Month: October 2022

Liu, Wen-Qiang’s team published research in Journal of the American Chemical Society in 2019 | CAS: 1779-49-3

Methyltriphenylphosphonium bromide(cas: 1779-49-3) is used for methylenation through the Wittig reaction. It is utilized in the synthesis of an enyne and 9-isopropenyl -phenanthrene by using sodium amide as reagent. Application In Synthesis of Methyltriphenylphosphonium bromide

In 2019,Journal of the American Chemical Society included an article by Liu, Wen-Qiang; Lei, Tao; Zhou, Shuai; Yang, Xiu-Long; Li, Jian; Chen, Bin; Sivaguru, Jayaraman; Tung, Chen-Ho; Wu, Li-Zhu. Application In Synthesis of Methyltriphenylphosphonium bromide. The article was titled 《Cobaloxime Catalysis: Selective Synthesis of Alkenylphosphine Oxides under Visible Light》. The information in the text is summarized as follows:

Direct activation of H-phosphine oxide to react with an unsaturated C-C bond is a straightforward approach for accessing alkenylphosphine oxides, which shows significant applications in both synthetic and material fields. However, expensive metals and strong oxidants are typically required to realize the transformation. Here, the authors demonstrate the utility of earth-abundant cobaloxime to convert H-phosphine oxide into its reactive radical species under visible light irradiation The radical species thus generated can be used to functionalize alkenes and alkynes without any external photosensitizer and oxidant. The coupling with terminal alkene generates E-alkenylphosphine oxide with excellent chemo- and stereoselectivity. The reaction with terminal alkyne yields linear E-alkenylphosphine oxide via neutral radical addition, while addition with internal ones generates cyclic benzophosphine oxides and H. Mechanistic studies on radical trapping experiments, ESR studies, and spectroscopic measurements confirm the formation of phosphinoyl radical and Co intermediates that are from capturing the electron and proton eliminated from H-phosphine oxide. The highlight of the authors’ mechanistic study is the dual role played by cobaloxime, viz., both as the visible light absorber to activate the P(O)-H bond as well as a H transfer agent to influence the reaction pathway. This synergetic feature of the cobaloxime catalyst preforming multiple functions under ambient condition provides a convergent synthetic approach to vinylphosphine oxides directly from H-phosphine oxides and alkenes (or alkynes). After reading the article, we found that the author used Methyltriphenylphosphonium bromide(cas: 1779-49-3Application In Synthesis of Methyltriphenylphosphonium bromide)

Methyltriphenylphosphonium bromide(cas: 1779-49-3) is used for methylenation through the Wittig reaction. It is utilized in the synthesis of an enyne and 9-isopropenyl -phenanthrene by using sodium amide as reagent. Application In Synthesis of Methyltriphenylphosphonium bromide

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zheng, Danqing’s team published research in Angewandte Chemie, International Edition in 2019 | CAS: 5437-45-6

Benzyl 2-bromoacetate(cas: 5437-45-6) belongs to benzyl acetate. Benzyl acetate is a synthetic chemical produced for industry from benzyl alcohol and acetic acid, but is also naturally present in the essential oils of many plants, including jasmine and ylang ylang.Quality Control of Benzyl 2-bromoacetate

In 2019,Angewandte Chemie, International Edition included an article by Zheng, Danqing; Studer, Armido. Quality Control of Benzyl 2-bromoacetate. The article was titled 《Asymmetric Synthesis of Heterocyclic γ-Amino-Acid and Diamine Derivatives by Three-Component Radical Cascade Reactions》. The information in the text is summarized as follows:

An enantioselective three-component radical reaction of quinolines or pyridines with enamides and α-bromo carbonyl compounds by dual photoredox and chiral Bronsted acid catalysis is presented. A range of valuable chiral γ-amino-acid derivatives are accessible in high chemo-, regio-, and enantioselectivity from simple, readily available starting materials under mild reaction conditions. Using the same strategy, the asym. synthesis of 1,2-diamine derivatives is also reported. Thus, e.g., 4-methylquinoline + N-vinylacetamide + Me bromoacetate → I (88%, 96:4 er). In the experimental materials used by the author, we found Benzyl 2-bromoacetate(cas: 5437-45-6Quality Control of Benzyl 2-bromoacetate)

Benzyl 2-bromoacetate(cas: 5437-45-6) belongs to benzyl acetate. Benzyl acetate is a synthetic chemical produced for industry from benzyl alcohol and acetic acid, but is also naturally present in the essential oils of many plants, including jasmine and ylang ylang.Quality Control of Benzyl 2-bromoacetate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wang, Jian-Ta’s team published research in Bioorganic & Medicinal Chemistry Letters in 2019 | CAS: 14660-52-7

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Related Products of 14660-52-7

In 2019,Bioorganic & Medicinal Chemistry Letters included an article by Wang, Jian-Ta; Peng, Jin-Gang; Zhang, Ji-Quan; Wang, Zhong-Xiao; Zhang, Yi; Zhou, Xun-Rong; Miao, Jing; Tang, Lei. Related Products of 14660-52-7. The article was titled 《Novel berberine-based derivatives with potent hypoglycemic activity》. The information in the text is summarized as follows:

Four series of berberine derivatives were designed and synthesized. All the synthetic compounds were screened for in vitro glucose consumption activity in HepG2 cell lines. The results showed that most of the tested compounds exhibited potent hypoglycemic activity, and the most potent compound I exhibited its potency by 3.23-fold of berberine, 1.39-fold of metformin and 1.20-fold of rosiglitazone, resp. Western blot assay indicated these novel berberine-based derivatives executed their glucose-decreasing activity via the activation of AMPK pathway. In the experiment, the researchers used many compounds, for example, Ethyl 5-bromovalerate(cas: 14660-52-7Related Products of 14660-52-7)

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Related Products of 14660-52-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Filian, Hossein’s team published research in Journal of the Iranian Chemical Society in 2019 | CAS: 6630-33-7

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.HPLC of Formula: 6630-33-7Synthetic applications of o-Bromobenzaldehyde include: synthesis of aza-fused polycyclic quinolines through copper-catalyzed cascade reaction, preparation of 1-substituted indazoles by CuI-catalyzed coupling with N-aryl hydrazides.

In 2019,Journal of the Iranian Chemical Society included an article by Filian, Hossein; Ghorbani-Choghamarani, Arash; Tahanpesar, Elham. HPLC of Formula: 6630-33-7. The article was titled 《Ni-guanidine@MCM-41 NPs: a new catalyst for the synthesis of 4,4′-(arylmethylene)-bis-(3-methyl-1-phenyl-1H-pyrazol-5-ols) and symmetric di-aryl sulfides》. The information in the text is summarized as follows:

In this work, the surface of mesoporous MCM-41 was modified with guanidine, and then, Nickel particles have become immobilized on its surface (Ni-guanidine@MCM-41NPs). This heterogeneous catalyst has been identified by various techniques including: low-angle X-ray diffraction, SEM, energy-dispersive X-ray spectroscopy, inductively coupled plasma, thermal gravimetric anal. and N2 adsorption-desorption measurement isotherms, and its catalytic application was studied in the synthesis of 4,4′-(arylmethylene)-bis-(3-methyl-1-phenyl-1H-pyrazol-5-ol) derivatives and sym. di-aryl sulfides. The prepared organometallic complex could be isolated, post-reaction, by simple filtration for several consecutive cycles without a notable change in its catalytic activity. After reading the article, we found that the author used o-Bromobenzaldehyde(cas: 6630-33-7HPLC of Formula: 6630-33-7)

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.HPLC of Formula: 6630-33-7Synthetic applications of o-Bromobenzaldehyde include: synthesis of aza-fused polycyclic quinolines through copper-catalyzed cascade reaction, preparation of 1-substituted indazoles by CuI-catalyzed coupling with N-aryl hydrazides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Mikhailov, I E’s team published research in Russian Journal of General Chemistry in 2017-03-31 | 3893-18-3

Russian Journal of General Chemistry published new progress about Photoluminescence. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Related Products of 3893-18-3.

Mikhailov, I. E.; Vikrishchuk, N. I.; Popov, L. D.; Beldovskaya, A. D.; Dushenko, G. A.; Revinskii, Yu. V.; Kurbatov, S. V. published the artcile< 5-(2-Hydroxyphenyl)-1,2-dimethyl(1-methyl-2-vinylaryl)-1H-1,3,4-triazoles and their complexes with Zn(II)>, Related Products of 3893-18-3, the main research area is zinc substituted triazolylphenolate chelate preparation luminescence.

The interaction of 2,3-dimethyl-4-oxo-1,3-benzoxazinium and 2-[β-(4-bromophenylvinyl)]-3-methyl-4-oxo-1,3-benzoxazinium perchlorates with hydrazine hydrate has afforded the corresponding triazoles that were used as ligands for the synthesis of zinc complexes L2Zn. Luminescent properties of the prepared complexes were studied.

Russian Journal of General Chemistry published new progress about Photoluminescence. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Related Products of 3893-18-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Takebayashi, Satoshi’s team published research in Nature Catalysis in 2022-06-30 | 576-83-0

Nature Catalysis published new progress about Crystal structure. 576-83-0 belongs to class bromides-buliding-blocks, and the molecular formula is C9H11Br, Reference of 576-83-0.

Takebayashi, Satoshi; Iron, Mark A.; Feller, Moran; Rivada-Wheelaghan, Orestes; Leitus, Gregory; Diskin-Posner, Yael; Shimon, Linda J. W.; Avram, Liat; Carmieli, Raanan; Wolf, Sharon G.; Cohen-Ofri, Ilit; Sanguramath, Rajashekharayya A.; Shenhar, Roy; Eisen, Moris; Milstein, David published the artcile< Iron-catalyzed ring-opening metathesis polymerization of olefins and mechanistic studies>, Reference of 576-83-0, the main research area is mechanistic iron catalyzed ring opening metathesis polymerization olefin.

The olefin metathesis reaction is among the most widely applicable catalytic reactions for carbon-carbon double bond formation. Currently, Mo- and Ru-carbene catalysts are the most common choices for this reaction. It has been suggested that an iron-based catalyst would be a desirable economical and biocompatible substitute of the Ru catalysts; however, practical solutions in this regard are still lacking. Here, we report the discovery and mechanistic studies of three-coordinate iron(II) catalysts for ring-opening metathesis polymerization of olefins. Remarkably, their reactivity enabled the formation of polynorbornene with stereoregularity and high mol. weight (>107 g mol-1). The polymerization in the presence of styrene revealed cross metathesis reactivity with iron catalysts. Mechanistic studies suggest the possible role of metal-ligand cooperation in formation of the productive catalyst. This work opens the door to the development of iron complexes that can be economical and biocompatible catalysts for olefin metathesis reactions.

Nature Catalysis published new progress about Crystal structure. 576-83-0 belongs to class bromides-buliding-blocks, and the molecular formula is C9H11Br, Reference of 576-83-0.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Ghorbani-Choghamarani, Arash’s team published research in ChemistrySelect in 2019 | 401-78-5

ChemistrySelect published new progress about Aryl halides Role: RCT (Reactant), RACT (Reactant or Reagent). 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Computed Properties of 401-78-5.

Ghorbani-Choghamarani, Arash; Taherinia, Zahra published the artcile< New revolution in biaryl synthesis: transition metal-free C-C bond formation promoted by the mixture of 2-mercaptoethanol/KOH/DMSO>, Computed Properties of 401-78-5, the main research area is biaryl preparation; phenylboronic acid aryl halide transition metal free Suzuki type.

Biaryls RR1 [R = C6H5; R1 = C6H5, 3-MeOC6H4, 4-O2NC6H4, etc.] were synthesized via transition metal-free C-C cross coupling reaction of aryl halides with phenylboronic acid that was believed to be a new revolution in Suzuki type reactions. Carbon-carbon bond formation could be promoted by a mixture of 2-mercaptoethanol/KOH/DMSO without the aid of any transition metals. It has been suggested that this reaction proceeded through radical species, hence the electron transfer route was suggested for operation during oxidation of 2-mercaptoethanol in DMSO.

ChemistrySelect published new progress about Aryl halides Role: RCT (Reactant), RACT (Reactant or Reagent). 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Computed Properties of 401-78-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Grover, Nitika’s team published research in European Journal of Organic Chemistry in 2020-10-12 | 184239-35-8

European Journal of Organic Chemistry published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 184239-35-8 belongs to class bromides-buliding-blocks, and the molecular formula is C26H18Br2, Electric Literature of 184239-35-8.

Grover, Nitika; Emandi, Ganapathi; Twamley, Brendan; Khurana, Bhavya; Sol, Vincent; Senge, Mathias O. published the artcile< Synthesis and Structure of meso-Substituted Dibenzihomoporphyrins>, Electric Literature of 184239-35-8, the main research area is dibenzihomoporphyrin preparation absorption structure singlet oxygen photosensitizer; Expanded porphyrins; Homoporphyrins; Non‐aromatic; Photosensitizer; Porphyrinoids.

Bench-stable meso-substituted di(p/m-benzi)homoporphyrins were synthesized through acid-catalyzed condensation of dipyrrole derivatives with aryl aldehydes. The insertion of a 1,1,2,2-tetraphenylethene (TPE) or but-2-ene-2,3-diyldibenzene unit in the porphyrin framework results in the formation of dibenzihomoporphyrins, merging the features of hydrocarbons and porphyrins. Single crystal X-ray analyses established the non-planar structure of these mols., with the phenylene rings out of the mean plane, as defined by the dipyrromethene moiety and the two meso-carbon atoms. Spectroscopic and structural investigations show that the macrocycles exhibit characteristics of both TPE or but-2-ene-2,3-diyldibenzene and dipyrromethene units indicating the non-aromatic characteristics of the compounds synthesized. Addnl., the dibenzihomoporphyrins were found to generate singlet oxygen, potentially allowing their use as photosensitizers.

European Journal of Organic Chemistry published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 184239-35-8 belongs to class bromides-buliding-blocks, and the molecular formula is C26H18Br2, Electric Literature of 184239-35-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Kieltsch, Iris’s team published research in Angewandte Chemie, International Edition in 2007-02-28 | 2252-45-1

Angewandte Chemie, International Edition published new progress about Esters Role: RCT (Reactant), RACT (Reactant or Reagent) (α-nitro). 2252-45-1 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3S, Application In Synthesis of 2252-45-1.

Kieltsch, Iris; Eisenberger, Patrick; Togni, Antonio published the artcile< Mild electrophilic trifluoromethylation of carbon- and sulfur-centered nucleophiles by a hypervalent iodine(III)-CF3 reagent>, Application In Synthesis of 2252-45-1, the main research area is ketoester hypervalent iodine reagent electrophilic trifluoromethylation; nitroester hypervalent iodine reagent electrophilic trifluoromethylation; thiol hypervalent iodine reagent electrophilic trifluoromethylation; trifluoromethyl substituted derivative preparation; hypervalent iodine electrophilic trifluoromethylation reagent crystal structure.

Inexpensive, recyclable, and activable: these were the features of a new mild electrophilic trifluoromethylation reagent that could be used to transfer a CF3 group to C-centered nucleophiles, such as β-keto esters and α-nitro esters, and to S-centered nucleophiles.

Angewandte Chemie, International Edition published new progress about Esters Role: RCT (Reactant), RACT (Reactant or Reagent) (α-nitro). 2252-45-1 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3S, Application In Synthesis of 2252-45-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Lamola, Jairus L’s team published research in RSC Advances in 2021 | 576-83-0

RSC Advances published new progress about Aryl halides Role: RCT (Reactant), RACT (Reactant or Reagent). 576-83-0 belongs to class bromides-buliding-blocks, and the molecular formula is C9H11Br, HPLC of Formula: 576-83-0.

Lamola, Jairus L.; Moshapo, Paseka T.; Holzapfel, Cedric W.; Maumela, Munaka Christopher published the artcile< Evaluation of P-bridged biaryl phosphine ligands in palladium-catalyzed Suzuki-Miyaura cross-coupling reactions>, HPLC of Formula: 576-83-0, the main research area is phosphacyclic ligand preparation; biaryl preparation; aryl halide phenylboronic acid Suzuki Miyaura coupling palladium catalyst.

A family of biaryl phosphacyclic ligands derived from phobane and phosphatrioxa-adamantane frameworks was described. The rigid biaryl phosphacycles were efficient for synthesis of biaryls ArAr1 [Ar = 3-MeC6H4, 2-naphthyl, 2-thienyl, etc.; Ar1 = Ph, 2-MeC6H4, 2,6-di-MeC6H3] via palladium-catalyzed Suzuki-Miyaura cross-coupling of aryl bromides/chlorides with phenylboronic acids. In particular, coupling reactions of the challenging sterically hindered and heterocyclic substrates were viable at room temperature

RSC Advances published new progress about Aryl halides Role: RCT (Reactant), RACT (Reactant or Reagent). 576-83-0 belongs to class bromides-buliding-blocks, and the molecular formula is C9H11Br, HPLC of Formula: 576-83-0.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary