Month: October 2022

Quality Control of 1,4-Bis(bromomethyl)benzeneIn 2020 ,《Host-Guest Recognition and Fluorescence of a Tetraphenylethene-Based Octacationic Cage》 was published in Angewandte Chemie, International Edition. The article was written by Duan, Honghong; Li, Yawen; Li, Qingfang; Wang, Pinpin; Liu, Xueru; Cheng, Lin; Yu, Yang; Cao, Liping. The article contains the following contents:

We report the synthesis and characterization of a three-dimensional tetraphenylethene-based octacationic cage that shows host-guest recognition of polycyclic aromatic hydrocarbons (e.g. coronene) in organic media and water-soluble dyes (e.g. sulforhodamine 101) in aqueous media through CH···π, π-π, and/or electrostatic interactions. The cage⊃coronene exhibits a cuboid internal cavity with a size of approx. 17.2×11.0x6.96 Å3 and a “”hamburger””-type host-guest complex, which is hierarchically stacked into 1D nanotubes and a 3D supramol. framework. The free cage possesses a similar cavity in the crystalline state. Furthermore, a host-guest complex formed between the octacationic cage and sulforhodamine 101 had a higher absolute quantum yield (φF=28.5%), larger excitation-emission gap (Δλex-em=211 nm), and longer emission lifetime (τ=7.0 ns) as compared to the guest (φF=10.5%; Δλex-em=11 nm; τ=4.9 ns), and purer emission (ΔλFWHM=38 nm) as compared to the host (ΔλFWHM=111 nm). In the experiment, the researchers used many compounds, for example, 1,4-Bis(bromomethyl)benzene(cas: 623-24-5Quality Control of 1,4-Bis(bromomethyl)benzene)

1,4-Bis(bromomethyl)benzene(cas: 623-24-5) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Quality Control of 1,4-Bis(bromomethyl)benzene Alkyl bromides are mainly used as alkylating agents and also find application as a solvent to extract oil from seeds and wool.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《1,3-Adamantanedicarboxylate and 1,3-Adamantanediacetate as Uranyl Ion Linkers: Effect of Counterions, Solvents and Differences in Flexibility》 was written by Thuery, Pierre; Atoini, Youssef; Harrowfield, Jack. Electric Literature of C19H18BrPThis research focused onuranyl adamantanediacetate adamantanedicarboxylate coordination polymer preparation crystal structure; photoluminescence luminescence uranyl adamantanediacetate adamantanedicarboxylate coordination polymer. The article conveys some information:

Seven homo- or heterometallic uranyl ion complexes with 1,3-adamantanedicarboxylic acid (H2ADC) or 1,3-adamantanediacetic acid (H2ADA) have been synthesized under solvo-hydrothermal conditions in the presence of different counterions and organic cosolvents, and characterized by their crystal structure and uranyl emission spectrum. [PPh3Me][UO2(ADC)(NO3)] (1) crystallizes as a simple monoperiodic chain, but [PPh4]2[(UO2)2(ADC)3]·2H2O (2) and [PPh4]2[(UO2)2(ADA)3] (3) display trough-like monoperiodic polymers (assembled in pairs in 3) in the cavity of which the counterions are located. A similar arrangement is found in [Ni(cyclen)(H2O)][(UO2)2(ADC)3]·H2O (4). Diaxial bonding of NiII in [(UO2)2(ADC)2Ni(R,S-Me6cyclam)(HCOO)2]·CH3CN (5) and [UO2(ADA)2Ni(R,S-Me6cyclam)] (6) results in bridging monoperiodic uranyl-containing subunits into neutral, diperiodic networks. [UO2(ADA)(DMPU)] (7), containing coordinated N,N’-dimethylpropyleneurea, is also a diperiodic assembly with the common fes topol. type. Except complex 6 which is non-luminescent, all complexes give solid-state emission spectra displaying the usual vibronic fine structure, albeit with low photoluminescence quantum yields. In the experiment, the researchers used many compounds, for example, Methyltriphenylphosphonium bromide(cas: 1779-49-3Electric Literature of C19H18BrP)

Methyltriphenylphosphonium bromide(cas: 1779-49-3) is a lipophilic molecule with a cation allowing for it to be used to deliver molecules to specific cell components. Also considered an antineoplastic agent.Electric Literature of C19H18BrP

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Catalytic Boration of Alkyl Halides with Borane without Hydrodehalogenation Enabled by Titanium Catalyst》 was written by Wang, Xianjin; Cui, Penglei; Xia, Chungu; Wu, Lipeng. HPLC of Formula: 7051-34-5This research focused ontitanium catalyzed boration alkyl pseudohalide borane radical pathway; alkyl boronate ester preparation; alkyl halides; boration; boronate ester; pinacolborane; titanium. The article conveys some information:

An unprecedented and general Ti-catalyzed boration of alkyl (pseudo)halides (alkyl-X, X = I, Br, Cl, OMs) with borane (HBpin, HBcat) is reported. The use of Ti catalyst can successfully suppress the undesired hydrodehalogenation products that prevail using other transition-metal catalysts. Synthetically useful alkyl boronate esters are readily obtained from various (primary, secondary, and tertiary) alkyl electrophiles, including unactivated alkyl chlorides, with tolerance of other reducing functional groups such as ester, alkene, and carbamate. Preliminary studies on the mechanism revealed a possible radical reaction pathway. Further extension of the authors’ strategy to aryl bromides is also demonstrated. The experimental part of the paper was very detailed, including the reaction process of (Bromomethyl)cyclopropane(cas: 7051-34-5HPLC of Formula: 7051-34-5)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.HPLC of Formula: 7051-34-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Chemical Targeting of Voltage Sensitive Dyes to Specific Cells and Molecules in the Brain》 was written by Fiala, Tomas; Wang, Jihang; Dunn, Matthew; Sebej, Peter; Choi, Se Joon; Nwadibia, Ekeoma C.; Fialova, Eva; Martinez, Diana M.; Cheetham, Claire E.; Fogle, Keri J.; Palladino, Michael J.; Freyberg, Zachary; Sulzer, David; Sames, Dalibor. Quality Control of Ethyl 5-bromovalerateThis research focused onvoltage sensitive fluorescent dye brain. The article conveys some information:

Voltage sensitive fluorescent dyes (VSDs) are important tools for probing signal transduction in neurons and other excitable cells. The impact of these highly lipophilic sensors has, however, been limited due to the lack of cell-specific targeting methods in brain tissue or living animals. The authors address this key challenge by introducing a nongenetic mol. platform for cell- and mol.-specific targeting of synthetic VSDs in the brain. The authors employ a dextran polymer particle to overcome the inherent lipophilicity of VSDs by dynamic encapsulation and high-affinity ligands to target the construct to specific neuronal cells utilizing only native components of the neurotransmission machinery at physiol. expression levels. Dichloropane, a monoamine transporter ligand, enables targeting of dense dopaminergic axons in the mouse striatum and sparse noradrenergic axons in the mouse cortex in acute brain slices. PFQX in conjunction with ligand-directed acyl imidazole chem. enables covalent labeling of AMPA-type glutamate receptors in the same brain regions. Probe variants bearing either a classical electrochromic ANEP dye or state-of-the-art VoltageFluor-type dye respond to membrane potential changes in a similar manner to the parent dyes, as shown by whole-cell patch recording. The authors demonstrate the feasibility of optical voltage recording with the probes in brain tissue with one-photon and two-photon fluorescence microscopy and define the signal limits of optical voltage imaging with synthetic sensors under a low photon budget determined by the native expression levels of the target proteins. This work demonstrates the feasibility of a chem. targeting approach and expands the possibilities of cell-specific imaging and pharmacol. After reading the article, we found that the author used Ethyl 5-bromovalerate(cas: 14660-52-7Quality Control of Ethyl 5-bromovalerate)

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Quality Control of Ethyl 5-bromovalerate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Formula: C4H6BrFO2On September 4, 2019 ,《Three-Component Ruthenium-Catalyzed Direct Meta-Selective C-H Activation of Arenes: A New Approach to the Alkylarylation of Alkenes》 was published in Journal of the American Chemical Society. The article was written by Wang, Xin-Gang; Li, Yuke; Liu, Hong-Chao; Zhang, Bo-Sheng; Gou, Xue-Ya; Wang, Qiang; Ma, Jun-Wei; Liang, Yong-Min. The article contains the following contents:

Multicomponent reactions are fundamentally different from two-component reactions, as multicomponent reactions can enable the efficient and step-economical construction of complex mol. scaffolds from simple precursors. Here, an unprecedented three-component direct C-H addition was achieved in the challenging meta-selective fashion. Fluoroalkyl halides and a wide range of alkenes, including vinylarenes, unactivated alkenes, and internal alkenes, were employed as the coupling partners of arenes in this strategy. The detailed mechanism presented is supported by kinetic isotope studies, radical clock experiments, and d. functional theory calculations Moreover, this strategy provided access to various fluoride-containing bioactive 1,1-diarylalkanes and other challenging synthetically potential products. In addition to this study using Ethylbromofluoroacetate, there are many other studies that have used Ethylbromofluoroacetate(cas: 401-55-8Formula: C4H6BrFO2) was used in this study.

Ethylbromofluoroacetate(cas: 401-55-8) is a member of organofluorine compounds. Organofluorine compounds, which have carbon-fluorine bonds, show unique features such as high thermal and chemical stability, high surface activity, no light-absorbing ability, high pharmacological effect, and so on. Owing to their specific characters, they are indispensable chemicals for industry and our daily lives.Formula: C4H6BrFO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Application of 583-69-7On October 20, 2021 ,《A Molecular Replication Process Drives Supramolecular Polymerization》 was published in Journal of the American Chemical Society. The article was written by Feng, Yuanning; Philp, Douglas. The article contains the following contents:

Supramol. polymers are materials in which the connections between monomers in the polymer main chain are non-covalent bonds. This area has seen rapid expansion in the last two decades and has been exploited in several applications. However, suitable contiguous hydrogen-bond arrays can be difficult to synthesize, placing some limitations on the deployment of supramol. polymers. We have designed a hydrogen-bonded polymer assembled from a bifunctional monomer composed of two replicating templates separated by a rigid spacer. This design allows the autocatalytic formation of the polymer main chain through the self-templating properties of the replicators and drives the synthesis of the bifunctional monomer from its constituent components in solution The template-directed 1,3-dipolar cycloaddition reaction between nitrone and maleimide proceeds with high diastereoselectivity, affording the bifunctional monomer. The high binding affinity between the self-complementary replicating templates that allows the bifunctional monomer to polymerize in solution is derived from the pos. cooperativity associated with this binding process. The assembly of the polymer in solution has been investigated by diffusion-ordered NMR spectroscopy. Both microcrystalline and thin films of the polymeric material can be prepared readily and have been characterized by powder X-ray diffraction and SEM. These results demonstrate that the approach described here is a valid one for the construction of supramol. polymers and can be extended to systems where the rigid spacer between the replicating templates is replaced by one carrying addnl. function. After reading the article, we found that the author used 2-Bromobenzene-1,4-diol(cas: 583-69-7Application of 583-69-7)

2-Bromobenzene-1,4-diol(cas: 583-69-7) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Application of 583-69-7 Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《CuH-Catalyzed Asymmetric Hydroamidation of Vinylarenes》 were Zhou, Yujing; Engl, Oliver D.; Bandar, Jeffrey S.; Chant, Emma D.; Buchwald, Stephen L.. And the article was published in Angewandte Chemie, International Edition in 2018. COA of Formula: C8H4BrF3O2 The author mentioned the following in the article:

A CuH-catalyzed enantioselective hydroamidation reaction of vinylarenes was developed using readily accessible 1,4,2-dioxazol-5-ones as electrophilic amidating reagents. This method provides a straightforward and efficient approach to synthesize chiral amides in good yields with high levels of enantiopurity under mild conditions. Moreover, this transformation tolerates substrates bearing a broad range of functional groups. The experimental process involved the reaction of 3-Bromo-4-(trifluoromethoxy)benzaldehyde(cas: 85366-66-1COA of Formula: C8H4BrF3O2)

3-Bromo-4-(trifluoromethoxy)benzaldehyde(cas: 85366-66-1) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. COA of Formula: C8H4BrF3O2 The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2015,Zhang, Xi-Sha; Zhang, Yun-Fei; Li, Zhao-Wei; Luo, Fei-Xian; Shi, Zhang-Jie published 《Synthesis of Dibenzo[c,e]oxepin-5(7H)-ones from Benzyl Thioethers and Carboxylic Acids: Rhodium-Catalyzed Double C-H Activation Controlled by Different Directing Groups》.Angewandte Chemie, International Edition published the findings.COA of Formula: C8H7BrO2 The information in the text is summarized as follows:

A rhodium(III)-catalyzed cross-coupling of benzyl thioethers and aryl carboxylic acids through the two directing groups is reported. Useful structures with diverse substituents were efficiently synthesized in one step with the cleavage of four bonds, such as carbon-hydrogen bond (C-H bond), carbon-sulfur bond (C-S bond), oxygen-hydrogen bond (O-H bond) and the formation of two bonds (carbon-carbon bond C-C bond) and carbon-oxygen bond (C-O bond) formation. The formed structure is the privileged core in natural products and bioactive mols. This work highlights the power of using two different directing groups to enhance the selectivity of a double C-H activation, the first of such examples in cross-oxidative coupling. Under optimized conditions the synthesis of the target compounds was achieved using di-μ-chlorodichlorobis[(1,2,3,4,5-η)-1,2,3,4,5-pentamethyl-2,4-cyclopentadien-1-yl]dirhodium or tris(acetonitrile)[(1,2,3,4,5-η)-1,2,3,4,5-pentamethyl-2,4-cyclopentadien-1-yl]rhodium(2+) bis[hexafluoroantimonate] as catalysts. Starting materials included benzyl thioethers, such as [(Methylthio)methyl]benzene derivatives and benzoic acid derivatives The title compounds thus formed included Dibenz[c,e]oxepin-5(7H)-one derivatives, 3,9-dimethyldibenz[c,e]oxepin-5(7H)-one. After reading the article, we found that the author used 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2COA of Formula: C8H7BrO2)

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.Organobromine chemicals are produced naturally by an array of biological and other chemical processes in our environment. Organobromine compounds are produced naturally by marine creatures (sponges, corals, sea slugs, tunicates, sea fans) and seaweed, plants, fungi, lichen, algae, bacteria, microbes, and some mammals. COA of Formula: C8H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2017,Luan, Shenglin; Ge, Qi; Chen, Yedong; Dai, Mingyang; Yang, Jinyu; Li, Kun; Liu, Dan; Zhao, Linxiang published 《Discovery and structure-activity relationship studies of N-substituted indole derivatives as novel Mcl-1 inhibitors》.Bioorganic & Medicinal Chemistry Letters published the findings.Recommanded Product: 1129-28-8 The information in the text is summarized as follows:

Myeloid cell leukemia-1 (Mcl-1) is an important antiapoptotic protein functioning through protein-protein interactions. The authors discovered LSL-A6 (2-((2-carbamoyl-1-(3-(4-methoxyphenoxy)propyl)-1H-indol-6-yl)oxy)acetic acid)with a novel N-substituted indole scaffold to interfere Mcl-1 binding as a novel Mcl-1 inhibitor. Mol. modeling indicated that this compound binds with Mcl-1 by interaction with P2 and R263 hot-spots. Structure modification focused on several moieties including indole core, hydrophobic tail and acidic chain were conducted and structure-activity relationship was analyzed. The most potent compound 24d which exhibited Ki value of 110 nM for interfering Mcl-1 binding was obtained after hit-to-lead modification. In the experiment, the researchers used Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Recommanded Product: 1129-28-8)

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.Organobromine chemicals are produced naturally by an array of biological and other chemical processes in our environment. Organobromine compounds are produced naturally by marine creatures (sponges, corals, sea slugs, tunicates, sea fans) and seaweed, plants, fungi, lichen, algae, bacteria, microbes, and some mammals. Recommanded Product: 1129-28-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2017,van Haren, Matthijs J.; Taig, Rebecca; Kuppens, Jilles; Sastre Torano, Javier; Moret, Ed E.; Parsons, Richard B.; Sartini, Davide; Emanuelli, Monica; Martin, Nathaniel I. published 《Inhibitors of nicotinamide N-methyltransferase designed to mimic the methylation reaction transition state》.Organic & Biomolecular Chemistry published the findings.Related Products of 1129-28-8 The information in the text is summarized as follows:

Nicotinamide N-methyltransferase (NNMT) is an enzyme that catalyzes the methylation of nicotinamide to form N’-methylnicotinamide. Both NNMT and its methylated product have recently been linked to a variety of diseases, suggesting a role for the enzyme as a therapeutic target beyond its previously ascribed metabolic function in detoxification. We here describe the systematic development of NNMT inhibitors derived from the structures of the substrates involved in the methylation reaction. By covalently linking fragments of the NNMT substrates a diverse library of bisubstrate-like compounds was prepared The ability of these compounds to inhibit NNMT was evaluated providing valuable insights into the structural tolerances of the enzyme active site. These studies led to the identification of new NNMT inhibitors that mimic the transition state of the methylation reaction and inhibit the enzyme with activity on par with established methyltransferase inhibitors. After reading the article, we found that the author used Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Related Products of 1129-28-8)

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.Organobromine chemicals are produced naturally by an array of biological and other chemical processes in our environment. Organobromine compounds are produced naturally by marine creatures (sponges, corals, sea slugs, tunicates, sea fans) and seaweed, plants, fungi, lichen, algae, bacteria, microbes, and some mammals. Related Products of 1129-28-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary