Month: October 2022

Park, Sangshin; Kang, Seokwoo; Kwon, Hyukmin; Lee, Seungeun; Park, Jongwook published their research in Journal of Nanoscience and Nanotechnology in 2021. The article was titled 《Anthracene green fluorescent derivatives based on optimized side groups for highly efficient organic light-emitting diode emitters》.Name: 9,10-Dibromoanthracene The article contains the following contents:

Two green fluorescent materials, N,N,N′,N′-Tetra-o-tolyl-anthracene-9,10-diamine (o-Me-TAD) and N,N′-bis(2,5-dimethylphenyl)-N,N′-di-o-tolylanthracene-9,10-diamine (DMe-o-Me-TAD) including anthracene and diphenylamine moiety, were synthesized by Buchwald-Hartwig amination. In solution state, PL maximum wavelength of o-Me-TAD and DMe-o-Me-TAD is 518 nm and 520 nm. The doped device using o-Me-TAD as green fluorescent dopant exhibited CE of 19.78 cd/A and EQE of 5.97%. The doped device using DMe-o-Me-TAD as dopant exhibited CE of 22.37 cd/A and EQE of 7.02% without roll-off. Doped devices fabricated using o-Me-TAD and DMe-o-Me-TAD show the EL peaks at 522 and 523 nm corresponding to the Commission Internationale de L′Eclairage (CIE) coordinates of (0.29, 0.63) and (0.27, 0.61). The results came from multiple reactions, including the reaction of 9,10-Dibromoanthracene(cas: 523-27-3Name: 9,10-Dibromoanthracene)

9,10-Dibromoanthracene(cas: 523-27-3) can be sublimated and oxidized to generate anthraquinone. Soluble in hot benzene and hot toluene, slightly soluble in alcohol, ether and cold benzene, insoluble in water.Name: 9,10-Dibromoanthracene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Schaeker-Huebner, Linda; Warstat, Robin; Ahlert, Heinz; Mishra, Pankaj; Kraft, Fabian B.; Schliehe-Diecks, Julian; Schoeler, Andrea; Borkhardt, Arndt; Breit, Bernhard; Bhatia, Sanil; Huegle, Martin; Guenther, Stefan; Hansen, Finn K. published their research in Journal of Medicinal Chemistry in 2021. The article was titled 《4-Acyl Pyrrole Capped HDAC Inhibitors: A New Scaffold for Hybrid Inhibitors of BET Proteins and Histone Deacetylases as Antileukemia Drug Leads》.SDS of cas: 17696-11-6 The article contains the following contents:

Multitarget drugs are an emerging alternative to combination therapies. In three iterative cycles of design, synthesis, and biol. evaluation, we developed a novel type of potent hybrid inhibitors of bromodomain, and extra-terminal (BET) proteins and histone deacetylases (HDACs) based on the BET inhibitor XD14 and well-established HDAC inhibitors. The most promising new hybrids, 49 and 61, displayed submicromolar inhibitory activity against HDAC1-3 and 6, and BRD4(1), and possess potent antileukemia activity. 49 induced apoptosis more effectively than the combination of ricolinostat and birabresib (1:1). The most balanced dual inhibitor, 61, induced significantly more apoptosis than the related control compounds 62 (no BRD4(1) affinity) and 63 (no HDAC inhibition) as well as the 1:1 combination of both. Addnl., 61 (I) was well tolerated in an in vivo zebrafish toxicity model. Overall, our data suggest an advantage of dual HDAC/BET inhibitors over the combination of two single targeted compounds In the experiment, the researchers used 8-Bromooctanoic acid(cas: 17696-11-6SDS of cas: 17696-11-6)

8-Bromooctanoic acid(cas: 17696-11-6) acid is used in the synthesis of 8-(N-Methyl-4,4′-bipyridinyl)- octanoic acid. 8-Mercaptooctanoic acid was prepared from 8-bromooctanoic acid. And 8-Bromooctanoic Acid is a useful compound for sonodynamic therapy.SDS of cas: 17696-11-6

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Xie, Yun-Dong; Xu, Yan-Hong; Liu, Ji-Ping; Wang, Bin; Shi, Yong-Heng; Wang, Wei; Wang, Xiao-Ping; Sun, Meng; Xu, Xin-Ya; Bian, Xiao-Li published their research in Bioorganic & Medicinal Chemistry Letters in 2021. The article was titled 《1,3-Benzodioxole-based fibrate derivatives as potential hypolipidemic and hepatoprotective agents》.Recommanded Product: Ethyl 5-bromovalerate The article contains the following contents:

A series of target compounds 1,3-benzodioxole-based fibrate derivatives were designed and synthesized. All the target compounds were preliminarily evaluated by hyperlipidemia mice induced by Triton WR-1339, in which compound I displayed a greater anti-hyperlipidemia activity than other compounds as well as pos. drug fenofibrate (FF). I showed a significant reduction of plasma lipids, such as triglycerides (TG), total cholesterol (TC) and low-d. lipoprotein cholesterin (LDL-C), in high fat diet (HFD) induced hyperlipidemic mice. In addition, hepatic transaminases (AST and ALT) were ameliorated after administration of I, in particular the AST, and the histopathol. examination showed that I improved the hepatic lipid accumulation. The expression of PPAR-α involved in lipids metabolism was up-regulated in the liver tissues of 12-treated group. Other significant activity such as antioxidant, and anti-inflammation was confirmed and reinforced the effects of I as a potential hypolipidemia and hepatoprotective agent.Ethyl 5-bromovalerate(cas: 14660-52-7Recommanded Product: Ethyl 5-bromovalerate) was used in this study.

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Recommanded Product: Ethyl 5-bromovalerate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Erdogan, Merve; Kilic, Burcu; Sagkan, Rahsan Ilikci; Aksakal, Fatma; Ercetin, Tugba; Gulcan, Hayrettin O.; Dogruer, Deniz S. published their research in European Journal of Medicinal Chemistry in 2021. The article was titled 《Design, synthesis and biological evaluation of new benzoxazolone/benzothiazolone derivatives as multi-target agents against Alzheimer’s disease》.Recommanded Product: 14660-52-7 The article contains the following contents:

In this study, four series of compounds I [R = N(Me)(Bn), N(CH2)2CH(Ph)(CH2)2, N(CH2)2N(Bn)(CH2)2, etc.; X = O, S], II [n = 2,3] and III with benzoxazolone and benzothiazolone cores were designed, synthesized and evaluated as multifunctional agents against Alzheimer’s disease (AD). Addnl., in order to shed light on the effect of the carbonyl groups of benzoxazolone/benzothiazolone, benzoxazole/benzothiazole-containing analogs were also synthesized and evaluated. Inhibition potency of all final compounds towards cholinesterase enzymes and their antioxidant activity were tested. Subsequently, the anti-inflammatory activity, cytotoxicity, apoptosis, and Aβ aggregation inhibition tests were also performed for selected compounds The results indicated that compounds II [R = N(CH2)2CH(Ph)(CH2)2, X = S, n = 3] and III [R = N(CH2)2CH(Ph)(CH2)2, X = S] were considered as promising multi-functional agents for further investigation against AD. The reversibility, kinetic and mol. docking studies were also performed for the compounds with the highest AChE III [R = N(CH2)2CH(Ph)(CH2)2, X = S] and BChE II [R = N(CH2)2CH(Ph)(CH2)2, X = S, n = 3] inhibitory activities.Ethyl 5-bromovalerate(cas: 14660-52-7Recommanded Product: 14660-52-7) was used in this study.

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Recommanded Product: 14660-52-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Park, Sangshin; Kwon, Hyukmin; Kang, Seokwoo; Park, Sunwoo; Jung, Hyocheol; Lee, Seungeun; Park, Jongwook published their research in Journal of Nanoscience and Nanotechnology in 2021. The article was titled 《Synthesis and electroluminescence property of anthracene green fluorescent derivatives based on optimized side groups》.Computed Properties of C14H8Br2 The article contains the following contents:

As new green fluorescent emitters, anthracenes I [R = 3-Me, 4-Me] were synthesized and the properties were evaluated. In solution state, photoluminescence (PL) maximum wavelength was 517 nm for I [R = 3-Me] and 529 nm for I [R = 4-Me] . In electroluminescence (EL) spectra, EL maximum wavelength of I [R = 3-Me] was 518 nm and I [R = 4-Me] was 533 nm. The doped device using I [R = 3-Me] as green fluorescent dopant exhibited current efficiency (CE) of 17.41 cd/A and external quantum efficiency (EQE) of 7.41%. The doped device with I [R = 4-Me] was optimized in order to achieve a green OLED with high efficiency. After reading the article, we found that the author used 9,10-Dibromoanthracene(cas: 523-27-3Computed Properties of C14H8Br2)

9,10-Dibromoanthracene(cas: 523-27-3) can be sublimated and oxidized to generate anthraquinone. Soluble in hot benzene and hot toluene, slightly soluble in alcohol, ether and cold benzene, insoluble in water.Computed Properties of C14H8Br2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Baiula, Monica; Cirillo, Martina; Martelli, Giulia; Giraldi, Valentina; Gasparini, Elisa; Anelli, Alessandro Claudio; Spampinato, Santi Mario; Giacomini, Daria published their research in ACS Pharmacology & Translational Science in 2021. The article was titled 《Selective Integrin Ligands Promote Cell Internalization of the Antineoplastic Agent Fluorouracil》.Recommanded Product: 5437-45-6 The article contains the following contents:

Drug conjugates consisting of an antineoplastic drug and a targeting receptor ligand could be effective to overcome the heavy side effects of unselective anticancer agents. To address this need, we report here the results of a project aimed to study agonist and antagonist integrin ligands as targeting head of mol. cargoes for the selective delivery of 5-fluorouracil (5-FU) to cancer or noncancer cells. Initially, two fluorescent β-lactam-based integrin ligands were synthesized and tested for an effective and selective internalization mediated by α4β1 or α5β1 integrins in Jurkat and K562 cells, resp. No cellular uptake was observed for both fluorescent compounds in HEK293 noncancerous control cells. Afterward, three conjugates composed of the β-lactam-based integrin ligand, suitable linkers, and 5-FU were realized. The best compound E (I), acting as α5β1 integrin agonist, is able to selectively deliver 5-FU into tumor cells, successfully leading to cancer cell death. The results came from multiple reactions, including the reaction of Benzyl 2-bromoacetate(cas: 5437-45-6Recommanded Product: 5437-45-6)

Benzyl 2-bromoacetate(cas: 5437-45-6) belongs to benzyl acetate. Benzyl acetate is an aromatic chemical, usually appearing as a clear liquid with a moderate sweet-jasmine fragrance. This compound appears as a component of some of our fragrance blends.Recommanded Product: 5437-45-6

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Song, Xianghai; Zhang, Xinyu; Wang, Mei; Li, Xin; Zhu, Zhi; Huo, Pengwei; Yan, Yongsheng published their research in Journal of Colloid and Interface Science in 2021. The article was titled 《Fabricating intramolecular donor-acceptor system via covalent bonding of carbazole to carbon nitride for excellent photocatalytic performance towards CO2 conversion》.Recommanded Product: 3,6-Dibromo-9H-carbazole The article contains the following contents:

Photocatalytic conversion of CO2 into hydrocarbon fuels is an ideal technol. of mitigating greenhouse effect caused by excessive emission of CO2. However, the high recombination rate of electron-hole pairs and limited charge carriers transport speed constrained the catalytic performance of many semiconductor catalysts. In this contribution, a series of carbon nitride (g-CN) samples with intramol. donor-acceptor (D-A) system were successfully prepared by introducing organic donor into their structures. Characterization results confirmed that carbazole was successful connected to the structure of g-CN via chem. bond. The formation of intramol. D-A system greatly enlarged the light response region of g-CN-xDbc. In addition, a new charge transfer transition mode was formed in g-CN-0.01Dbc due to the incorporation carbazole, which enable it to use light with energy lower than the intrinsic absorption of g-CN. Meanwhile, the D-A structure led to the spatial separation of electrons and holes in g-CN-xDbc and significantly decreased the recombination rate of electron-hole pairs. The g-CN-0.01Dbc presented the best catalytic performance and the CO evolution rate was 9.6 times higher than that of g-CN. Moreover, the reaction was performed in water without any additive, which made it green and sustainable. DFT simulation confirmed the D-A structure and charge carrier migration direction in the prepared samples. After reading the article, we found that the author used 3,6-Dibromo-9H-carbazole(cas: 6825-20-3Recommanded Product: 3,6-Dibromo-9H-carbazole)

3,6-Dibromo-9H-carbazole(cas: 6825-20-3) is used as a reagent in the synthesis of P7C3-A20 which is a potent neuroprotective agent. And it has been used in the preparation of N-(2-hydroxyethyl)-3,6-dibromocarbazole.Recommanded Product: 3,6-Dibromo-9H-carbazole

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Espina-Casado, Jorge; Fernandez-Gonzalez, Alfonso; Diaz-Garcia, Marta E.; Badia-Laino, Rosana published their research in Sensors and Actuators, B: Chemical in 2021. The article was titled 《Smart carbon dots as chemosensor for control of water contamination in organic media》.Name: Methyl 3-bromopropanoate The article contains the following contents:

A novel nanoprobe was synthesized by functionalizing gluthatione/citric acid-carbon dots (CDs) with a benzo-isoquinolin-based mol., Me 3-(4-(2-(5-((methylsulfonyl)oxy)pentyl)-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinolin-6-yl)piperazin-1-yl)propanoate (water chemosensor, WCS), to detect trace amounts of water in non-aqueous media via on-off fluorescence. The design and synthesis of the free mol. WCS and the functionalized nanoprobe (CD-WCS) are described in detail and as well as their full characterization by different spectroscopic methods. WCS was found to be an excellent indicator of pH in aqueous media and exhibited, in solvents of different polarity, solvatochromic behavior. On the other hand, the modified fluorescence intensity of CD-WCS was found to be an excellent indicator for water in non-aqueous media (organic solvents and oil-based lubricants). In these media, CD-WCS showed weak fluorescence intensity due to a photoinduced electron transfer (PET) process. Sequential addition of trace amount of water led to revival of CD-WCS fluorescence intensity. The fluorescence on-off mechanisms are proposed for WCS in aqueous media as well as for CD-WCS in non-aqueous media. The anal. performance characteristics of CD-WCS showed a limit of detection for water of 0.00021% (volume/volume) in toluene and 0.00014% volume/volume in base-oil lubricant. The potential application of CD-WCS as chemosensor of water contamination in oil-based lubricants as well as green anti-wear/anti-friction lubricant additive are outlined. The experimental part of the paper was very detailed, including the reaction process of Methyl 3-bromopropanoate(cas: 3395-91-3Name: Methyl 3-bromopropanoate)

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Name: Methyl 3-bromopropanoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Abdul-Amir, R. M.; Al-Hassan, N. M. Abdu; Ghadban, H. published their research in Journal of Physics: Conference Series in 2021. The article was titled 《Synthesis of some new heterocyclic compounds derived from p-chlorobenzoylchloride and investigation of biological effectiveness》.Formula: C7H5BrO The article contains the following contents:

1,3-Oxazole-5-one blends I [R = 2-Cl, 3-O2N, 2-Br] were set up by cyclization of compound {[(4-chlorophenyl)carbonyl]amino}acetic acid with aromatic aldehyde auxiliaries. The starting compound {[(4-chlorophenyl)carbonyl]amino}acetic acid was expeditiously procured by the reaction of 4-chlorobenzoylchloride with aminoacetic acid. Blends I were changed over into a grouping of subordinates by the reaction with ethylenediamine to masterminded II [R1 = 2-Cl, 3-O2N, 2-Br; R2 = H2N] which then on reaction with aromatic aldehyde subsidiaries form organized II [R1 = 2-Cl, 3-O2N, 2-Br; R2 = (2-chlorophenyl)methyleneamino, (3-nitrophenyl)methyleneamino, (2-bromophenyl)methyleneamino]. Each new compound was depicted by proton at. attractive reverberation (1H-NMR), Fourier changes IR spectroscopy (FTIR) and UV spectroscopy. In addition to this study using o-Bromobenzaldehyde, there are many other studies that have used o-Bromobenzaldehyde(cas: 6630-33-7Formula: C7H5BrO) was used in this study.

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Formula: C7H5BrOSynthetic applications of o-Bromobenzaldehyde include: synthesis of aza-fused polycyclic quinolines through copper-catalyzed cascade reaction, preparation of 1-substituted indazoles by CuI-catalyzed coupling with N-aryl hydrazides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Percec, Virgil; Wang, Shitao; Huang, Ning; Partridge, Benjamin E.; Wang, Xuefeng; Sahoo, Dipankar; Hoffman, David J.; Malineni, Jagadeesh; Peterca, Mihai; Jezorek, Ryan L.; Zhang, Na; Daud, Hina; Sung, Paul D.; McClure, Emily R.; Song, Se Lin published their research in Journal of the American Chemical Society in 2021. The article was titled 《An Accelerated Modular-Orthogonal Ni-Catalyzed Methodology to Symmetric and Nonsymmetric Constitutional Isomeric AB2 to AB9 Dendrons Exhibiting Unprecedented Self-Organizing Principles》.Application of 2675-79-8 The article contains the following contents:

Three libraries consisting of 30 sym. and nonsym. constitutional isomeric phenolic acids with unprecedented sequenced patterns, including two AB2, three AB3, eight AB4, five AB5, six AB6, three AB7, two AB8, and one AB9 synthesized by accelerated modular-orthogonal Ni-catalyzed borylation and cross-coupling were reported. A single etherification step with 4-(n-dodecyloxy)benzyl chloride transformed all these phenolic acids, of interest also for other applications, into self-assembling dendrons. Despite this synthetic simplicity, they led to a diversity of unprecedented self-organizing principles: lamellar structures of interest for biol. membrane mimics, helical columnar assemblies from rigid-solid angle dendrons forming Tobacco Mosaic Virus-like assemblies, columnar organizations from adaptable-solid angle dendrons forming disordered micellar-like nonhelical columns, columns from supramol. spheres, five body-centered cubic phases displaying supramol. orientational memory, rarely encountered in previous libraries forming predominantly Frank-Kasper phases, and two Frank-Kasper phases. Lessons from these self-organizing principles, discovered within a single generation of self-assembling dendrons, might help elaborate design principles for complex helical and nonhelical organizations of synthetic and biol. matter. In the part of experimental materials, we found many familiar compounds, such as 1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8Application of 2675-79-8)

1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.Application of 2675-79-81-Bromo-3,4,5-trimethoxybenzene can be used to synthesize N,N′-diarylated indolo[3,2-b]carbazole derivatives, which can find applications in electrophotography.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary