sulfur is distributed homogeneously in the polymeric aerogel. Porosimetry of the mesoporous aerogel indicates the effective average pore diameters are about 12 nm. Thermogravimetric anal. (TGA) establishes greater thermal stability of the PMHS-DVT product than either of the pure unreacted components. TGA coupled with mass spectrometric (TG-MS) identification of the volatiles released during pyrolysis shows that sulfur is driven from the crosslinked polymer as thiophene and its derivatives Recorded mass spectra support the hypothesis that crosslinking DVT bridges between PMHS chains in the polymeric aerogel, and that this results in a more thermally stable monolith. The experimental part of the paper was very detailed, including the reaction process of 2,5-Dibromothiophene(cas: 3141-27-3Name: 2,5-Dibromothiophene)

2,5-Dibromothiophene(cas: 3141-27-3) , is mainly used as pharmaceutical intermediate and synthesis intermediate. 2,5-Dibromothiophene polymerizes by debromination with magnesium catalyzed by nickel compounds to form poly(2,5- thienylene) .Name: 2,5-Dibromothiophene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 1,4-Bis(bromomethyl)benzeneIn 2020 ,《Precisely Controlled Multidimensional Covalent Frameworks: Polymerization of Supramolecular Colloids》 was published in Angewandte Chemie, International Edition. The article was written by Li, Yongguang; Wu, Shanshan; Zhang, Lingling; Xu, Xin; Fang, Yajun; Yi, Juzhen; Kim, Jehan; Shen, Bowen; Lee, Myongsoo; Huang, Liping; Zhang, Liwei; Bao, Junhui; Ji, Hongbing; Huang, Zhegang. The article contains the following contents:

Rapid and selective removal of micropollutants from water is important for the reuse of water resources. Despite hollow frameworks with specific functionalized porous walls for the selective adsorption based on a series of interactions, tailoring a stable shape of nanometer- and micrometer-sized architectures for the removal of specific pollutants remains a challenge. Here, exactly controlled sheets, tubes, and spherical frameworks were presented from the crosslinking of supramol. colloids in polar solvents. The frameworks strongly depended on the architecture of original supramol. colloids. As the entropy of colloids increased, the initial laminar framework rolled up into hollow tubules, and then further curled into hollow spheres. These shape-persistent frameworks showed unprecedented selectivity as well as specific recognition for the shape of pollutants, thus contributing to efficient pollutant separation In the experiment, the researchers used 1,4-Bis(bromomethyl)benzene(cas: 623-24-5Reference of 1,4-Bis(bromomethyl)benzene)

1,4-Bis(bromomethyl)benzene(cas: 623-24-5) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Reference of 1,4-Bis(bromomethyl)benzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《A Copper(I)-Catalyzed Radical-Relay Reaction Enabling the Intermolecular 1,2-Alkylborylation of Unactivated Olefins》 was written by Akiyama, Sota; Oyama, Natsuki; Endo, Tsubura; Kubota, Koji; Ito, Hajime. Name: Ethylbromofluoroacetate And the article was included in Journal of the American Chemical Society on April 7 ,2021. The article conveys some information:

The 1st catalytic intermol. 1,2-alkylborylation reaction via a radical-relay mechanism between unactivated olefins, bis(pinacolato)diboron, and an alkyl electrophile is reported. Successful implementation of this method requires that the competing boryl substitution of the alkyl electrophile is retarded to facilitate the radical relay. This challenge was overcome using electronically or sterically demanding alkyl electrophiles, which results in the simultaneous and highly regioselective introduction of a gem-difluoro, monofluoro, tertiary, or secondary alkyl group and a boryl group across the C:C double bond.Ethylbromofluoroacetate(cas: 401-55-8Name: Ethylbromofluoroacetate) was used in this study.

Ethylbromofluoroacetate(cas: 401-55-8) is a member of organofluorine compounds. Organofluorine compounds, which have carbon-fluorine bonds, show unique features such as high thermal and chemical stability, high surface activity, no light-absorbing ability, high pharmacological effect, and so on. Owing to their specific characters, they are indispensable chemicals for industry and our daily lives.Name: Ethylbromofluoroacetate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary