Month: October 2022

Sun, Wangsheng; Zhu, Gongming; Hong, Liang; Wang, Rui published the artcile< The Marriage of Organocatalysis with Metal Catalysis: Access to Multisubstituted Chiral 2,5-Dihydropyrroles by Cascade Iminium/Enamine-Metal Cooperative Catalysis [Erratum to document cited in CA156:362840]>, Product Details of C9H7BrO, the main research area is erratum enantioselective aza Michael carbocyclization reaction unsaturated aldehyde tosylpropargylamine; organo metal cooperative catalyst enantioselective synthesis erratum; pyrrole aryl dihydro enantioselective synthesis erratum.

On page 13962, Reference 14 contained an incorrect CCDC number; the corrected number is given.

Chemistry – A European Journal published new progress about Amines, propargyl Role: RCT (Reactant), RACT (Reactant or Reagent). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Product Details of C9H7BrO.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Thanikachalam, Venugopal; Jayabharathi, Jayaraman; Karunakaran, Uthirapathy; Anudeebhana, Jagathratchagan; Thilagavathy, Shanmugam; Sivaraj, Seker published the artcile< Angular shaped AIE generator based luminophores for mechanochromism: An explosive sensor>, Reference of 3893-18-3, the main research area is aggregation induced emission enhancement generator based luminophore mechanochromism.

We have synthesized (E)-N,N-diphenyl-4-(2-(2-(4′-(1,2,2-triphenylvinyl)-[1,1′-biphenyl]- 4-yl)vinyl)- 1H-phenanthro[9,10-d]imidazol-1-yl)aniline (TPE-DBPPI) and (E)- 2-(4′-(2-(1-(4-(diphenylamino)phenyl)- 1H-phenanthro[9,10-d]imidazol-2-yl)vinyl)-[1,1′-biphenyl]- 4-yl)- 3,3-diphenylacrylonitrile (TPA-PPICN) consist of triphenylamine (donor), phenanthroimidazole (acceptor) and tetraphenylethylene (AIE generator). The twisted TPE-DBPPI and TPA-PPICN depict aggregation induced emission enhancement (AIEE) and demonstrated mechanochromic (MC) behavior between blue and green emission. The restricted-intramol.-rotation (RIR) of aryl rings of TPE (TPE-DBPPI) and TPA (TPA-PPICN) in the aggregated phase reduced the non-radiative relaxation channel hence, increase of emission intensity with high photoluminescence quantum yield (PLQY) in film state was observed The PLQY of TPE-DBPPI / TPA-PPICN in various phases are of 58/76% (pristine), 62/83% (grinding) and 65/88% (annealing). The film optical studies and powder XRD (PXRD) analyses implies that the change of twisted crystalline phase of TPE-DBPPI and TPA-PPICN to planar amorphous state results in mechanochromism. Also, these materials detect picric acid in aqueous and film owing to the proton-binding ability of azomethine nitrogen of imidazole which was confirmed by both NMR and DFT studies. The high neg. ΔGet [- 3.01 eV (TPE-DBPPI) and – 3.06 eV (TPA-PPICN)] indicates the thermodn. feasibility of photo electron transfer (PET) process.

Materials Today Communications published new progress about Absorption. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Reference of 3893-18-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Ikeuchi, Yutaka; Taguchi, Takeo; Hanzawa, Yuji published the artcile< Zirconocene-Mediated and/or Catalyzed Unprecedented Coupling Reactions of Alkoxymethyl-Substituted Styrene Derivatives>, Safety of Methyl 2-bromo-5-fluorobenzoate, the main research area is alkoxymethylstyrene alkoxy cleavage regioselective stereoselective homodimerization heterodimerization; hydrochrysene stereoselective preparation; aryl hydronaphthalene stereoselective preparation; zirconocene mediated stereoselective cyclization dimerization coupling ortho alkoxymethyl styrene; dependence product zirconocene mediated reaction alkoxymethyl styrene.

2-(Alkoxymethyl)styrenes I (R = H, Me; R1 = H, F, MeO; R2 = Me, PhCH2) undergo a variety of reactions involving cleavage of the alkoxy group with zirconocene generated from zirconocene dichloride and either butyllithium or butylmagnesium chloride. I (R = H) react with stoichiometric amounts of zirconocene to give 4-substituted-2-methylstyrenes or 4-substituted-2-(deuteromethyl)styrenes, while with two equivalent of zirconocene, I (R = R1 = H; R2 = PhCH2) gives 3-ethyl-1-(2-methylphenyl)butane or a trideuterated derivative; in the presence of catalytic zirconocene and 3 equivalent of butylmagnesium chloride, I (R = H; R1 = H, F; R2 = PhCH2) give mainly hexahydrochrysenes II (R = H; R1 = H, F) in 52-57% yields. In the presence of either catalytic or stoichiometric amounts of zirconocene, I (R = Me; R1 = H, F, MeO; R2 = Me, PhCH2) give II (R = Me; R1 = H, F, MeO) in 29-89% yields; with I (R = Me; R1 = F; R2 = Me), the aryltetrahydronaphthalene III {R1 = F; R3 = 2-[(MeO)Me2C]C6H4} is obtained in the presence of stoichiometric zirconocene in 28-50% yields as a single stereoisomer. I (R = Me; R1 = H; R2 = Me) couples with excess amounts of arylethylenes R3CH:CH2 [R3 = Ph, 4-FC6H4, 3,5-(F3C)2C6H3, 4-MeOC6H4, 2-MeOC6H4] in the presence of stoichiometric zirconocene to yield aryldihydronaphthalenes III [R1 = H; R3 = Ph, 4-FC6H4, 3,5-(F3C)2C6H3, 4-MeOC6H4, 2-MeOC6H4] in 11-85% yields (as single stereoisomers) in addition to 5-60% yields of II (R = Me; R1 = H).

Journal of Organic Chemistry published new progress about Aryl alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 6942-39-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H6BrFO2, Safety of Methyl 2-bromo-5-fluorobenzoate.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Schmidt, Michael A. published the artcile< Effect of Terminal Alkylation of Aryl and Heteroaryl Hydrazines in the Fischer Indole Synthesis>, Recommanded Product: Ethyl 5-bromothiophene-2-carboxylate, the main research area is Fischer indole synthesis; hydrazine ketone alkylation amidation cross coupling.

The effect of alkylation on the terminal position of aryl and heteroaryl hydrazines in the Fischer indole synthesis was examined Compared to their unalkylated counterparts, reactions using alkylated s provided indole products with higher yields and faster rates. The reactions can be conducted at lower temperatures and are compatible with acid-sensitive functionality. The terminally alkylated hydrazines were readily prepared by a new two-step sequence and held as stable hydrazinium salts. The mild formation of the salts along with the favorable Fischer indole reaction conditions highlights the potential of this approach in later-stage synthetic use.

Journal of Organic Chemistry published new progress about Alkylation. 5751-83-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H7BrO2S, Recommanded Product: Ethyl 5-bromothiophene-2-carboxylate.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wu, Ping; Zhang, Xueguo; Chen, Baohua published the artcile< Direct synthesis of 2,4,5-trisubstituted imidazoles and di/tri-substituted pyrimidines via cycloadditions of α,β-unsaturated ketones/aldehydes and N'-hydroxyl imidamides>, Application of C9H7BrO, the main research area is hydroxyamidine phenyl arylpropenone iron catalyst iodine promoter cycloaddition; aroyl phenylimidazole regioselective preparation green chem; unsaturated carbonyl compound hydroxyamidine iron catalyst cycloaddition green chem; diarylpyrimidine regioselective preparation.

An efficient route for the synthesis of 5-acetylimidazoles and di/trisubstituted pyrimidines via iron-catalyzed cross-dehydrogenative coupling (CDC), with excellent tolerance and yields was developed. α,β-Unsaturated aldehydes/ketones and N’-hydroxyl imidamides underwent [3+2] and [3+3] cycloadditions in two processes, involving iron-mediated Michael reaction, Robinson Annulation and 1,5-electrocyclization.

Tetrahedron Letters published new progress about [3+2] Cycloaddition reaction (regioselective). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Application of C9H7BrO.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhang, Jingjing; Yang, Jin-Dong; Cheng, Jin-Pei published the artcile< Exploiting the radical reactivity of diazaphosphinanes in hydrodehalogenations and cascade cyclizations>, Synthetic Route of 576-83-0, the main research area is arene preparation; aryl bromide hydrodehalogenation bis tertbutyl diazaphosphinane mediated; dihydro indene preparation chemoselective; bromide aryl cascade cyclization bis tertbutyl diazaphosphinane mediated.

Radical reactivity of diazaphosphinanes to implement hydrodehalogenations of aryl bromides and their cascade cyclization by hydride transfer was reported to give aromatic hydrocarbons R-H [R = Ph, 2-naphthyl, 4-MeOC6H4, etc.] and dihydro-indene derivatives I [X = NH, O, S]. These reactions featured a broad substrate scope, high efficiency and simplicity of manipulation. The radical reactivity of diazaphosphinanes disclosed here differed from their well-established hydridic reactivity and hence opened a new avenue for diazaphosphinane applications in organic syntheses.

Chemical Science published new progress about Aromatic hydrocarbons Role: SPN (Synthetic Preparation), PREP (Preparation). 576-83-0 belongs to class bromides-buliding-blocks, and the molecular formula is C9H11Br, Synthetic Route of 576-83-0.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Lu, Ru-Qiang; Wu, Shuang; Yang, Lin-Lin; Gao, Wen-Bin; Qu, Hang; Wang, Xiao-Ye; Chen, Jun-Bo; Tang, Chun; Shi, Hai-Yan; Cao, Xiao-Yu published the artcile< Stable Diindeno-Fused Corannulene Regioisomers with Open-Shell Singlet Ground States and Large Diradical Characters>, Related Products of 576-83-0, the main research area is diindeno corannulene regioisomer singlet triplet diradical crystal structure; corannulene; macrocycles; polycycles; radicals; structure elucidation.

The synthesis of open-shell polycyclic hydrocarbons with large diradical characters is challenging because of their high reactivities. Herein, two diindeno-fused corannulene regioisomers DIC-1 and DIC-2, curved fragments of fullerene C104, were synthesized that exhibit open-shell singlet ground states. The incorporation of the curved and non-alternant corannulene moiety within diradical systems leads to significant diradical characters as high as 0.98 for DIC-1 and 0.89 for DIC-2. Such high diradical characters can presumably be ascribed to the re-aromatization of the corannulene π system. Although the DIC compounds have large diradical characters, they display excellent stability under ambient conditions. The half-lives are 37 days for DIC-1 and 6.6 days for DIC-2 in solution This work offers a new design strategy towards diradicaloids with large diradical characters yet maintain high stability.

Angewandte Chemie, International Edition published new progress about Acylation, regioselective. 576-83-0 belongs to class bromides-buliding-blocks, and the molecular formula is C9H11Br, Related Products of 576-83-0.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Bolchi, Cristiano; Pallavicini, Marco; Rusconi, Chiara; Diomede, Luisa; Ferri, Nicola; Corsini, Alberto; Fumagalli, Laura; Pedretti, Alessandro; Vistoli, Giulio; Valoti, Ermanno published the artcile< Peptidomimetic inhibitors of farnesyltransferase with high in vitro activity and significant cellular potency>, Safety of 2-Bromo-4-nitrobenzoic acid, the main research area is peptidomimetic inhibitor farnesyltransferase antiproliferative aorta smooth muscle atherosclerosis.

2-O-Tolyl or 2-o-anisyl substituted 4-hydroxy- and 4-carboxybenzamides of methionine, etherified and amidified with 2-hydroxymethyl- and 2-aminomethylpyridodioxane, resp., are described as inhibitors of Ras protein farnesyltransferase (FTase). Of the sixteen compounds, resulting from the substitution pattern of benzamide and the configuration of the two stereocenters, seven inhibited FTase activity with potencies in the nanomolar range. They were all 2-oxymethylpyridodioxane ethers and, among them, the four o-tolyl substituted stereoisomers also showed micromolar antiproliferative effect on human aortic smooth muscle cells interfering with Ras farnesylation. The docking anal. enlightened significant differences in enzyme interaction between oxymethylpyridodioxane and aminomethylpyridodioxane derivatives

Bioorganic & Medicinal Chemistry Letters published new progress about Antiatherosclerotics. 16426-64-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrNO4, Safety of 2-Bromo-4-nitrobenzoic acid.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Achard, Thierry; Belokon’, Yuri N.; Fuentes, Jose A.; North, Michael; Parsons, Teresa published the artcile< Influence of aromatic substituents on metal(II)salen catalyzed, asymmetric synthesis of α-methyl α-amino acids>, Electric Literature of 81107-97-3, the main research area is amino acid methyl asym synthesis; alanine derivative asym benzylation salen copper catalyst mol structure; transition metal Schiff base complex catalyst preparation mol structure.

The influence of substituents on both the aromatic rings of the catalyst, and the benzylidene unit of the substrate are investigated in the (salen)copper(II) catalyzed asym. benzylation of alanine derivatives Catalysts with electron-donating, and electron-withdrawing substituents of various sizes and at various locations on the aromatic rings of the salen ligand were prepared, but all exhibited inferior enantioselectivity to the parent (salen)copper(II) complex. In contrast, the introduction of halogenated substituents onto the aromatic ring of the N-benzylidene alanine Me ester substrate was found to enhance the enantioselectivity of the alkylation with a para-chloro substituent giving optimal results. A new procedure for the preparation of the catalysts which avoids the need for chromatog. on sephadex LH20 is reported, and the optimal catalyst obtained in this way was found to be a cobalt(salen) complex.

Tetrahedron published new progress about Amino acids Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 81107-97-3 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3O, Electric Literature of 81107-97-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary