Month: October 2022

In 2022,Kundu, Gourab; Opincal, Filip; Sperger, Theresa; Schoenebeck, Franziska published an article in Angewandte Chemie, International Edition. The title of the article was 《Air-Stable PdI Dimer Enabled Remote Functionalization: Access to Fluorinated 1,1-Diaryl Alkanes with Unprecedented Speed》.Recommanded Product: 7073-94-1 The author mentioned the following in the article:

This work features a remote arylation in less than 10 min reaction time at room temperature over a distance of up to 11 carbons. The unprecedented speed was enabled by the air-stable PdI dimer [Pd(μ-I)(PCy2t-Bu)]2, which in contrast to its PtBu3 counterpart does not trigger direct coupling at the initiation site, but regioconvergent and chemoselective remote functionalization to yield valuable fluorinated 1,1-diaryl alkanes. This study combined exptl. and computational studies rationalize the origins of switchability, which were primarily due to differences in dispersion interactions. In the experiment, the researchers used 1-Bromo-2-isopropylbenzene(cas: 7073-94-1Recommanded Product: 7073-94-1)

1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. Recommanded Product: 7073-94-1 Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Zhang, Qingyu; Chan, Yung-Yin; Zhang, Muyin; Yeung, Ying-Yeung; Ke, Zhihai published an article in Angewandte Chemie, International Edition. The title of the article was 《Hypervalent Chalcogenonium…π Bonding Catalysis》.Application of 2635-13-4 The author mentioned the following in the article:

A proof-of-concept study of hypervalent chalcogenonium…π bonding catalysis was performed. A new catalytic strategy using 1,2-oxaselenolium salts as chalcogen bond donors and alkenes as chalcogen bond acceptors is described. The feasibility of this concept is demonstrated by the use of trisubstituted selenonium salts in the metal-free catalytic hydrofunctionalization and polymerization of alkenes via unconventional seleniranium ion-like intermediates. The results indicate that counter anions have a significant effect on the catalysis based on hypervalent chalcogenonium…π bonding interactions. In addition to this study using 5-Bromobenzo[d][1,3]dioxole, there are many other studies that have used 5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4Application of 2635-13-4) was used in this study.

Furthermore, the coupling of 5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4) with β-methallyl alcohol was catalyzed by Pd(OAc)2 in combination with P(t-Bu)3.Application of 2635-13-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Nozawa-Kumada, Kanako; Ono, Kanako; Kurosu, Satoshi; Shigeno, Masanori; Kondo, Yoshinori published an article in Organic & Biomolecular Chemistry. The title of the article was 《Copper-catalyzed aerobic benzylic C(sp3)-H lactonization of 2-alkylbenzamides via N-centered radicals》.Formula: C9H11Br The author mentioned the following in the article:

Copper-catalyzed aerobic C(sp3)-H functionalization of 2-alkylbenzamides for the synthesis of benzolactones were reported. This reaction proceeded via 1,5-hydrogen atom transfer of N-centered radicals directly generated by N-H bond cleavage and did not require the synthesis of pre-functionalized N-centered radical precursors or the use of strong stoichiometric oxidants. In the experiment, the researchers used many compounds, for example, 1-Bromo-2-isopropylbenzene(cas: 7073-94-1Formula: C9H11Br)

1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds.Organobromine chemicals are produced naturally by an array of biological and other chemical processes in our environment. Some of these compounds are identical to man-made organobromine compounds, such as methyl bromide, bromoform, and bromophenols, but many others are entirely new moleclar entities, often possessing extraordinary and important biological properties. Formula: C9H11Br

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Zhang, Dapeng; Atochina-Vasserman, Elena N.; Lu, Juncheng; Maurya, Devendra S.; Xiao, Qi; Liu, Matthew; Adamson, Jasper; Ona, Nathan; Reagan, Erin K.; Ni, Houping; Weissman, Drew; Percec, Virgil published an article in Journal of the American Chemical Society. The title of the article was 《The Unexpected Importance of the Primary Structure of the Hydrophobic Part of One-Component Ionizable Amphiphilic Janus Dendrimers in Targeted mRNA Delivery Activity》.Name: 4-Bromobutanoic acid The author mentioned the following in the article:

Viral and synthetic vectors for delivery of nucleic acids impacted genetic nanomedicine by aiding the rapid development of the extraordinarily efficient Covid-19 vaccines. Access to targeted delivery of nucleic acids is expected to expand the field of nanomedicine beyond most expectations. Both viral and synthetic vectors have advantages and disadvantages. The major advantage of the synthetic vectors is their unlimited synthetic capability. The four-component lipid nanoparticles (LNPs) are the leading nonviral vector for mRNA used by Pfizer and Moderna in Covid-19 vaccines. Their synthetic capacity inspired us to develop a one-component multifunctional sequence-defined ionizable amphiphilic Janus dendrimer (IAJD) delivery system for mRNA. The first experiments on IAJDs provided, through a rational-library design combined with orthogonal-modular accelerated synthesis and sequence control in their hydrophilic part, some of the most active synthetic vectors for the delivery of mRNA to lung. The second experiments employed a similar strategy, generating, by a less complex hydrophilic structure, a library of IAJDs targeting spleen, liver, and lung. Here, we report preliminary studies designing the hydrophobic region of IAJDs by using dissimilar alkyl lengths and demonstrate the unexpectedly important role of the primary structure of the hydrophobic part of IAJDs by increasing up to 90.2-fold the activity of targeted delivery of mRNA to spleen, lymph nodes, liver, and lung. The principles of the design strategy reported here and in previous publications indicate that IAJDs could have a profound impact on the future of genetic nanomedicine. After reading the article, we found that the author used 4-Bromobutanoic acid(cas: 2623-87-2Name: 4-Bromobutanoic acid)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Name: 4-Bromobutanoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Sun, Yuxiang; Yang, Lili; Chen, Changzhi; Li, Cui; Zheng, Minghui; Jin, Rong; Wang, Wenwen; Yang, Nan; Li, Yinming; Liu, Guorui published an article in Rapid Communications in Mass Spectrometry. The title of the article was 《Method development for determination of polyhalogenated carbazoles in industrial waste through gas chromatography/triple quadrupole tandem mass spectrometry》.Application In Synthesis of 3,6-Dibromo-9H-carbazole The author mentioned the following in the article:

Polyhalogenated carbazoles (PHCZs) are dioxin-like compounds that are ubiquitous in the environment. However, their unintentional emissions from industrial sources have received little attention and there is no method available for determination of PHCZs in industrial waste. This research develops a method for determination of PHCZs in industrial waste. In this research, a glass column packed with activated silica serves as a rapid and efficient clean-up pretreatment for purification An isotope dilution gas chromatog./triple quadrupole tandem mass spectrometry method was established for simultaneous determination of eleven PHCZs in industrial samples. The regression coefficients of the standard curves for the congeners were all >0.99. The method detection limit ranged from 1.46 to 3.82 ng/mL for liquid samples and from 0.009 to 0.021 ng/g for solid samples. The precision described by the relative standard deviation ranged from 2.4% to 18.4% for liquid samples and from 5.5% to 35.8% for solid samples. The recovery ranges for the liquid and solid samples were 82%-123% and 83%-137%, resp. 3-Chlorocarbazole (3-CCZ) and 36-dichlorocarbazole (36-CCZ) can be detected in both chem. bottom liquid from vinyl chloride production and fly ash from medical waste incineration by this method. An efficient method is established for determination of PHCZs from industrial waste. The discovery of 3-CCZ and 36-CCZ highlights the importance of identification of potential industrial sources of PHCZs and clarification of their contribution to environmental risks. Our method could be applied to investigate industrial emission of PHCZs. The experimental part of the paper was very detailed, including the reaction process of 3,6-Dibromo-9H-carbazole(cas: 6825-20-3Application In Synthesis of 3,6-Dibromo-9H-carbazole)

3,6-Dibromo-9H-carbazole(cas: 6825-20-3) is used as a pharmaceutical intermediate, and also an important intermediate of synthesizing optoelectronic materials. It has been used in the preparation of N-(2-hydroxyethyl)-3,6-dibromocarbazole.Application In Synthesis of 3,6-Dibromo-9H-carbazole

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Product Details of 13465-09-3In 2020 ,《Synthesis, properties and structures of gallium(III) and indium(III) halide complexes with neutral pnictine coordination》 appeared in Journal of Organometallic Chemistry. The author of the article were Cairns, Kelsey R.; Greenacre, Victoria K.; Grose, Laura A.; Levason, William; Reid, Gillian; Robinson, Fred. The article conveys some information:

A series of Group 13 halide complexes of SbnBu3, [GaX3(SbnBu3)] and [InX3(SbnBu3)] (X = Cl, Br, I) have been prepared by reaction of the appropriate trihalide with SbnBu3 in n-hexane or CH2Cl2 solution, and characterized by microanal., IR, 1H, 13C{1H} and 71Ga NMR spectroscopy. X-ray crystal structures are reported for [InX3(SbnBu3)] (X = Cl, Br) and [GaX3(SbnBu3)]. Similar pseudo-tetrahedral complexes of AsEt3, [GaCl3(AsEt3)], [InCl3(AsEt3)] and the five-coordinate [InCl3(AsEt3)2] were also obtained and their structures determined Attempts to use [InCl3(SbR3)] and [GaCl3(SbR3)] (R = nBu, Et) as single source precursors for low pressure CVD growth of InSb or GaSb films were unsuccessful, instead producing elemental antimony, while [GaCl3(AsEt3)] and [InCl3(AsEt3)] failed to produce any deposition under similar conditions. In the part of experimental materials, we found many familiar compounds, such as Indium(III) bromide(cas: 13465-09-3Product Details of 13465-09-3)

Indium(III) bromide(cas: 13465-09-3) is used in organic synthesis as a water tolerant Lewis acid. It efficiently catalyzes the three-component coupling of β-keto esters, aldehydes and urea (or thiourea) to afford the corresponding dihydropyrimidinones.Product Details of 13465-09-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

HPLC of Formula: 17696-11-6In 2020 ,《Discovery of potent small molecule PROTACs targeting mutant EGFR》 appeared in European Journal of Medicinal Chemistry. The author of the article were Zhao, Hong-Yi; Yang, Xue-Yan; Lei, Hao; Xi, Xiao-Xiao; Lu, She-Min; Zhang, Jun-Jie; Xin, Minhang; Zhang, San-Qi. The article conveys some information:

Epidermal growth factor receptor (EGFR) is an important therapeutic target for the treatment of non-small cell lung cancer. A number of efficacious EGFR tyrosine kinase inhibitors have been developed. However, acquired drug resistance largely encumbered their clin. practicability. Therefore, there is an urgent need to develop new therapeutic regime. Herein, we designed and synthesized a set of EGFR-targeting small mol. PROTACs which showed promising efficacy. In particular, VHL-recruiting compound P3 showed potent anti-proliferative activity against HCC827 and H1975 cell lines with IC50 values of 0.83 and 203.01 nM, resp. Furthermore, both EGFRdel19 and EGFRL858R/T790M could be significantly induced to be degraded under treatment of P3 with DC50 values of 0.51 and 126.2 nM, resp. Compound P3 was able to dramatically suppress EGFR pathway signal transduction. Moreover, compound P3 could significantly induce cell apoptosis, arrest cell cycle and suppress cell colony formation. In addition, we identified that ubiquitination was indispensable in the degradation process, and found that the degradation was related to autophagy. Our work would provide an alternative approach for development of potentially effective EGFR degraders and give a new clue for investigation of PROTAC-induced protein degradation After reading the article, we found that the author used 8-Bromooctanoic acid(cas: 17696-11-6HPLC of Formula: 17696-11-6)

8-Bromooctanoic acid(cas: 17696-11-6) acid is used in the synthesis of 8-(N-Methyl-4,4′-bipyridinyl)- octanoic acid. 8-Mercaptooctanoic acid was prepared from 8-bromooctanoic acid.HPLC of Formula: 17696-11-6

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 14516-54-2In 2022 ,《Basic Promotors Impact Thermodynamics and Catalyst Speciation in Homogeneous Carbonyl Hydrogenation》 appeared in Journal of the American Chemical Society. The author of the article were Yang, Wenjun; Kalavalapalli, Tejas Y.; Krieger, Annika M.; Khvorost, Taras A.; Chernyshov, Ivan Yu.; Weber, Manuela; Uslamin, Evgeny A.; Pidko, Evgeny A.; Filonenko, Georgy A.. The article conveys some information:

Homogeneously catalyzed reactions often make use of additives and promotors that affect reactivity patterns and improve catalytic performance. While the role of reaction promotors is often discussed in view of their chem. reactivity, we demonstrate that they can be involved in catalysis indirectly. In particular, we demonstrate that promotors can adjust the thermodn. of key transformations in homogeneous hydrogenation catalysis and enable reactions that would be unfavorable otherwise. We identified this phenomenon in a set of well-established and new Mn pincer catalysts that suffer from persistent product inhibition in ester hydrogenation. Although alkoxide base additives do not directly participate in inhibitory transformations, they can affect the equilibrium constants of these processes. Exptl., we confirm that by varying the base promotor concentration one can control catalyst speciation and inflict substantial changes to the standard free energies of the key steps in the catalytic cycle. Despite the fact that the latter are universally assumed to be constant, we demonstrate that reaction thermodn. and catalyst state are subject to external control. These results suggest that reaction promotors can be viewed as an integral component of the reaction medium, on its own capable of improving the catalytic performance and reshaping the seemingly rigid thermodn. landscape of the catalytic transformation. In addition to this study using Bromopentacarbonylmanganese(I), there are many other studies that have used Bromopentacarbonylmanganese(I)(cas: 14516-54-2Related Products of 14516-54-2) was used in this study.

Bromopentacarbonylmanganese(I)(cas: 14516-54-2) has many other uses. It is used in the formation of (eta6-arene)tricarbonylmanganese(I) by reacting with arene (arene= hexamethyl benzene, 1,2,4,5-tetramethyl benzene, mesitylene, p-xylene and toluene) in the presence silver salt.Related Products of 14516-54-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Quality Control of Ethyl 3-bromopropanoateIn 2021 ,《Discovery of a cryptic site at the interface 2 of TEAD – Towards a new family of YAP/TAZ-TEAD inhibitors》 appeared in European Journal of Medicinal Chemistry. The author of the article were Sturbaut, Manon; Bailly, Fabrice; Coevoet, Mathilde; Sileo, Pasquale; Pugniere, Martine; Liberelle, Maxime; Magnez, Romain; Thuru, Xavier; Chartier-Harlin, Marie-Christine; Melnyk, Patricia; Gelin, Muriel; Allemand, Frederic; Guichou, Jean-Francois; Cotelle, Philippe. The article conveys some information:

The Hippo pathway is involved in organ size control and tissue homeostasis by regulating cell growth, proliferation and apoptosis. It controls the phosphorylation of the transcription co-activator YAP (Yes associated protein) and TAZ (Transcriptional coactivator with PDZ-binding motif) in order to control their nuclear import and their interaction with TEAD (Transcriptional Enhanced Associated Domain). YAP, TAZ and TEADs are dysregulated in several cancers making YAP/TAZ-TEAD interaction a new emerging anti-cancer target. We report the synthesis of a set of trisubstituted pyrazoles which bind to hTEAD2 at the interface 2 revealing for the first time a cryptic pocket created by the movement of the phenol ring of Y382. Compound I disrupts YAP/TAZ-TEAD interaction in HEK293T cells and inhibits TEAD target genes and cell proliferation in MDA-MB-231 cells. Compound I is therefore the first inhibitor of YAP/TAZ-TEAD targeting interface 2. This mol. could serve with other pan-TEAD inhibitors such as interface 3 ligands, for the delineation of the relative importance of VGLL vs YAP/TAZ in a given cellular model. The results came from multiple reactions, including the reaction of Ethyl 3-bromopropanoate(cas: 539-74-2Quality Control of Ethyl 3-bromopropanoate)

Ethyl 3-bromopropanoate(cas: 539-74-2) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Quality Control of Ethyl 3-bromopropanoate Due to the reactivity of bromide, they are used as potential precursors or important intermediates in organic synthesis.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Recommanded Product: 1779-49-3In 2019 ,《Chiral Bronsted Acid Catalyzed Dynamic Kinetic Asymmetric Hydroamination of Racemic Allenes and Asymmetric Hydroamination of Dienes》 appeared in Angewandte Chemie, International Edition. The author of the article were Lin, Jin-Shun; Li, Tao-Tao; Jiao, Guan-Yuan; Gu, Qiang-Shuai; Cheng, Jiang-Tao; Lv, Ling; Liu, Xin-Yuan. The article conveys some information:

The first highly efficient and practical chiral Bronsted acid catalyzed dynamic kinetic asym. hydroamination (DyKAH) of racemic allenes and asym. hydroamination of unactivated dienes with both high E/Z selectivity and enantioselectivity are described herein. The transformation proceeds through a new catalytic asym. model involving a highly reactive π-allylic carbocationic intermediate, generated from racemic allenes or dienes through a proton transfer mediated by an activating/directing thiourea group. This method affords expedient access to structurally diverse enantioenriched, potentially bioactive alkenyl-containing aza-heterocycles and bicyclic aza-heterocycles. In the part of experimental materials, we found many familiar compounds, such as Methyltriphenylphosphonium bromide(cas: 1779-49-3Recommanded Product: 1779-49-3)

Methyltriphenylphosphonium bromide(cas: 1779-49-3) is a lipophilic molecule with a cation allowing for it to be used to deliver molecules to specific cell components. Also considered an antineoplastic agent.Recommanded Product: 1779-49-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary