Month: October 2022

Liu, Yun-Mei; Li, Yang; Liu, Rong-Fang; Xiao, Jie; Zhou, Bin-Ning; Zhang, Qi-Zhi; Song, Jian-Xin published their research in Journal of Asian Natural Products Research in 2021. The article was titled 《Synthesis, characterization and preliminary biological evaluation of chrysin amino acid derivatives that induce apoptosis and EGFR downregulation》.Product Details of 14660-52-7 The article contains the following contents:

Chrysin amino acid derivatives were synthesized to evaluate for their antiproliferative activities. Among them, N-(7-((5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy)valeryl)-L-leucine () displayed the most remarkable inhibitory activities against MCF-7 cells with IC50 values of 16.6 microM. Preliminary mechanistic studies showed that could inhibit the colony formation and migration of MCF-7 cells. Flow cytometry anal. demonstrated that mediated cell apoptosis and the prolongation of cell cycle progression in G1/S-phase against MCF-7 cells. Besides, displayed the moderate inhibition against EGFR. Western blot assay suggested that significantly inhibited EGFR phosphorylation. Mol. docking showed that can bind the EGFR kinase well. In addition to this study using Ethyl 5-bromovalerate, there are many other studies that have used Ethyl 5-bromovalerate(cas: 14660-52-7Product Details of 14660-52-7) was used in this study.

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Product Details of 14660-52-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Liu, Chenguang; Wang, Mingyang; Liu, Shihan; Wang, Yujie; Peng, Yong; Lan, Yu; Liu, Qiang published their research in Angewandte Chemie, International Edition in 2021. The article was titled 《Manganese-Catalyzed Asymmetric Hydrogenation of Quinolines Enabled by π-π Interaction**》.Synthetic Route of C5BrMnO5 The article contains the following contents:

The non-noble metal-catalyzed asym. hydrogenation of N-heteroaromatics, quinolines, is reported. A new chiral pincer manganese catalyst showed outstanding catalytic activity in the asym. hydrogenation of quinolines, affording high yields and enantioselectivities (up to 97% ee). A turnover number of 3840 was reached at a low catalyst loading (S/C=4000), which is competitive with the activity of most effective noble metal catalysts for this reaction. The precise regulation of the enantioselectivity were ensured by a π-π interaction. In the experimental materials used by the author, we found Bromopentacarbonylmanganese(I)(cas: 14516-54-2Synthetic Route of C5BrMnO5)

Bromopentacarbonylmanganese(I)(cas: 14516-54-2) has many other uses. It is used in the formation of (eta6-arene)tricarbonylmanganese(I) by reacting with arene (arene= hexamethyl benzene, 1,2,4,5-tetramethyl benzene, mesitylene, p-xylene and toluene) in the presence silver salt.Synthetic Route of C5BrMnO5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wickrama-Arachchige, Anura Upasanta-Kumara; Guruge, Keerthi S.; Inagaki, Yuriko; Tani, Hinako; Dharmaratne, Tilak Siri; Niizuma, Yasuaki; Ohura, Takeshi published their research in Food Chemistry in 2021. The article was titled 《Halogenated polycyclic aromatic hydrocarbons in edible aquatic species of two Asian countries: Congener profiles, biomagnification, and human risk assessment》.Application In Synthesis of 9,10-Dibromoanthracene The article contains the following contents:

Seventy-five contaminants including chlorinated/brominated/parent polycyclic aromatic hydrocarbons (Cl/Br/PAHs) were investigated in 29 edible aquatic species from the Indian Ocean near Sri Lanka and 10 species from the Pacific Ocean near Japan. Concentrations of total ClPAHs and BrPAHs in the samples were 2.6-57 and 0.30-9.5 ng/g-dry weight from the Indian Ocean, and 0.35-18 and 0.03-3.3 ng/g-dry weight from the Pacific Ocean, resp. Comparing the profiles of Cl/BrPAHs among the samples, congeners of chlorinated and brominated pyrene were predominant components and enhanced the potential for biomagnification in the sample from the off-shore pelagic environment in the Indian Ocean. The incremental lifetime cancer risks estimated by intake of the targets in consuming aquatic organisms showed that approx. one-third of studied organisms exceeded the acceptable risk level for Sri Lankans. In the experiment, the researchers used many compounds, for example, 9,10-Dibromoanthracene(cas: 523-27-3Application In Synthesis of 9,10-Dibromoanthracene)

9,10-Dibromoanthracene(cas: 523-27-3) can be sublimated and oxidized to generate anthraquinone. Soluble in hot benzene and hot toluene, slightly soluble in alcohol, ether and cold benzene, insoluble in water.Application In Synthesis of 9,10-Dibromoanthracene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wang, Bingbing; Peng, Pan; Ma, Wan; Liu, Zhao; Huang, Cheng; Cao, Yangmin; Hu, Ping; Qi, Xiaotian; Lu, Qingquan published their research in Journal of the American Chemical Society in 2021. The article was titled 《Electrochemical Borylation of Alkyl Halides: Fast, Scalable Access to Alkyl Boronic Esters》.HPLC of Formula: 14660-52-7 The article contains the following contents:

Herein, a fast, scalable, and transition-metal-free borylation of alkyl halides (X = I, Br, Cl) enabled by electroreduction is reported. This process provides an efficient and practical access to primary, secondary, and tertiary boronic esters at a high current. More than 70 examples, including the late-stage borylation of natural products and drug derivatives, are furnished at room temperature, thereby demonstrating the broad utility and functional-group tolerance of this protocol. Mechanistic studies disclosed that B2cat2 serves as both a reagent and a cathodic mediator, enabling electroreduction of difficult-to-reduce alkyl bromides or chlorides at a low potential. The experimental process involved the reaction of Ethyl 5-bromovalerate(cas: 14660-52-7HPLC of Formula: 14660-52-7)

Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.HPLC of Formula: 14660-52-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

McCurdy, Ryan D.; Jacobse, Peter H.; Piskun, Ilya; Veber, Gregory C.; Rizzo, Daniel J.; Zuzak, Rafal; Mutlu, Zafer; Bokor, Jeffrey; Crommie, Michael F.; Fischer, Felix R. published an article in 2021. The article was titled 《Synergetic Bottom-Up Synthesis of Graphene Nanoribbons by Matrix-Assisted Direct Transfer》, and you may find the article in Journal of the American Chemical Society.Product Details of 523-27-3 The information in the text is summarized as follows:

The scope of graphene nanoribbon (GNR) structures accessible through bottom-up approaches is defined by the intrinsic limitations of either all-on-surface or all-solution-based synthesis. Here, we report a hybrid bottom-up synthesis of GNRs based on a Matrix-Assisted Direct (MAD) transfer technique that successfully leverages tech. advantages inherent to both solution-based and on-surface synthesis while sidestepping their drawbacks. Critical structural parameters tightly controlled in solution-based polymerization reactions can seamlessly be translated into the structure of the corresponding GNRs. The transformative potential of the synergetic bottom-up approaches facilitated by the MAD transfer techniques is highlighted by the synthesis of chevron-type GNRs (cGNRs) featuring narrow length distributions and a nitrogen core-doped armchair GNR (N4-7-ANGR) that remains inaccessible using either a solution-based or an on-surface bottom-up approach alone. The results came from multiple reactions, including the reaction of 9,10-Dibromoanthracene(cas: 523-27-3Product Details of 523-27-3)

9,10-Dibromoanthracene(cas: 523-27-3) is synthesized by the bromination of anthracene. The bromination reaction is carried out at room temperature using carbon tetrachloride as a solvent. Using 80-85% anthracene as raw material, adding bromine to react for half an hour, the yield is 83-88%.Product Details of 523-27-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Pecnard, Shannon; Provot, Olivier; Levaique, Helene; Bignon, Jerome; Askenatzis, Laurie; Saller, Francois; Borgel, Delphine; Michallet, Sophie; Laisne, Marie-Catherine; Lafanechere, Laurence; Alami, Mouad; Hamze, Abdallah published an article in 2021. The article was titled 《Cyclic bridged analogs of isoCA-4: Design, synthesis and biological evaluation》, and you may find the article in European Journal of Medicinal Chemistry.Related Products of 2675-79-8 The information in the text is summarized as follows:

In this work, a series of cyclic bridged analogs of isocombretastatin A-4 (isoCA-4) with Ph or pyridine linkers were designed and synthesized. The synthesis of the desired analogs was performed by the formation of nitro-vinyl intermediates, followed by a Cadogan cyclization. Structure activity relationship (SAR) study demonstrates the critical role of the combination of quinaldine as ring A, pyridine as the linker, and indole as ring B in the same mol., for the cytotoxic activity. Among all tested compounds, compound I showed the highest antiproliferative activity against a panel of cancer cell lines with average IC50 values of 5.6 nM. Also, compound I showed high antiproliferative activity against the MDR1-overexpressing K562R cell line; thus, it was 1.5- and 12-fold more active than the reference compounds, isoCA-4 and CA-4, resp. Moreover, I displayed a strong antiproliferative activity against the colon-carcinoma cells (HT-29), which are resistant to combretastatin A-4 and isoCA-4, and it was found to be 8000-fold more active than natural CA-4. Compound I also effectively inhibited tubulin polymerization both in vitro and in cells, and induced cell cycle arrest in G2/M phase. Next, we demonstrated that compound I dose-dependently caused caspase-induced apoptosis of K562 cells through mitochondrial dysfunction. Finally, we evaluated the effect of compound I in human no cancer cells compared to the reference compound We demonstrated that I was 73 times less cytotoxic than isoCA-4 in quiescent peripheral blood lymphocytes (PBLs). In summary, these results suggest that compound I represents a promising tubulin inhibitor worthy of further investigation. In the experiment, the researchers used 1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8Related Products of 2675-79-8)

1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.Related Products of 2675-79-81-Bromo-3,4,5-trimethoxybenzene can be used to synthesize analogs of HA14-1, which shows promising anticancer properties.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,King, Andrew J.; Zhukhovitskiy, Aleksandr V. published an article in Angewandte Chemie, International Edition. The title of the article was 《A Chain-Growth Mechanism for Conjugated Polymer Synthesis Facilitated by Dinuclear Complexes with Redox-Active Ligands》.Synthetic Route of C4H2Br2S The author mentioned the following in the article:

Conjugated polymers are widely used in energy conversion and sensor applications, but their synthesis relies on imprecise step-growth or narrow-scope chain-growth methods, typically based on transition metal (TM)-catalyzed cross-coupling. Here we report that a dinickel complex with a redox-active naphthyridine diimine ligand accesses new chain-growth mechanistic manifolds for both donor and acceptor conjugated polymers, represented by poly(3-hexylthiophene), poly(2,3-bis(2-ethylhexyl)thienopyrazine), and poly(2-(2-octyldodecyl)benzotriazole). For the latter, our method is particularly effective: we achieve high ds.p. (DP) (>100) with moderate dispersities (D) of ≈1.4. Mechanistic anal. supports a radical/radical anion chain-growth mechanism with organometallic intermediates instead of TM-catalyzed cross-couplings. Hence, our work develops new mechanisms for conjugated polymer synthesis and furnishes insights about the elementary reactivity of dinuclear complexes.2,5-Dibromothiophene(cas: 3141-27-3Synthetic Route of C4H2Br2S) was used in this study.

2,5-Dibromothiophene(cas: 3141-27-3) , is mainly used as pharmaceutical intermediate and synthesis intermediate. 2,5-Dibromothiophene may be used in the preparation of soluble α,ω-diformyl-a-oligothiophenes.Synthetic Route of C4H2Br2S

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Xue, Cece; Peng, Min; Zhang, Zhikai; Han, Xue; Wang, Qing; Li, Conger; Liu, Haiming; Li, Tao; Yu, Na; Ren, Yi published an article in Macromolecules (Washington, DC, United States). The title of the article was 《Conjugated Boron Porous Polymers Having Strong p-π* Conjugation for Amine Sensing and Absorption》.Recommanded Product: 3141-27-3 The author mentioned the following in the article:

Conjugated porous polymers (CPPs) have drawn significant attention in materials science. We envisioned that simple building blocks may provide a more general platform for constructing functional CPPs. Herein, we report a new synthetic strategy to incorporate a simple boron element building block into CPPs by using efficient boron/tin (B/Sn) exchange reaction, which is distinct from the commonly employed Pd-catalyzed C-C coupling toward CPPs in the literature. More importantly, this synthetic strategy allows us to construct the first example of the CPPs having the nonprotected B-centers and the highest B-content reported to date, which is beneficial for strong Lewis acid-base interactions. The boron (B)-CPPs exhibit the well-defined chem. structures and the microsized porous structures. This synthetic protocol also allows us to access the B-CPPs having the smallest aromatic linker between the B-centers, which can enhance the electronic communications of the adjacent B-centers and increase Lewis acidity of the B-centers. Because of the strong electronic communications of the adjacent B-centers via the p-π* coupling, the B-CPPs exhibit higher Lewis acidity compared to that of the B-monomer. Combining the high microporosity, the high Lewis acidity, and small steric protection of the B-centers endows these B-CPPs with excellent triethylamine and pyridine sensing and absorptivity properties.2,5-Dibromothiophene(cas: 3141-27-3Recommanded Product: 3141-27-3) was used in this study.

2,5-Dibromothiophene(cas: 3141-27-3) , is mainly used as pharmaceutical intermediate and synthesis intermediate. 2,5-Dibromothiophene may be used in the preparation of soluble α,ω-diformyl-a-oligothiophenes.Recommanded Product: 3141-27-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Cromwell, Simon; Sutio, Randy; Zhang, Changhe; Such, Georgina K.; Lupton, David W. published an article in Angewandte Chemie, International Edition. The title of the article was 《Lewis Base Catalyzed Synthesis of Sulfur Heterocycles via the C1-Pyridinium Enolate》.Formula: C4H7BrO2 The author mentioned the following in the article:

Herein, a reaction cascade in which a C1-pyridinium enolate undergos addition to dithioesters, trithiocarbonates and xanthates was reported. The reaction provided access to a range of dihydrothiophenes I [R = cyclohexyl, Ph, SBn, etc.; R1 = R2 = H; R1 = Me; R2 = CN, Ph] and dihydrothiopyrans II [R3 = H, Me, OMe, F] and III [R4 = H, Me, F]. Mechanistic investigations, including isolation of intermediates, electronic correlation, and kinetic isotope effect studies support the viability of an activated acid intermediate giving rise to the C1-pyridinium enolate which undergoes turnover limiting cyclization. Subsequent formation of a β-thiolactone regenerates the catalyst with loss of carbon oxysulfide providing the observed products. The experimental part of the paper was very detailed, including the reaction process of 4-Bromobutanoic acid(cas: 2623-87-2Formula: C4H7BrO2)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Formula: C4H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Echemendia, Radell; De Jesus, Matheus P.; Furniel, Lucas G.; Day, David Philip; Burtoloso, Antonio C. B. published an article in European Journal of Organic Chemistry. The title of the article was 《Molecular Iodine Mediated Oxidation of Arylated α-Carbonyl Sulfoxonium Ylides to 1,2-Dicarbonyl-Containing Compounds》.Category: bromides-buliding-blocks The author mentioned the following in the article:

In this work, a new oxidative, mol. iodine-mediated transformation on sterically encumbered arylated sulfoxonium ylides, which give access to 1,2-dicarbonyl containing compounds was reported. Twenty-six examples were realized (47-92% yields), with structural diversity modified at two key sites on the sulfoxonium ylide reactants. Furthermore, the protocol benefits from the use of inexpensive mol. iodine to mediate the oxidation and, from a sustainability viewpoint, short reaction times (30 min), ambient temperature, and Et acetate as a greener reaction solvent. Exptl. studies also gave insight to the mechanism of the reaction, involving DMSO as an oxygen source. The results came from multiple reactions, including the reaction of 5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4Category: bromides-buliding-blocks)

Furthermore, the coupling of 5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4) with β-methallyl alcohol was catalyzed by Pd(OAc)2 in combination with P(t-Bu)3.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary