Month: October 2022

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 585-76-2, formula is C7H5BrO2, Name is 3-Bromobenzoic acid. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Synthetic Route of 585-76-2.

Ranganatha, V. Lakshmi;Ramu, Ramith;V, Rashmi;Martiz, Reshma Mary;Khanum, Shaukath Ara research published 《 Synthesis, characterization, and antimicrobial analysis of 5-phenyl-4-((2-(piperazin-1-yl)ethyl)thio)-1,2,3-oxadiazole analogs through in-vitro and in-silico approach》, the research content is summarized as follows. A sequence of novel 1,2,3-oxadiazole derivatives I [R¹ = H, Cl, Br etc; R² = H, methoxy, Br etc; R³ = H, CH₃, Br, etc.] having 2-[(piperazin-1-yl)ethyl]thio moiety were synthesized by multistep synthesis. The newly synthesized compounds I were well characterized and their antimicrobial activities were carried out by disk diffusion and broth dilution methods. Further, among the series of compounds I, compound I [R¹ = R² = H; R ³= Cl] demonstrated a good inhibition against all the tested strains. Also, in-silico analyses including mol. docking simulations, mol. dynamics simulations and binding free energy calculations predicted that the compound I [R¹= R² = H; R³ = Cl] was an extensive and stable interaction with the target proteins. In addition, ADMET anal. also predicted that I [R¹ = R² = H; R³ = Cl] demonstrated no toxicity and carcinogenicity. This makes I [R¹= R² = H; R³ = Cl] one of the potent antimicrobial agents which can be used as a potential drug in the near future.

Synthetic Route of 585-76-2, 3-bromobenzoic acid is a bromobenzoic acid carrying a single bromo subsituent at the 3-position.
3-Bromobenzoic acid, also known as 3-Bromobenzoic acid, is a useful research compound. Its molecular formula is C7H5BrO2 and its molecular weight is 201.02 g/mol. The purity is usually 95%.
3-bromobenzoic acid is used as a reagent in the synthesis of deoxypodophyllotoxin derivatives with insecticidal activity. Also used as a reagent in the synthesis of thiazole derivatives with antibacterial activity.
3-bromobenzoic acid is a molecule that is classified as a Group P2. It has an electronegativity of 1.3 and an acidity of 0.8, which are both in the middle range of values for this group. 3-Bromobenzoic acid is soluble in water and is soluble in ethanol, acetone, and ether. The chemical structure of 3-bromobenzoic acid can be determined by its monoclonal antibody binding sites, electrochemical impedance spectroscopy data, and Langmuir adsorption isotherm data. 3-Bromobenzoic acid reacts with hydrochloric acid to form benzoate and HCl gas. Chronic exposure to 3-bromobenzoic acid has been shown to cause glutamate dehydrogenase inhibition, leading to an accumulation of p-hydroxybenzoic acid in the body. , 585-76-2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 5392-10-9, formula is C9H9BrO3, Name is 2-Bromo-4,5-dimethoxybenzaldehyde. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Reference of 5392-10-9.

Ramesh, Golla;Ramulu, Bokka Venkat;Balamurugan, Rengarajan research published 《 Activation of o-Propargyl Alcohol Benzaldehydes under Acetalization Conditions for Intramolecular Electrophile Intercepted Meyer-Schuster Rearrangement》, the research content is summarized as follows. The reactivity of o-propargyl alc.-containing benzaldehydes I [R¹ = H, 5-O₂N, 5-MeO, 4,5-(MeO)₂; R² = R³ = Me, Ph; R² = H, R³ = Ph, 4-MeC₆H₄, 1,3-benzodioxol-5-yl, etc.; R² = Me, R³ = Ph, 4-ClC₆H₄, 2-naphthyl, etc.; R² = Ph, R³ = 4-BrC₆H₄, 4-ClC₆H₄, 4-MeC₆H₄] has been increased tremendously toward Bronsted acid-catalyzed intramol. electrophile-intercepted Meyer-Schuster (M-S) rearrangement under acetalization conditions using tri-Me orthoformate. The in situ formed acetal transfers the methoxy group intramolecularly to generate the M-S intermediate in even less reactive substrates, and the formed oxocarbenium ion makes the carbonyl more electrophilic for an effective intramol. trapping of the M-S intermediate to furnish the indanone derivatives II. This procedure was applied to propargyl alc.-functionalized cycloalkenecarboxaldehydes to afford the corresponding cycloalkane-fused (alkylidene)(methoxy)cyclopentenones.

5392-10-9, 2-Bromo-4,5-dimethoxybenzaldehyde is a useful research compound. Its molecular formula is C9H9BrO3 and its molecular weight is 245.07 g/mol. The purity is usually 95%.
2-Bromo-4,5-dimethoxybenzaldehyde is a synthetic compound that has been shown to be an effective agent for inducing apoptosis in leukemia cells. It is an efficient method for synthesizing the compound and ha2-Bromo-4,5-dimethoxybenzaldehyde induces cell death by topoisomerase-mediated DNA cleavage, which results in chromosomal fragmentation and high levels of reactive oxygen species in the cell., Reference of 5392-10-9

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 90-59-5, formula is C7H4Br2O2, Name is 3,5-Dibromo-2-hydroxybenzaldehyde. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Category: bromides-buliding-blocks.

Rambabu, Aveli;Daravath, Sreenu;Shankar, Dasari Shiva;Shivaraj research published 《 DNA-binding, -cleavage and antimicrobial investigation on mononuclear Cu(II) Schiff base complexes originated from Riluzole》, the research content is summarized as follows. Two mononuclear metal complexes, [Cu(L₁)₂] (1) and [Cu(L₂)₂] (2) of the resp. Schiff bases, HL₁ = 2-((E)-(6-(trifluoromethoxy)benzo[d]thiazol-2-ylimino)methyl)-4-methoxyphenol and HL₂ = 2-((E)-(6-(trifluoromethoxy)benzo[d]thiazol-2-ylimino)methyl)-4,6-dibromophenol were synthesized and well characterized by anal. and various spectroscopic techniques like elemental anal., NMR, mass spectrometry, IR, UV, ESR and thermogravimetric analyses. These spectral studies gave a square planar geometry for both the complexes. These complexes underwent DNA investigation against calf thymus DNA and supercoiled pBR322 DNA. The complexes bound the DNA through an intercalation mode and the binding affinity order follows as 1 > 2 > HL₂ > HL₁. Both complexes show good cleavage ability against double-stranded pBR322 DNA under oxidative and photolytic conditions. In vitro antimicrobial study resulted in both complexes have shown marked biocidal potential compared to resp. free ligands.

90-59-5, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

3,5-Dibromosalicylaldehyde, also known as 3,5-Dibromosalicylaldehyde, is a useful research compound. Its molecular formula is C7H4Br2O2 and its molecular weight is 279.91 g/mol. The purity is usually 95%.

3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes. 3,5-Dibromosalicylaldehyde can be used in the synthesis of Schiff base and can be used as reactant for synthesis of Schiff base ligands which forms mononuclear complexes with copper(II), nickel(II), zinc(II) and cobalt(II).

3,5-Dibromosalicylaldehyde is a copper complex that has been synthesized from 3,5-dibromosalicylaldehyde and copper chloride. FTIR spectroscopy revealed that the coordination geometry of the copper complex is octahedral with two nitrogen atoms in the equatorial plane. The presence of hydrogen bonding interactions was confirmed by homologous protein adsorption experiments. This chemical structure was determined using X-ray crystallography and fluorescence probe experiments. The copper complex showed high affinity for malonic acid, which is an ester hydrochloride. The molecular mechanism of this interaction is based on adsorption, which occurs through hydrogen bonding interactions and hydrophobic interactions. Structural analysis revealed that the polymeric matrix consists of a three-dimensional network of crosslinked chains, while FTIR analysis indicated a possible disulfide bond between two cysteine residues., Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic compounds having carbon bonded to bromine are called organic bromides. 90-59-5, formula is C7H4Br2O2, Name is 3,5-Dibromo-2-hydroxybenzaldehyde. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Product Details of C7H4Br2O2.

Rajnak, Cyril;Micova, Romana;Moncol, Jan;Dlhan, Lubor;Kruger, Christoph;Renz, Franz;Boca, Roman research published 《 Spin-crossover in an iron(III) complex showing a broad thermal hysteresis》, the research content is summarized as follows. A pentadentate Schiff-base ligand ^3,5Cl-L^2- and NCSe^– form an iron(III) mononuclear complex [Fe(^3,5Cl-L)(NCSe)], which shows a thermally induced spin crossover with a broad hysteresis width of 24 K between 123 K (warming) and 99 K (cooling). Analogous complexes of the [Fe(^3,5X-L)(Y)] type, where X = Cl or Br and Y = Cl^–, N₃^–, NCS^–, and NCSe^–, are high-spin over the whole temperature interval.

Product Details of C7H4Br2O2, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

3,5-Dibromosalicylaldehyde, also known as 3,5-Dibromosalicylaldehyde, is a useful research compound. Its molecular formula is C7H4Br2O2 and its molecular weight is 279.91 g/mol. The purity is usually 95%.

3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes. 3,5-Dibromosalicylaldehyde can be used in the synthesis of Schiff base and can be used as reactant for synthesis of Schiff base ligands which forms mononuclear complexes with copper(II), nickel(II), zinc(II) and cobalt(II).

3,5-Dibromosalicylaldehyde is a copper complex that has been synthesized from 3,5-dibromosalicylaldehyde and copper chloride. FTIR spectroscopy revealed that the coordination geometry of the copper complex is octahedral with two nitrogen atoms in the equatorial plane. The presence of hydrogen bonding interactions was confirmed by homologous protein adsorption experiments. This chemical structure was determined using X-ray crystallography and fluorescence probe experiments. The copper complex showed high affinity for malonic acid, which is an ester hydrochloride. The molecular mechanism of this interaction is based on adsorption, which occurs through hydrogen bonding interactions and hydrophobic interactions. Structural analysis revealed that the polymeric matrix consists of a three-dimensional network of crosslinked chains, while FTIR analysis indicated a possible disulfide bond between two cysteine residues., 90-59-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 4897-84-1, formula is C5H9BrO2, Name is Methyl 4-bromobutanoate. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. COA of Formula: C5H9BrO2.

Rajappan, Kumar;Tanis, Steven P.;Mukthavaram, Rajesh;Roberts, Scott;Nguyen, Michelle;Tachikawa, Kiyoshi;Sagi, Amit;Sablad, Marciano;Limphong, Pattraranee;Leu, Angel;Yu, Hailong;Chivukula, Padmanabh;Payne, Joseph E.;Karmali, Priya research published 《 Property-Driven Design and Development of Lipids for Efficient Delivery of siRNA》, the research content is summarized as follows. Ionizable cationic lipids are critical components involved in nanoparticle formulations, which are utilized in delivery platforms for RNA therapeutics. While general criteria regarding lipophilicity and measured pK_a in formulation are understood to have impacts on utility in vivo, greater granularity with respect to the impacts of the structure on calculated and measured physicochem. parameters and the subsequent performance of those ionizable cationic lipids in in vivo studies would be beneficial. Herein, we describe structural alterations made within a lipid class exemplified by 4, which allow us to tune calculated and measured physicochem. parameters for improved performance, resulting in substantial improvements vs. the state of the art at the outset of these studies, resulting in good in vivo activity within a range of measured basicity (pK_a = 6.0-6.6) and lipophilicity (cLogD = 10-14).

4897-84-1, Methyl 4-bromobutyrate,also as known as 4-Bromobutyric acid methyl ester, is a useful research compound. Its molecular formula is C5H9BrO2 and its molecular weight is 181.03 g/mol. The purity is usually 95%.
4-Bromobutyric acid methyl ester is a synthetic compound that can be used to inhibit the activity of the G1 phase cyclin-dependent kinases. It has been shown to inhibit protein synthesis by alkylating the amino groups of proteins and fatty acids. 4-Bromobutyric acid methyl ester also inhibits the growth of cancer cell lines, such as renal carcinoma cells. The mechanism of action for this drug is not well understood, but it may be due to its ability to bind with monoclonal antibodies and enter kidney cells by passive diffusion., COA of Formula: C5H9BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 1575-37-7, formula is C6H7BrN2, Name is 4-Bromobenzene-1,2-diamine. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Recommanded Product: 4-Bromobenzene-1,2-diamine.

Raja, Dineshkumar;Philips, Abigail;Sundaramurthy, Devikala;Chandru Senadi, Gopal research published 《 Sustainable Synthesis of 2-Hydroxymethylbenzimidazoles using D-Fructose as a C₂ Synthon》, the research content is summarized as follows. D-fructose, a biomass-derived carbohydrate had been identified as an environmentally benign C2 synthon in the preparation of synthetically useful 2-hydroxymethylbenzimidazole derivatives I [R = H, 5-F, 5,6-di-Cl, etc.; R¹ = H, (CH₂)₅CH₃, CH₂CH=CH₂, CH₂CCH, Ph, Bn, etc.] by coupling with 1,2-phenylenediamines. Proof of concept was established by synthesizing 23 examples using BF₃.OEt₂ (20 mol%), TBHP (5.5 M, decane) (1.0 equivalent) in CH₃CN at 90°C for 1 h. The pivotal features of this method included metal-free conditions, short time, good functional group tolerance, gram scale feasibility and the synthesis of benzimidazole fused 1,4-oxazine. Control studies with conventional C2 synthons did not produce the desired product, thus suggesting a new reaction pathway from D-fructose.

Recommanded Product: 4-Bromobenzene-1,2-diamine, 4-Bromo-1,2-diaminobenzene can be obtained from 1,2-diaminobenzene via acetylation followed by bromination and alkaline hydrolysis.
4-Bromobenzene-1,2-diamine, also known as 4-Bromobenzene-1,2-diamine, is a useful research compound. Its molecular formula is C6H7BrN2 and its molecular weight is 187.04 g/mol. The purity is usually 95%.
4-Bromo-1,2-diaminobenzene is a dye that is used in diagnostic
procedures to detect the presence of amide groups. 4-Bromo-1,2-diaminobenzene can be used as an inhibitor for cationic polymerization reactions. It also has tuberculostatic activity and inhibits the growth of Mycobacterium tuberculosis. This compound reacts with aniline to form a benzimidazole derivative that contains a reactive amine group. The reaction between this amine group and different electrophiles generates benzimidazole compounds with different properties that are useful in nucleophilic attack reactions. The reaction between 4-bromo-1,2-diaminobenzene and methyl ethyl sulfide produces a luminescent probe that can be used to detect hydrogen bonds., 1575-37-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 70-23-5, formula is C5H7BrO3, The most pervasive is the naturally produced bromomethane. COA of Formula: C5H7BrO3

Rai, Ganesha;Urban, Daniel J.;Mott, Bryan T.;Hu, Xin;Yang, Shyh-Ming;Benavides, Gloria A.;Johnson, Michelle S.;Squadrito, Giuseppe L.;Brimacombe, Kyle R.;Lee, Tobie D.;Cheff, Dorian M.;Zhu, Hu;Henderson, Mark J.;Pohida, Katherine;Sulikowski, Gary A.;Dranow, David M.;Kabir, Md;Shah, Pranav;Padilha, Elias;Tao, Dingyin;Fang, Yuhong;Christov, Plamen P.;Kim, Kwangho;Jana, Somnath;Muttil, Pavan;Anderson, Tamara;Kunda, Nitesh K.;Hathaway, Helen J.;Kusewitt, Donna F.;Oshima, Nobu;Cherukuri, Murali;Davies, Douglas R.;Norenberg, Jeffrey P.;Sklar, Larry A.;Moore, William J.;Dang, Chi V.;Stott, Gordon M.;Neckers, Leonard;Flint, Andrew J.;Darley-Usmar, Victor M.;Simeonov, Anton;Waterson, Alex G.;Jadhav, Ajit;Hall, Matthew D.;Maloney, David J. research published 《 Pyrazole-Based Lactate Dehydrogenase Inhibitors with Optimized Cell Activity and Pharmacokinetic Properties》, the research content is summarized as follows. Lactate dehydrogenase (LDH) catalyzes the conversion of pyruvate to lactate, with concomitant oxidation of reduced NAD as the final step in the glycolytic pathway. Glycolysis plays an important role in the metabolic plasticity of cancer cells and has long been recognized as a potential therapeutic target. Thus, potent, selective inhibitors of LDH represent an attractive therapeutic approach. However, to date, pharmacol. agents have failed to achieve significant target engagement in vivo, possibly because the protein is present in cells at very high concentrations We report herein a lead optimization campaign focused on a pyrazole-based series of compounds, using structure-based design concepts, coupled with optimization of cellular potency, in vitro drug-target residence times, and in vivo PK properties, to identify first-in-class inhibitors that demonstrate LDH inhibition in vivo. The lead compounds, named NCATS-SM1440 (43)(I) and NCATS-SM1441 (52)(II), possess desirable attributes for further studying the effect of in vivo LDH inhibition.

COA of Formula: C5H7BrO3, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., 70-23-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic compounds having carbon bonded to bromine are called organic bromides. 5445-17-0, formula is C4H7BrO2, Name is Methyl 2-bromopropanoate. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Computed Properties of 5445-17-0.

Raffa, Patrizio;Kassi, Adamantia;Gosschalk, Julian;Migliore, Nicola;Polgar, Lorenzo Massimo;Picchioni, Francesco research published 《 A Structure-Properties Relationship Study of Self-Healing Materials Based on Styrene and Furfuryl Methacrylate Cross-Linked via Diels-Alder Chemistry》, the research content is summarized as follows. A series of copolymers of styrene and furfuryl methacrylate characterized by various mol. structures (linear and star, block and random) is synthesized via atom transfer radical polymerization, and cross-linked with a bismaleimide by means of thermally reversible Diels-Alder (DA) reaction, to obtain self-healing materials. The prepared materials are studied in terms of gelation, swelling, thermal, and dynamic-mech. anal., with the aim of correlating relevant properties to their chem. structure. It is found that the furan/styrene ratio, as well as the mol. architecture, have a major influence on the properties. It is also found that the reversibility of the DA reaction is not complete in the solid state for materials with high crosslinking d. This study provides some important tools for the design of materials characterized by thermally reversible behavior, which find usually application as self-healing thermosets, coatings, or adhesives.

5445-17-0, Methyl 2-bromopropionate, also known as Methyl 2-bromopropionate, is a useful research compound. Its molecular formula is C4H7BrO2 and its molecular weight is 167 g/mol. The purity is usually 95%.
Methyl 2-bromopropionate is used in the synthesis of poly(ADP-Ribose)polymerase inhibitors derived from benzoxazin-3-one. Also used in the synthesis of 5-HT2C antagonists affecting serotonin levels.
Methyl 2-bromopropanoate is a chemical compound that can be synthesized in an asymmetric manner. The reaction of methyl 2-bromopropanoate with hydrochloric acid gives the corresponding carboxylic acid, methyl propanoate, and hydrogen bromide in a 1:1 ratio. It has been shown that methyl 2-bromopropanoate is a potential catalyst for the reduction of chloride to chloride ion via the borohydride reduction method. Methyl 2-bromopropanoate has also been used as a model system for studying halides and copper complexes. Magnetic resonance spectroscopy studies have revealed that this chemical compound has a high redox potential and kinetic properties., Computed Properties of 5445-17-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 6911-87-1, formula is C7H8BrN, Name is 4-Bromo-N-methylaniline. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Safety of 4-Bromo-N-methylaniline.

Radhoff, Niklas;Studer, Armido research published 《 Oxindole synthesis via polar-radical crossover of ketene-derived amide enolates in a formal [3 + 2] cycloaddition》, the research content is summarized as follows. Simple, efficient and transition-metal free method for the preparation of valuable and sterically hindered 3,3-disubstituted oxindoles via polar-radical crossover of ketene derived amide enolates. Various easily accessible N-alkyl and N-arylanilines are added to disubstituted ketenes and the resulting amide enolates undergo upon single electron transfer oxidation a homolytic aromatic substitution (HAS) to provided 3,3-disubstituted oxindoles in good to excellent yields. A variety of substituted anilines and a 3-amino pyridine engage in this oxidative formal [3 + 2] cycloaddition and cyclic ketenes provided spirooxindoles. Both substrates and reagents were readily available and tolerance to functional groups was broad.

Safety of 4-Bromo-N-methylaniline, 4-Bromo-N-methylaniline is a aniline based compound known to exhibit mutagenic properties.
4-Bromo-N-methylaniline is a useful research compound. Its molecular formula is C7H8BrN and its molecular weight is 186.05 g/mol. The purity is usually 95%.
4-Bromophenylmethylamine is an organic compound that has anti-inflammatory properties and is used as a pharmaceutical. It belongs to the group of amines. The hydrolysis of 4-bromophenylmethylamine by hydrochloric acid produces phenol and bromamine (NHBr). The reaction system can be used to synthesize a number of compounds, including anilines, benzofurans, and other aromatic compounds. 4-Bromophenylmethylamine reacts with muscle tissue in a similar manner as acetaminophen does. This drug also has been shown to have significant effects on the energy metabolism in the muscles of rats that are given carbon source., 6911-87-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic compounds having carbon bonded to bromine are called organic bromides. 5392-10-9, formula is C9H9BrO3, Name is 2-Bromo-4,5-dimethoxybenzaldehyde. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Electric Literature of 5392-10-9.

Qu, Zhonghua;Tian, Tong;Tan, Yongbo;Ji, Xiaochen;Deng, Guo-Jun;Huang, Huawen research published 《 Redox-neutral ketyl radical coupling/cyclization of carbonyls with N-aryl acrylamides through consecutive photoinduced electron transfer》, the research content is summarized as follows. While the reductive ketyl couplings of carbonyls was widely explored,in this work on a redox-neutral umpolung carbonyl coupling reaction through ketyl radical formation by consecutive photoinduced electron transfer (ConPET) under metal- and additive-free conditions were reported. The donor-acceptor cyanoarene-based fluorophore, 1,2,3,5-tetrakis(carbazol-9-yl)-4,6-dicyanobenzene (4CzIPN), was used as an efficient photocatalyst. It undergoes ConPET to form the excited radical anion (4CzIPN -*) possessing high reductive potential without an external electron donor. This mild and simple photocatalytic system allows highly efficient coupling/cyclization of N-aryl acrylamides and carbonyls and provides straightforward access to structurally useful hydroxyalkyl oxindoles with formal 100% atom economy.

5392-10-9, 2-Bromo-4,5-dimethoxybenzaldehyde is a useful research compound. Its molecular formula is C9H9BrO3 and its molecular weight is 245.07 g/mol. The purity is usually 95%.
2-Bromo-4,5-dimethoxybenzaldehyde is a synthetic compound that has been shown to be an effective agent for inducing apoptosis in leukemia cells. It is an efficient method for synthesizing the compound and ha2-Bromo-4,5-dimethoxybenzaldehyde induces cell death by topoisomerase-mediated DNA cleavage, which results in chromosomal fragmentation and high levels of reactive oxygen species in the cell., Electric Literature of 5392-10-9

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary